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Rare Metals 2023年第5期42卷 1545-1556页

作者： yu-Jia Wang Xue-Wen yu peng Zhang Zheng-Jie Wang Lei Yan Liang He Ze-Kai Wang Zhi-Qiang Shi Tianjin Key Laboratory of Advanced Fibers and Energy Storage School of Materials Science and EngineeringTiangong UniversityTianjin300387China College of New Energy Ningbo University of TechnologyNingbo315211China

Dual-ion batteries(DIBs)have attracted tremendous attention owing to their high operating voltage and are considered promising candidates for low-cost clean energy storage ***,the decomposition of electrolytes and collapse of the cathode structure may lead to low Coulombic efficiency(CE)and low cycling stability of ***-layered electrode materials can accommodate the intercalation/deintercalation of large anions,which is believed to overcome these ***,expanded mesocarbon microbeads(200HRO-MCMB)possessing an enlarged interlayer spacing(0.405 nm)were prepared via modified Hummers and subcritical hydrothermal reduction *** the indispensable electrochemical activation,200HRO-MCMB(hydrothermal reduction at 200℃)exhibited a high specific capacity(120 mAh·g^(-1)at50 mA·g^(-1))when used as a cathode for a sodium-based DIB,and the CE significantly improved within the 2.0-4.5 V voltage ***,the cycling stability exceeded over 600 ***,this cathode possessed enlarged interlayers that decreased the barrier of PF6^(-)transport,and the battery storage mechanism corresponded to a transitioning state between double-layer capacitance and Faradaic ***,this work will expand the scope of the practical application of low-cost sodium-based DIBs.

关键词： Expanded mesocarbon microbeads Sodiumbased dual-ion batteries Interlayer spacing

超声引导下经皮经肝注射吲哚菁绿与声诺维混合剂在腹腔镜肝锥形单元切除中的应用研究

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中国实用外科杂志 2024年第2期44卷 211-215,223页

作者：程东辉杨冲蒋佶朋左邦佑曹文斌吴昊杨文昊游欣雨张宇四川省医学科学院四川省人民医院肝胆胰外科四川成都610072

目的探讨超声引导下经皮经肝注射吲哚菁绿(ICG)与声诺维混合剂在腹腔镜肝锥形单元切除中的应用价值。方法回顾性分析四川省人民医院2022年1月至2023年5月超声引导下经皮经肝注射ICG与声诺维混合剂并行ICG荧光成像辅助腹腔镜肝锥形单元... 详细信息

目的探讨超声引导下经皮经肝注射吲哚菁绿(ICG)与声诺维混合剂在腹腔镜肝锥形单元切除中的应用价值。方法回顾性分析四川省人民医院2022年1月至2023年5月超声引导下经皮经肝注射ICG与声诺维混合剂并行ICG荧光成像辅助腹腔镜肝锥形单元切除术的16例病人临床资料。观察指标包括肿瘤荧光显像情况、锥形单元荧光染色情况、病人围手术期指标以及随访情况等。结果16例病人的ICG荧光染色均成功显示肝锥形单元边界且肝脏锥形单元荧光显像均完整包含肿瘤,其中15例病人肝锥形单元荧光边界距离肿瘤边界>1cm,1例病人肝锥形单元ICG荧光显像边界距离肿瘤边界较近约0.5 cm。术后解剖标本切缘距离肿瘤达0.5~1.6cm。16例病人中3例病人穿刺2支门静脉分支,13例病人穿刺1支门静脉分支,与术前评估相似。手术时长在62~121 min,中位时长89 min。术中出血30~110 mL,中位出血量80 mL,术中无输血,无中转开放手术病例。截止至2023-07-12,随访时间2~14个月,病人均未出现术后复发。结论超声引导下经皮经肝注射ICG与声诺维混合剂辅助腹腔镜肝锥形单元切除安全可行,其对于肝脏恶性肿瘤的长期疗效值得进一步研究。

关键词：肝锥形单位肝切除术腹腔镜荧光成像吲哚菁绿声诺维

2017—2022年新疆生产建设兵团手足口病流行特征及病原学分析

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医学动物防制 2024年第5期40卷 463-466页

作者：赵倩成彦彪于亚乐郭景霞何尧王童敏新疆生产建设兵团疾病预防控制中心新疆维吾尔自治区乌鲁木齐830002

目的了解2017—2022年新疆生产建设兵团(简称“兵团”)手足口病流行特征和病原学特点,为科学防控提供参考依据。方法通过中国疾病预防控制信息系统获取2017—2022年兵团手足口病病例资料,从兵团疾病预防控制中心获取病原学资料,采用描... 详细信息

