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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG yun HE Ying LU Xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG Xue Yong MA Hong Xia yu peng cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina Qingdao chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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基于激光雷达扫描的观览车摆角测量方法

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激光与红外 2024年第7期54卷 1045-1052页

作者：余鹏程熊芝董佳乐黄荔生胡诚湖北工业大学机械工程学院湖北武汉430068 湖北省现代制造质量工程重点实验室湖北武汉430068 江西省检验检测认证总院特种设备检验检测研究院江西南昌330029 江西省检验检测认证总院特种设备检验检测研究院鹰潭检测分院江西鹰潭335000

针对现有的倾角仪在测量大型观览车最大摆角时存在的安装复杂、测量效率低下问题,本文提出了一种结合特征滤波与投影转换的摆角测量方法。该方法综合使用激光雷达与监控相机的数据,实现对大型观览车摆角的非接触式精确测量。首先,通过... 详细信息

针对现有的倾角仪在测量大型观览车最大摆角时存在的安装复杂、测量效率低下问题,本文提出了一种结合特征滤波与投影转换的摆角测量方法。该方法综合使用激光雷达与监控相机的数据,实现对大型观览车摆角的非接触式精确测量。首先,通过方向特征滤波器选取摆臂部分的点云;接着,利用形状特征滤波器移除不规则形状的点云;然后,将这些点云投影至二维平面,并用最小二乘法拟合边缘直线来解算摆角。最后,通过等比例模型实验得到该方法角度测量平均误差绝对值为0.29°,最大误差绝对值为0.45°。实验结果表明,该方法能有效提升大型观览车摆角的测量效率并确保测量精度。

关键词：激光点云观览车特征滤波投影变换摆角测量

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基于GIS的合肥市中心城区医疗服务空间可达性研究

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河南城建学院学报 2024年第3期33卷 65-71,97页

作者：谢鹏黄云峰于鹏诚安徽理工大学土木建筑学院安徽淮南232001

城市医疗设施资源配置和卫生服务的均衡性对居民生活质量的提升至关重要。以合肥市中心城区为例,运用地理信息系统(GIS)技术,采用多种出行模式下的改进潜能模型法,结合基尼系数和四象限筛选等方法,对不同时间阈值下的城市医疗设施的可... 详细信息

城市医疗设施资源配置和卫生服务的均衡性对居民生活质量的提升至关重要。以合肥市中心城区为例,运用地理信息系统(GIS)技术,采用多种出行模式下的改进潜能模型法,结合基尼系数和四象限筛选等方法,对不同时间阈值下的城市医疗设施的可达性及均衡性进行综合评价,提出了优化合肥市中心城区医疗服务空间的建议。结果显示:合肥市中心城区医疗设施空间可达性差异明显,整体上呈现中心紧密、四周松散的空间特征;通过识别分析可达性较低的区域,建议改善杏林街道社区卫生服务中心,改善后可达性和服务效率明显提升。

关键词：医疗设施 GIS 改进潜能模型空间可达性优化选址

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数据驱动的公路典型风险场景聚类与特征分析

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科学技术与工程 2024年第8期24卷 3426-3433页

作者：胡伟超陈艳艳于鹏程于士杰牛世峰北京工业大学城市交通学院北京100124 公安部道路交通安全研究中心北京100062 长安大学汽车学院西安710064

为了明晰公路交通中典型风险场景,提高公路测试场景构建和公路安全分析的针对性和指导性。收集不同区域代表性省份5年约60000条公路交通事故数据作为数据源,筛选确定关键分类变量,分别针对7类典型公路路段和路口开展典型交通冲突形式聚... 详细信息

为了明晰公路交通中典型风险场景,提高公路测试场景构建和公路安全分析的针对性和指导性。收集不同区域代表性省份5年约60000条公路交通事故数据作为数据源,筛选确定关键分类变量,分别针对7类典型公路路段和路口开展典型交通冲突形式聚类分析,共获取16类典型风险场景,然后构建场景风险特征表征参数,针对典型风险场景的风险特征进行对比分析,进而深入分析道路和环境因素对场景事故数量和发生事故严重程度的影响特征。结果表明:路表情况、防护设施类型、交通信号方式、照明条件、天气和能见度等因素都对部分场景的风险度有较大影响,路面状况因素对场景风险度影响不大。

关键词：交通安全风险特征 K均值聚类公路典型风险场景

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Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research(International) 2024年第4期31卷 909-923页

作者： Xing-yu Chen Lin cheng cheng-yang Hu yu-peng Zhang Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

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Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1344-1354页

作者： peng-bo Liu Shu-sen cheng yu-qing Xue Xiao-man cheng Zhao Liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

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Multi-objective optimization and evaluation of supercritical CO_(2) Brayton cycle for nuclear power generation

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Nuclear Science and Techniques 2024年第2期35卷 183-209页

