检索结果-南通市图书馆

Association of Visit-to-Visit Variabilities in Metabolic Factors with Chronic Kidney Disease in Chinese Adults living in shanghai

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第10期34卷 761-772页

作者： li ling WANG Fei XU Min LU Jie li ZHAO Zhi yun li Mian WANG Tian Ge WANG Shuang yuan BI yu Fang XU yu CAI Wei Min NING Guang Department of Clinical Pharmacy and Pharmaceutical Management School of PharmacyFudan UniversityShanghai 201203China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease(CKD)in shanghai community *** We used data from a cohort study of community residents who participated in three examinations in 2008,2009,and 201.,*** plasma glucose(FPG)level,blood pressure(BP),and lipid levels were determined in 2,1.9 participants at all three visits,and CKD was evaluated between the second and the third ***-to-visit variabilities in metabolic factors were described by coefficients of variation(CV)at three visits.A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of *** was defined as the estimated glomerular filtration rate1.73 m2 or urinary albumin-to-creatinine ratio≥30 mg/*** A total of 200(9.5%)participants had CKD at the third *** with the lowest quartile of CV,the highest quartile was associated with a 70%increased risk of CKD for FPG[odds ratio,OR=1.70;95%confidence interval(CI)1.06–2.72],62%for systolic BP(OR=1.62,95%CI 1.04–2.50),and 85%for low-density lipoprotein cholesterol(OR=1.85,95%CI 1.23–2.80).Furthermore,the risk of CKD increased significantly with an increasing variability *** with participants with score 0,participants with scores of 1.{1. 3 were associated with 58%(OR=1.58,95%CI 1.08–2.32),1.1.(OR=2.21.95%CI 1.40–3.49),and 548%(OR=6.48,95%CI 3.1.–1..21.higher risks of CKD,*** The visit-to-visit variabilities in metabolic factors were significantly associated with the risks of CKD in shanghai community residents.

关键词： Chronic kidney disease Cohort Metabolic factor Visit-to-visit variability

Design, Synthesis and Biological Activities of Novel 4,5-Disubstituted-3-S-（β-D-acetylglycosyl）- 1.2,4-triazole Derivatives

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2017年第5期33卷 758-764页

作者： CHENG Dandan WEI Wei li yuxin HUA Xuewen ZHOU yunyun liU Jingbo li Yonghong yu Shujing XIONG lixia li Zhengming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)College of Chemistry Nankai University Tianjin 300071 P. R. China College of Agriculture Liaocheng University Liaocheng 252000 P. R. China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200433 P. R. China

A series of novel 4,5-disubstituted-3-S-（β-D-acetylglycosyl）-l,2,4-triazole derivatives was designed and synthesized via the strategy of introducing S-β-D-acetylglycosyl fragments into 1.2,4-triazole ring. The structures of 1. target compounds were characterized by means of lH NMR, 1.C NMR and high-resolution mass spectrometer （HRMS）. The results of insecticidal activity indicated that compound 5a displayed 60% lethality rate at 1.0 mg/L concentration. More importantly, the introduction of the carbohydrate fragment to the 1.2,4-triazole core could im- prove the insecticidal activities since the insecticidal activities of compounds 5 were better than those of compounds 4 and this result was also supported by calcium imaging technique. The antifungal activity of the target compounds showed that some novel compounds displayed moderate to good inhibition rate against Sclerotinia sclerotiorum and Botrytis cinerea, in which compound 5p exhibited 78.8% inhibition rate against Sclerotinia sclerotiorum and 68.6% inhibition rate against Botrytis cinerea. The herbicidal activities of compounds 5 against Brassica campestris indi- cated that most of the target compounds showed moderate to good activities, especially compound 5g which showed 52.9% herbicidal activity at the concentration of 200 mg/L.

