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Cellular & Molecular Immunology 2021年第6期18卷 1596-1598页

作者： Xueling Jin liyuan Cui Weijie Zhao Xinyi li Lu liu Yanhong li Qiang Fu Dajin li Min yu Meirong Du NHC Key Lab of Reproduction Regulation(shanghai {1. of Planned Parenthood Research) Hospital of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghaiChina shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases ShanghaiChina Department of Immunology Binzhou Medical CollegeYantaiChina Department of Obstetrics and Gynecology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy Macao University of Science and TechnologyMacaoSARChina

In early pregnancy,the decidua is populated by a large number of natural killer cells(NKs),most of which are CD56bright with a strong capacity to secrete cytokines,differing from peripheral and cord blood NK cells(pNKs and cNKs).1.2,3 It is generally believed that uterine NKs are recruited from the peripheral blood and are further educated to develop a decidual NK cell(dNK)-like phenotype in the microenvironment at the maternal-fetal interface.4 However,the defined mechanisms involved in this education remain unclear.

关键词： CD56 pregnancy fetal

De Novo and Inherited SETD1. Variants in Early-onset Epilepsy

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Neuroscience Bulletin 2019年第6期35卷 1045-1057页

作者： Xiuya yu lin Yang Jin li Wanxing li Dongzhi li Ran Wang Kai Wu Wenhao Chen Yi Zhang Zilong Qiu Wenhao Zhou Division of Neonatology Children's Hospital of Fudan UniversityShanghai 201102China Clinical Genetic Center Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China institute of Biomedicine Sciences Fudan UniversityShanghai 200032China Department of Prenatal Diagnosis The Women and Children's Medical CenterGuangzhou 510623China Euler Genomics Beijing 102206China School of life Sciences Peking UniversityBeijing 100191China institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Laboratory of Neonatal Diseases Ministry of HealthChildren's Hospital of Fudan UniversityShanghai 201102China

Early-onset epilepsy is a neurological abnormality in childhood, and it is especially common in the first2 years after birth. Seizures in early life mostly result from structural or metabolic disorders in the brain, and the genetic causes of idiopathic seizures have been extensively investigated. In this study, we identified four missense mutations in the SETD1.A gene(SET domain-containing 1.A, histone lysine methyltransferase): three de novo mutations in three individuals and one inherited mutation in a four-generation family. Whole-exome sequencing indicated that all four of these mutations were responsible for the seizures. Mutations of SETD1.A have been implicated in schizophrenia and developmental disorders, so we examined the role of the four mutations(R91. C, Q269 R, G1.69 R, and R1.92 H) in neural development. We found that their expression in mouse primary cortical neurons affected excitatory synapse development. Moreover, expression of the R91. C mutation also affected the migration of cortical neurons in the mouse *** further identified two common genes(Neurl4 and Usp39) affected by mutations of SETD1.A. These results suggested that the mutations of SETD1.A play a fundamental role in abnormal synaptic function and the development of neurons, so they may be pathogenic factors for neurodevelopmental disorders.

关键词： Early-onset epilepsy Whole-exome sequencing SETD1. Neural development

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中职生性知识和性教育状况及相关因素分析

中国学校卫生 2024年第5期45卷 659-664页

作者：贾欣房宇航金焰左霞云余春艳廉启国李立鹤洪苹涂晓雯复旦大学公共卫生学院/上海市生物医药技术研究院/上海市疾病与健康基因组学重点实验室/国家卫生健康委员会生育调节药械重点实验室上海200037 陕西新航公共卫生研究中心中国计划生育协会

目的了解上海和陕西中职生的性与生殖健康知识、性教育状况及相关因素,为中职校开展性教育提供科学依据。方法2021.4—6月,采用方便与整群抽样相结合的方法在上海市和陕西省3座城市(商洛、安康和宝鸡)共选取6所中职学校一至三年级31.0... 详细信息

