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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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Energy Spectrum of a Degenerate Fermi Gas at the BEC-BCS Crossover

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Communications in Theoretical Physics 2007年第5X期48卷 855-858页

作者： fang yuan Beijing National Laboratory for Condensed Matter Physics Institute of Physics the Chinese Academy of Sciences Beijing 100080 China

A theoretical study of the BCS-BEC crossover is presented. Starting from a two-channel Boson-Fermion resonance model, the BCS-Bogoiubov mean-field method and the Green＇s function method are adopted. The result shows that we can end up with a BCS-type theory but with a composite order parameter. Calculation shows that the Bose condensate of BCS Cooper pairs is proportional to the molecular BEC of Bose molecules. The resonance superfluid phase is indicated by the energy spectrum with an obvious interpretation of the transition mechanism.

关键词： degenerate Fermi gas BEC-BCS crossover Feshbach resonance

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Airline Alliance Revenue Distribution Considering Horizontal and Vertical Competition

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第S1期35卷 20-26页

作者： Le Meilong fang yuan College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Considering the existence of multi-level fares in the alliance,and the existence of horizontal competition and vertical competition at the same time,this paper intends to maximize the revenue of airline alliance and fairly distribute the revenue to member ***,a model is built under the centralized mechanism,in which all airlines in the alliance are regarded as a *** solving the model,the shadow price of each flight leg on the code-sharing route is *** is used to calculate the proportion of the revenue ***,the centralized model is decomposed into the single airline model by the *** seat allocation among airlines and distributed revenue can be gotten by solving the *** typical examples are designed to test *** results show that,the model can effectively reflect the managerial principal of the airline alliance,that is maximizing total revenue and fairly distributing the revenue among member airlines.

关键词： airline alliance revenue management proportion of revenue distribution vertical competition horizontal competition

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Modified min-sum SCAN decoding algorithm for polar codes

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The Journal of China Universities of Posts and Telecommunications 2018年第6期25卷 90-96页

作者： yuan fang Tian Bin State Key Laboratory of Integrated Services Networks Xidian UniversityXi'an 710071China Collaborative Innovation Center of Information Sensing and Understanding at Xidian University Xi'an 710071China China Electronics Technology Croup Corporation Key Laboratory of Aerospace Information Applications Shijiazhuang 050081China

The state-of-the-art soft-output decoder of polar codes is the soft cancellation(SCAN) decoding algorithm, which performs well at the cost of plentiful computations. Based on the SCAN decoding algorithm, a modified method with revised iterative formula is proposed, marked modified min-sum SCAN(MMS-SCAN). The proposed algorithm simplifies the update formula of nodes and reduces the complexity of iterative decoding process by the piecewise approximation function. Meanwhile, the bit error rate(BER) of the proposed method can approach the performance of original SCAN decoding method without performance loss. The simulation reveals that the MMS-SCAN decoding algorithm can achieve the effect that the BER curve almost coincides with the original SCAN decoding curve.

关键词： polar codes MMS-SCAN iterative formula the piecewise approximation function

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Effects of creep characteristics of natural gas hydrate-bearing sediments on wellbore stability

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Petroleum Science 2022年第1期19卷 220-233页

作者： Yang Li yuan-fang Cheng Chuan-Liang Yan Zhi-yuan Wang Li-fang Song School of Petroleum Engineering China University of Petroleum(East China)66 West Changjiang RoadHuangdao DistrictQingdao 266000China

Natural gas hydrate(NGH)reservoirs consist of the types of sediments with weak cementation,low strength,high plasticity,and high *** on the kinetics and thermodynamic characteristics of NGH decomposition,herein a heat-fluid-solid coupling model was established for studying the wellbore stability in an NGH-bearing formation to analyze the effects of the creep characteristics of NGH-bearing sediments during long-term *** results demonstrated that the creep characteristics of sediments resulted in larger plastic yield range,thus aggravating the plastic strain accumulation around the ***,the creep characteristics of NGH-bearing sediments could enhance the effects induced by the difference in horizontal in situ stress,as a result,the plastic strain in the formation around the wellbore increased nonlinearly with increasing difference in in situ *** lower the pore pressure,the greater the stress concentration effects and the higher the plastic strain at the ***,the lower the initial NGH saturation,the greater the initial plastic strain and yield range and the higher the equivalent creep *** plastic strain at the wellbore increased nonlinearly with decreasing initial saturation.