目的了解2017—2022年新疆生产建设兵团(简称“兵团”)手足口病流行特征和病原学特点,为科学防控提供参考依据。方法通过中国疾病预防控制信息系统获取2017—2022年兵团手足口病病例资料,从兵团疾病预防控制中心获取病原学资料,采用描述性流行病学方法对兵团手足口病病例流行病学特征进行分析。结果2017—2022年兵团共报告手足口病2884例,年均发病率为15.64/10万,无重症和死亡病例;发病时间呈双峰分布,5~6月为最高峰,9~10月为次高峰;发病年龄以5岁以下儿童为主,构成比为83.91%,男女比例为1.41∶1,男女发病率差异有统计学意义(χ^(2)=47.41,P<0.001);兵团14个师均有发病,北疆地区发病率(10个师,年均发病率为86.63/10万)明显高于南疆地区(4个师,年均发病率为42.84/10万),差异有统计学意义(χ^(2)=192.38,P<0.001)。病原学监测结果显示,兵团手足口病以其他肠道病毒和柯萨奇病毒A16(Coxsackievirus A16,Cox A16)型为主,构成比为85.00%,肠道病毒71(Enterovirus 71,EV 71)型整体处于下降趋势,但从2021年起有所上升,其他肠道病毒总体在50.00%上下波动。结论兵团手足口病的流行有明显的地区、时间、人群分布特点,应有针对性开展防控措施,降低发病率。针对病原谱变化,对其他肠道病毒进一步分型,明确兵团手足口病发病优势病原,为疫情防控提供支持。

关键词：新疆生产建设兵团手足口病流行特征病原学肠道病毒防控措施分析

Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma

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Biomedical and Environmental Sciences 2022年第7期35卷 622-632页

作者： JIAO Ning JI Wan Sheng ZHANG Biao SHANG yu Kui ZHANG yu Chen yu Wei Qun JIN Hai Long LI Chao ZHANG cheng Ying YAN cheng yuE Wen ZHANG Qing Weifang Medical university Weifang 261053ShandongChina Department of Organ Transplantation The Third Medical Center of PLA General HospitalBeijing 100039China Clinical Research Center Affiliated Hospital of Weifang Medical UniversityWeifang 261042ShandongChina Stem Cell and Regenerative Medicine Lab Institute of Health Service and Transfusion MedicineBeijing 100850China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100083China Senior Department of Ophthalmology The Third Medical Center of PLA General HospitalBeijing 100039China Department of General Practice The Third Medical Center of PLA General HospitalBeijing 100039China

Objective To investigate the regulatory relationship of Protein Phosphatase 2 Regulatory Subunit B"Alpha(PPP2R3A)and hexokinase 1(HK1)in glycolysis of hepatocellular carcinoma(HCC).Methods In HepG2 and Huh7 cells,PPP2R3A expression was silenced by small interfering RNA(siRNA)and overexpression by plasmid *** PPP2R3A-related genes were searched by RNA *** levels were measured by glucose uptake and lactate ***-PCR,ELISA,western blot and immunofluorescence assay were performed to detect the changes of PPP2R3A and *** proliferation,migration and invasion assay were used to study the roles of HK1 regulation by *** RNA sequencing data revealed that PPP2R3A siRNA significantly downregulated the expression of ***2R3A gene overexpression promotes,while gene silencing suppresses,the level of HK1 and glycolysis in HCC *** HCC tissue samples,PPP2R3A and HK1 were colocalized in the cytoplasm,and their expression showed a positive ***1 inhibition abrogated the promotion of glycolysis,proliferation,migration and invasion by PPP2R3A overexpression in liver cancer *** Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC,which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.

关键词： Hepatocellular carcinoma PPP2R3A Hexokinase 1 Glycolysis

基于生物信息学对心肌缺血再灌注损伤关键基因的筛选及实验验证

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中国病理生理杂志 2024年第3期40卷 473-483页

作者：王建茹李兴渊谢世阳程彦玲郭红鑫朱明军于瑞河南中医药大学第一附属医院心脏中心河南郑州450000

目的:运用生物信息学分析方法挖掘参与心肌缺血再灌注损伤(MIRI)的关键基因。方法:首先,从数据库中下载大鼠MIRI相关数据集GSE122020、E-MEXP-2098和E-GEOD-4105。其次,一方面利用微阵列数据线性模型(limma)包筛选各数据集中的差异表达... 详细信息

