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Oncocytic adrenocortical tumor with uncertain malignant potential in pediatric population: A case report and review of literature

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World Journal of Clinical Cases 2021年第20期9卷 5675-5682页

作者： Xiao-Chun Chen yun-Man Tang yu mao Dao-Rui Qin Department of Pediatric Surgery Sichuan Academy of Medical Sciences Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Oncocytic adrenocortical tumor(OACT)is rare,with few cases reported in the *** more than 20 cases in children have been *** clinical characteristics,diagnosis,treatment and prognosis of children with OACT are summarized based on a literature review,in order to improve the understanding of OACT in *** SUMMARY We report a case of a 17-mo-old patient who was admitted to our hospital due to symptoms of odynuria and fever,which are clinical features consistent with a functional adrenocortical *** patient was diagnosed with OACT of uncertain malignant *** tomography indicated a soft tissue giant tumor in the right adrenal region,approximately 4.3 cm×5.5 cm in *** nodular and speckled calcifications were observed in the *** patient received robot-assisted laparoscopic right adrenal tumor *** pathological results were consistent with OACT,and immunohistochemical results showed cytokeratin+/-,chromogranin A+,synaptophysin-,neuronspecific enolase-,S100-,Ki67 about 10%,CD34-and D2-40-.After surgery,urinary tract ultrasonography was reviewed monthly,catecholamine hormone and sex hormone levels were examined every 2 mo and computed tomography was performed every 6 *** date,no tumor metastasis or recurrence has been identified in this *** levels of sex hormones and catecholamine hormones decreased to normal 1 mo after *** OACT is rare in the pediatric population,with few cases reported in the *** most pediatric OACTs are benign,malignant cases have been *** resection is the preferred option in most patients.

关键词： Oncocytic adrenocortical tumor Adrenocortical tumor Robotic surgery Children Case report

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大尺寸壁板结构的高声强噪声试验系统研究

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环境技术 2024年第9期42卷 176-180页

作者：余坤茂蔡李娟张呈波郭剑天津航天瑞莱科技有限公司上海201100 上海航天控制技术研究所上海201100

为获取某飞机壁板在高声强噪声激励下的疲劳寿命,本文提出了一种适用于大尺寸壁板结构的噪声试验方法。本方法结合大尺寸壁板试验工件的特点,设计了具有较小矩形截面积的气流通道,既能实现大尺寸壁板试验工件的安装,又能实现高声强噪声... 详细信息

为获取某飞机壁板在高声强噪声激励下的疲劳寿命,本文提出了一种适用于大尺寸壁板结构的噪声试验方法。本方法结合大尺寸壁板试验工件的特点,设计了具有较小矩形截面积的气流通道,既能实现大尺寸壁板试验工件的安装,又能实现高声强噪声激励的施加;并采用了工作段两侧面同时固定试验工件的方案,有效的缩短试验周期,提高试验效率。研究结果表明:与现有技术相比较,本文提出的高声强噪声试验系统适用于大尺寸壁板结构的高声强噪声试验系统,能够有效考核大尺寸壁板结构耐受高声强噪声的能力,且造价较低,对工程实际应用一定实践价值。

关键词：噪声试验系统大尺寸壁板结构高声强噪声试验

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意大利蜜蜂MAPK信号通路相关基因和全长转录本鉴定及分析

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应用昆虫学报 2024年第2期61卷 246-257页

作者：范小雪荆欣康婧高旭泽张艺琼姚雨彤毛予立牛庆生陈大福付中民郭睿福建农林大学蜂学与生物医药学院天然生物毒素国家地方联合工程实验室福建省蜂疗研究所吉林省养蜂科学研究所

【目的】利用纳米孔（Nanopore）测序数据鉴定意大利蜜蜂Apis mellifera ligustica丝裂原活化蛋白激酶（Mitogen activated protein kinase,MAPK）信号通路相关基因和全长转录本，并发掘MAPK信号通路相关基因的可变多聚腺苷酸化（Altern... 详细信息

