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Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy:A retrospective study

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World Journal of Gastroenterology 2022年第15期28卷 1574-1587页

作者： Zi-Bo yuan Hong-Bo Fang Quan-Kai Feng tao Li Jie Li Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Henan Research Centre for Organ Transplantation the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant *** is an effective treatment for early ICC,but postoperative recurrence greatly affects patient *** on recurrent ICC after hepatectomy are *** To investigate the clinical characteristics of patients with recurrent ICC after hepatectomy,analyse prognostic factors and explore diagnosis and treatment *** A retrospective analysis was performed on all ICC patients undergoing hepatectomy from January 2013 to August *** with postoperative recurrence were selected according to the inclusion and exclusion *** overall survival was plotted by the Kaplan-Meier method,and differences were assessed by univariate survival analysis using the log-rank *** analysis of cumulative survival was performed using the Cox proportional risk *** During the 8-year study period,103 patients underwent ICC-related hepatectomy,and 54 exhibited postoperative *** median disease-free survival(DFS)was 6 mo,the median overall survival(OS)was 9 mo,and the cumulative OS rates at 1,2 and 3 years after the operation were 40.7%,14.8%and 7.4%,*** median OS after recurrence was 4 mo,and the cumulative OS rates at 1,2 and 3 years after recurrence were 16.1%,6.7%and 3.4%,*** analysis showed that alcohol consumption[hazard ratio(HR)=4.64,95%confidence interval(CI):1.53-14.04,P=0.007]and DFS<6 mo(HR=3.47,95%CI:1.59-7.60,P=0.002)were independent risk factors for the cumulative survival of patients with recurrence,while treatment after recurrence(HR=0.21,95%CI:0.08-0.55,P=0.001)was an independent protective *** median OS time of patients receiving multimodality therapy after recurrence of ICC was 7 mo,which was significantly higher than that of patients receiving only local therapy(3 mo),patients receiving systematic therapy(4 mo)and patients receiving the best supportive therapy(1 mo).Patients

关键词： Intrahepatic cholangiocarcinoma Hepatectomy Recurrence Multimodality therapy Prognosis

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2022年第2期12卷 558-580页

作者： Danyu Du Chan Liu Mengyao Qin Xiao Zhang tao Xi Shengtao yuan Haiping Hao Jing Xiong Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Research Center of Biotechnology School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Screening China Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjing 210009China

Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence *** efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of ***,limitations exist in current strategies including chemoresistance for *** initiation and progression is driven by reprogramming of metabolism,in particular during HCC ***,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC *** this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical *** also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC ***,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed.

关键词： Metabolic dysregulation Hepatocellular carcinoma Glycolysis Tricarboxylic acid cycle Pentose phosphate pathway Fatty acidβ-oxidation Glutamine metabolism Cancer therapy

高职院校传统文化教育融入新时代工匠精神的育人机制研究

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文化创新比较研究 2021年第8期5卷 134-136页

作者：李新赵艳辉练琪琪袁涛王文芬李久霖滕晓丽江苏建筑职业技术学院江苏徐州221116 中电建生态环境集团有限公司广东深圳518102

从探寻传统文化与新时代工匠精神融合育人的角度入手,围绕高职院校传统文化教育体系、高职院校传统文化教育现状调查、高职院校一体化融合育人的机制构建3个方面,探讨传统文化对人文素养形成的促进作用,分析传统文化与工匠精神融合的体... 详细信息

从探寻传统文化与新时代工匠精神融合育人的角度入手,围绕高职院校传统文化教育体系、高职院校传统文化教育现状调查、高职院校一体化融合育人的机制构建3个方面,探讨传统文化对人文素养形成的促进作用,分析传统文化与工匠精神融合的体制,阐述存在的问题及成因,为合理构建研究体系提供现实依据,提出了在新时代高职院校一体化融合育人机制构建的路径及建议。

关键词：传统文化新时代工匠精神融合一体化育人机制

Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease

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Chinese Journal of Natural Medicines 2022年第2期20卷 111-119页

作者： WEN Jing ZHANG yuan-Qiang LIU Dong-Qing YAO Xu-tao JIANG Hua ZHANG Yu-Bin Department of Biochemistry School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China

