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High-risk human papilloma virus infection and cervical neoplasm in female inflammatory bowel disease patients:a cross-sectional study

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Gastroenterology Report 2019年第5期7卷 338-344,I0002页

作者： Miao Li Qing-Fan Yang Qian Cao Jian Tang Yu Gao Min Zhi Kang Chao Ming-Li Su Wei-Min huang Yan Yi Sui-Yan Xia ling-Jie huang yuan Zhao Xiao-hong wang Xiao-Ying Liu Lin Lin Pin-Jin Hu Xiang Gao Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Obstetrical Department The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Medical Diagnostic Center The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and aim:This cross-sectional study investigated the prevalence and risk factors of high-risk human papilloma virus(HPV)infection,especially types 16 and 18,and cervical neoplasia in female Inflammatory bowel disease(IBD)***:From July 2014 to January 2017,sexually active,female,Chinese IBD patients(21–60 years)and age-matched controls underwent cervical ThinPrep cytology testing(TCT)and high-risk HPV-DNA detection,and completed questionnaires about awareness of cervical cancer and *** dysplasia was categorized as cervical intraepithelial neoplasia(CIN)1,2 and ***:Of 124 IBD patients(30 ulcerative colitis and 94 Crohn’s disease),17(13.7%)had high-risk HPV among whom 9(7.3%)had HPV 16/18 infection and 4(3.2%)had cervical CIN(3 CIN 3,1 CIN 1)by *** 372 controls,33(8.9%)had high-risk HPV and only 1(0.3%)had HPV 16 *** TCT detected atypical squamous cells of unknown significance in one control;no control had *** HPV 16/18 infection rate and CIN prevalence were significantly higher in IBD patients than controls(both P<0.001).The HPV-infection rate was higher in patients administered methotrexate[P=0.005,odds ratio(95%confidence interval)4.76(1.471–15.402)]or more than two immunosuppressants[P=0.013,odds ratio(95%confidence interval)3.64(1.255–10.562)].Thiopurine,steroid,infliximab and disease behavior/location were not associated with HPV *** 29.3%of patients had undergone cervical-cancer *** of HPV infection and HPVrelated cervical cancer was poor(28.2%).Conclusions:Female IBD patients are at increased risk of high-risk HPV infection and cervical neoplasia,which may be associated with *** and routine follow-up with HPV-DNA testing and TCT are recommended,especially in female Chinese IBD patients.

关键词： Inflammatory bowel disease high-risk human papilloma virus cervical intraepithelial neoplasia

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三峡库区典型农耕地的氮素淋溶与评价

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土壤学报 2010年第4期47卷 674-683页

作者：袁玲王容萍黄建国西南大学资源环境学院重庆400716 广东省科学院生态环境研究所广州510000

试验选择重庆市三峡库区典型、具有代表性的菜地和坡耕地,于2005至2007年将改进后的离子交换树脂吸附装置分别埋入20cm、30cm、40cm深度的土壤中,中雨、大雨之后或按月收集树脂吸附的NO3--N和NH4+-N,连续三年原位定点研究了两种土壤的... 详细信息

试验选择重庆市三峡库区典型、具有代表性的菜地和坡耕地,于2005至2007年将改进后的离子交换树脂吸附装置分别埋入20cm、30cm、40cm深度的土壤中,中雨、大雨之后或按月收集树脂吸附的NO3--N和NH4+-N,连续三年原位定点研究了两种土壤的氮素淋溶状况。结果表明,菜地的氮素淋失量(74.58kghm-2a-1)高于降雨输入量(56.9kghm-2a-1),坡耕地的(46.01kghm-2a-1)则相反,说明菜地的氮素淋失局部影响当地水环境,农耕地可能不是区域水体富营养化的主要原因。NO3--N占土壤氮素总淋溶量的90%以上,主要发生在施肥后的第一次中雨、大雨中。此外,NO3--N淋溶量耕作层>心土层>底土层,前者远远高于后两者。在整个降雨季节,土壤NO3--N淋溶量前期高,峰值出现在5月份;在雨季后期,土壤NO3--N淋失量很低,故对水体的影响甚小。NO3--N淋溶与土壤碱解氮呈指数正相关。由此可见,三峡库区降低土壤氮素淋溶的主要对象是菜地,有效措施包括控制氮肥用量,降低土壤有效氮库,抑制硝化作用等。

关键词：土壤氮淋溶三峡库区

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Adsorption mechanism of styryl phosphonate ester as collector in ilmenite flotation

