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Microstructure and Mechanical Properties of High-Nitrogen Austenitic Stainless Steels Subjected to Equal-Channel Angular Pressing

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 140-149,104页

作者： Fu-yuan dong Peng Zhang Jian-Chao Pang Qi-Qiang Duan yi-Bin Ren Ke yang Zhe-feng Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Three high-nitrogen stainless steels with different N contents were successfully processed by equal-channel angular pressing for one pass, and their microstructures and mechanical properties were investigated. It was found that the microstructure of the billet was heterogeneous across the billet thickness, resulting in the difference in the mechanical properties due to the different deformation conditions. A relatively low strength, high uniform elongation, and high work- hardening rate for the samples at the bottom of the billet was achieved in comparison with those processed at the top. Meanwhile, it was observed that the density of deformation twins increased with the content of N; accordingly, the strength and elongation of the alloys increase with the content of N, resulting in a good strength-ductility combination.

关键词： High-nitrogen stainless (HNS) steels Equal-channel angular pressing (ECAP) N content Twinning Strength Ductility

Genome-wide analysis of OCT4 binding sites in glioblastoma cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 812-819页

作者： xue-feng FAN wei-yi ZHANG Na ZHAO wei YU dong DING xu HONG Li-sha LI Hua-rong ZHANG Shu Zheng Biao-yang LIN Key Laboratory of Cancer Prevention and Intervention of Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences of Zhefiang Province Cancer Institute the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Systems Biology Div＆ion Zhejiang-California International Nanosystems Institute （ZCNI） Zhejiang University Hangzhou 310029 China

OCT4, a member of the POU family of gene products, is an octamer motif-binding transcription factor. As it is known to play a crucial role in cancer processes including proliferation, invasion, and chemoradioresistance, it is important to identify the direct targets of OCT4 in living cancer cells. Here, chromatin immunoprecipitation-sequencing （ChlP-seq） was used to identify OCT4 binding sites in glioblastoma cancer cells. The results showed that 5438 OCT4 binding sites were localized in the glioblastoma cancer genome and that these sites contained a consensus sequence TTTkswTw （k=T or G, s=C or G, w=A or T）, which occurred 3931 times in 2312 OCT4 binding regions. Furthermore, binding motifs of some other transcription factors were identified in OCT4 binding regions. Our results provide a valuable dataset for understanding gene regulation mechanisms underlying the function of OCT4 in glioblastoma cancer.

关键词： OCT4 Chromatin immunoprecipitation-sequencing (ChlP-seq) DNA binding region Glioblastoma

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-yuan Hu Ding Ding Yu Song Ya-feng Deng Cheng-Ming Zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

Prediction of natural fracture in shale oil reservoir based on R/S analysis and conventional logs

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Frontiers of Earth Science 2021年第3期15卷 705-718页

作者： Haoran xu wei JU Xiaobing NIU Shengbin feng yuan YOU Hui yang Sijia LIU Wenbo LUAN Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process(Ministry of Education)China University of Mining and Technology Xuzhou 221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Institute of Exploration and Development PetroChina Changqing Oilfield CompanyXi'an 710018China School of Computer Science and Technology China University of Mining and TechnologyXuzhou 221116China

Investigation into natural fractures is extremely important for the exploration and development of low-permeability *** studies have proven that abundant oil resources are present in the Upper Triassic Yanchang Formation Chang 7 oil-bearing layer of the Ordos Basin,which are accumulated in typical low-permeability shale *** fractures are important storage spaces and flow pathways for shale *** this study,characteristics of natural fractures in the Chang 7 oil-bearing layer are first *** results indicate that most fractures are shear fractures in the Heshui region,which are characterized by high-angle,unfilled,and ENE-WSW-trending ***,natural fracture distributions in the Yanchang Formation Chang 7 oil-bearing layer of the study area are predicted based on the R/S analysis *** of AC,CAL,ILD,LL8,and DEN are selected and used for fracture prediction in this study,and the R(n)/S(n)curves of each log are *** quadratic derivatives are calculated to identify the concave points in the R(n)/S(n)curve,indicating the location where natural fracture *** the difference in sensitivity of each log to natural fracture,gray prediction analysis is used to construct a new parameter,fracture prediction indicator K,to quantitatively predict fracture *** addition,fracture development among different wells is *** results show that parameter K responds well to fracture *** minor errors may probably be caused by the heterogeneity of the reservoir,limitation of core range and fracture size,dip angle,filling minerals,etc.