【目的】利用纳米孔（Nanopore）测序数据鉴定意大利蜜蜂Apis mellifera ligustica丝裂原活化蛋白激酶（Mitogen activated protein kinase,MAPK）信号通路相关基因和全长转录本，并发掘MAPK信号通路相关基因的可变多聚腺苷酸化（Alternativepolyadenylation,APA）位点及可变剪接（Alternative splicing,AS）事件，以期加深对意大利蜜蜂MAPK信号通路的认识，为持续深入开展相关基因和剪接体（Isoform）的功能研究提供数据资源和基础。【方法】采用Blast工具将所有全长转录本比对到Nr数据库和KEGG数据库，再根据注释信息筛选出MAPK信号通路相关基因和全长转录本。利用gffcompare软件将MAPK信号通路相关全长转录本与西方蜜蜂参考基因组（Amel＿HAv3.1）上注释的转录本进行比较以优化已注释基因结构。采用TAPIS pipeline预测APA位点，并通过MEME软件鉴定所有APA位点上游50 bp的基序（motif）。使用Astalavista软件鉴定AS事件并统计不同类型的AS事件数目。通过PCR验证MAPK信号通路相关基因的AS事件。【结果】共鉴定到意大利蜜蜂MAPK信号通路相关的83个基因与443条全长转录本。同时延长了1个基因的5′UTR和3′UTR，延长了12个基因的5′UTR，延长了10个基因的3′UTR。共鉴定到52个MAPK信号通路相关基因含有1个及以上的APA位点，并在APA位点上游鉴定到2个motif。共鉴定到MAPK信号通路相关的13个基因的21次AS事件，其中最丰富的类型为外显子跳跃（Exonskipping,ES）。PCR结果证实了骨形态发生蛋白受体1b基因的4次ES事件和EtsDNA结合蛋白pokkuri基因的1次ES事件的真实性。【结论】首次鉴定到意大利蜜蜂MAPK信号通路相关的83个基因和446条全长转录本，优化了该信号通路中西方蜜蜂参考基因组已注释的21个基因的结构，发掘出MAPK信号通路相关基因的406个APA位点和52次AS事件，证实了MAPK信号通路相关基因AS事件的真实性。

关键词：意大利蜜蜂 MAPK信号通路全长转录本可变剪接可变多聚腺苷酸化

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改性硅溶胶对路用泡沫混凝土力学性能的影响及应用研究

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化学工程师 2024年第7期38卷 103-106页

作者：余茂林沈海玉罗盛王友军孙旭兵中国人民解放军陆军勤务学院重庆401331 96784部队河南洛阳471000

采用硅烷偶联剂KH560作为硅溶胶改性剂,研究了改性硅溶胶及未改性硅溶胶掺入质量对泡沫混凝土7d、28d抗折强度、抗压强度、导热系数及过度路桥段载荷沉降值的影响。实验结果表明,KH560可以显著降低硅溶胶的团聚程度,降低纳米硅溶胶的平... 详细信息

采用硅烷偶联剂KH560作为硅溶胶改性剂,研究了改性硅溶胶及未改性硅溶胶掺入质量对泡沫混凝土7d、28d抗折强度、抗压强度、导热系数及过度路桥段载荷沉降值的影响。实验结果表明,KH560可以显著降低硅溶胶的团聚程度,降低纳米硅溶胶的平均粒径,提升纳米溶胶的表面活性。当泡沫混凝土中加入质量分数为3%的改性硅溶胶时,泡沫混凝土力学性能及保温隔热性能达到最优,此时泡沫混凝土28d龄期抗折强度、抗压强度分别为13.7、57.9MPa,28d龄期导热系数为0.24W·(m·K)^(-1),同时在过度路桥段具有实际使用价值。

关键词： KH560 硅溶胶泡沫混凝土力学性能导热系数硅烷偶联剂

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Finite-size analysis of eight-state continuous-variable quantum key distribution with the linear optics cloning machine

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Chinese Physics B 2018年第9期27卷 205-212页

作者： Hang Zhang yu mao Duan Huang Ying Guo Xlaodong Wu and Ling Zhang＊ School of Information Science and Engineering Central South UniversityChangsha 410083China

We propose a method to improve the secret key rate of an eight-state continuous-variable quantum key distribution（CVQKD） by using a linear optics cloning machine（LOCM）. In the proposed scheme, an LOCM is exploited to compensate for the imperfections of Bob＇s apparatus, so that the generated secret key rate of the eight-state protocol could be well enhanced. We investigate the security of our proposed protocol in a finite-size scenario so as to further approach the practical value of a secret key rate. Numeric simulation shows that the LOCM with reasonable tuning gain λ and transmittance τcan effectively improve the secret key rate of eight-state CVQKD in both an asymptotic limit and a finite-size ***, we obtain the tightest bound of the secure distance by taking the finite-size effect into account, which is more practical than that obtained in the asymptotic limit.

