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World Journal of Traditional Chinese Medicine 2024年第2期10卷 180-190页

作者： Meng-yuan Hu Tian-Xing Yi Qi-Rui Liu Xin-yu Zhang Ai-Ping Chen yu-ying Wang Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang yu-ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang yu-ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.

关键词： Artificial intelligence climacteric syndrome medication rules network pharmacology Professor Wang yu-ying

Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance hydrogen production activity

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Frontiers in Energy 2024年第1期18卷 89-100页

作者： Zhouzhou WANG Qingwei WU Jieming WANG ying yu Institute of Nanoscience and Nanotechnology College of Physical Science and TechnologyCentral China Normal UniversityWuhan 430079China

Hydrogen production from photoelectrochemical(PEC)water splitting has been regarded as a promising way to utilize renewable and endless solar ***,semiconductor film grown on photoelectrode suffers from numerous challenges,leading to the poor PEC ***,a straightforward sol-gel method with the ligand-induced growth strategy was employed to obtain dense and homogeneous copper bismuthate photocathodes for PEC hydrogen evolution *** various characterizations,it was found that the nucleation and surface growth of CuBi_(2)O_(4)layer induced by 2-methoxyethanol ligand(2-CuBi_(2)O_(4))demonstrated a decent crystallinity and coverage,as well as a large grain size and a low oxygen vacancy concentration,leading to the good ability of light absorption and carrier ***,under simulated sunlight irradiation(AM1.5G,100 mW/cm^(2)),the 2-CuBi_(2)O_(4)photocathode achieved an enhanced photocurrent density of−1.34 mA·cm^(−2)at 0.4 V versus the reversible hydrogen electrode and a promising applied bias photon-to-current efficiency of 0.586%.This surface modification by ligand growth strategy will shed light on the future design of advanced photoelectrodes for PEC water splitting.

关键词： copper bismuthate photocathode ligand growth strategy dense film PEC

Multi-physical fields distribution in billet during helical electromagnetic stirring:A numerical simulation research

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China Foundry 2024年第1期21卷 51-59页

作者： Dong Pan Qing-tao Guo Kai-lun Zhang Fu-zhi yu yu-ying Li yu-bao Xiao State Key Laboratory of Metal Materials for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Electromagnetic stirring is one of the widely applied techniques to modify the quality of casting *** from conventional rotate stirring,the helical stirring is more professional in assisting multi-dimensional flow of molten metal and eliminating solidification *** this study,the single-winding helical stirring(SWHS)was introduced,offering advantages such as smaller volume and lower electromagnetic shielding compared to traditional helical stirring *** a comprehensive numerical simulation,the stirring parameters of SWHS were adjusted to yoke inclination angle of 43°and frequency of 12 *** higher electromagnetic force and flow velocity in drawing direction,as well as the lower temperature gradient induced by the SWHS,are positive factors for homogeneous solidification of *** experimental results on Al-8%Si alloy and 0.4%C-1.1%Mn steel demonstrate that compared to rotate stirring,the SWHS process can induce better billet quality and is more effective in accelerating the equiaxed expansion and reducing element *** SWHS process can enhance the equiaxed ratio of the billet by 58.3%and reduce segregation degree of carbon element by 10.97%.Consequently,SWHS holds great promise as a potential approach for improving the quality of continuous casting billets.

关键词： billet electromagnetic stirring helical solidification element segregation numerical simulation

Taxonomy of Two New Peritrich Ciliates(Protozoa:Ciliophora)from Inland Saltwaters of China

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Journal of Ocean University of China 2024年第3期23卷 811-821页

作者： yu ying ZHANG Yong LIANG Ziyao LI Jiqiu LIN Xiaofeng Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems Fujian Provincial Key Laboratory of Coastal Ecology and Environmental StudiesCollege of the Environment and EcologyXiamen UniversityXiamen 361102China School of Life Science South China Normal UniversityGuangzhou 510631China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China

