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某车型发动机后悬置支架NVH性能分析与优化

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广西科技大学学报 2017年第1期28卷 65-72页

作者：王俊鹏袁丽芸刘灿礼金浩广西科技大学汽车与工程学院广西柳州545006

针对某车型全加速工况下引起的车内噪声及底板振动问题,应用LMS公司的***动态测试系统对发动机动力总成进行振动、噪声和不平顺性测试,通过频谱分析和模态实验响应分析找到引发车内噪声和振动的相关故障频率;通过Hyperworks软件对发动... 详细信息

针对某车型全加速工况下引起的车内噪声及底板振动问题,应用LMS公司的***动态测试系统对发动机动力总成进行振动、噪声和不平顺性测试,通过频谱分析和模态实验响应分析找到引发车内噪声和振动的相关故障频率;通过Hyperworks软件对发动机后悬置支架进行仿真计算,对比试验结果和仿真结果,发现其低阶固有频率过低,与发动机的工作状态频率发生共振,使车内声品质变差,主观感觉底板有明显抖动.为此提出改进发动机后悬置支架结构来改变支架固有频率的方案,使其与发动机工作频率错开.进一步试验发现,车内噪声和底板抖动问题得到明显改善.

关键词：发动机后悬置支架固有频率模态实验仿真分析

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang yuan liting Yang Guisheng liang Yifeng Cheng limin Wu Chunfu lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang yuan-Ming Pan Wei li Rui-Qiong Ma Jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

基于AHP灰色理论的道路交通流数据质量评价

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山东科学 2017年第1期30卷 69-75页

作者：庄广新谷远利马韵楠赵莹北京交通大学城市交通复杂系统理论与技术教育部重点实验室北京100044 北京铁路局北京西站北京100055

交通流信息采集的过程中由于受到设备自身及外在环境等因素的影响,所采集的数据容易出现失真、缺失和冗余等质量问题,无法满足智能化交通管理的要求。本文以准确度、完整度和时效性等3个数据特性作为评价指标,提出了基于层次分析法与灰... 详细信息

交通流信息采集的过程中由于受到设备自身及外在环境等因素的影响,所采集的数据容易出现失真、缺失和冗余等质量问题,无法满足智能化交通管理的要求。本文以准确度、完整度和时效性等3个数据特性作为评价指标,提出了基于层次分析法与灰色聚类分析的道路交通流数据质量评价方法,采用层次分析法确定评价指标的权重,采用灰色系统理论白化权函数建立各指标关联度矩阵模型,结合北京市二环路实测数据进行了实例分析,证明了方法的可行性。

关键词：交通工程数据质量评价 AHP灰色理论道路交通流

Geodynamic processes of the continental deep subduction: Constraints from the fine crustal structure beneath the Pamir plateau

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Science China Earth Sciences 2020年第5期63卷 649-661页

作者： Wei li yun CHEN Ping TAN Xiaohui yuan State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China Institute of Disaster Prevention Sanhe 065201China Deutsches GeoForschungsZentrum GFZ Telegrafenberg14473 PotsdamGermany

The Pamir plateau,located north of the western syntaxis of the India-Eurasia collision system,is regarded as one of the most possible places of the ongoing continental deep *** on a N-S trending linear seismic array across the Pamir plateau,we use the methods of the harmonic analysis of receiver functions and the cubic spline interpolation of surface wave dispersions to coordinate their resolutions,and perform a joint inversion of these datasets to construct a 2-D S-wave velocity model of the crust and uppermost mantle there.A spatial configuration among the intermediate-depth seismicity,Moho topography,and low-velocity anomalies within the crust and upper mantle is revealed,which provides new seismological constraints on the geodynamic processes of the continental *** results not only further confirm the deep subduction of the Asian continental lower crust beneath the Pamir plateau,but also indicate the importance of the metamorphic dehydration of the subducting continental crustal material in the genesis of the intermediate-depth seismicity and the crustal deformation.

关键词： Pamir plateau Continental deep subduction Intermediate-depth seismicity Low-velocity zone Receiver function Ambient noise Joint inversion

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传递矩阵法分析平行四边形板的自由振动问题

广西科技大学学报 2017年第2期28卷 99-105页

作者：刘灿礼袁丽芸王俊鹏施国强广西科技大学汽车与交通学院广西柳州545006

针对平行四边形薄板的自由振动问题,采用传递矩阵法,结合摄动理论分析平行四边形板,并通过与有限元法对比验证该方法的精确性.首先,利用坐标变换公式将平行四边形板的求解域转换到矩形板域,并将控制方程及其对应的边界条件变换到矩形板... 详细信息

针对平行四边形薄板的自由振动问题,采用传递矩阵法,结合摄动理论分析平行四边形板,并通过与有限元法对比验证该方法的精确性.首先,利用坐标变换公式将平行四边形板的求解域转换到矩形板域,并将控制方程及其对应的边界条件变换到矩形板域内;随后,结合Fourier级数展开以及摄动理论,将平形四边行板的振动控制方程写为一阶常微分矩阵的形式;再运用传递矩阵法对该一阶常微分矩阵方程进行求解,得到平形四边行板的振动固有频率.算例结果表明,在平行四边形板偏角较小的范围内,所提出的传递矩阵法可精确应用于平行四边形板的动力学特性分析.