关键词： continuous-variable quantum key distribution linear optics cloning machine finite-size

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Nitric oxide donating anti-glaucoma drugs:advances and prospects

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Chinese Journal of Natural Medicines 2020年第4期18卷 275-283页

作者： mao yu-Jie WU Jian-Bing YANG Ze-Qiu ZHANG Yi-Hua HUANG Zhang-Jian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China

Glaucoma is a disease that causes irreversible blindness. Reducing intraocular pressure(IOP) is the main treatment at present. Nitric oxide(NO), an endogenous gas signaling molecule, can increase aqueous humor outflow facility, inhibit aqueous humor production thereby reducing IOP, as well as regulate eye blood flow and protect the optic nerve. Therefore, NO donating antiglaucoma drugs have broad research prospects. In this review, we summarize NO-mediated therapy for glaucoma, and the state of the art of some NO donating molecules, including latanoprostene bunod in market and some other candidate compounds, for the intervention of glaucoma, as well as prospects and challenges ahead in this field.

关键词： Nitric oxide Glaucoma Intraocular pressure Trabecular meshwork Prostaglandin analogues

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Structural Asymmetry of Dorsolateral Prefrontal Cortex Correlates with Depressive Symptoms： Evidence from Healthy Individuals and Patients with Major Depressive Disorder

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Neuroscience Bulletin 2016年第3期32卷 217-226页

作者： Wei Liu yu mao Dongtao Wei Junyi Yang Xue Du Peng Xie Jiang Qiu Key Laboratory of Cognition and Personality (SWU) Ministry of Education Chongqing 400715 China Department of Psychology Southwest UniversityChongqing 400715 China Institute of Neuroscience Chongqing Medical UniversityChongqing 400016 China Chongqing Key Laboratory of Neurobiology Chongqing 400016 China Department of Neurology First Affiliated HospitalChongqing Medical University Chongqing 400016 China

In this study,we investigated the role of structural asymmetry of the dorsolateral prefrontal cortex（DLPFC） in the continuum of depression from healthy individuals to *** magnetic resonance imaging was performed in 70 patients with major depressive disorder（MDD）,49 matched controls,and 349 healthy university students to calculate structural asymmetry indexes of the ***-episode,treatment-naive MDD patients showed a relatively lower asymmetry index than healthy controls,and their asymmetry index was negatively correlated with the depressive *** abnormality was normalized by antidepressants in medicated MDD ***,the asymmetry index was negatively correlated with the depressive symptoms in university students;this was replicated at two time points in a subgroup of students,suggesting good test-retest *** findings are consistent with previous studiesthat support the imbalance hypothesis of MDD and suggest a potential structural basis underlying the functional asymmetry of the DLPFC in *** future,the structural index of the DLPFC may become a potential biomarker to evaluate individuals＇ risk for the onset of MDD.

关键词： Major depressive disorder Structuralmagnetic resonance imaging Dorsolateral prefrontalcortex Structural asymmetry

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Semi-supervised learning via manifold regularization

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The Journal of China Universities of Posts and Telecommunications 2012年第6期19卷 79-88页

作者： mao yu ZHOU Yan-quan LI Rui-fan WANG Xiao-jie ZHONG Yi-xin School of Telecommunication Engineering Beijing University of Posts and Telecommunications

This paper proposes a novel graph-based transductive learning algorithm based on manifold regularization. First, the manifold regularization was introduced to probabilistic discriminant model for semi-supervised classification task. And then a variation of the expectation maximization （EM） algorithm was derived to solve the optimization problem, which leads to an iterative algorithm. Although our method is developed in probabilistic framework, there is no need to make assumption about the specific form of data distribution. Besides, the crucial updating formula has closed form. This method was evaluated for text categorization on two standard datasets, 20 news group and Reuters-21578. Experiments show that our approach outperforms the state-of-the-art graph-based transductive learning methods.

