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Elaborating strengthen mechanism of Pt-Ir solid solution superalloy at finite temperature

Rare Metals 2024年第3期43卷 1243-1256页

作者： Wei yu Xiao-yu chong yun-Xuan Zhou Meng-Di Gan Ying-Xue Liang Yan Wei Ai-Min Zhang Chang-Yi Hu Xing-yu Gao Li Chen Hai-Feng Song Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China yunnan Precious Metals Laboratory Co.LTD Kunming650106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China

Pt-Ir alloy is potential superalloys used above 1300℃because of their high strength and creep ***,the ductility of Pt-Ir alloy has rapidly deteriorated with the increase of Ir,resulting in poor *** work quantitatively evaluated the solid solution strengthening(SSS)and grain refinement strengthening(GRS)of Pt-Ir alloy using first-principles calculations combined with experimental ***,the stretching force constants in the second nearest neighbor region(SFC^(2nd))of pure Ir(193.7 eV·nm^(-2))are 3.40 times that of pure Pt(57.0 eV·nm^(-2)),i.e.,the interatomic interaction is greatly enhanced with the increase of Ir content,which leads to the decrease of ductility,and modulus misfit plays a dominant role in ***,the physical mechanisms responsible for the hardness(H_(V))of Pt-Ir alloy,using the power-law-scaled function of electron work function coupled SSS and GRS,are attributed to the electron redistribution caused by different Ir ***,a thorough assessment of the thermodynamic characteristics of Pt-Ir binary alloy was conducted,culminating in development of a mapping model that effectively relates enmposition,temperature and *** results revealed that the compressive strength incrcases with the Ir content,and the highest strength was observed in Pt_(0.25)Ir_(0.75).This study provides valuable insights into the Pt-Ir alloy system.

关键词： Elastic properties Phonon Solid solution strengthen Force constants CALPHAD

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Field released transgenic papaya effect on soil microbial communities and enzyme activities

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Journal of Environmental Sciences 2006年第4期18卷 734-740页

作者： WEI Xiang-dong ZOU Hui-ling CHU Lee-min LIAO Bin YE Chang-min LAN chong-yu School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Department of Biology The Chinese University ofHong Kong Shatin Hong Kong China

Soil properties, microbial communities and enzyme activities were studied in soil amended with replicase （RP）-transgenic or non-transgenic papaya under field conditions. Compared with non-transgenic papaya, significant differences （P〈0.05） were observed in total nitrogen in soils grown with transgenic papaya. There were also significant differences （P〈0.05） in the total number of colony forming units （CFUs） of bacteria, actinomycetes and fungi between soils amended with RP-transgenic plants and non-transgenic plants. Compared with non-transgenic papaya, the total CFUs of bacteria, actinomycetes and fungi in soil with transgenic papaya increased by 0.43-1.1, 0.21-0.80 and 0.46-0.73 times respectively. Significantly higher （P〈0.05） CFUs of bacteria, actinomycetes and fungi resistant to kanamycin （Km） were obtained in soils with RP-transgenic papaya than those with non-transgenic papaya in all concentrations of Km. Higher resistance quotients for Km＇（kanamycin resistant） bacteria, actinomycetes and fungi were found in soil planted with RP-transgenic papaya, and the resistance quotients for Km＇ bacteria, actinomycetes and fungi in soils with transgenic papaya increased 1.6-4.46, 0.63-2.5 and 0.75-2.30 times. RP-transgenic papaya and non-transgenic papaya produced significantly different enzyme activities in arylsulfatase （5.4-5.9x）, polyphenol oxidase （0.7-1.4x）, invertase （0.5-0.79x）, cellulase （0.23-0.35x） and phosphodiesterase （0.16-0.2x）. The former three soil enzymes appeared to be more sensitive to the transgenic papaya than the others, and could be useful parameters in assessing the effects of transgenic papaya. Transgenic papaya could alter soil chemical properties, enzyme activities and microbial communities.

关键词： transgenic papaya soil microbes enzyme activity kanamycin resistance resistance quotient

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Using hybrid transcription factors to study gene function in rice

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Science China(Life Sciences) 2015年第11期58卷 1160-1162页

作者： ZHAO Tao LIU Jun LI Hong-yu LIN Jian-Zhong BIAN Ming-Di ZHANG Chun-yu ZHANG Yong-Xing PENG yu-chong LIU Bin LIN ChenTao Institute of Crop Sciences Chinese Academy of Agricultural Sciences College of Biology Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan University Laboratory of Soil and Plant Molecular Genetics College of Plant Science Jilin University Department of Molecular Cell & Developmental Biology University of California

Dear Editors,Transcription factors （TF） play important roles in plant growth and development, which determine crop productivi- ty, quality, and stress tolerance. However, the basic mecha- nism governing transcription regulation by TF remains largely unclear in plants. It is well known that TF proteins contain at least two functional domains, the DNA-binding domain and the transcription regulatory domain. The VP16 transcription activation domain of human Herpes simplex virus and the EAR transcription suppression domain of many plant TF proteins are two of the best-known transcrip- tion regulatory domains [1,2].

