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卡瑞利珠单抗联合阿帕替尼治疗局部晚期微卫星不稳定性高或错配修复缺陷型结直肠癌患者的临床研究

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中国临床药理学杂志 2024年第16期40卷 2400-2400页

作者： yu j H 吴焕贤

中山大学肿瘤防治中心和广州市中医院开展了一项单组、开放标签、I期临床试验(NEOCAP),旨在探索程序性死亡受体1(programmed death-1,PD-1)阻断加血管生成抑制药的新辅助治疗的有效性和安全性,以及在局部晚期错配修复缺陷型结直肠癌患... 详细信息

中山大学肿瘤防治中心和广州市中医院开展了一项单组、开放标签、I期临床试验(NEOCAP),旨在探索程序性死亡受体1(programmed death-1,PD-1)阻断加血管生成抑制药的新辅助治疗的有效性和安全性,以及在局部晚期错配修复缺陷型结直肠癌患者中保留器官的可行性。

关键词：阿帕替尼新辅助治疗结直肠癌患者微卫星不稳定性肿瘤防治中心有效性和安全性局部晚期

Formation of High-quality Advanced High-k Oxide Layers at Low Temperature by Excimer UV Lamp-assisted Photo-CVD and Sol-gel Processing

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Chemical Research in Chinese Universities 2004年第4期20卷 396-402页

作者： yu j. j. Electronic & Electrical Engineering University College London

We have successfully demonstrated that high quality and high dielectric constant layers can be fabricated by low temperature photo-induced or -assisted processing. Ta_2O_5 and ZrO_2 have been deposited at t<400 ℃ by means of a UV photo-CVD technique and HfO_2 by photo-assisted sol-gel processing with the aid of excimer lamps. The UV annealing of as-grown layers was found to significantly improve their electrical properties. Low leakage current densities on the order of 10 -8 A/cm 2 at 1 MV/cm for deposited ultrathin Ta_2O_5 films and ca.10 -6 A/cm 2 for the photo-CVD ZrO_2 layers and photo-irradiated sol-gel HfO_2 layers have been readily achieved. The improvement in the leakage properties of these layers is attributed to the UV-generated active oxygen species O( 1D) which strongly oxidize any suboxides to form more stoichiometric oxides on removing certain defects, oxygen vacancies and impurities present in the as-prepared layers. The photo-CVD Ta_2O_5 films deposited across 10.16-cm Si wafers exhibit a high thickness uniformity with a variation of less than \{±2.0%\} being obtained for ultrathin ca.10 nm thick films. The lamp technology can in principle be extended to larger area wafers, providing a promising low temperature route to the fabrication of a range of high quality thin films for future ULSI technology.

关键词： Excimer lamp High-kdielectrics Thin film Chemical vapour deposition(CVD) Sol-gel processing

Surface Modification of Nanometer Silica by N, N'-dicyclohexyl- carbodiimide Mediated Amidation

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Chinese Chemical Letters 2001年第10期12卷 933-934页

作者： Guo, ZX yu, j yu, j Tsing Hua Univ Dept Chem Engn Inst Polymer Sci & Engn Beijing 100084 Peoples R China

A potentially versatile procedure for surface modification of nanometer silica is illustrated by N, N-dicyclohexylcarbodiimide (DCC) mediated amidation of stearic acid.

关键词： Nanometer silica surface modification DCC acid amidation.

HIGH-TEMPERATURE TENSILE FRACTURE BEHAVIOR OF DIRECTIONALLY SOLIDIFIED Ni,Cr,Al-TaC EUTECTIC SUPERALLOY

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 455-459页

作者： j.Zhang j.j.yu H.Z.Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an 710072ChinaInstitute of Metal Research Chinese Academy of Sciences Shenyang 110016 ChinaState Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an 710072China

The high-temperature tensile fracture behavior of the Ni, Cr, Al-TaC eutectic superal-loy directionally solidified under high temperature gradient is investigated. The high-temperature tensile fracture of this in situ composite has ductile character with lots of ductile nests whose diameters decrease with the increasing solidification rates. The maximum σb and δ are respectively 668.5MPa and 19.6%. There is α TaC whisker in the center of each nest, and the deformation of γ' and TaC is uneven. The high-temperature tensile behavior cannot be explained by the rule of mixtures but is decided by the formation of the plastic deformation band. The crack extension model is given.