目的了解上海和陕西中职生的性与生殖健康知识、性教育状况及相关因素,为中职校开展性教育提供科学依据。方法2021.4—6月,采用方便与整群抽样相结合的方法在上海市和陕西省3座城市(商洛、安康和宝鸡)共选取6所中职学校一至三年级31.0名中职生进行调查。采用自行设计的调查问卷进行线上调查,调查内容包括个人特征、家庭背景、家庭及学校性教育现况、青少年的性与生殖健康(SRH)知识及来源。采用t检验和χ^(2)检验进行组间比较,对SRH知识总分按四分位数进行分组拟合多分类有序Logistic回归模型分析。结果中职生性与生殖健康知识总均分为(51.36±21.61.,在不同维度的知识得分中,以性骚扰/性侵害知识得分(66.45±42.27)较高,生殖生理(47.67±31.94)和避孕知识得分(43.85±26.81.较低。两地中职生最主要的知识来源是学校/老师、网络、同学或朋友。学校性教育主题以青春期发育与保健为主(占比超过80%),与父母讨论SRH最多的话题是人际关系(占比超过55%),且两地中职生的报告率差异均有统计学意义(χ^(2)值分别为28.56,32.02,P值均1.62,0.72,1.20,1.58,2.09,1.1.,1.1.,1.66,1.62,1.69,1.22,P值均<0.05)。结论上海和陕西中职生的性与生殖健康知识水平普遍偏低。应加强学校老师和家长的培训,提高其性教育意识和性教育能力,推动中职生性教育的开展。

关键词：性知识健康教育回归分析学生

Formamidinium-incorporated Dion-Jacobson phase 2D perovskites for highly efficient and stable photovoltaics

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Journal of Energy Chemistry 2021年第6期30卷 632-638,I0015页

作者： Sajjad Ahmad Wei yu Ruixue Lu Yang liu Tonggang Jiu Shuping Pang Xin Guo Can li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyDalian 116023LiaoningChina Qingdao institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101ShandongChina University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Fudan UniversityShanghai 200438China

Dion-Jacobson phase two-dimensional(DJ 2D)perovskites,recently attracting considerable interests,exhibit excellent environmental stability and structural tunability,but their solar cells still offer unsatisfactory power conversion efficiencies(PCEs).Herein,we develop DJ 2D perovskites employing formamidinium(FA+)as a ternary cation in the perovskite cages((PDA)(FA)x(MA)3-xPb4 I1.,χ=0,0.1.,0.3 and 0.6,PDA=1.3-propanediammonium)for highly efficient and stable perovskite solar cells(PSCs).We found that the DJ 2D perovskite with a 1.%FA+fraction presents improved crystallinity,preferred vertical orientation,and longer charge carrier lifetime compared to that without FA+*** a result,the FAdoped DJ 2D PSCs exhibit a champion PCE of 1..74%with superior device *** unencapsulated devices sustain over 92%of its initial PCE after storage at a constant relative humidity(RH)of 65%for 6000 h,90%by heat at 85℃in air for 800 h,and 94%under 1.sun illumination for 5000 *** findings demonstrate that the incorporation of FA cation into the DJ 2D perovskite is a promising strategy to develop highly efficient and stable DJ 2D PSCs.

关键词： Dion-Jacobson 2D perovskites Perovskite solar cells Formamidinium doping Power conversion efficiency

Neuroinflammation Mediates Faster Brachial Plexus Regeneration in Subjects with Cerebral Injury

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Neuroscience Bulletin 2021年第11期37卷 1542-1554页

作者： Fan Su Guobao Wang Tie li Su Jiang Aiping yu Xiaomin Wang Wendong Xu Department of Hand Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai200040China Department of Hand and Upper Extremity Surgery Jing’an District Central HospitalFudan UniversityShanghai200040China The National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai200040China institute of Brain Science State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai200040China Co-innovation Center of Neuroregeneration Nantong University226000NantongChina