关键词： 1.2,4-Triazole S-β-D-acetylglycosyl Biological activity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

流动人口生殖健康服务满意度影响因素分析

中国公共卫生 2016年第8期32卷 1037-1041页

作者：武俊青于传宁李玉艳刘俊童琦上海复旦大学计划生育科学研究所国家人口和计划生育委员会计划生育药具重点实验室上海200032 重庆市人口和计划生育科学技术研究院

目的探讨重庆市育龄流动人口生殖健康服务满意度影响因素。方法 201.年3—5月,采用二阶段随机整群抽样方法抽取1.342名育龄流动人口,采取结构式问卷进行调查。结果单因素分析结果显示,年龄大(χ2=1..05,P=0.000 3)、女性(χ2=1..36,P=0.... 详细信息

目的探讨重庆市育龄流动人口生殖健康服务满意度影响因素。方法 201.年3—5月,采用二阶段随机整群抽样方法抽取1.342名育龄流动人口,采取结构式问卷进行调查。结果单因素分析结果显示,年龄大(χ2=1..05,P=0.000 3)、女性(χ2=1..36,P=0.000)、服务业和其他职业(χ2=62.89,P=0.000)、低学历(χ2=50.1.,P=0.000)、农业户口(χ2=1..99,P=0.000)、未婚有性生活(χ2=1..1.,P=0.000 2)、未参加医保(χ2=7.91.P=0.004 9)的研究对象对服务的满意率相对较高;不同避孕方法选择中,选择结扎的满意率最高,为94.65%(53/56);不同避孕方法选择主体中,本人决定避孕方法的满意率最高,为92.82%(41./446);不同服务场所中,在医院和社区/单位/工厂卫生服务中心的满意率最高,分别为91.88%(385/41.)和91.96%(41./448);多因素分析结果表明,性别、学历、职业、婚姻状况和生殖健康服务场所对生殖健康服务满意度均有影响。结论重庆市育龄流动人口对生殖健康服务的满意度受到年龄、性别、职业、婚姻状况和生殖健康服务提供场所的影响。

关键词：流动人口生殖健康服务满意度

STCF conceptual design report (Volume 1.: Physics & detector

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal University Wuhan 430079China Central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 1. Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China institute of Advanced Science Facilities Shenzhen 518107China institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China institute of Physics Academia SinicaTaipeiTaiwan 11529China institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×1.^(35) cm^(–2)·s^(–1. or *** STCF will produce a data sample about a factor of 1.0 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

电针合用抗抑郁药能明显减少小鼠强迫游泳实验中的静止时间

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

针刺研究 2002年第2期27卷 119-123页

作者：俞瑾李晓艳曹小定吴根诚复旦大学医学院针刺原理研究所医学神经生物学国家重点实验室上海200032

目的 :本实验采用小鼠强迫游泳实验的方法 ,观察针刺合用抗抑郁药后小鼠在水中的静止时间 ,以此来分析抑郁程度的改善情况。方法 :实验分下列各组 :①生理盐水组 ;②电针加生理盐水组 ;③药物组 ,分别观察了氯丙咪嗪 (氯米帕明 2 .5mg/k... 详细信息

目的 :本实验采用小鼠强迫游泳实验的方法 ,观察针刺合用抗抑郁药后小鼠在水中的静止时间 ,以此来分析抑郁程度的改善情况。方法 :实验分下列各组 :①生理盐水组 ;②电针加生理盐水组 ;③药物组 ,分别观察了氯丙咪嗪 (氯米帕明 2 .5mg/kg、5mg/kg、1.0mg/kg、2 0mg/kg、60mg/kg)、芬氟明 ( 1..5mg/kg、3mg/kg、1.2mg/kg)和吗氯贝胺 ( 1.0mg/kg、2 0mg/kg、40mg/kg)等三种药物的作用 ;④上述药物加电针组。结果 :电针能使小鼠在水中静止的时间显著减少 ,腹腔注射 (ip)上述三种药物也能减少小鼠在水中静止的时间 ,并表现出一定的剂量依赖关系。在电针加药组中 ,分别选用三种药物的小剂量 (抗抑郁效果很弱或几乎无效 )与电针合用。氯丙咪嗪( 2 .5mg/kg)、芬氟明 ( 1..5mg/kg)与电针合用后 ,小鼠在水中静止时间与单用药物组或单电针组相比显著减少。而吗氯贝胺 ( 1.0mg/kg)与电针合用虽也有这种趋势 ,但统计学上尚未达到显著性差异。结论 :电针具有抗抑郁作用。

