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Chinese Chemical Letters 2008年第8期19卷 904-906页

作者： Bo Wang Chuan ming yu Zhi wei Chen wei Ke Su College of Pharmaceutical Sciences Zhejiang University of Technology Zhejiang Key Laboratory of Pharmaceutical Engineering Hangzhou 310014 China

A mild and simple method for the synthesis of dialkyl chlorophosphates is described, bis（trichloromethyl） carbonate （BTC） is used as the effective reagent for the conversion of dialkyl phosphites to their correspo... 详细信息

关键词： Bis(trichloromethyl) carbonate Dialkyl chlorophosphate Tdalkyl phosphite Synthesis

In situ generated,tetrahydrosalen stabilized yttrium borohydride complex:Efficient initiator for the ring-opening polymerization of ε-caprolactone

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Chinese Chemical Letters 2009年第11期20卷 1357-1360页

作者： Jing Huang Jian Fang yu Guang ming Wu wei Lin Sun Zhi Quan Shen Key Laboratory of Macromolecule Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

In this paper, we report the preparation of a new tertrahydrosalen-stabilized yttrium complex which was employed as an initiator-precursor for the polymerization of ε-caprolactone （ε-CL） in the presence of NaBH4 to give interesting hydroxytelechelic poly（ε-caprolactone）（PCL）. The effect of [monomer]/[initiator] （[CL]/[I]）, temperature and time on the polymerization was investigated. It was found that under the condition： [CL]/[I] = 1200, 55℃, toluene： 0.5 mL, ε-CL： 0.5 mL, PCL with Mw = 32,600 and PDI = 1.47 was obtained.

关键词： Tetrahydrosalen Yttrium complex Ring-opening polymerization ε-Caprolactone

Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery

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Chinese Medical Sciences Journal 2009年第1期24卷 55-59页

作者： yue-Dina Fan Jian-chun yu wei-ming Kang Qun Zhang Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complicati

关键词： glutamine dipepfide glutathione total parenteral nutrition abdominal operation

Laparoscopic Partial Splenectomy for Giant Hemangioma Misdiagnosed as Splenic Cyst:a Case Report

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Chinese Medical Sciences Journal 2010年第3期25卷 189-192页

作者： Jin Wang Jian-chun yu wei-ming Kang Zhi-qiang Ma Department of General Surgery Peking Union Medical College Hospital ChineseAcademy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

ALTHOUGH unusual, hemangioma is the most common type of primary splenic neoplasm.1 Usually, splenic hemangioma appears as solid mass, but sometimes it presents cystic corn-ponent as well, which is difficult to discriminate from some other lesions, such as abscess, simple cyst, parasitic cyst, and lymphangioma.2 Preoperative diagnosis of splenic hemangioma mainly depends on imaging study （e.g. ultrasonography, CT, MRI）.

关键词： splenic hemangioma splenic cyst laparoscopic partial splenectomy misdiagnosis

Investigating the mechanisms of isochorismate synthase:An approach to improve salicylic acid synthesis and increase resistance to Fusarium head blight in wheat

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The Crop Journal 2024年第4期12卷 1054-1063页

作者： Ya-Zhou Zhang Jie Man Dan Xu Lan Wen Yinghui Li Mei Deng Qian-Tao Jiang Qiang Xu Guo-yue Chen yu-ming wei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina

Salicylic acid(SA),a vital endogenous hormone,plays a crucial role in plant growth and the response to abiotic and biotic *** synthase(ICS)and phenylalanine ammonia lyase(PAL)are critical rate-limiting enzymes for SA *** head blight(FHB)seriously threatens the safety of wheat production,but increasing the content of SA can enhance FHB ***,the pathway of SA synthesis and regulation in wheat remains *** this study,three wheat ICS(TaICSA,TaICSB,and TaICSD)were identified,and their functions were validated in vitro for isomerizing chorismate to *** mutation of one or two homoeoalleles of TaICSA,TaICSB,and TaICSD in the wheat variety‘Cadenza’reduced SA levels under ultraviolet treatment and Fusarium graminearum infection,further enhancing sensitivity to *** of TaICSA can significantly enhance SA levels and resistance to *** further study SA synthesis pathways in wheat and avoid interference with pathogenicity related genes,the leaves of wild-type Cadenza and different TaICS mutant lines were subjected to ultraviolet treatment for transcriptomic *** results showed that 37 PALs might be involved in endogenous SA synthesis,and 82 WRKY and MYB family transcription factors may regulate the expression of ICS and *** results were further confirmed by *** conclusion,this study expands our knowledge of SA biosynthesis and identifies TaICSA,as well as several additional candidate genes that encode transcription factors for regulating endogenous SA levels,as part of an efficient strategy for enhancing FHB resistance in wheat.

