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Regulation of CD8^(+)T memory and exhaustion by the mTOR signals

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Cellular & Molecular Immunology 2023年第9期20卷 1023-1039页

作者： Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang yuheng Han haihui yu Ningbo Wu Yiting Xie Bing Su Shanghai Institute of Immunology Department of Immunology and Microbiologyand The Ministry of Education Key Laboratory of Cell Death and DifferentiationShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Tumor Biology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Center for Immune-Related Diseases at Shanghai Institute of Immunology Department of GastroenterologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism Shanghai Jiao Tong University School of MedicineShanghaiChina Key Laboratory of Molecular Radiation Oncology of Hunan Province Xiangya HospitalCentral South UniversityChangshaChina

CD8^(+)T cells are the key executioners of the adaptive immune arm,which mediates antitumor and antiviral ***ïve CD8^(+)T cells develop in the thymus and are quickly activated in the periphery after encountering a cognate antigen,which induces these cells to proliferate and differentiate into effector cells that fight the initial ***,a fraction of these cells become long-lived memory CD8^(+)T cells that combat future ***,the generation and maintenance of memory cells is profoundly affected by various in vivo conditions,such as the mode of primary activation(e.g.,acute *** immunization)or fluctuations in host metabolic,inflammatory,or aging ***,many T cells may be lost or become exhausted and no longer *** intracellular signaling pathways,transcription factors,epigenetic modifications,and metabolic processes are involved in this ***,understanding the cellular and molecular basis for the generation and fate of memory and exhausted CD8^(+)cells is central for harnessing cellular *** this review,we focus on mammalian target of rapamycin(mTOR),particularly signaling mediated by mTOR complex(mTORC)2 in memory and exhausted CD8^(+)T cells at the molecular level.

关键词： mTOR Sin1 CD8^(+)T cell T-cell memory T-cell exhaustion

Study on Soil Improvement Measure of Plant Landscape Construction in Saline and Alkaline Area in Tianjin

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Journal of Northeast Agricultural University(English Edition) 2006年第2期13卷 163-168页

作者： GENG Meiyun CHEN Yajun HU haihui yu Lei College of Horticulture Northeast Agricultural University Harbin Heilongjiang 150030 PRC

A detailed research in soil improving measure was conducted during the process of plants that were cultivated in Tianjin saline and alkaline area. The results showed that the commonly used measures could improve the soil, and also we got some useful advices and suggestions for plants cultivating in Tianiin saline and alkaline areas.

关键词： saline and alkaline area the view of the plant soil improving measure

Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment

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Cellular & Molecular Immunology 2024年第1期21卷 47-59页

作者： yu Zheng haihui Jiang Naixue Yang Shaoping Shen Daosheng Huang Lemei Jia Jing Ling Longchen Xu Mingxiao Li Kefu yu Xiaohui Ren Yong Cui Xun Lan Song Lin Xin Lin Institute for Immunology and School of Medicine Tsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina.National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain Disorders and Beijing Key Laboratory of Brain TumorBeijing100070China Department of Neurosurgery Peking University Third HospitalPeking UniversityBeijing100191China Tsinghua-Peking Center for Life Sciences Beijing100084China

A highly immunosuppressive tumor microenvironment(TME)and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma(HGG).Here,we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C)to establish a robust antitumor immune response in this registered clinical trial(NCT03392545).During the follow-up,12/27(44.4%)patients who achieved tumor control concomitant with survival benefit were regarded as responders in our *** found that the T-cell receptor(TCR)repertoire in the TME was reshaped after poly(I:C)*** on the RNA-seq analysis of tumor samples,the expression of annexin A1(ANXA1)was significantly upregulated in the tumor cells of nonresponders,which was further validated at the protein *** vitro and in vivo experiments showed that ANXA1 could induce the production of M2-like macrophages and microglia via its surface receptor formyl peptide receptor 1(FPR1)to establish a Treg cell-driven immunosuppressive TME and suppress the antitumor immune response facilitated by poly(I:C).The ANXA1/FPR1 signaling axis can inhibit the innate immune response of glioma patients by promoting an anti-inflammatory and Treg-driven ***,ANXA1 could serve as a reliable predictor of response to poly(I:C),with a notable predictive accuracy rate of 92.3%.In light of these notable findings,this study unveils a new perspective of immunotherapy for gliomas.

关键词： glioma ANXA1 TLR3 poly(I:C) immunotherapy

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国外企业社会责任研究综述

改革与战略 2010年第3期26卷 174-178页

作者：禹海慧曾鹃湖南涉外经济学院工商管理系湖南长沙410205

我国企业在经济转型时期所引发诸多社会问题,激发了国内学术界与企业界对于企业社会责任探讨的浓厚兴趣。文章总结了国外企业社会责任的研究历程,包括学者的论战、概念的界定、不同学科视野和相关衍生理论及实践研究,并对当前国外企业... 详细信息

我国企业在经济转型时期所引发诸多社会问题,激发了国内学术界与企业界对于企业社会责任探讨的浓厚兴趣。文章总结了国外企业社会责任的研究历程,包括学者的论战、概念的界定、不同学科视野和相关衍生理论及实践研究,并对当前国外企业社会责任研究的前沿问题与研究趋势进行了展望。

