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咪达唑仑对老年全麻骨科手术患者机体应激反应、BDNF、S100β水平的影响

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医药论坛杂志 2024年第5期45卷 515-519页

作者：彭程苏孟勤谢峥嵘南阳市中医院麻醉科河南南阳473000 河南省省立医院麻醉科郑州451199 河南省胸科医院麻醉科郑州450008

目的分析咪达唑仑对老年全麻骨科手术患者机体应激反应、血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、中枢神经特异性蛋白S100β水平的影响。方法选取2019年1月—2020年12月南阳市中医院的111例择期老年全麻骨科... 详细信息

目的分析咪达唑仑对老年全麻骨科手术患者机体应激反应、血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、中枢神经特异性蛋白S100β水平的影响。方法选取2019年1月—2020年12月南阳市中医院的111例择期老年全麻骨科手术患者按随机数字表法分对照组(n=56)、观察组(n=55);对照组麻醉方案以丙泊酚为主,观察组以咪达唑仑为主;比较两组手术情况、血流动力学、应激反应及血清BDNF、S100β水平,并统计麻醉相关并发症发生率。结果两组手术时间、术中出血量及总麻醉时长无统计学意义(P>0.05),但观察组苏醒时间显著较对照组长(P<0.05);观察组T2~T4时的心率(HR),T1~T5时的平均动脉压(MAP)及T4时的脉搏血氧饱和度(SpO2)显著高于对照组(P<0.05);观察组术毕、术毕6 h、术毕24 h时的中性粒细胞计数(PMN)、丙二醛(MDA)显著低于对照组,超氧化物歧化酶(SOD)活性显著高于对照组(P<0.05);观察组术后1 d、3 d时BDNF高于对照组,S100β低于对照组(P<0.05);观察组不良反应发生率低于对照组(7.27%vs 21.43%,P<0.05)。结论较丙泊酚,应用咪达唑仑可显著减轻老年骨科手术患者应激反应,降低术后认知障碍风险,减轻不良反应,且应用咪达唑仑血流动力学相对更稳定。

关键词：老年骨科手术全身麻醉咪达唑仑应激反应血清脑源性神经营养因子中枢神经特异性蛋白S100β

Role of hippocampal dentate gyrus neurons in the protective effects of heat shock factor 1 on working memory

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Neural Regeneration Research 2011年第9期6卷 686-691页

作者： Min peng Xiongzhao Zhu Ming cheng Xiangyi Chen Shuqiao Yao Department of Mental Health Nanshan Hospital Affiliated to Guangdong Medical College Shenzhen 518052 Guangdong Province China Research Center of Mental Psychology Xiangya Second Hospital of Central South University Changsha 410011 Hunan Province China Department of Psychosomatic Disease Second People's Hospital of Hunan Province Changsha 410011 Hunan Province China

Increasing evidence suggests that heat shock factor 1 exerts endogenous protective effects on working memory under conditions of chronic psychological stress. However, the precise underlying mechanisms remain poorly understood. This study examined the protective factors affecting working memory in heat shock transcription factor 1 gene knockout mice. The results indicated that the number of correct T maze alternations decreased following mild chronic psychological stress in knockout mice. This change was accompanied by a decrease in neurogenesis and an increase in neuronal apoptosis in the hippocampal dentate gyrus. The number of correct T maze alternations was positively correlated with neurogenesis in hippocampal dentate gyrus, and negatively correlated with neuronal apoptosis. In wild type mice, no significant difference was detected in the number of correct T maze alternations or neuronal apoptosis in hippocampal dentate gyrus. These results indicate that the heat shock factor 1 gene has an endogenous protective role in working memory during mild chronic psychological stress associated with dentate gyrus neuronal apoptosis Moreover, dentate gyrus neurogenesis appears to participate in the protective mechanism.

