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Comparison of visual performance with iTrace analyzer following femtosecond laser-assisted cataract surgery with bilateral implantation of two different trifocal intraocular lenses

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1773-1781页

作者： Rui-Hong Ju Hao-Kun Qu Zhe-Ming Wu Yun Chen Li-Nan Wu yuan long Zheng Wang Aier Eye Hospital Jinan UniversityGuangzhou 510071Guangdong ProvinceChina

AIM:To compare the postoperative binocular visual performance with an iTrace analyzer following femtosecond laser-assisted cataract surgery(FLACS)combined with bilateral implantation of two different types of diffractive trifocal intraocular lenses(IOL).METHODS:During this retrospective observational study,patients who received bilateral FLACS combined with implantation of two different types of diffractive trifocal IOLs were *** to the IOLs’different types and design,the patients were divided into AT LISA tri839MP group(tri839 group)and AcrySof PanOptix TFNT00 group(TFNT group).Study parameters included preoperative and postoperative uncorrected distance visual acuity(UDVA)at 5 m,uncorrected near visual acuity(UNVA)at 30 cm and 40 cm,uncorrected intermediate visual acuity(UIVA)at 60 cm and 80 cm,postoperative refractive status,objective visual qualities and total high order aberrations(HOAs)*** postoperative complications were also ***:Totally 56 eyes of 28 patients(tri839 group,n=26;TFNT group,n=30)were *** baseline characteristics between groups were not statistically significantly *** was not significantly different between groups except for 1wk follow-up due to the postoperative corneal *** group showed statistically significant better UNIA at 60 cm than tri839 group at the 1wk(0.05±0.19 vs 0.15±0.10 logMAR,P=0.013),1mo(0.05±0.12 vs 0.15±0.09 logMAR,P=0.001)and 3mo(0.04±0.12 vs 0.15±0.11 logMAR,P=0.001)follow-up,while tri839 group showed statistically significant better UNIA at 80 cm than TFNT group at the 1d(0.14±0.15 vs 0.20±0.14 logMAR,P=0.041)and 1mo(0.09±0.07 vs 0.14±0.10 logMAR,P=0.042)*** refractive status showed stable at every *** transfer function(MTF)values and strehl ratio(SR)values were improved and HOAs were lower significantly after ***:FLACS with bilateral implantations of both tri839 and TFNT00 can achieve satisfactory

关键词： femtosecond laser-assisted cataract surgery visual performance binocular AT LISA tri839MP AcrySof PanOptix TFNT00 iTrace

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Breast Cancer Resistance Protein Expression and 5-Fluorouracil Resistance

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Biomedical and Environmental Sciences 2008年第4期21卷 290-295页

作者： JIAN-HUI yuan JIN-QUAN CHENG long-yuan JIANG WEI-DONG JI LIANG-FENG GUO JIAN-JUN LIU XING-YUN XU JING-SONG HE XIAN-MING WANG ZHI-XIONG ZHUANG Faculty of Preventive Medicine School of Public Health Sun Yat-Sen University Guangzhou 510080Guangdong China Toxicology Laboratory Municipal Center for Disease Control and PreventionShenzhen 518020 Guangdong China Department of Emergency The Second Affiliated Hospital of Sun Yat-Sen University Guangzhou 510120 Guangdong China Department of General Surgery Shenzhen Second People＇s Hospital Shenzhen 518035 Guangdong China

Objective To filtrate breast cancer resistance protein （BCRP）-mediated resistant agents and to investigate clinical relationship between BCRP expression and drug resistance. Methods MTT assay was performed to filtrate BCRP-mediated resistant agents with BCRP expression cell model and to detect chemosensitivity of breast cancer tissue specimens to these agents. A high performance liquid chromatography （HPLC） assay was established, and was used to measure the relative dose of intracellular retention resistant agents. RT-PCR and immunohistochemistry （IHC） were employed to investigate the BCRP expression in breast cancer tissue specimens. Results MTT assay showed that the expression of BCRP increased with the increasing resistance of 5-fluorouracil （5-Fu）（P〈0.05, n=3） in the cell model, while HPLC assay indicated that the intracellular retention dose of 5-Fu was significantly correlated with the expression of BCRP （t=-0.897, P〈0.05, n=3）. A total of 140 breast cancer tissue specimens were collected. BCRP-positive expression was detected in forty-seven specimens by both RT-PCR and IHC. As shown by MTT assay subsequently, the resistance index （RI） of 47 BCRP-positive breast cancer tissue specimens to 5-Fu was 7-12 times as high as that of adjacent normal tissue samples. BCRP expression was related to 5-Fu resistance （R2=0.8124, P〈0.01）. Conclusion Resistance to 5-Fu can be mediated by BCRR Clinical chemotherapy for breast cancer patients can be optimized based on BCRP-positive expression.