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Transactions of Nonferrous Metals Society of China 2022年第12期32卷 4088-4098页

作者： Yan-ling XU Kai-hua huang hong-qiang LI Wei huang Cheng LIU Si-yuan YANG School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510530China Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Wuhan Institute of TechnologyWuhan 430205China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China

A styryl phosphonate ester(SPE) collector was used to improve the flotation performance of ilmenite, and the adsorption mechanism and model were revealed and established, respectively. Microflotation tests showed that SPE exhibited a stronger collecting ability for ilmenite than the traditional collector styrene phosphonic acid(SPA). Zeta potential measurements revealed that both SPE and SPA could negatively shift the zeta potential of ilmenite, while SPE had more effects than SPA, suggesting the stronger adsorption of SPE. The analysis of X-ray photoelectron spectroscopy confirmed the chemisorption of SPA and SPE onto the Fe/Ti sites of ilmenite. According to frontier orbital theory, the chemical activities of SPE are greater than those of SPA. The partial densities of states analysis indicated that the PO—H groups of the collectors could interact with the Ti/Fe atoms of the ilmenite surface to generate a stable four-membered ring. The bonding model of the collector and(104) ilmenite surface showed that the adsorption energy of SPE was higher than that of SPA. Overall, SPE presented a better collecting ability and interaction effect for ilmenite flotation than SPA, and had the potential to replace SPA in the industry.

关键词： styryl phosphonate ester ilmenite flotation collector X-ray photoelectron spectroscopy density functional theory adsorption mechanism

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Molecular mechanisms of apoptosis in hepatocellular carcinoma cells induced by ethanol extracts of Solanum lyratum Thumb through the mitochondrial pathway

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World Journal of Gastroenterology 2017年第6期23卷 1010-1017页

作者： Xiao-Qiang Mo hong-Yu Wei Gan-Rong huang ling-yuan Xu Yu-Li Chen Jiang Qi Wei Xian Yan-Chun Qin Lian-Deng Wei Li-Juan Zhao Yan-Qiang huang Wei Xing hong-Qin Pu Peng-Ya Wei Chao-Gan Li Qiu-Chun Liang Breeding Base of Microbial Infection Key Laboratory in the West Guangxi Youjiang Medical University for Nationalities Affiliated Hospital of Youjiang Medical University for Nationalities

AIM To explore the induction effects and mechanism of Solanum lyratum Thumb(ST) on human hepatocellularcarcinoma SMMC-7721 cells through the mitochondrial *** The experiments were conducted on three groups: an experimental group (with ST ethanol extracts' concentration being 2.5, 5 and 10 mg/L), a negative control group (with only nutrient solution, 0 mg/L ST ethanol extracts), and a positive control group (2.5 mg/L DDP). The inhibition rate of cell proliferation was checked by using the methyl thiazolyl tetrazolium method, and cell apoptosis was tested by TUNEL method. Furthermore, RT-PCR was used to examine m RNA expression of Fas, Fas L, caspase-8, caspase-3, p53 and Bcl-2 *** Compared with the negative control group, the inhibition and apoptosis rates of the experimental group with different concentrations of ST extracts on human hepatocellular carcinoma SMMC-7721 cells significantly increased(P<0.05). Besides, the m RNA expression of Fas L and Bcl-2 significantly decreased(P<0.05) while the m RNA expression of Fas, caspase-8, caspase-3 and p53 increased significantly. When compared with the positive control group, the experimental groups with 5 mg/L ST ethanol extracts showed effects similar to the positive control *** ST ethanol extracts induced the apoptosis of hepatocellular carcinoma SMMC-7721 cells through up-regulated Fas, caspase-8, caspse-3 and p53, and down-regulated Fas L and Bcl-2 in the mitochondrial pathway.

关键词： Solanum lyratum Thumb hepatocellular carcinoma cell cell apoptosis mitochondrial pathway molecular mechanism

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Chemosensitization role of endocrine hormones in cancer chemotherapy

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Chinese Medical Journal 2013年第1期126卷 175-180页

作者： huang Jian-bo JI Guang-yan XING Lei wang Zi-wei LI hong-yuan REN Guo-sheng WU Kai-nan KONG ling-quan Department of Endocrine and Breast Surgery First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Department of Gastrointestinal Surgery First Affiliated Hospital Chongqing Medical University Chongqing 400016 China

The endocrine changes of cancer patients on initial confirmed diagnosis and during chemotherapy havebeen gradually realized and clarified, as well as the dependences of different tumors on corresponding hormones. The prevalent endocrinotherapy suppresses tumor progression through downregulating dependent hormone level or completely inhibitting its combination with receptors. Because of the different and even antagonistic mechanisms, endocrinotherapy should not be used with chemotherapy at the same time, or it will reduce the chemotherapeutic efficacy, which is a widely accepted principle in clinic.