关键词： Salicylic acid Chorismate Isochorismate RNA-seq Phenylalamine ammonia lyase

Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists

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Acta Pharmacologica Sinica 2007年第1期28卷 125-131页

作者： Rui ZHANG Pang-ke YAN Cai-hong ZHOU Jia-yu LIAO ming-wei WANG~2 The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China The National Center for Drug Screening Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China

Aim:To develop homogeneous calcium mobilization assay for high-throughputscreening(HTS)of mas-related gene(Mrg)receptor ***:CHO-Klcells stably expressing the full-length MrgD receptor and a calcium-sensitive dyewere used to develop an HTS assay based on intracellular calcium *** was applied to large-scale screening of a library containing 8000 syntheticcompounds and natural product extracts,cAMP measurements were carried outto verify the bioactivities of the hits found by the calcium mobilization *** approaches were also employed in the identification of the MrgA1 recep-tor agonists following HTS of 16000 ***:EC50values of the positivecontrol compounds(μ-alanine for MrgD receptor and dynorphin A for MrgA1receptor)determined by the calcium mobilization assay were consistent with thosereported in the literature,and the Z’factors were 0.65 and 0.50 for MrgD andMrgA1 receptor assay,*** 31 compounds for the MrgD receptorand 48 compounds for the MrgA1 receptor showing20% of the maximal agonistactivities found in the controls were initially identified as *** screen-ing confirmed that 2 compounds for each receptor possessed specific *** cAMP level measurements indicated that the 2 confirmedhits displayed the functionality of the MrgD receptor ***:Aseries of validation studies demonstrated that the homogeneous calcium mobili-zation assay developed was highly efficient,amenable to automation and a robusttool to screen potential MrgD and MrgA1 receptor *** application maybe expanded to other G-protein coupled receptors that mobilize calcium influxupon activation.

关键词： mas-related gene receptor calcium mobilization assay high-throughput screening

In vitro and in vivo evaluation of fisetin as an anticancer agent for breast cancer

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中国药理学与毒理学杂志 2016年第10期30卷 1072-1073页

作者： SUN Xu yu ming-wei MA Xue-man YANG Yong CAO Ke-xin SUN Jia-qi WANG Xiao-min Beijing Hospital of Traditional Chinese Medicine Capital Medical University

OBJECTIVE This study aims to explore the anticancer effect of fisetin for breast cancer in vivo and in *** Viability of cultured breast cancer cells including 4T1,Mcf-7 and MDA-MB-231 were determined using MTT assay and electric cell-substrate impedance sensing(ECIS).Cell migratory ability was evaluated by wound healing *** apoptosis was quantified using the AnnexinⅤ/propidium iodide(PI)detection kit and analyzed by flow ***,the potential anti-tumor and anti-metastatic mechanism was investigated by Western *** of tumor growth and metastasis was evaluated by assessment of tumor weight,volume and analysis of bioluminescent signal after a homograft ***,intraperitoneal were respectively administered in different *** we found that fisetin inhibited the proliferation and induced apoptosis of breast cel *** study showed that fisetin inhibited migration of breast cancer ***,our data demonstrated theanticancer activity of fisetin by oral *** addition,the PI3K/AKT/m TORstatus in breast cancer cells may contribute to fisetin anticancer *** Fisetin exerts anti-tumor growth and anti-metastatic effects in breast cancer cells,that is,at least partly,associated with decreased downregulation of PI3K/AKT/m TOR expression,The absolute bioavailability of intraperitoneal administration is relatively lower than that of intragastric administration,the anticancer effect of fisetin in vivo needs more study to address the solubility issue.

关键词： breast cancer fisetin solubility

Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei yu ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all P<0.01).Moreover,Scorpiones,Scolopendra and Gekko inhibited the phosphorylation of AKT and ribosomal protein S6 kinase(p70S6K)(P<0.05 or P<0.01).In addition,they also decreased the expression of CD31,MVD,bFGF,TGF-β1 and VEGF compared with the model group(P<0.05 or P<0.01).Conclusion:Scorpiones,Scolopendra and Gekko all showed beneficial effects on lung cancer by ameliorating the hypoxic tumor microenvironment via PI3K/AKT/mTOR/HIF-1αsignaling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑yuan yu Jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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曲韵研究

艺术百家 2011年第1期27卷 125-133页

作者：俞为民南京大学文学院江苏南京210093

曲韵是曲体文学格律的一个重要内容,曲韵有南北之分,南北曲韵皆是随着曲体文学的产生与发展逐步规范统一的。而在南北曲韵各自规范与统一的过程中,相互之间也产生了影响,并逐步出现融合的现象,这一现象在明清时期的南北曲韵谱中得到了... 详细信息

曲韵是曲体文学格律的一个重要内容,曲韵有南北之分,南北曲韵皆是随着曲体文学的产生与发展逐步规范统一的。而在南北曲韵各自规范与统一的过程中,相互之间也产生了影响,并逐步出现融合的现象,这一现象在明清时期的南北曲韵谱中得到了体现。

关键词：戏曲艺术音乐艺术南北曲曲韵《中原音韵》韵谱