关键词：平行四边形板传递矩阵法摄动法一阶常微分矩阵方程

Dynamic and inner-dressing control of four-wave mixing in periodically-driven atomic system

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Chinese Physics B 2019年第10期28卷 327-331页

作者： yuan-yuan li li li yun-Zhe Zhang Lei Zhang Institute of Physics Xi’an University

Four-wave-mixing(FWM) process is examined by using density matrix formalism in a periodically-driven atomic medium. Numerical result shows that FWM signals can be controlled by selecting different dynamic parameters of the probe field and strengths of the inner-dressing fields. It is also shown that the controllable FWM process is dominantly influenced by the evolution of atomic population difference and two-photon coherence. This dynamic and inner-dressing control of FWM is probably used for optimizing the optical nonlinear process and information processing.

关键词： four-wave-mixing dynamic control inner-dressing

5-羟甲基糠醛在CuPd(111)上的加氢反应机理研究

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原子与分子物理学报 2025年第4期42卷 53-57页

作者：张兴云周广丽石云山东临沂大学化学化工学院临沂276000

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生... 详细信息

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生成2,5-二羟甲基呋喃;第二种反应路径是侧链上的醛基碳先加氢原还原生成F-CH_(2)O中间体,生成的F-CH_(2)O进一步加氢还原生成2,5-二羟甲基呋喃.计算了两种竞争反应路径的活化能垒和反应热,结果表明,5-羟甲基糠醛在CuPd(111)面加氢还原生成2,5-二羟甲基呋喃的最佳反应路径为:F-CHO→F-CHOH→F-CH_(2)OH.

关键词： 5-羟甲基糠醛活化能垒反应热

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吴茱萸碱调控FOXM1表达促进结肠癌耐药细胞HCT8/5-FU凋亡

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中国药理学通报 2025年第1期41卷 35-43页

作者：马静陈地龙万源媛何佳明陈按李芸莹王慧敏李静重庆医科大学干细胞与组织工程重庆市重点实验室基础医学院组织学与胚胎学教研室重庆400016 重庆市药品监督管理局重庆市食品药品检验检测研究院国家药品监督管理局麻醉精神药品质量监测重点实验室重庆401121 重庆三峡医药高等专科学校重庆404120

目的研究吴茱萸碱(evodiamine,EVO)调控叉头盒蛋白M1(fork-head box protein M1,FOXM1)对结直肠癌耐药细胞HCT8/5-FU增殖和凋亡的影响。方法采用CCK-8法与EdU实验技术,评估EVO对细胞增殖活性的作用效果;通过克隆形成实验,探讨EVO对细胞... 详细信息

目的研究吴茱萸碱(evodiamine,EVO)调控叉头盒蛋白M1(fork-head box protein M1,FOXM1)对结直肠癌耐药细胞HCT8/5-FU增殖和凋亡的影响。方法采用CCK-8法与EdU实验技术,评估EVO对细胞增殖活性的作用效果;通过克隆形成实验,探讨EVO对细胞克隆形成能力的影响;采用流式细胞术对凋亡细胞比例进行量化;蛋白质免疫印迹分析技术检测Bcl-2、Bax、FOXM1、β-catenin、c-MYC、CyclinD1蛋白水平的变化;分子对接探究EVO与FOXM1的相互作用关系;裸鼠移植瘤模型验证EVO在体内对HCT8/5-FU细胞的影响。结果CCK-8实验显示EVO抑制HCT8/5-FU细胞增殖且呈时间和浓度依赖性;EdU实验发现EVO处理组新增殖细胞明显减少;克隆形成实验结果显示EVO明显抑制HCT8/5-FU细胞的克隆形成能力;流式细胞计数发现EVO组细胞的凋亡率明显增高;Western blot显示FOXM1、β-catenin在HCT8/5-FU细胞中明显高表达,EVO能下调细胞中FOXM1、β-catenin、c-MYC、CyclinD1、Bcl-2表达,上调Bax表达;分子对接显示EVO与FOXM1之间具有较强的互作能力;体内实验显示EVO能明显抑制HCT8/5-FU皮下移植瘤的生长且能调控相关蛋白的表达;HE染色发现EVO组的瘤体细胞核固缩和碎裂明显。结论EVO可能通过下调FOXM1蛋白表达抑制Wnt通路激活,从而抑制HCT8/5-FU细胞增殖诱导其凋亡。

关键词：吴茱萸碱结肠癌耐药增殖凋亡 FOXM1