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Microglial Calcium Homeostasis Modulator 2:Novel Anti-neuroinflammation Target for the Treatment of Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第4期40卷 553-556页

作者： yuan dong Li Tang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Qingdao Institute of Measurement Technology Qingdao266000China

Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are the most common causes of *** drugs for such diseases can only provide temporary help with the symptoms,leaving the discovery of new drugs urgently in *** cells are the local immune cells in the nervous system and have been recognized as the key player in neuroinflammation that contributes to the process of neurodegeneration[1],raising the discussion of aiming microglia as the therapeutic target for clinical treatment of neurodegenerative diseases.

关键词： inflammation degenerative drugs

Interleukins in Epilepsy:Friend or Foe

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Neuroscience Bulletin 2024年第5期40卷 635-657页

作者： yuan dong Xia Zhang Ying Wang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA02115USA

Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million *** in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ***(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and *** are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in ***,both protective and destructive effects have been reported for many *** may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved *** this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关键词： Epilepsy Interleukins Neuroinflammation

Local search yields a PTAS for fixed-dimensional k-means problem with penalties

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Journal of the Operations Research Society of China 2024年第2期12卷 351-362页

作者： Fan yuan Da-Chuan Xu dong-Lei Du dong-Mei Zhang Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFrederictonNB E3B 9Y2Canada School of Computer Science and Technology Shandong Jianzhu UniversityJinan 250101ShandongChina

We study a problem called the k-means problem with penalties(k-MPWP),which is a natural generalization of the typical k-means *** this problem,we have a set D of client points in R^(d),a set F of possible centers in R^(d),and a penalty cost Pj>O for each point j∈*** are also given an integer k which is the size of the center point *** want to find a center point set S■F with size k,choose a penalized subset of clients P■D,and assign every client in D\P to its open *** goal is to minimize the sum of the squared distances between every point in D\P to its assigned centre point and the sum of the penalty costs for all clients in *** using the multi-swap local search technique and under the fixed-dimensional Euclidean space setting,we present a polynomial-time approximation scheme(PTAS)for the k-MPWP.

关键词： Approximation algorithm k-means Local search Penalty

卡瑞利珠单抗辅助治疗晚期非小细胞肺癌及对肿瘤标志物的影响和安全性分析

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四川生理科学杂志 2024年第2期46卷 267-269,293页

作者：李焕焕聂志勇吴涛袁冬冬张悦姗刘文会安阳市肿瘤医院肿瘤内科河南安阳455001

目的:探讨卡瑞利珠单抗辅助治疗晚期非小细胞肺癌及对肿瘤标志物的影响和安全性。方法:按随机数字表法将2020年8月至2022年8月本院收治的86例晚期非小细胞肺癌患者分为对照组(43例,采用注射用培美曲塞二钠+顺铂注射液化疗方案)和研究组... 详细信息

目的:探讨卡瑞利珠单抗辅助治疗晚期非小细胞肺癌及对肿瘤标志物的影响和安全性。方法:按随机数字表法将2020年8月至2022年8月本院收治的86例晚期非小细胞肺癌患者分为对照组(43例,采用注射用培美曲塞二钠+顺铂注射液化疗方案)和研究组(43例,给予注射用卡瑞利珠单抗辅助注射用培美曲塞二钠、顺铂注射液治疗)。21 d为1个化疗周期,于治疗3个周期后对患者的疗效进行评估。将两组患者治疗后临床总有效率,治疗前后血清肿瘤标志物水平,生活质量评分,以及不良反应的发生情况进行对比。结果:治疗后,研究组患者的临床总有效率(65.12%),比对照组(41.86%)高(P0.05)。结论:将卡瑞利珠单抗辅助治疗药物应用于晚期非小细胞肺癌患者的治疗中,有助于患者临床总有效率的提高,降低血清CA125、CEA、CYFRA21-1等指标水平,提升生活质量,且不会使不良反应增加。