关键词： Natural gas hydrates Wellbore stability Creep Plastic yield

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Controlled Self-assembly of Thermo-responsive Amphiphilic H-shaped Polymer for Adjustable Drug Release

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Chinese Journal of Polymer Science 2018年第3期36卷 406-416页

作者： Yang Bai fang-yuan Xie Wei Tian College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Ministry of Education Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Macromolecular Science and Technology School of ScienceNorthwestern Polytechnical UniversityXi’an 710072China Department of Pharmacy Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200438 China

Despite the fact that some progress has been made in the self-assembly of H-shaped polymers, the corresponding self-assemblies that respond to external stimulus and are further utilized to adjust the release of drugs are still deficient. The stimuli-responsive segments with amphiphilic H-shaped structure are generally expected to enhance the controllability of self-assembly process. The synthesis and self-assembly behavior of thermo-responsive amphiphilic H-shaped polymers with poly（ethylene glycol）（PEG）, polytetrahydrofuran （PTHF） and poly（N-isopropyl acrylamide）（PNIPAM） as building blocks are reported in this paper. The inner architecture structure and size of complex micelles formed by H-shaped self-assemblies were effectively adjusted when the solution temperature was increased above the lower critical solution temperature of PNIPAM segments. Furthermore, it was found that the architecture of self-assemblies underwent a transition from the complex micelles based on primary micelles with hybrid PEG/PNIPAM shells to large complex micelles based on primary micelles with hybrid PTHF/PNIPAM cores and PEG shells during the thermal-induced self-assembly process. The adjustable release rate ofdoxorubicin （DOX） from the DOX-loaded complex micelles and basic cell experiments further proved the feasibility of these self-assemblies as the thermal-responsive drug delivery system.

关键词： H-shaped polymer Thermo-responsive polymer Amphiphilic polymer Self-assembly Drug release

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Temperature-responsive Behavior of Polymer Fluorescent System via Electrostatic Interaction Mediated Aggregation/Deaggregation

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Chinese Journal of Polymer Science 2016年第7期34卷 830-837页

作者： si-hua guo fang-yuan zheng fang zeng 吴水珠 College of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction between polyelectrolyte and charged fluorophore. As for the system, the excimer-monomer conversion, thermosensitive behavior and thermo-responsive reversibility were investigated experimentally. Temperature variation and temperature-distribution induced fluorescence changes can be observed directly by naked eyes. Thus, this polymer system holds promise for serving as a fluorescent thermometer.

关键词： Polymer fluorescent thermometer Temperature-responsive Electrostatic interaction Aggregation Deaggregation

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A fast and reliable overset unstructured grids approach

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Acta Mechanica Sinica 2013年第2期29卷 149-157页

作者： Zhong-Liang Kang Chao Yan Jian Yu yuan-yuan fang Institute of Fluid Mechanics Beihang University Academy of Beijing Gas GroupCo. Ltd

A cell-centred overset unstructured grids approach is *** this approach,the intergrid boundary is initially established based on the wall distance from the cell centre,and is then *** accelerate the intergrid-boundary definition much more,a neighbor-toneighbor donor search algorithm based on advancing-front method is modified with the help of minimum cuboid *** simplify the communications between different grid cell types and to obtain second-order spatial accuracy,a new interpolation method is constructed based on linear reconstruction,which employs only one layer of fringe cells along the intergrid *** unsteady flows with relative motion,the intergrid boundary can be redefined fast and *** numerical results show that the present dynamic overset unstructured grids approach is accurate and reliable.