关键词：抑郁症强迫游泳实验氯丙咪嗪芬氟明吗氯贝胺电针治疗

Pseudo-Wellens syndrome secondary to postexercise syncope

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2022年第4期13卷 334-336页

作者： Shu Fang Zhi-hao liu Qi Jin yu-xi li Wen-hui Ding Hao-yu Weng Tie-ci Yi Jian-ping li Department of Cardiology Peking University First HospitalBeijing 100034China Department of Cardiology Xiamen Cardiovascular HospitalXiamen UniversityXiamen 361004China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100034China

Dear editor,Wellens syndrome is characterized by electrocardiography(ECG)patterns of the biphasic or inverted T wave in the precordial leads with normal R wave progression and absence of Q waves,[1.2]which indicates occlusive lesions of the proximal left anterior descending(LAD)coronary artery and warrants.[1.These ECG changes usually occur during a pain-free interval and turn to a fatal consequence if without urgent intervention therapy.[1.3]However,in some cases,coronary stenosis was absent and ECG patterns manifested as Wellens syndrome,which was defined as pseudo-Wellens syndrome.

关键词： coronary editor consequence

上海地区妊娠高血压综合征患者人类白细胞抗原基因的多态性

在线全文

学校读者我要写书评

暂无评论

上海医科大学学报 1997年第5期24卷 373-375页

作者：毛羽张振钧范丽安吴乾渝上海医科大学妇产科医院 20011 上海第二医科大学上海市免疫学研究所 200025

研究人类白细胞抗原（HLA）与妊娠高血压综合征（PIH）关联的机制。采用非同位素标记的聚合酶链反应一顺序特异性寡核苷酸探针（PCR／SSO）杂交的方法，对30对PIH患者夫妇及1.对正常对照夫妇进行了HLA-DQB1.因型的检测。结果：PIH患者... 详细信息

研究人类白细胞抗原（HLA）与妊娠高血压综合征（PIH）关联的机制。采用非同位素标记的聚合酶链反应一顺序特异性寡核苷酸探针（PCR／SSO）杂交的方法，对30对PIH患者夫妇及1.对正常对照夫妇进行了HLA-DQB1.因型的检测。结果：PIH患者夫妇HLA－DQB1.0502等位基因频率增高。结论：HLA—DQB1.0502可能是PIH的易感基因。

关键词：白细胞抗原聚合酶链反应妊娠高血压综合征

Unveiling the origin of anomalous low-frequency Raman mode in CVD-grown monolayer WS_(2)

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第11期14卷 4314-4320页

作者： Qian Xiang Xiaofei yue Yanlong Wang Bin Du Jiajun Chen Shaoqian Zhang Gang li Chunxiao Cong Ting yu Qingwei li yuqi Jin Key Laboratory of Chemical Lasers Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China State Key Laboratory of ASIC&System School of Information Science and TechnologyFudan UniversityShanghai200433China School of Materials Science and Engineering Xi’an Polytechnic UniversityXi’an710048China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University637371SingaporeSingapore University of Chinese Academy of Sciences Beijing100049China

Substrates provide the necessary support for scientific explorations of numerous promising features and exciting potential applications in two-dimensional (2D) transition metal dichalcogenides (TMDs). To utilize substrate engineering to alter the properties of 2D TMDs and avoid introducing unwanted adverse effects, various experimental techniques, such as high-frequency Raman spectroscopy, have been used to understand the interactions between 2D TMDs and substrates. However, sample-substrate interaction in 2D TMDs is not yet fully understood due to the lack of systematic studies by techniques that are sensitive to 2D TMD-substrate interaction. This work systematically investigates the interaction between tungsten disulfide (WS_(2)) monolayers and substrates by low-frequency Raman spectroscopy, which is very sensitive to WS_(2)-substrate interaction. Strong coupling with substrates is clearly revealed in chemical vapor deposition (CVD)-grown monolayer WS_(2) by its low-wavenumber interface mode. It is demonstrated that the enhanced sample-substrate interaction leads to tensile strain on monolayer WS_(2), which is induced during the cooling process of CVD growth and could be released for monolayer WS_(2) sample after transfer or fabricated by an annealing-free method such as mechanical exfoliation. These results not only suggest the effectiveness of low-frequency Raman spectroscopy for probing sample-substrate interactions in 2D TMDs, but also provide guidance for the design of high-performance devices with the desired sample-substrate coupling strength based on 2D TMDs.