关键词： working memory T maze heat shock factor 1 chronic psychological stress dentate gyrus neurons apoptosis neurogenesis

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PMSM无模型滑模转速无差拍电流预测控制

电力电子技术 2024年第1期58卷 18-22,48页

作者：王巍王鹏程侯利民辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105

针对传统永磁电机调速系统易受到参数摄动影响而导致控制精度下降的问题,提出一种基于扩张状态观测器(ESO)的永磁同步电机(PMSM)无模型滑模转速无差拍电流预测控制策略。首先用参数摄动下的PMSM调速系统数学模型归纳出系统对应的超局部... 详细信息

针对传统永磁电机调速系统易受到参数摄动影响而导致控制精度下降的问题,提出一种基于扩张状态观测器(ESO)的永磁同步电机(PMSM)无模型滑模转速无差拍电流预测控制策略。首先用参数摄动下的PMSM调速系统数学模型归纳出系统对应的超局部模型,然后结合无差拍预测控制思想设计了电流环控制器,采用两步预测算法解决了传统无差拍算法存在的延时问题,并且提出校正算法进一步抑制实际的预测误差;利用变速率指数滑模趋近率设计了新型无模型滑模速度控制器,减弱抖振的同时提高了系统响应速度;并设计ESO对参数失配和扰动进行估计和补偿。最后,通过仿真与半实物实验验证了所提控制策略的有效性。

关键词：永磁同步电机无模型滑模转速扩张状态观测器

Stress analysis and damage evolution in individual plies of notched composite laminates subjected to in-plane loads

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Chinese Journal of Aeronautics 2017年第1期30卷 447-460页

作者： Hu Junshan Zhang Kaifu cheng Hui Liu Ping Zou peng Song Danlong The Ministry of Education Key Lab of Contemporary Design and Integrated Manufacturing Technology Northwestern Polytechnical University Xi'an 710072 China School of Mechanical Engineering Northwestern Polytechnical University Xi'an 710072 China

This work aims to investigate local stress distribution, damage evolution and failure of notched composite laminates under in-plane loads. An analytic method containing uniformed boundary equations using a complex variable approach is developed to present layer-by-layer stresses around the notch. The uniformed boundary equations established in series together with conformal mapping functions are capable of dealing with irregular boundary issues around the notch and at infinity. Stress results are employed to evaluate the damage initiation and propagation of notched composites by progressive damage analysis（PDA）. A user-defined subroutine is developed in the finite element（FE） model based on coupling theories for mixed failure criteria and damage mechanics to efficiently investigate damage evolution as well as failure modes. Carbon/epoxy laminates with a stacking sequence of [45°/0°/ 60°/90°]sare used to investigate surface strains, in-plane load capacity and microstructure of failure zones to provide analytic and FE methods with strong validation. Good agreement is observed between the analytic method, the FE model and experiments in terms of the stress（strain） distributions, damage evaluation and ultimate strength, and the layerby-layer stress components vary according to a combination effect of fiber orientation and loading type, causing diverse failure modes in individuals.

关键词： Damage evolution Failure mode Failure strength Layer-by-layer stresses User-defined subroutine

预后营养指数和HALP评分与中晚期前列腺癌病人预后的关系:一项多中心回顾性研究

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肠外与肠内营养 2024年第4期31卷 239-244,251页

作者：程元辉刘峰江琴周敏练玉颖董志甫重庆医药高等专科学校临床医学院重庆401331 温江区人民医院泌尿外科四川成都611130 四川省人民医院泌尿外科二病区四川成都610072 宜宾市第一人民医院肿瘤科四川宜宾644000 重庆医药高等专科学校护理学院重庆401331

目的:探讨预后营养指数(PNI)和HALP评分与中晚期前列腺癌病人预后的关系。方法:纳入2013年至2018年3所综合性三级医院收治的中晚期前列腺癌病人168例,回顾病人病历资料,随访总生存时间(OS)和无进展生存时间(PFS),采用受试者工作特征曲线... 详细信息