关键词： natural fracture prediction shale oil reservoir R/S analysis Chang 7 oil-bearing layer Ordos Basin

Enhanced visible-light photoelectrochemical performance via chemical vapor deposition of Fe2O3 on a WO3 film to form a heterojunction

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Rare Metals 2020年第7期39卷 841-849页

作者： yi-Fei Zhang Yu-Kun Zhu Chun-Xiao Lv Shou-Juan Lai Wen-Jia xu Jin Sun yuan-yuan Sun dong-Jiang yang School of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071China

A heterojunction photoanode of Fe2O3 loaded on a WO3 film on a fluorine-doped tin oxide substrate(FTO-WO3/Fe2O3)was prepared via a simple hydrothermal and chemical vapor deposition(CVD)growth *** photoanode showed higher photoelectrochemical(PEC)water-splitting activity than that of the pristine FTO-WO3 under simulated sunlight because of the synergistic effect of Fe2O3 and *** as-synthesized material was characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The photocurrent density was estimated by linear sweep voltammetry and further confirmed using intensity-modulated photocurrent *** demonstrated that the coated Fe2O3 enhanced the separation and migration efficiencies of the photoinduced electrons and holes,improving the PEC water-splitting *** FTO-WO3/Fe2O3 photoanode showed a 1.25 times enhancement in photocurrent density compared with *** result suggests that facile chemical vapor deposition growth is an effective way to fabricate heterojunctions and improve the properties of WO3 photoanodes for PEC water-splitting applications.

关键词： WO3 Fe2O3 Heterojunction Water splitting

Translocation and distribution of mercury in biomasses from subtropical forest ecosystems:evidence from stable mercury isotopes

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Acta Geochimica 2021年第1期40卷 42-50页

作者： yi Liu Che-Jen Lin wei yuan Zhiyun Lu Xinbin feng State Key Laboratory of Environmental Geochemistry Institute of Geochemistry.Chinese Academy of SciencesGuiyangChina University of Chinese Academy of Sciences BeijingChina Center for Advances in Water and Air Quality Lamar UniversityBeaumontTXUSA College of Environment and Energy South China University of TechnologyGuangzhouChina National Forest Ecosystem Research Station AilaoshanYunnanChina

To understand its source,distribution,storage,and translocation in the subtropical forest ecosystems,mercury(Hg)concentrations and stable isotopes in forest biomass tissues(foliage,branch,bark,and trunk)were investigated at Ailao Mountain National Nature Reserve,Southwest *** total Hg(THg)concentrations in the samples show the following trend:mature foliage(57±19 ng g-1)>bark(11±4.0 ng g-1)>branch(5.4±2.5 ng g-1)>trunk(1.6±0.7 ng g-1).Using the measured THg concentrations and the quantity of respective biomasses,the Hg pools in the forest are:wood(60±26μg m-2)>bark(51±18μg m-2)>foliage(41±11μg m-2)>branch(26±8.3μg m-2).The tree biomasses displayed negativeδ202Hg(-1.83‰to-3.84‰)andΔ199Hg(-0.18‰to-0.62‰).The observedΔ200Hg(-0.08‰to 0.04‰)is not significantly from zero.AΔ199Hg/Δ201Hg ratio of 1.05 was found in tree biomasses,suggesting that mercury has undergone Hg(Ⅱ)photoreduction processes.A Hg-isotope based binary mixing model suggests that Hg in the tree biomasses mainly originated from foliage uptake of atmospheric Hg0,constituting 67%,80%,and 77%of Hg in wood,branch,and bark,*** study sheds new light on the transportation and sources of Hg in the subtropical forest ecosystems.

关键词： Hg Subtropical forest ecosystem Hg stable isotope Hg-isotope based binary mixing model

Performance Assessment of a Novel Polygeneration System Based on the Integration of Waste Plasma Gasification,Tire Pyrolysis,Gas Turbine,Supercritical CO_(2)Cycle and Organic Rankine Cycle

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Journal of Thermal Science 2023年第6期32卷 2196-2214页

作者： feng Fuyuan LI Tongyu AN Jizhen CHEN heng WANG yi’nan xu Gang ZHAO Qinxin LIU Tong Beijing Key Laboratory of Emission Surveillance and Control for Thermal Power Generation North China Electric Power UniversityBeijing102206China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management Institute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou510650China Key Laboratory of Thermo-Fluid Science and Engineering of MOE Xi’an Jiaotong UniversityXi’an710049China