Our previous investigation suggested that faster seventh cervical nerve(C7)regeneration occurs in patients with cerebral injury undergoing contralateral C7 *** finding needed further verification,and the mechanism remained largely ***,Tinel’s test revealed faster C7 regeneration in patients with cerebral injury,which was further confirmed in mice by electrophysiological recordings and histological ***,we identified an altered systemic inflammatory response that led to the transformation of macrophage polarization as a mechanism underlying the increased nerve regeneration in patients with cerebral *** mice,we showed that,as a contributing factor,serum amyloid protein A1.SAA1.promoted C7 regeneration and interfered with macrophage polarization in *** results indicate that altered inflammation promotes the regenerative capacity of the C7 nerve by altering macrophage ***1.may be a therapeutic target to improve the recovery of injured peripheral nerves.

关键词： Nerve regeneration Cerebral injury Neuroinflammation Macrophage polarization Brachial plexus injury Nerve transfer Contralateral seventh cervical nerve transfer

Chemerin deficiency regulates adipogenesis is depot different through TIMP1

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Genes & Diseases 2021年第5期8卷 698-708页

作者： Cheng-Long Huang liu-ling Xiao Min Xu Jun li Shu-Fen li Cui-Song Zhu yu-li lin Rui He Xi li Biology Science institutes Chongqing Medical UniversityChongqing400016PR China Center for Translational Research in Hematologic Malignancies Houston Methodist Cancer CenterHouston Methodist Research InstituteHoustonTX 77030USA Key Laboratory of Metabolic Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai200032PR China shanghai Public Health Clinical Center Fudan UniversityShanghai201508PR China Department of Immunology Fudan University Shanghai Medical CollegeShanghai200032PR China

Adipocytes and immune cells are vital for the development of adipose ***-pokines secreted by adipocytes regulate adipogenesis and body *** is one of the ***,the function and mechanism of chemerin in adipose tissue are not fully *** with wild type(WT)mice,Rarres2^(-/-)mice gained weight and significantly increased fat distribution in subcutaneous adipose tissue(SAT),rather than visceral adipose tissue(VAT)on high fat diet(HFD).PPARg and C/EBPa,the master regulators of adipogenesis,were up-regulated in SAT and down-regulated in VAT in Rarres2^(-/-)mice comparing with WT *** of chemerin deficiency or not,the ratio of adipocyte-progenitors to total cells and the differentiation capacity of adipocyte-progenitors were similar in SAT and VAT,but macrophage infiltration in VAT was more severe than in SAT in Rarres2^(-/-)***,CD45þimmune cells supernatant from Rarres2^(-/-)SAT pro-moted the differentiation of adipocyte-progenitors and 3T3-L1.*** array assay of CD45þimmune cells supernatant revealed that metalloproteinase inhibitor 1.TIMP1.,an in-hibitor of adipogenesis,was reduced in Rarres2^(-/-)SAT,but increased in Rarres2^(-/-)*** we specifically knocked down chemerin in SAT,TIMP1.was down-regulated and adipogenesis was promoted with reducing infiltration of *** present study demonstrates that the effects of chemerin on adipose tissue is depot different,and specific knock down chemerin in SAT promote adipogenesis and improve glucose tolerance test(GTT)and insulin tolerance test(ITT).This suggests a potential therapeutic target for chemerin in the treatment of obesity related metabolic disorder.

关键词： Adipogenesis Adipose tissue depot Chemerin Inflammation TIMP1

The Nucleus Accumbens CRH–CRHR1.System Mediates Early-life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse

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Neuroscience Bulletin 2023年第1期39卷 41-56页

作者： Ting Wang yu-Nu Ma Chen-Chen Zhang Xiao liu Ya-Xin Sun Hong-li Wang Han Wang yu-Heng Zhong yun-Ai Su Ji-Tao li Tian-Mei Si Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing100191China Department of Pharmacology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai200032China

Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood,one of which is sleep *** the corticotropin-releasing hormone(CRH)–corticotropin-releasing hormone receptor 1.CRHR1.system and nucleus accumbens(NAc)play important roles in both stress responses and sleep-wake regulation,in this study we investigated whether the NAc CRH–CRHR1.system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult *** the limited nesting and bedding material paradigm from postnatal days 2 to 9,we found that early-life stress disrupted sleep-wake behaviors during adulthood,including increased wakefulness and decreased non-rapid eye movement(NREM)sleep time during the dark period and increased rapid eye movement(REM)sleep time during the light *** stress-induced sleep disturbances were accompanied by dendritic atrophy in the NAc and both were largely reversed by daily systemic administration of the CRHR1.antagonist antalarmin during stress ***,Crh overexpression in the NAc reproduced the effects of early-life stress on sleep-wake behavior and NAc morphology,whereas NAc Crhr1.knockdown reversed these effects(including increased wakefulness and reduced NREM sleep in the dark period and NAc dendritic atrophy).Together,our findings demonstrate the negative influence of early-life stress on sleep architecture and the structural plasticity of the NAc,and highlight the critical role of the NAc CRH–CRHR1.system in modulating these negative outcomes evoked by early-life stress.

关键词： Early-life stress Sleep CRH-CRHR1 Nucleus accumbens Morphology

miR-1.0b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1

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Journal of Molecular Cell Biology 2021年第6期13卷 422-432页

作者： yu-Cheng Wang Xiaohan Yao Mei Ma Huihui Zhang Hui Wang Lei Zhao Shengnan liu Chao Sun Peng li yuting Wu Xihua li Jingjing Jiang yuying li Yan li Hao Ying shanghai Xuhui District Central Hospital Zhongshan-Xuhui HospitalFudan UniversityShanghai 200001China CAS Key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China Department of Neuromuscular Disease Children’s Hospital of Fudan UniversityShanghai 201102China Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghai 200031China State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122China Key Laboratory of Food Safety Risk Assessment Ministry of HealthBeijing 100021China

Muscle regeneration after damage or during myopathies requires a fine cooperation between myoblast proliferation and myogenic differentiation.A growing body of evidence suggests that microRNAs play critical roles in myocyte proliferation and differentiation ***,the molecular mechanisms underlying the orchestration are not fully ***,we showed that miR-1.0b is able to repress myoblast proliferation and promote myogenic differentiation via targeting Sp1.transcription ***,overexpression of miR-1.0b is capable of improving the recovery of damaged muscle in a freeze injury ***,miR-1.0b expression is declined in the muscle of muscular dystrophy ***,these results indicated that miR-1.0b may play a role in skeletal muscle regeneration and myopathy ***,our findings suggest that the miR-1.0b/Sp1.axis may serve as a potential therapeutic target for the treatment of patients with muscle damage or severe myopathies.

关键词： miR-1.0b muscle regeneration proliferation differentiation Sp1

乌拉坦致C57BL/6J小鼠肺腺瘤动物模型方法研究

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中国药学杂志 2018年第9期53卷 701-706页

作者：陈晨盛云华王宇王巧旭谷舒怡胡玥唐黎明复旦大学药学院上海201203 上海市食品药品检验所药理毒理室上海201203

目的采用3种不同的造模方法,比较并优化乌拉坦致C57BL/6J小鼠肺腺瘤动物模型建立的方法。方法取雌性C57BL/6J小鼠,分成4组,阴性对照组和模型Ⅰ组,模型Ⅱ组,模型Ⅲ组。模型Ⅰ组腹腔注射800 mg·kg-1.拉坦,2次·周-1.连续5周;模型Ⅱ组腹... 详细信息