关键词：卡瑞利珠单抗晚期非小细胞肺癌肿瘤标志物安全性

血清VEGF、AFP检测对原发性肝癌PD-1抑制剂联合抗血管生成疗效的预测价值

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罕少疾病杂志 2024年第2期31卷 60-62页

作者：李焕焕聂志勇吴涛袁冬冬张悦姗刘文会安阳市肿瘤医院肿瘤内四科河南安阳455000

目的探讨原发性肝癌患者接受信迪利单抗联合贝伐珠单抗治疗前后血管内皮生长因子(VEGF)和甲胎蛋白(AFP)水平变化及联合检测的意义。方法收集80例符合条件的晚期肝癌患者,均接受信迪利单抗联合贝伐珠单抗治疗,分别在治疗前、2周期治疗后... 详细信息

目的探讨原发性肝癌患者接受信迪利单抗联合贝伐珠单抗治疗前后血管内皮生长因子(VEGF)和甲胎蛋白(AFP)水平变化及联合检测的意义。方法收集80例符合条件的晚期肝癌患者,均接受信迪利单抗联合贝伐珠单抗治疗,分别在治疗前、2周期治疗后检测血清AFP及VEGF水平的变化,同时按RECIST 1.1版判断近期疗效,直至疾病进展,分析近期疗效与血清VEGF、AFP水平变化之间的关系及联合检测的价值。结果80例患者中PR 19例,SD 40例,PD 21例,疾病有效率RR为23.75%,疾病控制率DCR为73.75%。无效组肿瘤分期IV期、多发性肿瘤者、肝功能Child-Pugh分级B级、肿瘤直径>3cm较有效组多,差异均有统计学意义(P<0.05)。与治疗前相比,治疗后血清VEGF及AFP的水平,PR患者显著降低(t=10.979,P=0.000;t=41.185,P=0.000),SD患者无明显差异(t=1.866,P=0.070;t=0.931,P=0.358),PD患者显著升高(t=-12.185,P=0.000;t=-8.001,P=0.000)。ROC曲线结果显示,VEGF、AFP及两者联合曲线下面积以两者联合最大。结论血清VEGF和AFP的检测有助于判断晚期肝癌患者信迪利单抗联合贝伐珠单抗联合治疗的疗效及可作为预测联合治疗预后的指标。

关键词：信迪利单抗贝伐珠单抗 VEGF AFP

Reliable calculations of nuclear binding energies by the Gaussian process of machine learning

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Nuclear Science and Techniques 2024年第6期35卷 130-144页

作者： Zi-Yi yuan dong Bai Zhen Wang Zhong-Zhou Ren School of Physics Science and Engineering Tongji UniversityShanghai 200092China College of Science Hohai UniversityNanjing 211100China Key Laboratory of Advanced Micro-Structure Materials Ministry of EducationShanghai 200092China

Reliable calculations of nuclear binding energies are crucial for advancing the research of nuclear physics. Machine learning provides an innovative approach to exploring complex physical problems. In this study, the nuclear binding energies are modeled directly using a machine-learning method called the Gaussian process. First, the binding energies for 2238 nuclei with Z > 20 and N > 20 are calculated using the Gaussian process in a physically motivated feature space, yielding an average deviation of 0.046 MeV and a standard deviation of 0.066 MeV. The results show the good learning ability of the Gaussian process in the studies of binding energies. Then, the predictive power of the Gaussian process is studied by calculating the binding energies for 108 nuclei newly included in AME2020. The theoretical results are in good agreement with the experimental data, reflecting the good predictive power of the Gaussian process. Moreover, the α-decay energies for 1169 nuclei with 50 ≤ Z ≤ 110 are derived from the theoretical binding energies calculated using the Gaussian process. The average deviation and the standard deviation are, respectively, 0.047 MeV and 0.070 MeV. Noticeably, the calculated α-decay energies for the two new isotopes ^ (204 )Ac(Huang et al. Phys Lett B 834, 137484(2022)) and ^ (207) Th(Yang et al. Phys Rev C 105, L051302(2022)) agree well with the latest experimental data. These results demonstrate that the Gaussian process is reliable for the calculations of nuclear binding energies. Finally, the α-decay properties of some unknown actinide nuclei are predicted using the Gaussian process. The predicted results can be useful guides for future research on binding energies and α-decay properties.