关键词：企业社会责任理论实践趋势

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Zr-4合金管材轧制折叠形成模型的研究

热加工工艺 2015年第19期44卷 169-171页

作者：于海慧于军辉李小宁国核宝钛锆业股份公司陕西宝鸡721013

利用电镜对Zr-4合金成品管材和准17.78 mm×2 mm管坯内表面缺陷形貌以及成品管材缺陷掰开面进行了观察,并建立了Zr-4合金成品管材折叠形成的模型。结果表明:成品管材内表面缺陷为折叠,这是由于管坯内表面存在缺陷在后续的轧制过程中导... 详细信息

利用电镜对Zr-4合金成品管材和准17.78 mm×2 mm管坯内表面缺陷形貌以及成品管材缺陷掰开面进行了观察,并建立了Zr-4合金成品管材折叠形成的模型。结果表明:成品管材内表面缺陷为折叠,这是由于管坯内表面存在缺陷在后续的轧制过程中导致折叠产生。经验证,建立的Zr-4合金管材折叠模型与试验结果一致,可对生产起到一定的指导作用。

关键词： Zr-4成品管材折叠内表面缺陷轧制

小城镇建筑风貌特色塑造及导控研究——以南江县为例

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建筑与文化 2018年第3期 62-63页

作者：余海慧重庆大学建筑城规学院

建筑对于城市风貌来说是其重点构成要素,建筑风貌特色的塑造对城市品牌形象的建立意义重大,也为南江县大力发展旅游业,实现"旅游强县"的目标提供有效的支撑。文章从城市建筑风貌特色的塑造和城市的导控设计[1]出发,在充分分析现状的基础... 详细信息

建筑对于城市风貌来说是其重点构成要素,建筑风貌特色的塑造对城市品牌形象的建立意义重大,也为南江县大力发展旅游业,实现"旅游强县"的目标提供有效的支撑。文章从城市建筑风貌特色的塑造和城市的导控设计[1]出发,在充分分析现状的基础上,通过对宏观-中观-微观建筑风貌要素的管控,为城市管理者推动城市良好风貌的建设提供依据。

关键词：南江县建筑风貌特色塑造风貌导控

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党内利益集团防范机制研究

沈阳干部学刊 2019年第4期21卷 27-30页

作者：于海会中共朝阳市委党校

习近平总书记明确要求:"党内政治生活和组织生活都要讲政治,讲原则,讲规矩……不允许搞团团伙伙,帮帮派派,不允许搞利益集团,进行利益交换。"本文论述了党内利益集团的实质、特点、形成及危害,探讨了防止党内利益集团形成的途径。

关键词：党内利益集团党内政治生活制度法规

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食品安全危机中的信托责任:异化与重构

上海管理科学 2012年第1期34卷 86-90页

作者：禹海慧湖南涉外经济学院管理学院湖南长沙410205

社会分工导致食品供应商与食品消费者产生委托代理关系,食品供应商需要对食品消费者承担信托责任,但是由于社会分工的日益细化,该种信托责任日益出现资本意志性、多元复杂性、非生态性等方面的异化。重构食品企业的信托责任需要进行顶... 详细信息

社会分工导致食品供应商与食品消费者产生委托代理关系,食品供应商需要对食品消费者承担信托责任,但是由于社会分工的日益细化,该种信托责任日益出现资本意志性、多元复杂性、非生态性等方面的异化。重构食品企业的信托责任需要进行顶层设计,食品供应商要树立食品安全危机意识,在经营理念中彰显社会责任;政府需要建立统一的委托代理机构,作为消费者的代言人,强化食品供应商的信托责任;建立一个公共的食品安全信息平台,降低食品供应商因为信息不对称而损害食品消费者利益的机会主义倾向。

关键词：社会分工食品安全委托代理信托责任危机管理

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三种无痛人工流产静脉麻醉的临床观察

中国当代医药 2010年第31期17卷 67-68页

作者：吴伟俞海汇湖南省湘潭市韶山医院湖南湘潭411300

目的:对3种不同的镇痛方法应用于人工流产术的临床效果进行对比分析。方法:将300例早期妊娠要求行无痛人工流产的孕妇随机分为3组:A组为丙泊酚静脉注射组,B组为舒芬太尼+丙泊酚组,C组为布托啡诺+丙泊酚组。观察3组的静脉注射痛、宫预松... 详细信息

目的:对3种不同的镇痛方法应用于人工流产术的临床效果进行对比分析。方法:将300例早期妊娠要求行无痛人工流产的孕妇随机分为3组:A组为丙泊酚静脉注射组,B组为舒芬太尼+丙泊酚组,C组为布托啡诺+丙泊酚组。观察3组的静脉注射痛、宫预松弛程度、头昏、呕吐、术中出血量、术后腹痛、体动及丙泊酚用量等。结果:B、C组宫颈松弛程度、术中体动与A组比较差异有统计学意义(P0.05),B组头昏发生率较A、C组差异有统计学意义(P<0.01)。结论:布托啡诺复合丙泊酚应用于无痛人工流产效果满意,不良反应少,值得在基层医院推广和应用。

关键词：异丙酚布托啡诺舒芬太尼人工流产麻醉