目的:探讨预后营养指数(PNI)和HALP评分与中晚期前列腺癌病人预后的关系。方法:纳入2013年至2018年3所综合性三级医院收治的中晚期前列腺癌病人168例,回顾病人病历资料,随访总生存时间(OS)和无进展生存时间(PFS),采用受试者工作特征曲线(ROC)曲线计算PNI和HALP评分预测病人预后的曲线下面积(AUC)和最佳截断值,Kaplan-Meier法绘制生存曲线,Log-rank检验和Cox回归分析病人OS和PFS的影响因素。结果:随访时间55(38.5,63)个月,随访期内死亡87例(51.79%),中位总生存时间和中位无进展生存时间分别为50个月和45个月,3年OS和PFS生存率分别为72.02%和64.29%。PNI和HALP评分预测病人预后的ROC曲线下面积分别为0.912和0.828,最佳截断值分别为46.30和31.64(P<0.05)。多因素Cox回归显示:PNI<46.3、HALP评分<31.64和年龄≥60岁是病人OS的危险因素,其HR(95%CI)分别为6.016(3.273~11.056)、2.537(1.531~4.205)和1.776(1.221~2.967),P<0.05;AJCC分期Ⅳ期、PNI<46.30和HALP<31.64均是病人PFS的危险因素,HR(95%CI)分别为2.777(1.381~5.419)、5.940(3.245~10.872)和2.481(1.498~4.109),P<0.05。结论:PNI和HALP评分可预测中晚期前列腺癌病人预后。

关键词：前列腺癌预后营养指数 HALP评分 Kaplan-Meier法预后

Dual-mode Switching Fault Ride-through Control Strategy for Self-synchronous Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 579-588页

作者： Xinshou Tian Yongning Chi peng cheng Wei He yunpeng Zhou Jianzhu Hu China Institute of Energy and Transportation Integrated Development North China Electric Power UniversityBeijing 102206China State Key Laboratory of Operation and Control of Renewable Energy&Storage Systems China Electric Power Research InstituteBeijing 100192China State Grid Zhejiang Electric Power Co. Economic and Technological Research InstituteHangzhouChina

The installed capacity of renewable energy generation has continued to grow rapidly in recent years along with the global energy transition towards a 100%renewable-based power *** the same time,the grid-connected large-scale renewable energy brings significant challenges to the safe and stable operation of the power system due to the loss of synchronous ***,self-synchronous wind turbines have attracted wide attention from both academia and ***,the understanding of the physical operation mechanisms of self-synchronous wind turbines is not *** particular,the transient characteristics and dynamic processes of wind turbines are fuzzy in the presence of grid ***,it is difficult to design an adaptive fault ride-through(FRT)control ***,a dual-mode switching FRT control strategy for self-synchronous wind turbines is *** FRT control strategies are *** one strategy,the amplitude and phase of the internal potential are directly calculated according to the voltage drop when a minor grid fault *** other dual-mode switching control strategy in the presence of a deep grid fault includes three parts:vector control during the grid fault,fault recovery vector control,and self-synchronous *** proposed control strategy can significantly mitigate transient overvoltage,overcurrent,and multifrequency oscillation,thereby resulting in enhanced transient ***,simulation results are provided to validate the proposed control strategy.

关键词： Dual-mode switching self-synchronous wind turbine transient stability fault ride-through(FRT)control

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基于物联网的生猪养殖系统的设计与实现

价值工程 2024年第13期43卷 123-126页

作者：赵玉徐鹏王立娟大连科技学院信息科学与技术学院大连116052

为了顺应畜牧养殖业智能化发展的趋势,基于物联网技术设计一种生猪养殖系统。该系统采用物联网三层架构分层设计,硬件采用STM32核心控制板以及多传感器实现温度、湿度、压力、声音以及射频等多模态信息的全面感知。利用Wi-Fi通信技术与... 详细信息