In this paper,a novel polygeneration system involving plasma gasifier,pyrolysis reactor,gas turbine(GT),supercritical CO_(2)(S-CO_(2))cycle,and organic Rankine cycle(ORC)has been *** the proposed scheme,the syngas is obtained by the gasification and the pyrolysis is first burned and drives the gas turbine for power generation,and then the resulting hot exhaust gas is applied to heat the working fluid for the supercritical CO_(2)cycle and the working fluid for the bottom organic Rankine *** addition to the electrical output,the pyrolysis subsystem also produces pyrolysis oil and ***,energy recovery is achieved while treating waste in a non-hazardous *** performance of the new scheme was examined by numerous methods,containing energy analysis,exergy analysis,and economic *** is found that the net total energy output of the polygeneration system could attain 19.89 MW with a net total energy efficiency of 52.77%,and the total exergy efficiency of 50.14%.Besides,the dynamic payback period for the restoration of the proposed project is only 3.31 years,and the relative net present value of 77552640 USD can be achieved during its 20-year lifetime.

关键词： polygeneration system waste plasma gasification tire pyrolysis gas turbine cycle supercritical CO_(2)cycle organic Rankine cycle

Metro train-induced vibrations on historic buildings in Chengdu,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第10期12卷 782-793页

作者： Meng MA Valeri MARKINE wei-ning LIU yang yuan feng ZHANG School of Civil Engineering Beijing Jiaotong University Beijing 100044 China Section of Road and Railway Engineering Department of Design and Construction Delft University of Technology Delft 2600GA the Netherlands

In this paper, the vibration influence on a monument caused by Chengdu Subway Line 2 is analyzed. Due to its elaborate and unique design, both structural and architectural damages should be avoided. First, the allowable root mean square （RMS） velocity at the foundation of the monument is derived and a site measurement is performed to obtain the background vibrations induced by road traffic. In addition, a train-track coupled model and 3D tunnel-soil-structure coupled finite element models are built to predict the dynamic response of the monument. Prediction models are checked by site measurement in Beijing Subway Line 5. Different kinds of fasteners and train speeds are compared and discussed as well. Results show that：（1） At a train speed of 72 km/h, all the traffic vibrations exceed the low limit no matter what kind of fastener is used, which is mainly due to the contribution of road traffic. Slowing down train speeds can cause effective vibration attenuation; （2） Vibrations drop dramatically with the train speed from 65 to 58 km/h. When the train speed is lower than 58 krn/h, vibrations are lower than allowable value even if the contribution of road traffic is considered.

关键词： Traffic vibrations Historic buildings Vibration prediction Numerical simulation _

Impact of seawater acidification on shell property of the Manila clam Ruditapes philippinarum grown within and without sediment

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Journal of Oceanology and Limnology 2020年第1期38卷 236-248页

作者： yuan Hongmei xu Xian yang feng ZHAO Liqiang YAN Xiwu Engineering Research Center of Shellfish Culture and Breeding of Liaoning Province Dalian Ocean UniversityDalian 116023China Ecological Monitoring and Evaluation Division Wuhan SINOECO Ecological Science&Technology Co.Ltd.Wuhan 430080China

Although the impact of ocean acidification on marine bivalves has been previously investigated under mainly controlled laboratory conditions,it is still unclear whether the impact of acidification on sediment-burrowing species differs between those within or without *** order to fill this gap in our knowledge,we compared shell properties of the infaunal Manila clam(Ruditapes philippinarum)exposed to three pH concentrations(7.4,7.7,and 8.0),within and without *** the first experiment(140 d),clams were exposed to seawater in an acidification system without sediment.A decrease in shell weight corresponding to the increase in dissolution rate was observed in the group ofpH 7.4,at which shell color disappeared or *** observations confirmed the changes of the external shell *** the second experiment(170 d),sediment was placed at the bottom of each exposure *** effects were found obvious in shell dissolution rate and shell color in the shell specimens exposed to overlying seawater but not found in the shell specimens exposed to *** the experimental period was longer in the second experiment,shell specimens in the first experiment were more seriously damaged than those in the second experiment under acidic seawater *** results,in relation to the defense function of the shell,show that marine bivalves in burrowing behavior are more adaptable to seawater acidification than those who do not burrow into sediment.

关键词： ocean acidification sediment Manila clam(Ruditapes philippinarum) shell properties