关键词：转录因子基因功能植物生长发育功能结构域应用水稻杂交单纯疱疹病毒

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In situ formed synaptic Zn@LiZn host derived from ZnO nanofiber decorated Zn foam for dendrite-free lithium metal anode

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Nano Research 2023年第6期16卷 8345-8353页

作者： Jian Bao Hai-Juan Pei Xin-Yang yue Xun-Lu Li Cui Ma Rui-Jie Luo chong-yu Du Yong-Ning Zhou Department of Materials Science Fudan UniversityShanghai 200433China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Lithium metal is regarded as the most promising anode material for next generation high energy density lithium batteries due to its high theoretical capacity and lowest potential versus standard hydrogen ***,lithium dendrite growth and huge volume change during cycling hinder its practical *** is of great importance to design advanced Li metal anodes to solve these ***,we report a ZnO-coated Zn foam as the host matrix to pre-store lithium through thermal infusing,achieving a Zn@ZnO foam supported Li composite electrode(LZO).Needlelike ZnO nanofibers grown on the Zn foam greatly increase the surface area and enhance the lithiophilicity of the Zn *** situ formed synaptic LiZn layer after lithium infusion can disperse local current density and lower Li diffusion barrier effectively,leading to homogeneous Li deposition behavior,thus suppressing dendrite *** porous Zn foam skeleton can accommodate volume variation of the electrode during longterm *** from these merits,the LZO anode exhibits much better cycle stability and rate capability in both symmetrical and full cells with low voltage hysteresis than the bare Li *** work opens a new opportunity in designing high performance composite Li anode for lithium-metal batteries.

关键词： lithium batteries anode LiZn alloy thermal infusion Li metal

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Outcome of nephrostomy balloon dilation for vesicourethral anastomotic strictures following radical prostatectomy： a retrospective study

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Asian Journal of Andrology 2014年第1期16卷 115-119页

作者： chong-yu Zhang yu Zhur Kin Li Laphong Ian Sonfat HOe Waihong Pun Hiofai Lao Vitalino Carvalho Ding-Yi Liu Zhou-Jun Shen LDepartment of Urology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Urology Conde S. Janurio Hospital Centre Macao China Department of Urology Pu Nan Hospital Shanghai China

To evaluate the efficacy of nephrostomy balloon dilation （NBD） for patients who developed vesicourethral anastomotic stricture （VAS） following radical prostatectomy. NBD was performed in patients who developed VAS following radical prostatectomy. Quality of life （QoL）, International Prostate Symptom Score （IPSS） and maximal urinary flow rate （Qmax） were evaluated. Four hundred and sixty-three prostate cancer patients underwent radical retropubic prostatectomy （RRP）, and 86 underwent laparoscopic radical prostatectomy （LRP）. Most patients （90.3%） had T2 or T3 prostate cancer and a pathological Gleason score of ; 7. Forty-five （8.2%） and four （4.7%） patients developed VAS due to radical or LRP, respectively. Forty （89%） patients underwent NBD, including three cases of repeat dilation. The median Qmax was 4 ml s- （interquartile range （IQR）, 2.3-5.6） before dilation and improved to 16 ml s- （IQR, 15-19） and 19 ml s-1 （IQR, 18-21） at the 1- and 12-month follow-up, respectively （P〈 0.01）. Fifteen （37.5%） patients had urinary incontinence prior to dilation, whereas only three （7.5%） patients had incontinence 12 months following dilation （P 〈 0.01）. The median IPSS score improved from 19 （IQR, 17-24） before dilation to 7 （IQR, 6-8） at 12 months following dilation, and the QoL score improved from 5 （IQR, 4-6） before dilation to 2 （IQR, 2-3） at 12 months following dilation （P 〈 0.01 in both）. VAS occurs in a small but significant proportion of patients following radical prostatectomy. NBD offers an effective remedy for VAS.

关键词： nephrostomy balloon dilation (NBD) quality of life (QoL) radical prostatectomy vesicourethral anastomotic stricture (VAS)

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Optically sizing single atmospheric particulates with a 10-nm resolution using a strong evanescent field

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Light(Science & Applications) 2018年第1期7卷 1087-1093页

作者： Xiao-chong yu Yanyan Zhi Shui-Jing Tang Bei-Bei Li Qihuang Gong Cheng-Wei Qiu yun-Feng Xiao State Key Laboratory for Mesoscopic Physics and School of Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore NUS Suzhou Research Institute(NUSRI) Suzhou 215123China SZU-NUS Collaborative Innovation Center for Optoelectronic Science&Technology Shenzhen UniversityShenzhen 518060China

Although an accurate evaluation of the distribution of ultrafine particulate matter in air is of utmost significance to public health,the usually used PM2.5 index fails to provide size distribution *** we demonstrate a low-profile and cavity-free size spectrometer for probing fine and ultrafine particulate matter by using the enhanced particle-perturbed scattering in strong optical evanescent fields of a nanofiber *** unprecedented size resolution reaches 10 nm for detecting single 100-nm-diameter nanoparticles by employing uniform nanofibers and controlling the polarizations of the probe *** size spectrometry was tested and used to retrieve the size distribution of particulate matter in the air of Beijing,yielding mass concentrations of nanoparticles,as a secondary exercise,consistent with the officially released *** nanofiber-array probe shows potential for the full monitoring of air pollution and for studying early-stage haze evolution and can be further extended to explore nanoparticle interactions.