关键词： interface mode monolayer tungsten disulfide low-frequency Raman spectroscopy sample-substrate interaction strain chemical vapor deposition

基于高叶酸小鼠睾丸转录组筛选牛繁殖力关键同源基因

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国畜牧兽医 2024年第7期51卷 2751-2765页

作者：吉虹锦冶倩楠李文龙李志鹏冯霞米思远史源钧张金柠郭健俞英中国农业大学动物科技学院农业农村部动物遗传育种与繁殖(家畜)重点实验室畜禽生物育种全国重点实验室北京100193 迪庆藏族自治州畜牧兽医科学研究院迪庆674499 西湖大学生命科学学院杭州310030 复旦大学上海200438 北京中医药大学岐黄学院北京100029

【目的】基于高叶酸小鼠睾丸转录组数据,筛选叶酸调控牛和小鼠繁殖力的同源基因,以期为通过叶酸改善雄性动物繁殖力奠定理论基础。【方法】选取24只健康、生长状况相近的1.周龄C57BL/6雄性小鼠,随机分为3组(n=8):CON、A和B组,分别饲喂2... 详细信息

【目的】基于高叶酸小鼠睾丸转录组数据,筛选叶酸调控牛和小鼠繁殖力的同源基因,以期为通过叶酸改善雄性动物繁殖力奠定理论基础。【方法】选取24只健康、生长状况相近的1.周龄C57BL/6雄性小鼠,随机分为3组(n=8):CON、A和B组,分别饲喂2、7和1. mg/kg叶酸,连续饲喂57 d。饲喂结束后分别测定3组小鼠左、右睾丸和精囊的重量,精子密度以及缓慢前进的精子比例,通过Illumina NovaseqTM6000高通量测序进行小鼠睾丸转录组测序分析,对测序结果进行差异表达基因(DEGs)、GO功能注释和蛋白互作网络(PPI)分析,筛选叶酸调控精液品质和繁殖力的关键基因,并结合荷斯坦种公牛繁殖力相关同源基因和数量性状基因座(QTLs)数据,进一步筛选叶酸调控牛和小鼠雄性繁殖力的同源基因。【结果】相较于CON组,B组小鼠左、右精囊重量均极显著增加(P1.,A和B组小鼠精液中缓慢前进的精子比例均极显著降低(P1.。经RNA-Seq分析发现,在A vs CON组中筛选出423个DEGs,在B vs CON组中筛选出661.DEGs,A vs CON和B vs CON组中共有的上调DEGs 85个、下调DEGs 40个。通过GO功能注释分析发现,A vs CON组的DEGs显著富集在叶酸代谢和精液品质调控相关的GO条目,B vs CON组的DEGs显著富集在叶酸代谢和生殖器官发育相关的GO条目,A vs CON和B vs CON两个组共有的上调DEGs显著富集在叶酸代谢和精液品质调控相关等功能,共有的下调DEGs显著富集在一碳代谢过程和单精受精作用功能。通过DEGs的PPI网络分析发现,筛选出的核心节点(hub)基因可能通过影响精液品质而影响雄性动物繁殖力。同时本研究中筛选出的hub基因均为奶牛的同源基因,并找出了不同浓度叶酸影响荷斯坦种公牛繁殖力的同源基因及其附近的QTLs,包括每次妊娠的授精次数QTL、精子活力QTL等。将hub基因进一步与前人荷斯坦种公牛精子转录组差异表达基因进行比对,筛选出叶酸调控牛和小鼠繁殖力的同源基因:Serpinb1.基因(牛同源基因为SERPINB1.。【结论】饲喂7和1. mg/kg叶酸能够降低精液中缓慢前进的精子比例,通过转录组测序筛选出的Serpinb1.基因(牛同源基因为SERPINB1.是叶酸调控雄性动物繁殖力的关键基因之一,可为畜牧业实际生产中大型乳用动物荷斯坦牛的养殖及选育提供参考信息。

关键词：繁殖力叶酸小鼠荷斯坦公牛转录组测序

维普期刊数据库博看期刊