关键词： Breast cancer resistance protein 5-fluorouracil Breast cancer Resistance Chemotherapy

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Expression of Interleukin-6 and Interleukin-6 Receptor in Ovine Oocytes During In vitro Maturation

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Journal of Integrative Agriculture 2012年第8期11卷 1333-1339页

作者： ZHAO Xi-an CANG Ming GAO Xiao-yu YANG Mei-ling yuan Jian-long ZHU Bing WANG Zhi-gang LIU Dong-jun Key Laboratory of Ministry of Education of China for Mammal Reproduction Biology and Biotechnology Inner Mongolia UniversityHohhot 010021P.R.China

To study the effects of interleukin-6 （IL-6） and its receptor （IL-6R） during in vitro maturation of ovine oocytes, the mRNA and protein expression levels of IL-6 and IL-6R, along with their localization, were examined during ovine oocytes maturation in vitro through real-time PCR, Western blotting, and immunohistochemistry. Specific patterns of expression of IL-6 and IL-6R were observed at both mRNA and protein levels at each stage of ovine oocytes maturation. IL-6 and IL-6R were distributed primarily on the surface of the cell membrane, with little expression in the cytoplasm or nucleus. IL-6 and IL-6R were expressed significantly at higher levels in the maturation around 4 h, and then decreased dramatically. However the level slightly elevated at 20-24 h. The role of IL-6 and IL-6R on oocytes maturation was studied through in vitro addition of recombinant human IL-6 in different concentrations. The addition of 10 ng mL-1 IL-6 significantly increased the rates of oocytes maturation （P〈0.05）, but did not affect the rates of development of the subsequence IVF ovine embryos. In summary, IL-6 is likely to play an important role in the early ovine oocytes maturation. The expression patterns of the IL-6 and IL-6R on the ovine oocytes maturation open up the possibility of regulatory role of the cytokine in ovine oocytes maturation.

关键词： IL-6 oocyte in vitro maturation real time PCR Western blotting

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Comparison Between a Tetraploid Turnip and Its Diploid Progenitor(Brassica rapa L.):The Adaptation to Salinity Stress

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Agricultural Sciences in China 2011年第3期10卷 363-375页

作者： MENG Hua-bing JIANG Si-si HUA Shui-jin LIN Xian-yong LI yuan-long GUO Wan-li JIANG Li-xi Institute of Crop Science College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 P.R.China Institute of Agricultural Chemistry College of Environmental and Resource Sciences Hangzhou 310029 P.R.China

Polyploidy is pursued in plant breeding programs due mainly to its ability to yield larger vegetative or reproductive organs. In controlled growth chamber experiments, a tetraploid turnip （cv. Aijiaohuang, 4n） and its diploid progenitor （cv. Aijiaohuang, 2n） were evaluated for their tolerance to salinity stress via investigations on a group of physiological parameters. The results indicate that the tetraploid turnip exhibit better adaptation to a high concentration salt medium （200 mmol L-1）, as evidenced by a less-affected germination rate and a healthier morphological appearance at the seedling stage. Furthermore, an extension of salinity stress up to a certain period of time at the 5-7-leaf stage shows differences between the tetraploid turnip and its diploid progenitor. The former had a higher K＋/Na＋ ratio in the roots, higher glutathione concentration and antioxidant activities in the leaves, and smaller reductions in photosynthetic capacity in terms of leaf chlorophyll content. Studies on the differences between an autopolyploid and its respective relative, from which the autopolyploid originated, in terms of their tolerance to salinity and/or other abiotic stresses, have remained rather limited. The comparison is interesting due to a homogenous genetic background.

