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Risk factors for postpartum posttraumatic stress disorder after emergency admission

World Journal of Emergency Medicine 2024年第2期15卷 121-125页

作者： Fengxia Du Jun Zha Yan Li Lichao Fang Shuyu Xia youjia yu Department of Obstetrics Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Anesthesiology the Second Affiliated Hospital of Wannan Medical CollegeWuhu 241000China Department of Anesthesiology Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Emergency and Intensive Care Unit Suzhou Xiangcheng People’s HospitalSuzhou 215131China

BACKGROUND:Postpartum posttraumatic stress disorder(PTSD)can occur in women who give birth after emergency *** identification of risk factors for this condition is crucial for developing effective preventive *** retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency ***:Medical records of women who gave birth after emergency admission were collected between March 2021 and April *** patients’general conditions and perinatal clinical indicators were *** puerperae were divided into PTSD group and control group based on symptom occurrence at six weeks *** logistic regression analysis was performed to identify risk ***:A total of 276 puerperae were included,with a PTSD incidence of 20.3% at six weeks *** logistic regression analysis identified emergency cesarean section(odds ratio[OR]=2.102;95%confidence interval[CI]:1.114-3.966,P=0.022),admission to the emergency department after midnight(12:00 AM)(OR=2.245;95%CI:1.170-4.305,P<0.001),and cervical dilation(OR=3.203;95%CI:1.670–6.141,P=0.039)as independent risk factors for postpartum *** pump use(OR=0.500;95%CI:0.259–0.966,P=0.015)was found to be a protective factor against postpartum ***:Emergency cesarean section,admission to the emergency department after midnight,and cervical dilation were identified as independent risk factors for postpartum PTSD,while analgesic pump use was a protective *** findings provide insights for developing more effective preventive measures for women who give birth after emergency admission.

关键词： Risk factors Posttraumatic stress disorder Emergency Delivery

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带状疱疹后神经痛患者介入治疗预后不良的危险因素和预测模型构建

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中华麻醉学杂志 2024年第4期44卷 442-446页

作者：俞又佳袁俊鹏徐慧婵李艳宋绍永金晓红苏州大学附属第四医院疼痛科苏州215125 苏州市相城人民医院麻醉疼痛科苏州215131 苏州大学附属第一医院疼痛科苏州215006 苏州大学医学中心苏州215125

目的筛选带状疱疹后神经痛(PHN)患者介入治疗预后不良的危险因素并构建预测模型。方法回顾性收集2020年3月至2023年8月在苏州大学附属第一医院行介入治疗的PHN患者的病历资料,包括患者基本信息、既往病史和手术史、症状、药物治疗情况... 详细信息

目的筛选带状疱疹后神经痛(PHN)患者介入治疗预后不良的危险因素并构建预测模型。方法回顾性收集2020年3月至2023年8月在苏州大学附属第一医院行介入治疗的PHN患者的病历资料,包括患者基本信息、既往病史和手术史、症状、药物治疗情况、临床疼痛评分、介入治疗前中性粒细胞/淋巴细胞比值(NLR)和介入治疗方法等。采用logistic回归分析筛选PHN患者介入治疗预后不良的危险因素,构建预后不良的列线图预测模型。采用C指数和Hosmer-Lemeshow检验评价列线图预测模型的区分度和校准度。绘制校准曲线和临床决策曲线进一步验证预测模型的准确性。结果多因素logistic回归分析结果显示:年龄增长、病程延长、NLR增高、使用免疫抑制剂和脉冲射频治疗是PHN患者介入治疗预后不良的独立危险因素(P<0.05)。基于此构建的PHN介入治疗预后不良列线图预测模型C指数为0.844;校准曲线显示:预测预后不良概率与实际预后不良发生率的一致性较好;临床决策曲线显示:在该预测模型中,准确性和净获益较好。结论年龄增长、病程延长、NLR增高、使用免疫抑制剂和脉冲射频治疗是PHN患者介入治疗预后不良的独立危险因素,基于此构建的列线图预测模型可有效预测PHN患者介入治疗预后不良的发生。