目的:运用生物信息学分析方法挖掘参与心肌缺血再灌注损伤(MIRI)的关键基因。方法:首先,从数据库中下载大鼠MIRI相关数据集GSE122020、E-MEXP-2098和E-GEOD-4105。其次,一方面利用微阵列数据线性模型(limma)包筛选各数据集中的差异表达基因(DEGs),再用稳健排序整合(RRA)方法筛选稳健DEGs;另一方面,利用替代变量分析(SVA)包将各数据集合并为1个数据集,再利用limma包筛选合并DEGs;将2种渠道的DEGs取交集获取共同DEGs。接着,构建共同DEGs的蛋白相互作用(PPI)网络,利用最大邻域组件密度(DMNC)算法筛选关键基因,并绘制关键基因的受试者工作特征(ROC)曲线,以评价其诊断效能。然后,构建MIRI大鼠模型,检测关键基因的mRNA和蛋白表达情况;并对关键基因参与MIRI的研究开展文献回顾分析。最后,对关键基因开展基因集富集分析(GSEA),进一步揭示其介导MIRI可能的机制。结果:共鉴定出143个稳健DEGs,48个合并DEGs,两者取交集后,获得48个共同DEGs。在共同DEGs的PPI网络中,共筛选出了5个关键基因,即MYC原癌基因bHLH转录因子(MYC)、前列腺素内过氧化物合酶2(PTGS2)、血红素加氧酶1(HMOX1)、胱天蛋白酶3(CASP3)和尿激酶型纤溶酶原激活物受体(PLAUR)。这些关键基因的ROC曲线下面积均大于0.8。在MIRI大鼠心肌组织中MYC、PTGS2、CASP3和PLAUR的mRNA和蛋白高表达,而HMOX1的mRNA和蛋白表达无显著差异。回顾文献,5个关键基因中仅PLAUR未被报道参与MIRI。PLAUR的GSEA结果显示,PLAUR的功能富集主要集中在NOD样受体信号通路、P53信号通路、Toll样受体信号通路、细胞凋亡和脂肪酸代谢等途径。结论:MYC、PTGS2、CASP3、HMOX1和PLAUR参与了MIRI的病理过程。PLAUR为潜在的关键基因,其可能通过调控NOD样受体信号通路、P53信号通路、Toll样受体信号通路、细胞凋亡和脂肪酸代谢等途径介导MIRI,结果可为进一步探讨MIRI的分子机制和治疗靶点提供参考。

关键词：心肌缺血再灌注损伤生物信息学分析稳健排序整合关键基因差异表达基因

地质雷达在卵石地层既有道路顶管施工中的应用

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工程与建设 2024年第3期38卷 601-602,621页

作者：马承禹周国贤马承林田浩邓峰何佳北京市建设工程质量第三检测所有限责任公司北京100037 北京京城地铁有限公司北京101300 北京市轨道交通建设管理有限公司北京100068 北京市公路事业发展中心北京101160

地下管线施工穿越卵石地层,易引起地面沉降、塌陷等情况,严重影响既有道路设施安全.选择具有针对性的施工方法,利用地质雷达配合地面沉降监测,可以有效控制道路沉降风险,保障民众的人身和财产安全.地质雷达在新建给水管道穿越道路中的... 详细信息

地下管线施工穿越卵石地层,易引起地面沉降、塌陷等情况,严重影响既有道路设施安全.选择具有针对性的施工方法,利用地质雷达配合地面沉降监测,可以有效控制道路沉降风险,保障民众的人身和财产安全.地质雷达在新建给水管道穿越道路中的应用可供其他类似项目借鉴.

关键词：地质雷达卵石层顶管施工

Role of interfacial electron transfer reactions on sulfamethoxazole degradation by reduced nontronite activating H_(2)O_(2)

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Journal of Environmental Sciences 2023年第2期124卷 688-698页

作者： Hao-Jie Cui Yaqi Ning CongWu Wei peng Dong cheng Lichu Yin Weijun Zhou Wenjuan Liao College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China College of Environment Zhejiang University of TechnologyHangzhou 310014China

It has been documented that organic contaminants can be degraded by hydroxyl radicals(•OH)produced by the activation of H2O2 by Fe(II)-bearing ***,the interfacial electron transfer reactions between structural Fe(Ⅱ)and H_(2)O_(2) for•OH generation and its effects on contaminant remediation are *** this study,we first investigated the relation between•OH generation sites and sulfamethoxazole(SMX)degradation by activating H2O2 using nontronite with different reduction ***(5.2–16.9μmol/L)degradation first increased and then decreased with an increase in the reduction extent of nontronite from 22% to 62%,while the•OH production increased *** treatment of edge sites and structural variation results revealed that interfacial electron transfer reactions between Fe(Ⅱ)and H2O2 occur at both the edge and basal *** enhancement on basal plane interfacial electron transfer reactions in a high reduction extent rNAu-2 leads to the enhancement on utilization efficiencies of structural Fe(Ⅱ)and H_(2)O_(2) for•OH ***,the•OH produced at the basal planes is less efficient in oxidizing SMX than that of at edge *** of SMX could be sustainable in the H_(2)O_(2)/rNAu-2 system through chemically *** results of this study show the importance role of•OH generation sites on antibiotic degradation and provide guidance and potential strategies for antibiotic degradation by Fe(Ⅱ)-bearing clay minerals in H2O2-based treatments.