关键词： endocrine hormones chemosensitization chemotherapy endocrinotherapy endocrinochemotherapy

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Seepage characteristics of a fractured silty mudstone under different confining pressures and temperatures

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Journal of Central South University 2020年第7期27卷 1907-1916页

作者： FU hong-yuan JIANG huang-bin QIU Xiang JI Yun-peng CHEN Wen ZENG ling School of Traffic&Transportation Engineering Changsha University of Science&TechnologyChangsha 410114China School of Civil Engineering Changsha University of Science&TechnologyChangsha 410114China Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux Universitéde LorraineMetz 57070France

To investigate the influence of confining pressures and temperatures on the seepage characteristics of fractured rocks, seepage tests were conducted on a fractured silty mudstone using a self-developed experimental system, and the effects of different factors on coefficient of permeability were discussed. The results showed that the increasing confining pressure will gradually decrease the coefficient of permeability, and this process is divided into two stages: 1) the fast decrease stage, which corresponds to a confining pressure less than 30 kPa, and 2) the slow decrease stage, which corresponds to a confining pressure larger than 30 kPa. Unlike confining pressure, an increase in temperature will increase the coefficient of permeability. It is noted that fracture surface roughness will also affect the variation of coefficient of permeability to a certain extent. Among the three examined factors, the effect of confining pressure increases is dominant on fracture permeability coefficient. The relationship between the confining pressure and coefficient of permeability can be quantified by an exponential function.

关键词： silty mudstone seepage characteristic confining pressure temperature permeability

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Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

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World Journal of Diabetes 2022年第10期13卷 877-887页

作者： Xiao-Fen Lian Dong-Hui Lu hong-Li Liu Yan-Jing Liu Xiu-Qun Han Yang Yang yuan Lin Qing-Xiang Zeng Zheng-Jie huang Feng Xie Cai-Hao huang hong-Mei Wu Ai-Mei Long ling-Ping Deng Fan Zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Research&Development Zhejiang MaiDa Gene Tech Co.LtdZhoushan 316000Zhejiang ProvinceChina Department of Endocrinology Huizhou Central People's HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβ-cell dysfunction is a fundamental part of the pathology of type 2 diabetes mellitus(T2DM).Cellular therapies offer novel opportunities for the treatment of T2DM to improve the function of isletβ-*** To evaluate the effectiveness and safety of human umbilical cord-mesenchymal stem cell(hUC-MSC)infusion in T2DM *** Sixteen patients were enrolled and received 1×10^(6) cells/kg per week for 3 wk as intravenous hUC-MSC *** effectiveness was evaluated by assessing fasting blood glucose,C-peptide,normal glycosylated hemoglobin A1c(HbA1c),insulin resistance index(homeostatic model assessment for insulin resistance),and isletβ-cell function(homeostasis model assessment ofβ-cell function).The dosage of hypoglycemic agents and safety were evaluated by monitoring the occurrence of any adverse events(AEs).RESULTS During the entire intervention period,the fasting plasma glucose level was significantly reduced[baseline:9.3400(8.3575,11.7725),day 14±3:6.5200(5.2200,8.6900);P<0.01].The HbA1c level was significantly reduced on day 84±3[baseline:7.8000(7.5250,8.6750),day 84±3:7.150(6.600,7.925);P<0.01].The patients’isletβ-cell function was significantly improved on day 28±3 of intervention[baseline:29.90(16.43,37.40),day 28±3:40.97(19.27,56.36);P<0.01].The dosage of hypoglycemic agents was reduced in all patients,of whom 6(50%)had a decrement of more than 50%and 1(6.25%)discontinued the hypoglycemic *** patients had transient fever,which occurred within 24 h after the second or third *** patient(2.08%)had asymptomatic nocturnal hypoglycemia after infusion on day 28±*** liver damage or other side effects were *** The results of this study suggest that hUC-MSC infusion can improve glycemia,restore isletβ-cell function,and reduce the dosage of hypoglycemic agents without serious ***,hUC-MSC infusion may be a novel option for the treatment of T2DM.