关键词： turnip (Brassica rapa) diploid tetraploid autopolyploid salinity tolerance

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The reactions of perfluoroalkanesulfonyl bromide with hetero-atom substituted olefinic bonds

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Acta Chimica Sinica(English Edition) 1988年第2期6卷 150-154页

作者： HUANG Wei-yuan CHEN Jian-long Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai Shanghai Institute of Organic Chemistry Academia Sinica Shanghai

Perfluoroalkanesulfonyl bromides reacted with vinyl bromide,vinyl acetate and trimethylvinyl silane to give the corresponding adducts with the evolution of *** reacted with trimethyl silyl enol ether followed by hydrolysis to give the corresponding α-bromoketones and perfluoroalkanesulfinic ***,perfluoroalkanesulfonyl chlorides reactedwith trimethyl silyl enol ether of pinacolone on UV irradiation to give the corresponding α-perfluo-roalkyl derivatives of *** mild condition,perfluoroalkanesulfonyl bromide alsobrominated phenol and anisole to give the correspondingp-bromo *** α,α-dichloro-trifluoroethanesulfinate reacted with bromine in water at 25℃ to form α,α-dichlorotrifluorcethane-sulfonyl bromide which was thermally less stable than but similar in reactivity to perfluoroalkanesul-fonyl bromide.

关键词： The reactions of perfluoroalkanesulfonyl bromide with hetero-atom substituted olefinic bonds

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Correlation of peripheral blood mir-146b and mir-155 expression with Treg immunity and myocardial injury in children with viral myocarditis

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Journal of Hainan Medical University 2017年第21期23卷 85-88页

作者： yuan long Yong Zhang Department of Cardiovascular Medicine Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science&Technology in Hubei ProvinceWuhan CityHubei Province430022

Objective: To study the correlation of peripheral blood mir-146b and mir-155 expression with Treg immunity and myocardial injury in children with viral myocarditis. Methods: The children who were diagnosed with viral myocarditis in Wuhan Children's Hospital between June 2014 and February 2017 were selected as the VMC group of the study, and the children who received physical examination during the same period were selected as the control group of the study. Peripheral blood was collected to determine the expression of mir-146b, mir-155 and immune transcription factors, and the serum was collected to determine the contents of immune cytokines and myocardial injury indexes. Results: Peripheral blood mir-146b and mir-155 expression of VMC group were significantly higher than those of control group;peripheral blood Foxp3 mRNA expression as well as serum IL-10 and TGF-β contents of VMC group was significantly lower than those of control group and negatively correlated with mir-146b and mir-155 expression while peripheral blood ROR-γt mRNA expression as well as serum IL-17, IL-21, CK-MB, cTnI, GrB, sFasL and caspase-3 contents was significantly higher than those of control group and positively correlated with mir-146b and mir-155 expression. Conclusion: Highly expressed mir-146b and mir-155 in peripheral blood of children with viral myocarditis can inhibit Treg immunity and increase myocardial injury.

关键词： Myocardial injury microRNA Regulatory T cells

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CHROMATOGRAPHIC SEPARATION OF THE ENANTIOMERS OF 3-PHENYL-1,2-EPOXYETHANE AND 1-PHENYL-1-PROPANOL ON A FUSED SILICA CAPILLARY COLUMN COATED WITH PERBENZYL-β-CYCLODEXTRIN

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Chinese Chemical Letters 1992年第11期3卷 901-902页

作者： Hong WANG Xiao Yu WANG yuan De long Tian Bao HUANG Chengdu Institute of Organic Chemistry Academia SinicaChengdu 610015

A β-cyclodextrin derivative, perbenzyl-β-cyclodextrin, was prepared and used as a chiral stationary phase for capillary gas chromatography. Using FID detector and the column temperature between 70 and 80℃, the chiral separations of racemic 3-phenyl-1, 2-epoxyethane and 1-phenyl-1-propanol on a 14m×0.23mm I. D. fused silica column with the β-cyclodextrin derivative were carried out and the optical purities of optically active 1-phenyl-1-propanol samples prepared by asymmetric synthesis were determined.