关键词： air pollution optical nanofiber single particulates size spectrometer

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Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

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Chinese Chemical Letters 2007年第11期18卷 1323-1326页

作者： Hong Gang Hu Ming Juan Wang Qing Jie Zhao Shi chong yu Chao Mei Liu Qiu Ye Wu Department of Chemistry College of Science Wayne State University Detroit MI 48202 United States Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

Protein tyrosine phosphatase 1 B （PTP1 B） has received considerable attention from the drug industry as a potential treatment for diabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.

关键词： Mangiferin Protein tyrosine phosphatase 1B Dedvates Inhibition

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Design synthesis and biological evaluation of 3-substituted triazole derivatives

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Chinese Chemical Letters 2011年第5期22卷 519-522页

作者： Bao Gang Wang Shi chong yu Xiao yun Chai Yong Zheng Yan Hong Gang Hu Qiu Ye Wu Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China Pharmacy Team Administrative Brigade of Postgraduate Second Military Medical University Shanghai 200433 China

Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal *** of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

关键词： Synthesis Triazole Antifungal activity 1 3-Dipolar cycloaddition

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Novel structures and mechanical properties of Zr_(2)N:Ab initio description under high pressures

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Chinese Physics B 2021年第1期30卷 434-442页

作者： Minru Wen Xing Xie Zhixun Xie Huafeng Dong Xin Zhang Fugen Wu chong-yu Wang School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou 510006China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China Department of Physics Tsinghua UniversityBeijing 100084China

With the formation of structural vacancies,zirconium nitrides(key materials for cutting coatings,super wearresistance,and thermal barrier coatings) display a variety of compositions and phases featuring both cation and nitrogen *** study presents a systematic exploration of the stable crystal structures of zirconium heminitride combining the evolutionary algorithm method and ab initio density functional theory calculations at pressures of 0 GPa,30 GPa,60 GPa,90 GPa,120 GPa,150 GPa,and 200 *** addition to the previously proposed phases P42/mnm-,Pnnn-,and Cmcm-Zr2 N,five new high-pressure Zr_(2)N phases of PA/nmm,IA/mcm,P2_(1)/m,P3 m1,and C2/m are *** enthalpy study of these candidate configurations reveals various structural phase transformations of Zr2 N under *** calculating the elastic constants and phonon dispersion,the mechanical and dynamical stabilities of all predicted structures are examined at ambient and high *** understand the structure-property relationships,the mechanical properties of all Zr_(2)N compounds are investigated,including the elastic moduli,Vickers hardness,and directional dependence of Young’s *** Cmncm-Zr2 N phase is found to belong to the brittle materials and has the highest Vickers hardness(12.9 GPa) among all candidate phases,while the I4/mcm-Zr2 N phase is the most ductile and has the lowest Vickers hardness(2.1 GPa).Furthermore,the electronic mechanism underlying the diverse mechanical behaviors of Zr2 N structures is discussed by analyzing the partial density of states.

关键词： phase transition phonon dispersion Zr_(2)N first-principles calculations

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Pathologic complete response to conversion therapy in hepatocellular carcinoma using patient-derived organoids:A case report

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World Journal of Gastrointestinal Oncology 2024年第11期16卷 4506-4513页

作者： Yong-Gang He Zheng Wang Jing Li Wang Xi chong-yu Zhao Xiao-Bing Huang Lu Zheng Department of Hepatobiliary The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND For primary liver cancer,the key to conversion therapy depends on the effectiveness of drug ***-derived tumor organoids have been demonstrated to improve the efficacy of conversion therapy by identifying individualtargeted effective drugs,but their clinical effects in liver cancer remain *** SUMMARY We described a patient with hepatocellular carcinoma(HCC)who achieved pathologic complete response(pCR)to conversion therapy guided by the patientderived organoid(PDO)drug sensitivity *** insufficiency of the remaining liver volume after hepatectomy,the patient obtained tumor reduction after treatment with the PDO-sensitive drugs and successfully underwent radical surgical ***,pCR was *** PDOs contributes to screening sensitive drugs for HCC patients to realize the personalized treatment and improve the conversion therapy efficacy.

关键词： Tumor organoids Hepatocellular carcinoma Drug sensitivity testing Conversion therapy Pathological response Case report

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