关键词： Type 2 diabetes Human umbilical cord mesenchymal stem cells Blood glucose Homeostasis model assessment ofβ-cell function Hypoglycemic agents

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Chinese Herbal Medicine for Ulcerative Colitis:A Systematic Review Protocol

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 16-19页

作者： hong Mi Linda Zhong Tao huang Cheng-yuan Lin ling Zhao Dong-dong Hu Hai-tao Xiao Zhao-xiang Bian Feng-bin Liu Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese Medicine School of Chinese medicine Hong Kong Baptist University

Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and *** and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be *** of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager *** and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.

关键词： Chinese herbal medicine Ulcerative colitis Systematic review Protocol

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Defect-rich N/O-co-doped porous carbon frameworks as anodes for superior potassium and sodium-ion batteries

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新型炭材料（中英文） 2024年第6期39卷 1144-1156页

作者： BAI ling LIU Qian hong Tao LI Hao-ran ZHU fang-yuan LIU Hai-gang LI Zi-quan huang Zhen-dong State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJi-angsu National Synergetic Innovation Center for Advanced MaterialsNanjing 210023China Shanghai Advanced Research Institute Shanghai 201210China

Carbon with its high electrical conductivity,excellent chemical stability,and structure ability is the most promising an-ode material for sodium and potassium ion *** developed a defect-rich porous carbon framework(DRPCF)built with N/O-co-doped mesoporous nanosheets and containing many defects using porous g-C_(3)N_(4)(PCN)and dopamine(DA)as raw *** prepared samples with PCN/DA mass ratios of 1/1,2/1 and 3/1 and found that the one with a mass ratio of 2/1 and a carbonization temperature of 700℃ in an Ar atmosphere(DRPCF-2/1-700),had a large specific surface area with an enormous pore volume and a large number of N/O heteroatom active defect *** of this,it had the best pseudocapacitive sodium and potassium ion stor-age performance.A half battery of Na//DRPCF-2/1-700 maintained a capacity of 328.2 mAh g^(-1) after being cycled at 1 A g^(-1) for 900 cycles,and a half battery of K//DRPC-2/1-700 maintained a capacity of 321.5 mAh g^(-1) after being cycled at 1 A g^(-1) for 1200 *** rate capability and cycling stability achieved by DRPCF-2/1-700 outperforms most reported carbon ***,ex-situ Raman spectroscopy analysis result confirms that the filling and removing of K^(+)and Na^(+)from the electrochemically active defects are responsible for the high capacity,superior rate and cycling performance of the DRPCF-2/1-700 sample.

关键词： Defect-rich porous carbon N/O-co-doping Anode materials Sodium ion batteries Potassium ion batteries

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青蒿素对外生菌根真菌化感效应

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生态学报 2013年第6期33卷 1791-1797页

作者：李倩袁玲王明霞黄玥黄建国西南大学资源环境学院微生物与植物营养重点实验室重庆400716

青蒿素是治疗疟疾的首选药物,主要从黄花蒿(Artemisia annua L.)中提取,然而黄花蒿在生长过程中会向周围环境分泌青蒿素。为正确评估青蒿素对森林生态系统中的重要成分""外生菌根真菌的影响,试验以重庆地区有代表性的两株外生菌根真菌... 详细信息

青蒿素是治疗疟疾的首选药物,主要从黄花蒿(Artemisia annua L.)中提取,然而黄花蒿在生长过程中会向周围环境分泌青蒿素。为正确评估青蒿素对森林生态系统中的重要成分""外生菌根真菌的影响,试验以重庆地区有代表性的两株外生菌根真菌——褐环乳牛肝菌(Suillus luteus)Sl 8和松乳菇(Lactarius delicious)Ld 3为材料,研究了青蒿素对菌丝生长,H+和有机酸分泌,以及养分吸收的影响。结果表明,在液体培养基中加入青蒿素,外生菌根真菌的生长受到明显抑制,菌丝生物量降幅高达26.89%(Ld 3)和89.13%(Sl 8);Ld 3分泌H+和草酸的能力增强,而Sl 8分泌量下降。随着青蒿素浓度的增加,菌丝的N、P、K含量及吸收量显著减少。当培养基中青蒿素达到80 mg/L时,Ld 3的N、P、K吸收量比不加青蒿素的处理分别降低了50.55%、46.30%和42.28%;Sl 8几乎丧失对N、P、K的吸收能力。说明青蒿素不同程度地抑制了外生菌根真菌的生长和养分吸收,但对H+和草酸的分泌作用因菌株不同而异。

关键词：青蒿素外生菌根真菌化感效应

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