Parkinson’s disease(PD)is a multifactorial disorder of the nervous system where a progressive loss of dopaminergic neurons ***,the pathogenesis of PD remains undefined,which becomes the main limitation for the development of clinical PD ***(DMTHB)is a novel derivative of natural product *** study was aimed to explore the neuroprotective effects and pharmacological mechanism of DMTHB on Parkinson’s disease using C57BL/6 mice.A PD model of mice was induced by administration of MPTP(20 mg·kg^(-1))and probenecid(200 mg·kg^(-1))twice per week for five *** mice were administered with DMTHB daily by gavage at the dose of 5 and 50 mg·kg^(-1)for one-week prophylactic treatment and five-week theraputic *** therapeutic effects of DMTHB were evaluated by behavior tests(the open field,rotarod and pole tests),immunohistochemical staining of tyrosine hydroxylase(TH),Nissl staining and biochemical *** molecular mechanisms of DMTHB on the key biomarkers of PD pathological states were analyzed by Western blot(WB)and *** treatment alleviated the behavioral disorder induced by *** staining and TH staining showed that the damage of dopaminergic neurons in the substantia nigra was remarkably suppressed by DMTHB *** blot results showed that the ratio of Bcl-2/Bax and TH increased,but the level ofα-synuclein(α-syn)was remarkably reduced,which indicated that the apoptosis of dopaminergic neurons in mice was significantly *** protein phosphorylation of p-PI3K,p-AKT and p-mTOR also increased about 2-fold,compared with the model ***,qRT-PCR results demonstrated that the mRNA levels of pro-inflammatory cytokines,IL-1βand TNF-α,were reduced,but the level of anti-inflammatory cytokine IL-10 increased after DMTHB ***,the cellular assay displayed that DMTHB was also a strong antioxidant to protect neuron cell line PC12 by scavenging *** th

关键词： Demethylenetetrahydroberberine Parkinson's disease Dopaminergic neurons Apoptosis Neuroinflammation

Effect of aspect ratio of elliptical stirred vessel on mixing time and flow field characteristics in the absence of baffles

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Chinese Journal of Chemical Engineering 2024年第1期65卷 63-74页

作者： yuan Yao Peiqiao Liu Qian Zhang Zequan Li Benjun Xi Changyuan tao Yundong Wang Zuohua Liu School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China Hubei Three Gorges Laboratory Yichang 443007China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Elliptical tanks were used as an alternative to circular tanks in order to improve mixing efficiency and reduce mixing time in unbaffled stirred tanks(USTs). Five different aspect ratios of elliptical vessels were designed to compare their mixing time and flow field. Computational fluid dynamics(CFD) simulations were performed using the k–ε model to calculate the mixing time and simulate turbulent flow field features, such as streamline shape, velocity distribution, vortex core region distribution, and turbulent kinetic energy(TKE) transfer. Visualization was also carried out to track the tinctorial evolution of the liquid phase. Results reveal that elliptical stirred tanks can significantly improve mixing performance in USTs. Specifically, the mixing time at an aspect ratio of 2.00 is only 45.3% of the one of a circular stirred tank. Furthermore, the secondary flow is strengthened and the vortex core region increases with the increase of aspect ratio. The axial velocity is more sensitive to the aspect ratio than the circumferential and radial velocity. Additionally, the TKE transfer in elliptical vessels is altered. These findings suggest that elliptical vessels offer a promising alternative to circular vessels for enhancing mixing performance in USTs.

关键词： Mixing time CFD Stirred tank Secondary flow Mixing performance

中国老年和中青年糖尿病患者使用双时相门冬胰岛素30的疗效及安全性：来自 A1 chieve 研究结果

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中华糖尿病杂志 2014年第7期6卷 513-519页

作者：李玉秀邢小燕柳洁高政南常宝成王战建庄晓明洪靖袁涛杨文英北京协和医学院北京协和医院内分泌科中国医学科学院 100730 中日友好医院内分泌科山西省人民医院内分泌科大连市中心医院内分泌科天津医科大学代谢病医院糖尿病肾病科河北医科大学第三医院内分泌科首都医科大学附属复兴医院内分泌科

目的：评价中国老年2型糖尿病（T2DM）患者使用双时相门冬胰岛素30（BIAsp30）的安全性及有效性，并与中青年患者研究结果进行比较。方法2008年11月至2011年3月从全国130家研究中心招募11020例T2DM患者进行前瞻性、多中心、开放、非干预... 详细信息

目的：评价中国老年2型糖尿病（T2DM）患者使用双时相门冬胰岛素30（BIAsp30）的安全性及有效性，并与中青年患者研究结果进行比较。方法2008年11月至2011年3月从全国130家研究中心招募11020例T2DM患者进行前瞻性、多中心、开放、非干预的A1 chieve研究，为期24周。本文分析所有在研究中使用BIAsp30治疗的患者。研究对象分为老年组（年龄＞65岁）和中青年组（年龄≤65岁），同时以研究前是否使用过胰岛素进行分组对比观察BIAsp30的疗效。各组糖化血红蛋白（ HbA1c）水平采用ANCOVA模型分析，低血糖事件采用McNemar′s配对比例检验分析。结果老年组1969例，中青年6508例接受BIAsp 30治疗。24周BIAsp30治疗期间无严重药物不良反应。老年组患者的总体夜间和重度低血糖事件分别从基线时的2.84、0.91和0.34次/患者年下降至2.00、0.41和0次/患者年，中青年组低血糖事件从基线时的2.19、0.48和0.10次/患者年，下降至1.39、0.23和0次/患者年。老年组和中青年组患者用药24周后HbA1c分别比基线时降低[治疗后（7.0±1.0）％和（7.0±1.0）％；基线（9.3±2.3）％和（9.6±2.3）％；老年t＝-33.47，P＜0.001；中青年t＝-67.94，P＜0.001]；老年和中青年组患者HbA1c＜7.0％的达标率比基线增高[基线为13.8％（223/1620）和9.5％（514/5390），治疗后为57.7％（682/1182）和55.0％（2124/3863）]。BIAsp 30治疗24周后，老年组和中青年组的空腹血糖均比基线降低[治疗后（6.8±1.2） mmol/L和（6.7±1.3） mmol/L；基线（9.8±3.5） mmol/L和（10.4±3.6） mmol/L，老年t＝-32.86，P＜0.001；中青年t＝-70.02，P＜0.001]；早餐后2 h血糖分别比基线时下降[治疗后（8.9±1.7）和（8.8±1.8） mmol/L；基线（13.9±4.8）和（14.4±4.9） mmol/L，老年 t ＝-34.14， P ＜0.001；中青年t＝-67.70，P＜0.001]。老年组和中青年组患者的生活质量均有所改善。结论 BIAsp30有效降低血糖，并不增加低血糖风险，特别是降低了夜间和重度低血糖风险，BIAsp30在老年和中青年患者中使用同样安全有效。

关键词：糖尿病,2型老年人胰岛素类似物双时相门冬胰岛素30

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AngioJet在慢性股腘动脉长段闭塞病变中的应用初步探索

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血管与腔内血管外科杂志 2021年第10期7卷 1256-1259页

作者：袁涛毕伟高翔孙欢欢池魁王志波张金文河北医科大学第二医院血管外科河北石家庄050000

目的探讨AngioJet机械血栓抽吸技术腔内治疗慢性股腘动脉长段闭塞病变的有效性及安全性。方法收集2019年5月至2020年5月河北医科大学第二医院收治的15例慢性股腘动脉长段闭塞病变患者的临床资料。观察全部患者的术中机械血栓抽吸时间、... 详细信息