为了顺应畜牧养殖业智能化发展的趋势,基于物联网技术设计一种生猪养殖系统。该系统采用物联网三层架构分层设计,硬件采用STM32核心控制板以及多传感器实现温度、湿度、压力、声音以及射频等多模态信息的全面感知。利用Wi-Fi通信技术与客户端进行数据交互,实现了实时监测和远程控制功能。针对养殖环境的差异,用户可通过在客户端操作界面调整温度、湿度、出粮量等阈值参数,实现自动换水、自动控温、远程投喂、以及远程开启照明等功能。这一设计能够有效解决养殖过程中因环境信息获取迟钝、人为误操作导致生猪死亡等问题。该系统不仅满足了规模化生猪养殖的基本需求,还在传统养殖的基础上使养殖作业更加智能、便捷。

关键词：物联网生猪养殖系统全面感知智能化

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甲状腺癌全切除术致甲状旁腺损伤对患者骨密度及骨代谢的影响

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临床与病理杂志 2024年第5期44卷 689-694页

作者：许昕丹柳卫程鹏袁冬兰南京医科大学第一附属医院核医学科南京210029 南京医科大学第一附属医院老年科南京210029

目的:当前,临床针对甲状腺癌的手术方式有全切、次全切、全切+颈淋巴结清扫等,不同的手术方式对甲状腺旁腺的损伤不同。越来越多的临床医生已经关注甲状腺旁保护对患者的意义。本研究旨在探讨甲状腺癌全切除术导致甲状旁腺损伤对患者骨... 详细信息

目的:当前,临床针对甲状腺癌的手术方式有全切、次全切、全切+颈淋巴结清扫等,不同的手术方式对甲状腺旁腺的损伤不同。越来越多的临床医生已经关注甲状腺旁保护对患者的意义。本研究旨在探讨甲状腺癌全切除术导致甲状旁腺损伤对患者骨密度及骨代谢的影响。方法:回顾性分析2017年3月至2019年6月南京医科大学第一附属医院收治的167例行甲状腺癌全切除术的患者,检测其甲状旁腺激素(parathyroid hormone,PTH)等指标评估甲状旁腺损伤情况。将甲状旁腺损伤患者纳入研究组,共87例;未损伤者纳入对照组,共80例。在术前术后均检测PTH、游离三碘甲腺原氨酸(free triiodothyronine,FT3)、游离四碘甲腺原氨酸(free tetraiodothyronine,FT4)、促甲状腺激素(thyroid stimulating hormone,TSH)、血钙、血磷及血镁水平,同时检测骨密度及骨代谢指标I型胶原氨基端延长肽(N-terminal propeptide of type 1 precollagen,P1NP)、I型胶原羧基末端肽(β-C-terminal telopeptide of typeⅠcollagen,CTX)水平。结果:研究组患者术后PTH和骨密度均低于对照组,骨代谢指标P1NP、CTX均低于对照组,血钙水平也低于对照组,但血磷水平高于对照组,差异均具有统计学意义(均P<0.05)。结论:甲状腺癌全切除术后并发甲状旁腺损伤的患者血清PTH水平显著降低,骨密度及骨代谢指标水平均下降,钙磷紊乱致骨钙流失速度加快,提示患者甲状旁腺损伤可能是骨质疏松的诱发因素。

关键词：甲状腺癌全切除术甲状旁腺损伤甲状旁腺功能减退骨密度骨代谢

The First Hyperpolarizabilities of Merocarbocyanines

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Chinese Chemical Letters 1998年第7期9卷 679-682页

作者： peng WANG You Ming CHANG yu XU cheng YE (Organic Solid Lab., Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080) Organic Solid Lab. Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The dot products mu(g)beta(CT) of first hyperpolarizability and ground state dipole moment of two merocarbocyanines were measured experimentally with solvatochromism and compared to the values obtained by AM1/FF calculation. The comparable result was also obtained by the measurement of second harmonic generation (SHG) for LB film of dye II. The mu(g)beta(CT) of dye II is larger than that of the well known NLO chromophore 4-N, N-dimethylamino-4'-nitrostilbene (DANS).

关键词： hyperpolarizability merocarbocyanine solvatochromism AM1/FF SHG