关键词： Reduced nontronite Electron transfer Sulfamethoxazole degradation Reaction sites Hydroxyl radicals

Numerical assessment of the erosion risk for cavitating twisted hydrofoil by three methods

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Journal of Hydrodynamics 2021年第4期33卷 698-711页

作者： Ting-ting Lei Huai-yu cheng Bin Ji Xiao-xing peng State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China National Key Laboratory on Ship Vibration and Noise China Ship Scientific Research CenterWuxi214082China

In this paper, the large eddy simulation (LES) method in conjunction with the Zwart cavitation model is adopted for the assessment of the erosion risk on a hydrofoil surface. The numerical results are in good agreement with the experiments. On this basis, three methods, namely the intensity function method (IFM), the time-averaged aggressiveness indicators (TAIs) and the gray level method (GLM), are applied for the assessment of the erosion risk. It is shown that the erosion intensity index of the IFM is extremely sensitive to the artificially selected thresholds, which greatly limits the application of the method. The erosion risk predicted by four indicators in the TAIs does not agree well with the experimental results. Further analysis demonstrates that the GLM using the instantaneous pressure field is relatively satisfactory, which can provide a reasonable assessment of the erosion and is not very sensitive to the artificially selected thresholds. To further improve the accuracy of the GLM for the erosion risk prediction, the time-average pressure field is adopted in the GLM for the erosion evaluation. It is suggested that the erosion assessment by using the time-averaged pressure field is in better agreement with the experimental results when compared with that by using the instantaneous pressure field.

关键词： Cavitating flow erosion numerical simulation threshold selection

基于安全系统工程的进出口烟花爆竹风险防控对策研究

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质量安全与检验检测 2024年第3期34卷 62-65页

作者：王鹏刘劲彪农渝郑西安中华人民共和国长沙海关湖南长沙410001

进出口烟花爆竹作为第Ⅰ类危险货物(爆炸品),其固有危险特性在设计、生产、仓储、运输、燃放等产品全生命周期的具体风险及其表现形式是海关检验监管工作中需要重点关注的对象。本文旨在运用安全系统工程理论,研究海关检验监管全流程中... 详细信息

进出口烟花爆竹作为第Ⅰ类危险货物(爆炸品),其固有危险特性在设计、生产、仓储、运输、燃放等产品全生命周期的具体风险及其表现形式是海关检验监管工作中需要重点关注的对象。本文旨在运用安全系统工程理论,研究海关检验监管全流程中构成整个系统安全的进出口烟花爆竹产品各单元的关系和相互影响,以协调各业务环节和进出口烟花爆竹各单元之间的关系,取得系统安全的最佳流程设计点,提出相应的风险防控措施建议。

关键词：进出口烟花爆竹安全系统工程风险

基于随机森林算法建立非急诊大手术后延迟拔管的预测模型

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临床麻醉学杂志 2024年第1期40卷 7-12页

作者：李鹏朱静文许开伟张玉傅海峰杜文文温州医科大学附属第一医院麻醉科 325000 浙江省人民医院麻醉科

目的基于随机森林算法分析非急诊大手术后延迟拔管的影响因素,建立并验证术后延迟拔管的预测模型。方法回顾性收集2018年1月至2022年12月全麻下行非急诊大手术的7528例患者的临床资料。根据术后2 h内是否拔管,将患者分为两组:非延迟拔管... 详细信息

目的基于随机森林算法分析非急诊大手术后延迟拔管的影响因素,建立并验证术后延迟拔管的预测模型。方法回顾性收集2018年1月至2022年12月全麻下行非急诊大手术的7528例患者的临床资料。根据术后2 h内是否拔管,将患者分为两组:非延迟拔管组(≤2 h)和延迟拔管组(>2 h)。将患者按照7∶3分为训练集和验证集,通过LASSO回归、Logistic回归筛选术后延迟拔管的预测因素,采用随机森林算法建立并验证预测模型。结果有123例(1.6%)出现术后延迟拔管。ASA分级、科室、术中使用氟比洛芬酯、右美托咪定、激素、术中出现低钙血症、重度贫血、术中输血、气道痉挛是术后延迟拔管的独立预测因素。基于随机森林算法建立的预测模型在验证集中的曲线下面积(AUC)为0.751(95%CI 0.742~0.778),敏感性98.1%,特异性41.9%。结论基于随机森林算法建立的非急诊大手术后拔管延迟的预测模型具有较好的预测性能,利用该模型有助于预防非急诊大手术后延迟拔管。

关键词：随机森林大手术延迟拔管危险因素预测模型