关键词： Nuclear binding energies decay Machine learning Gaussian process

Development of Spectral Features for Monitoring Rice Bacterial Leaf Blight Disease Using Broad-Band Remote Sensing Systems

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 745-762页

作者： Jingcheng Zhang Xingjian Zhou dong Shen Qimeng Yu Lin yuan Yingying dong College of Artificial Intelligence Hangzhou Dianzi UniversityHangzhou310018China School of Information Engineering Zhejiang University of Water Resources and Electric PowerHangzhou310018China Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing100094China

As an important rice disease, rice bacterial leaf blight (RBLB, caused by the bacterium Xanthomonas oryzae ***), has become widespread in east China in recent years. Significant losses in rice yield occurred as a result ofthe disease’s epidemic, making it imperative to monitor RBLB at a large scale. With the development of remotesensing technology, the broad-band sensors equipped with red-edge channels over multiple spatial resolutionsoffer numerous available data for large-scale monitoring of rice diseases. However, RBLB is characterized by rapiddispersal under suitable conditions, making it difficult to track the disease at a regional scale with a single sensorin practice. Therefore, it is necessary to identify or construct features that are effective across different sensors formonitoring RBLB. To achieve this goal, the spectral response of RBLB was first analyzed based on the canopyhyperspectral data. Using the relative spectral response (RSR) functions of four representative satellite or UAVsensors (i.e., Sentinel-2, GF-6, Planet, and Rededge-M) and the hyperspectral data, the corresponding broad-bandspectral data was simulated. According to a thorough band combination and sensitivity analysis, two novel spectralindices for monitoring RBLB that can be effective across multiple sensors (i.e., RBBRI and RBBDI) weredeveloped. An optimal feature set that includes the two novel indices and a classical vegetation index was *** capability of such a feature set in monitoring RBLB was assessed via FLDA and SVM algorithms. The resultdemonstrated that both constructed novel indices exhibited high sensitivity to the disease across multiple ***, the feature set yielded an overall accuracy above 90% for all sensors, which indicates its cross-sensorgenerality in monitoring RBLB. The outcome of this research permits disease monitoring with different remotesensing data over a large scale.

关键词： Rice bacterial leaf blight analysis of spectral response multispectral data simulation vegetation indices cross-sensor disease monitoring

Hydrogen-rich surface of MoC catalysts for efficient CO_(2)hydrogenation induced by a coupled hydrogen donator

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Nano Research 2024年第8期17卷 7762-7767页

作者： dong Xu Si-yuan Xia Qi-yuan Li Jie-Sheng Chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2)hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2)has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2)hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2)hydrogenation formic acid

New clinical trial design in precision medicine:discovery,development and direction

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1293-1321页

作者： Xiao-Peng Duan Bao-dong Qin Xiao-dong Jiao Ke Liu Zhan Wang yuan-Sheng Zang Department of Medical Oncology Changzheng HospitalNaval Medical UniversityShanghaiChina

In the era of precision medicine,it has been increasingly recognized that individuals with a certain disease are complex and different from each *** to the underestimation of the significant heterogeneity across participants in traditional"one-sizefits-all"trials,patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket,umbrella,and platform trial designs under the master protocol *** recent years,the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous *** the rapid increase in the number of basket,umbrella,and platform trials,the current clinical and research understanding of these new trial designs,as compared with traditional trial designs,remains *** majority of the research focuses on methodologies,and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial ***,we provide this comprehensive review of the discovery and development of basket,umbrella,and platform trials and their underlying logic from the perspective of precision ***,we discuss future directions on the potential development of these new clinical design in view of the"Precision Pro","Dynamic Precision",and"Intelligent Precision".This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic,which be essential to accelerate the progression of precision medicine.

关键词： clinical approval successive