关键词： Ni Cr Al-TaC eutectic superalloy directional solidification,in situ composite high-temperature tenslie fracture

Effect of Waterborne Epoxy on Performances of Cement Asphalt Mortar

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武汉理工大学学报 2010年第17期32卷 201-205,214页

作者： TIAN H yu j Y Key Laboratory of Silicate Materials Science and Engineering of Education Ministry Wuhan University of TechnologyWuhan 430070China

The waterborne epoxy modified cement asphalt mortars were prepared with varying content waterborne epoxy and a constant fluidity. The effects of waterborne epoxy emulsion on water/cement ratio,compressive and flexural strength,tensile bond strength,freezing and thawing damage,corrosion resistance of cement asphalt mortar cured for 7 and 28 d have been investigated. The results show that waterborne epoxy is very beneficial to the improvement of mechianical properties and durability of cement asphalt mortar. Waterborne epoxy can improve the flowing ability of cement asphalt mortar. With the increasing of waterborne epoxy content,compressive strength,flexural strength and bond strength all have increased obviously. The modified mortar shows higher resistance to corrosion and the freezing and thawing compared with control mortar.

关键词： cement asphalt mortar waterborne epoxy mechanical properties durability

Atomistic Simulation of the Orientation-dependent Plastic Deformation Mechanisms of Iron Nanopillars

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journal of Materials Science & Technology 2012年第2期28卷 164-168页

作者： Y. Zhang D.j. yu K.M. Wang Anshan-Normal University 43 Pingan Street Anshanll4005 China University of Science and Technology LiaoNing Anshanll4051 China

Tensile tests were performed on iron nanopillars oriented along [001] and [110] directions at a constant temperature of 300 K through molecular dynamics simulations with an embedded-atom interatomic potential for iron. The nanopillars were stretched until yielding to investigate the onset of their plastic deformation behaviors. Yielding was found to occur through two different mechanisms for [001] and [110] tensions. In the former case, plastic deformation is initiated by dislocation nucleation at the edges of the nanopillar, whereas in the latter case by phase transformation inside the nanopillar. The details during the onset of plastic deformation under the two different orientations were analyzed. The varying mechanisms during plastic deformation initiation are bound to influence the mechanical behavior of such nanoscale materials, especially those strongly textured.

关键词： Iron Molecular dynamics simulation Nanopillar Plastic deformation

Macro-experimental study from steady soliton to chaotic lattice soliton

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Chinese Science Bulletin 1997年第2期42卷 120-123页

作者： Lin, j Li, Y Lou, SY yu, j Huang, GX Department of Physics Zhejiang Normal University Jinhua China Institute of Modem Physics Ningbo Normal College Ningbo China Department of Physics Shaoxing Normal College Shaoxing China Department of Physics East China Normal University Shanghai China

OVER three decades, since the wide applications of the soliton phenomena in almost all the physical fields, the theoretical, experimental and applied studies of the soliton have become an active research topic. The direct macro-observation of the soliton phenomana is one of the important problems. Since the observation of Wu et al. on the nonpropagating fluid solitons in 1984, the nonlinear systems on the vibratmg table have offered us a good experimental field. Some nonlinear excitations of the macro-monatomic lattice have been observed by Denardo et al. Ref. reported the observation of the localized structure of the granular sys-

关键词： lattice soliton amplitude recurrence experimental study.

A MULTIGRID METHOD FOR NONLINEAR PARABOLIC PROBLEMS

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journal of Computational Mathematics 1996年第4期14卷 363-382页

作者： x.j. yu(Laborutory of Computational Physics, Institute of Applied Physics and ComputationalMathematics, Beijing, China) INST APPL PHYS & COMPUTAT MATH LAB COMPUTAT PHYSBEIJINGPEOPLES R CHINA

The multigrid algorithm in [13] is developed for solving nonlinear parabolic equations arising from the finite element discretization. The computational cost of the algorithm is approximate O(NkN) where N-k is the dim... 详细信息

关键词： Th Math A MULTIGRID METHOD FOR NONLINEAR PARABOLIC PROBLEMS UC

Effect of Organosilicon Coating Containing Light Stabilizer on UV Aging Resistance of Bitumen

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武汉理工大学学报 2010年第17期32卷 83-88页

作者： HUANG Y FENG Z G yu j Y Key Laboratory of Silicate Materials Science and Engineering of Education Ministry Wuhan University of TechnologyWuhan 430070China

Effects of organosilicon coating with light stabilizer UV326,UV531 and 770 on ultraviolet (UV) aging resistance of bitumen were investigated by testing the viscosity,softening point and the changes of chemical component before and after UV aging. The results show that UV aging resistance of bitumen is improved due to the good weatherability of organosilicon. And the UV aging resistance of bitumen is further enhanced by adding light stabilizer into organosilicon coating due to the good UV absorption of light stabilizers. Bitumen coated with organosilicon coating containing UV326 exhibits better UV aging resistance in comparison with bitumen coated with organosilicon containing UV531 or 770.

关键词： bitumen light stabilizer organosilicon coating UV aging