关键词： manifold regularization semi-supervised learning transductive learning expectation maximization algorithm classification text categorization

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PPAR gamma2:The main isoform of PPARγthat positively regulates the expression of the chicken Plin1 gene

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Journal of Integrative Agriculture 2022年第8期21卷 2357-2371页

作者： SUN yu-hang ZHAI Gui-ying PANG Yong-jia LI Rui LI yu-mao CAO Zhi-ping WANG Ning LI Hui WANG yu-xiang Key Laboratory of Chicken Genetics and Breeding Ministry of Agriculture and Rural AffairsHarbin 150030P.R.China Key Laboratory of Animal Genetics Breeding and ReproductionHeilongjiang General Colleges and UniversitiesHarbin 150030P.R.China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030P.R.China Fujian Sunnzer Biotechnology Development Co. Ltd.Guangze 354100P.R.China

Perilipin1(PLIN1)is a major phosphorylated protein that specifically coats the surface of neutral lipid droplets(LDs)in adipocytes and plays a crucial role in regulating the accumulation and hydrolysis of triacylglycerol(TG).Mammalian studies have shown that Plin1 gene transcription is mainly regulated by peroxisome proliferator-activated receptorgamma(PPARγ),the master regulator of ***,the regulatory mechanism of the chicken Plin1(c Plin1)gene is poorly *** present study aimed to investigate whether Plin1 is regulated by PPARγin chickens and identify its exact molecular *** gene and expression assays showed that PPARγ2,but not PPARγ1,activated(P<0.01)the cPlin1 gene *** electrophoretic mobility shift assay and mutational analysis revealed that PPARγ2 bound to a special site in the cPlin1 gene promoter to enhance its *** summary,our results show that PPARγpromotes the expression of the cPlin1 gene and that PPARγ2 is the main regulatory isoform.

关键词： chicken PPAR gamma isoform Plin1 transcriptional regulation

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基于RANKL/RANK/OPG信号轴探讨骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用

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中国现代医学杂志 2024年第7期34卷 27-33页

作者：方祥周正新朱磊芮仞许茂玉朱彩玉安徽中医药大学研究生院安徽合肥230038 安徽中医药大学第一附属医院骨科安徽合肥230038

目的观察骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用,并从核因子-κB受体活化因子配体/核因子-κB受体活化因子/骨保护素(RANKL/RANK/OPG)信号轴探讨其作用机制。方法采取腹腔注射脂多糖和臀肌注射醋酸泼尼松龙复制激素性股骨... 详细信息

目的观察骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用,并从核因子-κB受体活化因子配体/核因子-κB受体活化因子/骨保护素(RANKL/RANK/OPG)信号轴探讨其作用机制。方法采取腹腔注射脂多糖和臀肌注射醋酸泼尼松龙复制激素性股骨头缺血坏死(SONFH)动物模型,经核磁共振鉴定后,将模型复制成功的60只小鼠分成模型(MC)组、骨痹通消颗粒(GBTX)组及通络生骨胶囊(PC)组,每组20只,另设12只正常小鼠作为空白对照(NC)组。分别予以对应组灌胃相应药物12周后麻醉状态下取材,观察各组小鼠治疗前后的一般行为;酶联免疫吸附试验(ELISA)检测各组小鼠的骨碱性磷酸酶(BALP)和I型氨基端延长肽(PINP)含量;Western blotting和实时荧光定量聚合酶链反应(qRT-qPCR)检测各组RANK、RANKL、OPG、磷脂酰肌醇特异性磷脂酶Cγ2(PLCγ2)、组织蛋白酶K(CTSK)、抗酒石酸酸性磷酸酶(TRAP)的蛋白和基因表达。结果核磁共振显示,模型复制成功后的小鼠左侧髋部呈高信号状态。与NC组比较,MC组BALP、PINP水平,以及OPG蛋白和基因相对表达量均降低(P0.05),而PC组PLCγ2基因相对表达量较GBTX组下降(P<0.05)。结论骨痹通消颗粒可能通过上调OPG表达,抑制RANK、RANKL、PLCγ2、CTSK和TRAP表达,从而改善股骨头坏死情况。

关键词：激素性股骨头坏死骨痹通消颗粒 RANKL/RANK/OPG信号轴

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