关键词： CYCLODEXTRIN CHROMATOGRAPHIC SEPARATION OF THE ENANTIOMERS OF 3-PHENYL-1,2-EPOXYETHANE AND 1-PHENYL-1-PROPANOL ON A FUSED SILICA CAPILLARY COLUMN COATED WITH PERBENZYL long

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Study on Segmented Reflector Lamp Design Based on Error Analysis

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厦门大学学报（自然科学版） 2002年第S1期41卷 143-144页

作者： LIU Hong, yuan Ju-long (College of Mechanical & Electronical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)

This paper discusses the basic principle and design m ethod for light distribution of car lamp, introduces an important development: h igh efficient and flexible car lamp with reflecting light distribution-segmente d reflector (multi-patch) car lamp, and puts out a design method for segmented reflector based on error analysis. Unlike classical car lamp with refractive lig ht distribution, the method of reflecting light distribution gives car lamp desi gn more flexibility. In the case of guarantying the lightness of car lamp and sa tisfying the standard demand for the light distribution, the design of the exter ior of the car lamp has more freedom. The high gradient of car lamp is more suit able for the demand of streamline of the car exterior. The shape of segmented re flector obtained by theory calculating of car lamp reflecting light distribution is only an ideal shape, which usually has considerable differences with the fin al shape and will influences light distribution. There exist difference between the calculated reflector and manufactured reflector. Owing to light reflecting c haracter, the small diversification of the reflector will reduce the big diver sification of the light distribution shape on light distribution screen in 25 -meter place, so light distribution quality can’t be ensured. To ensure the re flector by light distribution calculation accordance to reflector by practical m anufacture, the error effect of surface shape must be reasonably considered name ly the error effect of manufacture tache. The paper establishes error-analyzing model for segmented reflector according to the analysis of error of making proc ess for segmented reflector. Based on this error-analyzing model and by use of the analyzing software developed for segmented reflector light distribution, it could reasonably consider reflector errors made by manufacturing, such as reflec tor surface spray-painting and plating aluminum, which could give out shapes of reflector patches fo

关键词： car lamp design light distribution segmented surface reflector

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Moon night sky brightness simulation for the Xinglong station

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Research in Astronomy and Astrophysics 2013年第10期13卷 1255-1268页

作者： Song Yao Hao-Tong Zhang Hai-long yuan Yong-Heng Zhao Yi-Qiao Dong Zhong-Rui Bai Li-Cai Deng Ya-Juan Lei Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Using a sky brightness monitor at the Xinglong station of National Astronomical Observatories,Chinese Academy of Sciences,we collected data from22 dark clear nights and 90 moon *** first measured the sky brightness variation with time for dark nights and found a clear correlation between sky brightness and human *** with a modified sky brightness model of moon nights and data from these nights,we derived the typical value for several important parameters in the *** these results,we calculated the sky brightness distribution under a given moon condition for the Xinglong ***,we simulated the sky brightness distribution of a moon night for a telescope with a 5 field of view（such as LAMOST）.These simulations will be helpful for determining the limiting magnitude and exposure time,as well as planning the survey for LAMOST during moon nights.

关键词： Moon scattering site testing telescopes

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Stressed carbon nanotube devices for high tunability,high quality factor, single mode GHz resonators

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Nano Research 2018年第11期11卷 5812-5822页

作者： Xinhe Wang Dong Zhu Xinhe Yang long yuan Haiou Li Jiangtao Wang Mo Chen Guangwei Deng Wenjie Liang Qunqing Li Shoushan Fan Guoping Guo Kaili Jiang State Key Laboratory of Low-Dimensional Quantum Physics Dept. of Physics and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua University Beijing 100084 China Key Laboratory of Quantum Information CAS University of Science and Technology of China Hefei230026 China Institute of Physics Chinese Academy of Sciences Beijing 100080 China Fert Beijing Research Institute School of Electrical and Information Engineering BDBC Beihang University Beijing I O019 I China Collaborative Innovation Center of Ouantum Matter Beijing 100084 China

The emerging applications of nanoelectromechanical systems (NEMS) in ground-state cooling, quantum manipulation, communication devices, etc., call for a nanoresonator with high frequency, quality factor, and tunability, as well as easy integration. Here we show that such a nanoresonator can be achieved by using a unique assembly technique that transfers the stressed inner shell of carbon nanotubes (CNTs) to a self-aligned device geometry. The as-fabricated nanoresonator shows excellent comprehensive performance, i.e., high frequency (2–3 GHz), high tunability (80–110 MHz/V), high quality factor (3 × 104), and single mode operation. The defect-free nature of the inner shell of the CNT gives rise to a high quality factor, and the preloaded tension improves the resonant frequency and tunability. This resonator with excellent performance also enables the integration of homogeneous devices and will play a key role in the emerging applications of NEMS.

关键词： carbon nanotube nanomechanical resonator stress high tunability high frequency

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