目的采用3种不同的造模方法,比较并优化乌拉坦致C57BL/6J小鼠肺腺瘤动物模型建立的方法。方法取雌性C57BL/6J小鼠,分成4组,阴性对照组和模型Ⅰ组,模型Ⅱ组,模型Ⅲ组。模型Ⅰ组腹腔注射800 mg·kg-1.拉坦,2次·周-1.连续5周;模型Ⅱ组腹腔注射1.000 mg·kg-1.拉坦,2次·周-1.连续5周;模型Ⅲ组腹腔注射1.000 mg·kg-1.拉坦,5 d·次-1.连续8次。阴性对照组给予等体积氯化钠注射液,给药方式与模型Ⅱ组相同。每周称量动物体重。所有组分别于第28周取主要脏器心、肝、脾、肺、肾、脑、胸腺,计算脏器指数,同时另取肺组织观察,计腺瘤数,量取肺腺瘤直径,并对肺、胸腺进行组织病理学检查。收集阴性对照组和模型组小鼠支气管肺泡灌洗液,对细胞进行分类计数分析。结果与阴性对照组相比,3种造模方法均1.0%诱导出肺腺瘤,模型Ⅰ组和模型Ⅲ组肿瘤数目均为6左右,模型Ⅱ组肿瘤数目大约为2。3组造模小鼠肺指数均增大,脑、脾、胸腺指数均减小,支气管肺泡灌洗液分析表明模型组淋巴细胞和多型核白细胞多于阴性对照组。结论 3种造模方法均1.0%诱导出肺腺瘤,综合检测各指标,模型Ⅰ组和Ⅲ组相对于模型Ⅱ组诱导肺肿瘤的数目相对较多,模型较稳定均一。

关键词：乌拉坦 C57BL/6J小鼠肺腺瘤动物模型

25-Hydroxyvitamin D Is Associated with Islet Homeostasis in Type-2 Diabetic Patients with Abdominal Obesity

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Current Medical Science 2023年第5期43卷 919-926页

作者： Qing li Wen ZHANG Bing HAN yu-ying WANG Heng WAN Min ZHANG Ning-jian WANG Ying-li LU institute and Department of Endocrinology and Metabolism Shanghai Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China institute and Department of Endocrinology and Metabolism Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China

Objective Isletαcells input is essential for insulin secretion fromβ*** present study aims to investigate the association between 25-hydroxyvitamin D[25(OH)D]and islet function homeostasis in type-2 diabetes(T2D)*** A total of 4670 T2D patients from seven communities in shanghai,{1. were *** anthropometric indices,biochemical parameters,serum 25(OH)D,and islet function[including C-peptide(C-p)and glucagon]were *** The fasting plasma glucose(FPG),glycated hemoglobin(HbA1.),glucagon,and C-p levels exhibited a significantly decreasing trend in T2D patients as the 25(OH)D levels ***,the population was divided into two groups:abdominal obesity and non-abdominal obesity *** adjustment,the 25(OH)D level was found to be associated with HbA1.,glucagon,and homeostasis model assessment ofβ(HOMA-β)in the non-abdominal obesity *** was a significant relationship between 25(OH)D and HbA1.,glucagon,HOMA-IR,baseline insulin or C-p in the abdominal obesity *** the abdominal obesity group,the ordinary least squares(OLS)regression and quantile regression revealed that 25(OH)D was obviously associated with glucagon and fasting C-p *** the abdominal obesity group,the moderate analysis revealed a significant interaction effect of 25(OH)D and glucagon on C-p(P=0.01.4).Furthermore,the conditional indirect effect of 25(OH)D on the glucagon/C-p ratio was significantly lower at 1.standard deviation(SD)below the mean(P=0.0002),and lower at the mean of the course of diabetes(P=0.0007).Conclusion 25(OH)D was found to be negatively correlated to glucagon and C-p in T2D patients with abdominal *** 25(OH)D influenced C-p in part by influencing *** effect of 25(OH)D on the glucagon/C-p ratio in T2D patients with abdominal obesity,in terms of islet homeostasis,is influenced by the course of diabetes.

关键词： 25-hydroxyvitamin D glucagon C-peptide isletαcells isletβcells type-2 diabetes