关键词：神经痛,带状疱疹后预后危险因素预测介入治疗

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Co_2O_3-doping Effect on the Formation of 3CaO 3Al_2O_3 CaSO_4

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Journal of Wuhan University of Technology(Materials Science) 2013年第2期28卷 347-351页

作者：郭惠玲谢峻林 TAN Chang yu youjia RAO Chengcheng Department of Pharmacy College of Bioengineering Hubei University of Technology Key Laboratory for Silicate Materials Science and Engineering of Ministry of Education Wuhan University of Technology

The Co2O3-doping effect on the formation of 3CaO · 3A12O3· CaSO from CaCO3-A12O3-CaSO4, 2H20 mixtures was investigated by means of SO2 emission behavior, chemical analysis, X-ray diffraction, differential thermal analysis and scanning electron microscopy. The experimental results show that CO2O3 addition increases the reactivity of the CaCO3-A12O3-CaSO4·2H2O system significantly, by reducing SO2 emissions in combustion andf-CaO contents in the clinkers, promoting the nucleation and growth of 3CaO·3A12O3-CaSO4, and intensifying the formation of 3CaO·3A12O3·CaSO4. Moreover, CO2O3 addition lowers the formation temperature of 3CaO·3A12O3·CaSO4 by 18 ℃, and similarly increases the thermal stability of it at a wider temperature range.

关键词： 3CaO · 3A12O3· CaSO Co2O3 SO2 emission thermal analysis

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Exosome Biomarkers in Cardiovascular Diseases and their Prospective Forensic Application in the Identification of Sudden Cardiac Death

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Journal of Forensic Science and Medicine 2022年第4期8卷 170-178页

作者： Ye Wang Jie Wang Li Hu Shuainan Huang yue Cao youjia yu Feng Chen Department of Forensic Medicine Nanjing Medical UniversityNanjingChina Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingChina

Sudden cardiac death(SCD)is a common cause of death due to the high prevalence and mortality of cardiovascular disease(CVD).Currently,the forensic identification of SCD relies on traditional histomorphological examination,lacking stable biomarkers with high specificity and *** studies have shown that exosomes(Exos)are ideal vectors and the application of Exos provides novel insight as the diagnostic biomarkers and treatment of CVD,and is hot research filed in *** review briefly describes the biology of Exos,including the biogenesis of Exos and the mechanisms of *** research progresses on Exos multi‑omics,i.e.,genomics,proteomics and metabolomics,and their roles in the diagnosis of different types of CVD,especially coronary heart disease and cardiomyopathy,are *** addition,the current difficulties of applications of Exos in forensic identification of SCD and the prospective forensic applications in the future are *** aim of this review is to summarize the current advances of Exos in CVD in a disease‑oriented manner,and to provide a reference for future forensic pathological identification of SCD,as well as the early diagnosis of SCD in clinic.

关键词： Cardiovascular disease cause of death exosomes forensic pathology sudden cardiac death

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Sudden Cardiac Death Due to Long QT Syndrome

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Journal of Forensic Science and Medicine 2022年第4期8卷 190-193页

作者： Jiayi Wu Wei Tang Kai Zhang Kai Li Jianwen Wang youjia yu Feng Chen Department of Forensic Medicine Nanjing Medical UniversityNanjingChina Department of Forensic Medicine Forensic Expertise Institute of Nanjing Medical UniversityNanjingChina Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingChina

Identification of sudden cardiac death(SCD)with a structurally normal heart remains an important challenge in forensic *** QT syndrome(LQTS)is known as an inherited or acquired channelopathy,which is characterized with prolonged QT interval,and is likely to cause SCD in young *** this circumstance,no specific pathological change in the heart can be found anatomically or histologically in the LQTS ***,postmortem LQTS diagnosis is mainly based on clinical manifestations and genetic ***,we reported a 26‑year‑old woman who was found dead at home with a history of unexplained *** clinical records and an electrocardiograph(ECG)obtained 3 months before her death showed a QTc interval of 539 ms which implicates the diagnosis of *** the autopsy and pathological examination findings lacked specificity,we noticed enhanced lipofuscin accumulation in cardiomyocytes,which might be related to *** excluding potential diseases and injuries,we made the postmortem diagnosis as LQTS according to ECG,clinical history,and forensic postmortem *** conclusion,we provided clinical and pathological features of an SCD case due to LQTS,which might enrich the understanding of forensic postmortem SCD diagnosis with nonstructural cardiac diseases.

关键词： Electrocardiograph long QT syndrome QT interval sudden cardiac death

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The histopathological features of the explanted lungs from an end-stage COVID-19 patient

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Forensic Sciences Research 2020年第4期5卷 348-350页

作者： Kai Li youjia yu Ding Li Changxing Luan Li Hu Jie Wang Jingjing Ding Yanfang yu Hang Yang Jingyu Chen Feng Chen Chuan Su Department of Forensic Medicine Nanjing Medical UniversityNanjingChina Wuxi Lung Transplantation Center Wuxi People's Hospital Affiliated with Nanjing Medical UniversityWuxiChina Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingChina Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Pathogen BiologyNanjing Medical UniversityNanjingChina

Although the pathological findings of coronavirus disease 2019(COVID-19)associated with acute respiratory distress syndrome(ARDS)have been reported in previous studies,the data of histopatho-logical features of end-stage COVID-19 lungs are still *** have previously reported the clini-cal features and managements of three COVID-19 patients with irreversible deterioration of pulmonary function who received lung transplantation(LT)after being supported by extracorporeal membrane oxygenation(ECMO)[1].

关键词： distress acute respiratory

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术前血浆氧化三甲胺浓度与老年患者术后谵妄的关系

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中华麻醉学杂志 2023年第8期43卷 942-945页

作者：薄惠龙查俊顾琴俞又佳李艳苏州市相城人民医院麻醉科苏州215131 皖南医学院第二附属医院麻醉科芜湖241000

目的:评价术前血浆氧化三甲胺(TMAO)浓度与老年患者术后谵妄(POD)的关系。方法:选取择期髋关节置换术患者180例,年龄≥65岁,ASA分级Ⅱ或Ⅲ级,BMI 17~30 kg/m^(2)。术前1 d采集静脉血样,采用高通量液相色谱-串联质谱法检测血浆TMAO浓度,... 详细信息

目的:评价术前血浆氧化三甲胺(TMAO)浓度与老年患者术后谵妄(POD)的关系。方法:选取择期髋关节置换术患者180例,年龄≥65岁,ASA分级Ⅱ或Ⅲ级,BMI 17~30 kg/m^(2)。术前1 d采集静脉血样,采用高通量液相色谱-串联质谱法检测血浆TMAO浓度,根据血浆TMAO浓度水平按三分位数分为3组:低水平组(L组,≤1.2μmol/L)、中水平组(M组,1.3~1.9μmol/L)、高水平组(H组,≥2.0μmol/L)。均采用腹股沟上髂筋膜间隙阻滞联合静脉全身麻醉。于术后1、2、3和7 d时采用中文版意识模糊评估量表诊断POD,根据患者是否发生POD,分为POD组和非POD组。采用二元logistic回归分析评价不同血浆TMAO浓度与POD的关系。采用受试者工作特征(ROC)曲线评价血浆TMAO浓度对POD发生的预测效能。结果:L组60例,M组67例,H组53例,POD发生率分别为12%、22%和32%。H组POD发生率高于L组(P<0.05)。POD组血浆TMAO浓度高于非POD组(P<0.05)。logistic回归分析显示,H组POD发生风险是L组的3.91倍(P<0.05)。术前血浆TMAO浓度预测POD的ROC曲线下面积为0.754(95%CI 0.671~0.838,P<0.05),约登指数为0.426时,血浆TMAO浓度最佳截断值为1.625μmol/L,特异度和灵敏度分别为0.795和0.631。结论:术前血浆TMAO浓度增高的老年患者POD的发生风险升高,且其对POD具有较好的预测价值。

关键词：老年人谵妄手术后并发症氧化三甲胺

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右美托咪定对丙泊酚增强创伤后应激障碍大鼠恐惧记忆效应的影响

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中华麻醉学杂志 2022年第2期42卷 231-234页

作者：俞又佳王鑫怡姚瑞朱杨子苏州市相城人民医院麻醉科苏州215131 徐州市第一人民医院麻醉科徐州221002 徐州市中心医院麻醉科徐州221009

目的:评价右美托咪定对丙泊酚增强创伤后应激障碍(PTSD)大鼠恐惧记忆效应的影响。方法:清洁级健康雄性SD大鼠220只,体重300~400 g,12~16周龄,行条件性恐惧记忆训练,建立PTSD模型。取120只大鼠,采用随机数字表法分为6组(n=20):对照组(C组... 详细信息

目的:评价右美托咪定对丙泊酚增强创伤后应激障碍(PTSD)大鼠恐惧记忆效应的影响。方法:清洁级健康雄性SD大鼠220只,体重300~400 g,12~16周龄,行条件性恐惧记忆训练,建立PTSD模型。取120只大鼠,采用随机数字表法分为6组(n=20):对照组(C组)、PTSD组、丙泊酚组(P1组)、丙泊酚+右美托咪定不同给药剂量组(P1+DEX10组、P1+DEX20组和P1+DEX40组)。C组大鼠条件性恐惧记忆训练时仅播放声音,不予以电击;训练结束后,PTSD组腹腔注射芝麻油1 ml/kg,P1组腹腔注射丙泊酚1 ml/kg,P1+DEX10组、P1+DEX20组和P1+DEX40组分别腹腔注射右美托咪定10、20及40μg/kg。给药结束后行条件性恐惧记忆检测,记录大鼠90 s内僵立行为时间,计算僵立行为时间百分比。记录给药期间SpO_(2)0.05)。与P2组比较,P2+DEX T0和P2+DEX_(T30)组僵立行为时间百分比降低(P0.05)。结论:右美托咪定可减轻丙泊酚增强PTSD大鼠恐惧记忆的效应,中等剂量(20μg/kg)早期给药(给予丙泊酚后30 min内)的效果最佳。

关键词：右美托咪啶二异丙酚应激障碍创伤后恐惧记忆巩固

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Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： WANG yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

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Topological Stability and Entropy for Certain Set-valued Maps

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Acta Mathematica Sinica,English Series 2024年第4期40卷 962-984页

作者： yu ZHANG yu Jun ZHU School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

In this paper,the dynamics(including shadowing property,expansiveness,topological stability and entropy)of several types of upper semi-continuous set-valued maps are mainly considered from differentiable dynamical systems points of *** is shown that(1)if f is a hyperbolic endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has theε-shadowing property,and moreover,if f is an expanding endomorphism then there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has the Lipschitz shadowing property;(2)when a set-valued map F is generated by finite expanding endomorphisms,it has the shadowing property,and moreover,if the collection of the generators has no coincidence point then F is expansive and hence is topologically stable;(3)if f is an expanding endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that h(F_(f,U,ε))=h(f);(4)when F is generated by finite expanding endomorphisms with no coincidence point,the entropy formula of F is ***,the dynamics of the set-valued maps based on discontinuous maps on the interval are also considered.

关键词： Set-valued map orbit space hyperbolic endomorphism perturbation shadowing expansiveness topological stability entropy

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