The inland saltwater lakes harbor exceptional ***,two new species of solitary sessile peritrich ciliates were isolated from Qinghai Lake,the largest inland saltwater lake in *** morphology,ciliature,silverline system,and molecular phylogeny were investigated based on live observation,silver staining,and analysis of the small subunit ribosomal DNA(SSU rDNA).Vorticella paraglobosa *** characterized mainly by its obconical or elongate bell-shaped zooid,C-shaped macronucleus,single ventrally located contractile vacuole,two-rowed infundibular polykinety 3,and 28-38 silverlines between peristome and aboral tro-chal band and 10-15 between aboral trochal band and *** cotyliformis *** from its congeners mainly by its double-layered peristomial lip,cup-shaped zooid,J-shaped macronucleus,single ventrally positioned contractile vacuole,three-rowed infundibular polykinety 3,and 70-85 silverlines between peristome and aboral trochal band and 21-25 between aboral trochal band and *** SSU rDNA sequences of the two new species were obtained,and the subsequent molecular phylogenetic analysis supported their taxonomic classification.

关键词： molecular phylogeny morphology new species Qinghai Lake taxonomy

Effect of information-motivation-behavioral skills model based perioperative nursing on pain in patients with gallstones

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2232-2241页

作者： Li Ma ying yu Bin-Juan Zhao Yan-Nan yu yu Li Department of Nursing Xi’an International Medical Center HospitalXi’an 710100Shaanxi ProvinceChina Department of Hepatobiliary Pancreatic and Spleen SurgeryXi’an International Medical Center HospitalXi’an 710100Shaanxi ProvinceChina

BACKGROUND The incidence of cholecystolithiasis is on the *** of information,motivation,and behavioral skills can play a positive role in promoting changes in individual health ***,reports on the effects of information-motivationbehavioral(IMB)skills model based high-quality nursing as a perioperative nursing intervention for patients with gallstones are *** To explore the application of IMB skills model based high-quality nursing in patients with *** Two hundred and sixteen patients with cholecystolithiasis treated at our hospital from January 2022 to January 2023 were enrolled and divided into a control,highquality,and combined nursing groups,with 72 patients in each *** control,high-quality,and combination groups received conventional,high-quality,and IMB skills model based perioperative nursing services,*** in clinical indicators,stress levels,degree of pain,emotional state,and quality of life were observed,and complications and nursing satisfaction among the three groups were *** After nursing,the time to recovery of gastrointestinal function in the high-quality and combined nursing groups was significantly shorter than that of the control group,with the recovery of gastrointestinal function being the fastest in the combined nursing group(P<0.05).After nursing intervention,cortisol and norepinephrine levels in the high-quality and combined nursing groups were closer to normal than those of the control group 24 h after surgery,with the combined nursing group having the closest to normal levels(P<0.05).After 3 and 7 d of intervention,the patients’pain significantly improved,which was more prominent in the highquality and combination ***,the pain score in the combination group was significantly lower than those of the control and high-quality nursing groups(P<0.05).After nursing intervention,the emotional states of all patients improved,and the scores of patients in

关键词： Biliary calculi Information-motivation-behavioral skills model High quality care Perioperative period Pain Application

Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1α/HK2 and SLC7A11 pathway

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Oncology Research 2024年第5期32卷 899-910页

作者： YIWEN ZHU LIU YANG ying yu ying XIONG PING XIAO XIAO FU XIN LUO Department of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang330006China Department of General Practice The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal *** there is no permanent therapy for this condition,it is necessary to develop a ***,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were *** experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were *** MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity *** reduced the Warburg effect and induced ferroptosis(FPT)in MG63 *** ferroptosis diminished HYSA’s anti-cancer activities in MG63 *** stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 ***-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°*** significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand ***,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 *** is a possible therapeutic option for OC or other cancers.

关键词： Hydroxysafflor yellow A Osteosarcoma HIF-1α FPT

Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy

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Genes & Diseases 2024年第1期11卷 1-3页

作者： Kaiyan Chen ying yu Zhiyu Huang Lei Gong yun Fan The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) HangzhouZhejiang 310022China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesHangzhouZhejiang 310022China Department of Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310022China Department of Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

With morphological features resembling hepatocellular carcinoma,hepatoid adenocarcinoma of the lung(HAL)is a rare and aggressive subtype of lung cancer with a 5-year survival of only 8%.1 Most HAL patients present increased serum alpha-fetoprotein(AFP)levels that are commonly related to poor *** insights into HAL have come from case series or reports,and TP53 is frequently mutated in *** heterogeneity of HAL complicates the *** no established standard,the management of HAL is modeled on that of classical lung adenocarcinoma,although with dismal outcomes.2 Herein,we reported the effective management of a stage IIIb HAL patient with perioperative chemoimmunotherapy and curative-intent *** patient remained disease-free and minimal residual disease(MRD)-negative for more than one year after surgery.