作者： Guo-peng yu Yong-Feng cheng Na Zhang Ping-Jian Ming Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle *** models of four Brayton cycle layouts are developed in this study for different reactors to reduce the cost and increase the thermohydraulic performance of nuclear power generation to promote the commercialization of nuclear *** analysis,multi-objective optimizations,and four decision-making methods are applied to obtain each Brayton scheme’s optimal thermohydraulic and economic *** show that for the same design thermal power scale of reactors,the higher the core’s exit temperature,the better the Brayton cycle’s thermo-economic *** the four-cycle layouts,the recompression cycle(RC)has the best overall performance,followed by the simple recuperation cycle(SR)and the intercooling cycle(IC),and the worst is the reheating cycle(RH).However,RH has the lowest total cost of investment(C_(tot))of$1619.85 million,and IC has the lowest levelized cost of energy(LCOE)of 0.012$/(kWh).The nuclear Brayton cycle system’s overall performance has been improved due to *** performance of the molten salt reactor combined with the intercooling cycle(MSR-IC)scheme has the greatest improvement,with the net output power(W_(net)),thermal efficiencyη_(t),and exergy efficiency(η_(e))improved by 8.58%,8.58%,and 11.21%,*** performance of the lead-cooled fast reactor combined with the simple recuperation cycle scheme was optimized to increase C_(tot) by 27.78%.In comparison,the internal rate of return(IRR)increased by only 7.8%,which is not friendly to investors with limited *** the nuclear Brayton cycle,the molten salt reactor combined with the recompression cycle scheme should receive priority,and the gas-cooled fast reactor combined with the reheating cycle scheme should be considered carefully.

关键词： Supercritical CO_(2)Brayton cycle Nuclear power generation Thermo-economic analysis Multi-objective optimization Decision-making methods

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A Weighted Flow related to a Trudinger–Moser Functional on Closed Riemann Surface

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2244-2262页

作者： peng Xiu yu School of Mathematics Renmin University of ChinaBeijing 100872P.R.China

In this paper,with(Σ,g)being a closed Riemann surface,we analyze the possible concentration behavior of a heat flow related to the Trudinger–Moser *** obtain a long time existence for the *** along some sequence of times t_(k)→+∞,we can deduce the convergence of the flow in H2(Σ).Furthermore,the limit function is a critical point of the Trudinger–Moser functional under certain constraint.

关键词： Trudinger-Moser inequality global convergence heat flow

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基于多时相RSEI的生态环境质量评价——以新民市为例

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湖北农业科学 2024年第4期63卷 56-60页

作者：王井利余鹏程蔡福刘慧楠高天娇沈阳建筑大学沈阳110168 中国气象局沈阳大气环境研究所沈阳110166

以辽宁省新民市作为研究对象,基于2014年、2017年、2020年的相近月份(5—6月)Landsat 8 OLI_TRIS数据,提取4个生态因子[绿度(NDVI)、湿度(WET)、干度(NDBSI)、热度(LST)],采用主成分分析法构建遥感生态指数(RSEI),对研究区域生态环境质... 详细信息

以辽宁省新民市作为研究对象,基于2014年、2017年、2020年的相近月份(5—6月)Landsat 8 OLI_TRIS数据,提取4个生态因子[绿度(NDVI)、湿度(WET)、干度(NDBSI)、热度(LST)],采用主成分分析法构建遥感生态指数(RSEI),对研究区域生态环境质量时空演变特征进行评价。结果表明,2014年、2017年、2020年新民市RSEI的均值分别为0.397、0.348、0.506,呈先降后升的趋势。2014—2020年,生态环境质量等级为差和较差的区域主要分布在西北区域,面积占比由62.5%降至33.2%;生态环境质量等级为较好和好的区域主要分布在东南区域,面积占比呈明显的先降低后升高趋势,由21.3%先下降到18.4%后上升到37.0%。4个因子中绿度和湿度对生态环境质量起到正面作用,其中湿度的正面影响较为显著;干度和热度起到负面作用,其中干度的负影响较为显著。

关键词：生态环境质量 Landsat8 OLI_TRIS 遥感生态指数(RSEI) 主成分分析新民市

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Unsupervised construction of health indicator for rotating machinery via multi-criterion feature selection and attentive variational autoencoder

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Science China(Technological Sciences) 2024年第5期67卷 1524-1537页

作者： LI Xinyu cheng ChangMing peng ZhiKe State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Ningxia UniversityYinchuan750021China

Health indicator(HI)construction is a crucial task in degradation evaluation and facilitates the prognostic and health management(PHM)of rotating *** interference from artificial labeling,the HI construction approaches in an unsupervised manner have attracted substantial ***,current unsupervised methods generally struggle with two problems:(1)ignorance of both redundancy between features and global variability of features during the feature selection process;(2)inadequate utilization of information from different sampling *** tackle these problems,this work develops a novel unsupervised approach for HI construction that integrates multi-criterion feature selection and the Attentive Variational Autoencoder(Attentive VAE).Explicitly,a multi-criterion feature selection(Mc FS)algorithm together with an elaborately designed metric is proposed to determine a superior feature subset,considering the relevance,the redundancy,and the global variability of features ***,for the adequate utilization of the information from distinct sampling moments,a deep learning model named Attentive VAE is *** Attentive VAE is solely fed with the selected features in the health state for model training and the HI is derived through the reconstruction error to reveal the degradation degree of *** case studies based on genuine experimental datasets are involved to quantitatively evaluate the superiority of the developed approach,demonstrating its superiority over other unsupervised methods for characterizing degradation *** effectiveness of both the Mc FS algorithm and the Attentive VAE is verified by ablation experiments,respectively.

关键词： health indicator(HI) unsupervised learning multi-criterion feature selection global variability attention mechanism

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