关键词： Overset unstructured grids·Dynamic grids·Intergrid-boundary definition·Interpolation

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Oil-source correlation of Lower-Triassic oil seepages in Ni＇erguan village, Southern Guizhou Depression, China

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Acta Geochimica 2016年第1期35卷 50-63页

作者： fang yuan Yuhong Liao Yunxin fang Ansong Geng The State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Wushan Guangzhou 510640People's Republic of China University of Chinese Academy of Sciences Beijing 100039People's Republic of China The Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological Survey Ministry of Land and Resources Guangzhou 510075 People's Republic of China

There are abundant bitumens and oil seepages stored in vugs in a Lower-Triassic Daye formation(T_1d)marlite in Ni'erguan village in the Southern Guizhou Depression. However, the source of those oil seepages has not been determined to date. Multiple suites of source rocks of different ages exist in the depression. Both the oil seepages and potential source rocks have undergone complicated secondary alterations, which have added to the difficulty of an oil-source correlation. For example, the main source rock, a Lower-Cambrian Niutitang Formation"(∈_1n) mudstone, is over mature, and other potential source rocks, both from the Permian and the Triassic, are still in the oil window. In addition, the T_1d oil seepages underwent a large amount of biodegradation. To minimize the influence of biodegradation and thermal maturation, special methods were employed in this oil-source correlation study. These methods included catalytic hydropyrolysis, to release covalently bound biomarkers from the over mature"kerogen of ∈_1n mudstone, sequential extraction, to obtain chloroform bitumen A and chloroform bitumen C from the T_1d marlite, and anhydrous pyrolysis, to release pyrolysates from the kerogen of T_1d marlite. Using the methods above, the biomarkers and n-alkanes releasedfrom the oil samples and source rocks were analysed by GC–MS and GC-C-IRMS. The oil-source correlation indicated that the T_1d oil seepage primarily originated from"the ∈_1n mudstone and was partially mixed with oil generated from the T_1d marlite. Furthermore, the seepage also demonstrated that the above methods were effective for the complicated oil-source correlation in the Southern Guizhou Depression.

关键词： Oil seepage Biomarker Carbon isotopic composition Catalytic hydropyrolysis Oil-source correlation

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Fluorescence Microscopic Image Analysis of Nucleic Acids Based on The Capillary Flow Directed Assembly Ring of Neutral Red-nucleic Acid Supramolecular Complexes

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Chemical Research in Chinese Universities 2003年第3期19卷 275-279页

作者： LI yuan fang HUANG Cheng zhi Laboratory of Supramolecular Chemistry and Biomedical Analysis College of Chemistry and Chemical EngineeringSouthwest Normal UniversityChongqing 400715P.R.China

It is critical to establish a direct and precise method with a high sensitivity and selectivity in analytical chemistry. In this research, making use of a well known phenomenon of capillary flow, we have proposed an image analysis method of nucleic acids at the price of a small amount of sample. When a droplet of the supramolecular complex solution, formed by neutral red and nucleic acids(NA) under an approximate neutral condition, was placed on the hydrophobic surface of dimethyl dichlorosilane pretreated glass slides, and it was evaporated, the supramolecular complex exhibited the periphery of the droplet due to the capillary effect, and accumulated there to form a red capillary flow directed assembly ring(CFDAR). A typical CFDAR has an outer diameter of (2 r ) about 1.18 mm and a ring width(2 δ ) of about 41 μm. Depending on the experimental conditions, a variety of CFDAR can be assembled. The experimental results are in agreement with our former theoretical discussion. It was found that when a droplet volume is 0.1 μL, the fluorescence intensity of the CFDAR formed by the NR NA is in proportion to the content of calf thymus DNA in the range of 0-0.28 ng, fish sperm DNA of 0-0.24 ng and yeast RNA of 0-0.16 ng with the limit of detection(3 σ ) of 1 7, 1.4 and 0.9 pg, respectively for the three nucleic acids.

关键词： Nuclei acids(NA) Neutral red(NR) Ring assembly Solid support surface Fluorescence imaging analysis

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