目的探讨AngioJet机械血栓抽吸技术腔内治疗慢性股腘动脉长段闭塞病变的有效性及安全性。方法收集2019年5月至2020年5月河北医科大学第二医院收治的15例慢性股腘动脉长段闭塞病变患者的临床资料。观察全部患者的术中机械血栓抽吸时间、尿激酶使用剂量、腔内介入治疗成功率及围手术期相关并发症的发生情况。比较抽吸前后的病变段长度。观察术后肌红蛋白尿的发生情况、血色素降低程度、术后即刻效应。比较术前、术后1周、术后6个月的踝肱指数(ABI),术前与术后6个月的Rutherford分级。观察术后6个月管腔丢失率和再干预率。结果15例慢性股腘动脉长段闭塞病变患者的腔内介入治疗成功率为100%(15/15)。围手术期,无死亡、心脑血管疾病、远端动脉栓塞或出血事件发生。术中机械血栓抽吸时间为(361.87±57.44)s,尿激酶使用剂量为(25.67±4.03)万U。抽吸后的平均病变段长度明显短于抽吸前,差异有统计学意义(P<0.01)。术后,有13例患者出现肌红蛋白尿,平均持续时间为(1.47±0.88)d。术后血色素较术前降低了(8.87±1.86)g/L。术后1例患者出现下肢肿胀,经硫酸镁持续湿敷后缓解。术后1周、术后6个月的ABI均高于术前,差异均有统计学意义(P<0.01)。术后6个月,管腔丢失患者2例,再干预患者1例。术后6个月,患者的Rutherford分级优于术前(P<0.05)。术后,造影检查结果显示,1例患者出现限流性夹层,植入一枚补救性支架。结论AngioJet机械血栓抽吸技术不仅能够有效去除慢性股腘动脉长段闭塞病变的血栓,缩短病变长度,降低病变狭窄率,还可有效降低远端栓塞风险,提高远期通畅率,并可减少留置溶栓导管所致的出血等不良事件的发生。

关键词：慢性股腘动脉闭塞 AngioJet 治疗效果安全性

A Potential Diode Laser Second Harmonic Generation Organic Crystal-MHBA

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Chinese Physics Letters 1991年第5期8卷 271-273页

作者： tao Xutang yuan Duorong ZHANG Nan JIANG Minhua SHAO Zhongshu Institute of Crystal Materials Shandong UniversityJinan 250100

A prospective new organic material:3-methoxy-4-hydroxy-benzaldehyde(MHBA)with powder second harmonic generation efficiency 30 times as large as that of urea and the cutoff wavelength of 370nm is *** belongs to monoclinic system space group P2_(1),and the unit cell parameters are:a=14.057Å,b=7.875Å,c=15.037Åandβ=115.45°,the general physicalchemical properties are also presented.

关键词： belongs benzaldehyde MHBA

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腹针结合基础针刺法治疗带状疱疹的临床疗效

保健医学研究与实践 2022年第9期19卷 43-46页

作者：李玉琴李全伟陈吉祥肖正军谢朝晖袁涛兰州大学第一医院疼痛科兰州730031

目的比较腹针结合基础针刺法与单纯西药治疗带状疱疹的临床疗效,为针灸临床治疗带状疱疹提供理论基础。方法选取2017年1月—2019年6月于兰州大学第一医院疼痛科门诊就诊的90例胸段带状疱疹患者为研究对象,依据双盲随机对照试验原则分为... 详细信息

目的比较腹针结合基础针刺法与单纯西药治疗带状疱疹的临床疗效,为针灸临床治疗带状疱疹提供理论基础。方法选取2017年1月—2019年6月于兰州大学第一医院疼痛科门诊就诊的90例胸段带状疱疹患者为研究对象,依据双盲随机对照试验原则分为针灸组与西药组,每组45例。针灸组患者采用腹针结合基础针刺法治疗,西药组患者采用伐昔洛韦、普瑞巴林与甲钴胺胶囊联合治疗,2组均治疗4周。比较2组患者的临床疗效、皮损消退时间,治疗前后视觉模拟评分法(VAS)评分,随访3个月带状疱疹后遗神经痛(PHN)发病情况及治疗期间不良反应发生情况。结果针灸组患者疗效优于西药组,差异有统计学意义(Z=-2.190,P=0.029)。2组患者治疗前VAS评分比较,差异无统计学意义(P>0.05);2组患者治疗后1周、2周、3周、4周VAS评分低于治疗前,且针灸组治疗后同一时间点VAS评分低于西药组,差异均有统计学意义(P<0.05)。针灸组患者不良反应发生率为8.89%(4/45),低于西药组的46.67%(21/45),差异有统计学意义(χ^(2)=16.006,P<0.05)。针灸组患者PHN发生率为2.22%(1/45),明显低于西药组的15.56%(7/45),但差异无统计学意义(χ^(2)=1.235,P=0.266)。结论腹针结合基础针刺法治疗带状疱疹的临床疗效优于单纯西药治疗,同时有助于加快皮损消退,减轻患者疼痛,降低PHN及不良反应发生风险。

关键词：腹针基础针刺带状疱疹伐昔洛韦普瑞巴林