关键词： adenocarcinoma patient lung

Tunable quantum dots in monolithic Fabry-Perot microcavities for high-performance single-photon sources

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Light(Science & Applications) 2024年第2期13卷 325-332页

作者： Jiawei Yang Yan Chen Zhixuan Rao Ziyang Zheng Changkun Song yujie Chen Kaili Xiong Pingxing Chen Chaofan Zhang Wei Wu ying yu Siyuan yu State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Institute for Quantum Science and Technology College of ScienceNational University of Defense TechnologyChangsha 410073China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Hunan Key Laboratory of Quantum Information Mechanism and Technology National University of Defense TechnologyChangsha 410073 HunanChina Hefei National Laboratory Hefei 230088China

Cavity-enhanced single quantum dots(QDs)are the main approach towards ultra-high-performance solid-state quantum light sources for scalable photonic quantum ***,harnessing the Purcell effect requires precise spectral and spatial alignment of the QDs’emission with the cavity mode,which is challenging for most *** we have successfully integrated miniaturized Fabry-Perot microcavities with a piezoelectric actuator,and demonstrated a bright single-photon source derived from a deterministically coupled QD within this *** the cavity-membrane structures,we have achieved large spectral tunability via strain *** resonance,a high Purcell factor of~9 is *** source delivers single photons with simultaneous high extraction efficiency of 0.58,high purity of 0.956(2)and high indistinguishability of 0.922(4).Together with its compact footprint,our scheme facilitates the scalable integration of indistinguishable quantum light sources on-chip,therefore removing a major barrier to the development of solid-state quantum information platforms based on QDs.

关键词： quantum removing purity

Modified NiFe-MOF with defects induced by-NH_(2)and-SH for enhanced adsorption and photocatalytic reduction of CO_(2)

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Journal of Materials Science & Technology 2024年第3期170卷 167-176页

作者： Ruting Huang Yeyin Zhang Wenqiang Li Wanxia Zhang Yong Fang Wenrui Zhang Anqi Cui yu ying Xianyang Shi Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui Province Key Laboratory of Wetland Ecosystem Protection and RestorationSchool of Resource and Environmental EngineeringAnhui UniversityHefei230601China Key Laboratory of Nutrient Cycling Resources and Environment of Anhui Institute of Soil and FertilizerAnhui Academy of Agricultural SciencesHefei230001China

In this study,a Ni-Fe metal-organic framework modified by-NH_(2)and-SH was synthesized using a sim-ple hydrothermal process for enhancing photocatalytic CO_(2)*** expected,the N2S-NiFe(NH_(2)-BDC/H_(4)DSBDC,2:1)displayed excellent photocatalytic CO_(2)reduction activity and high CO selectivity(12,412.23μmol g^(−1)h^(−1))under visible light irradiation(λ≥420 nm),which is 5 times that of ***,the excellent photocatalytic performance of N2S-NiFe can benefit from the rich defect trap site caused by the introduction of amino and sulfhydryl groups,accelerating charge transfer and promoting space charge separation,as supported by the photo-electrochemical *** better understand the CO_(2)adsorption mechanism,density functional theory calculations were performed,which revealed that the Niov site has more negative adsorption energy compared with the Feov *** study provides a simple strategy to establish efficient photocatalysts for CO_(2)reduction through the modification of organic ligands.

关键词： NiFe-MOF CO_(2)reduction Defect structure Photocatalytic

Advances in the differentiation of pluripotent stem cells into vascular cells

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World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： Yi-Chang Jiao ying-Xin Wang Wen-Zhu Liu Jing-Wen Xu yu-ying Zhao Chuan-Zhu Yan Fu-Chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Research Institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science Research Institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and *** in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death *** research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare *** mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is *** rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human *** review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular *** also introduces the application of these technologies in disease modeling,drug screening,and regenerative ***,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft