检索结果-南通市图书馆

Glucagon-like peptide-1 receptor agonists:Exploring the mechanisms from glycemic control to treatment of multisystemic diseases

引用

World Journal of Gastroenterology 2024年第36期30卷 4036-4043页

作者： Mo-Wei Kong yang yu Ying Wan yu Gao Chun-Xiang Zhang Department of Cardiology Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Endocrinology The Affiliated Hospital of Chengde Medical CollegeChengde 067000Hebei ProvinceChina Department of Cardiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Key Laboratory of Medical Electrophysiology Ministry of EducationInstitute of Cardiovascular ResearchBasic Medicine Research Innovation Center for Cardiometabolic DiseasesMinistry of EducationNucleic Acid Medicine of Luzhou Key LaboratorySouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associated fatty liver *** provide supplementary insights to their research,highlighting the broader systemic implications of GLP-1RAs,synthesizing the current understanding of their mechanisms and the trajectory of research in this ***-1RAs are revolutionizing the treatment of type 2 diabetes mellitus and *** glycemic control,GLP-1RAs demonstrate cardiovascular and renal protective effects,offering potential in managing diabetic kidney disease alongside renin–angiotensin–aldosterone system *** role in bone metabolism hints at benefits for diabetic osteoporosis,while the neuroprotective properties of GLP-1RAs show promise in Alzheimer's disease treatment by modulating neuronal insulin ***,they improve hormonal and metabolic profiles in polycystic ovary *** editorial highlights the multifaceted mechanisms of GLP-1RAs,emphasizing the need for ongoing research to fully realize their therapeutic potential across a range of multisystemic diseases.

关键词： Glucagon-like peptide-1 receptor agonists Glycemic control Multisystem diseases Mechanism of action Cardiovascular protection Renal disease Bone metabolism Non-alcoholic fatty liver disease Neuroprotection Polycystic ovary syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carrimycin in the treatment of acute promyelocytic leukemia combined with pulmonary tuberculosis: A case report

引用

World Journal of Clinical Cases 2024年第3期12卷 623-629页

作者： Fu-yu yang Lei Shao Jie Su Zhen-Meng Zhang Department of Infectious Diseases The Affiliated Central Hospital of Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Pulmonary tuberculosis(PTB)is prevalent in immunocompromised populations,including patients with hematologic malignancies,human immunodeficiency virus infections,and chronic *** treatment for acute promyelocytic leukemia(APL)combined with PTB is *** patients show an extremely poor ***,studies should establish efficient treatment options to improve patient survival and *** SUMMARY A 60-year-old male with pain in the right side of his chest and a fever for 4 d visited the outpatient department of our *** blood smear revealed 54%*** bone marrow examinations,variant APL with TNRC18-RARA fusion gene was *** computed tomography scan showed bilateral pneumonitis with bilateral pleural effusions,partial atelectasis in the lower lobes of both lungs,and the bronchoalveolar lavage fluid gene X-Pert test was positive,indicative of ***,ethambutol(EMB),and isoniazid(INH)were administered since he could not receive chemotherapy as the WBC count decreased *** one week of treatment with carrimycin,the patient recovered from fever and received *** was very effective and his white blood cells counts got back to *** being given five months with rifampin,EMB and INH and chemotherapy,the patient showed complete remission from pneumonia and *** We report a case of PTB treated successfully with carrimycin with APL that requires chemotherapy.

关键词： Carrimycin Hematologic disease Acute myeloid leukemia Acute promyelocytic leukemia Pulmonary tuberculosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanical Janus lattice with plug-switch orientation

引用

Theoretical & Applied Mechanics Letters 2024年第1期14卷 23-26页

作者： yupei Zhang Jiawei Zhong Zhengcai Zhao Ruiyu Bai Yanqi Yin yang yu Bo Li State Key Laboratory for Manufacturing System EngineeringShaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Qian Xuesen Honors College Xi’an Jiaotong UniversityXi’an 710049China

In recent years,materials with asymmetric mechanical response properties(mechanical Janus materials)have been found possess numerous potential applications,*** absorption and vibration *** this study,we propose a novel mechanical Janus lattice whose asymmetric mechanical response can be switched in orientation by a *** finite element analysis and experimental verification,this lattice exhibits asymmetric displacement responses to symmetric ***,with such a plug structure inside,individual lattices can switch the orientation of asymmetry and thus achieve reprogrammable design of a mechanical structure with chained *** reprogrammable asymmetry of this material will offer multiple functions in design of mechanical metamaterials.

关键词： Janus Non-reciprocity Programmability Mechanical metamaterial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

引用

Chinese Chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban Xi-yang yu Hai-Kuo Tian Zheng-Qing Huang Chun-Ran Chang Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e *** is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 *** work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired C_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyoxometalate as the assembly material to self-assembled Ni(OH)_(2) nanosheets with electrocatalytic performance

引用

Nano Research 2024年第8期17卷 7061-7067页

作者： Danyang He Tianyang Li Luozhen Jiang Fei Wang Zihao Xing Nan Wang Zhiyu Jia Guo-yu yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Advanced Research Institute Chinese Academy of ScienceShanghai 201210China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of ChemistryNortheast Normal UniversityChangchun 130024China

Developing non-noble metal-based electrocatalyst with high catalytic activity is essential for advancing hydrogen energy *** study introduces a hydrothermal method for synthesizing order Ni(OH)_(2) nanosheets,with H_(3)O_(40)PW_(12)(denoted as PW_(12))loaded onto reduced graphene oxide(rGO)coated on nickel foam(referred to as PW_(12)-Ni(OH)_(2)/rGO).This method contrasts with the electrodeposition of Ni(OH)_(2),where PW_(12) is added to the synthetic system to direct the assembly and morphology of the Ni(OH)_(2) through a hydrothermal *** this work,the nickel foam acts dual roles as both the substrate and the source of nickel for the formation of Ni(OH)_(2).The PW_(12)-Ni(OH)_(2)/rGO nanosheets,when successfully prepared and loaded onto the nickel foam(NF),exhibited superior electrocatalytic activity for the hydrogen evolution reaction(HER)in an alkaline electrolyte,achieving a current density of 10 mA·cm^(-2) at an overpotential of 69 ***,we endeavored to expand the application of this material towards the oxygen evolution reaction(OER)by preparing PW_(12)-(Fe/Co)Ni(OH)_(2)/rGO through the addition of metal *** nanocomposite displayed outstanding electrocatalytic activity in alkaline electrolytes,with a current density of 10 mA·cm^(-2)at an overpotential of 211 mV,and demonstrated excellent stability over a 50 h period in a 1 M KOH *** results presented in this paper offer an effective strategy for the preparation of polyoxometalate-based inorganic materials with diverse functionalities,applicable to both HER and OER.

关键词： polyoxometalate Ni(OH)_(2) assembly hydrogen evolution reaction oxygen evolution reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bilayer Compounded Polytetrafluoroethylene Membrane for Enhanced Oil-Water Emulsion Separation

引用

Chinese Journal of Polymer Science 2024年第6期42卷 838-850页

作者： yu-Liang yang Tai-Ran Zhang Yan-Ting Han Shao-yun Guo Qin-Gong Rong Jia-Bin Shen State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversitySichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyChengdu610065China West China Hospital/West China School of Nursing Sichuan UniversityChengdu610041China Shandong Senrong New Materials Co. Ltd.Zibo256401China

In order to achieve efficient and durable oil-water emulsion separation,the membranes possessing high separation efficiency and mechanical strength attract extensive attention and are in great *** present study,a kind of polytetrafluoroethylene(PTFE)-based bilayer membrane was fabricated by electrospinning fibrous PTFE(fPTFE)on an expanded PTFE(ePTFE)*** morphological observation revealed that the fibrous structure of the fPTFE layer could be tailored by controlling the formulation of spinning *** addition of appropriate polyoxyethylene(PEO)would make the fibers in the fPTFE layer finer and more *** a result,the compounded membrane exhibited a small pore size of approximately 1.25µm and a substantial porosity nearing 80%.This led to super-hydrophobicity,characterized by a high water contact angle(WCA)of 149.8°,and facilitated rapid oil *** water-in-oil emulsion separation experiment further confirmed that the compounded membrane not only had a high separation efficiency closing 100%,but such an outstanding separation capacity could be largely retained,either through multiple cycles of use or through strong acid(pH=1),strong alkali(pH=12),or high-temperature(100°C)***,the mechanical behavior of the bilayer membrane was basically contributed by that of each layer in terms of their volume *** significantly,the poor creep resistance of fPTFE layer was suppressed by compounding with ePTFE ***,this study has laid the groundwork for a novel approach to create PTFE-based compounded membranes with exceptional overall characteristics,showing promise for applications in the realm of emulsion separation.

关键词： ePTFE Electrospinning membrane Bilayer compounding Emulsion separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

引用

Research 2024年第1期2023卷 663-674页

作者： yang yu Zhe Wang Lingling Wang Qinghua Wang Rongfan Tang Sutong Xiang Qirui Deng Tingjun Hou Huiyong Sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous *** there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the ***,most of the drug resistance mechanisms still remain ***,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the *** this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identifying the real fracture hidden in rock microcrack zone by acoustic emission energy

引用

International Journal of Mining Science and Technology 2024年第6期34卷 731-746页

作者： yuekun Xing Bingxiang Huang Guangqing Zhang Binghong Li Hang Xu Xuejie Jiao yang yu Taisen Han Jinlong Chen State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing 102249China

Identifying the real fracture of rock hidden in acoustic emission(AE)source clusters(AE-depicted microcrack zone)remains challenging and *** we revealed the AE energy(representing dissipated energy)distribution rule in the rock microcrack zone and proposed an AE-energy-based method for identifying the real fracture.(1)A set of fracture experiments were performed on granite using wedgeloading,and the fracture process was detected and recorded by *** microcrack zone associated with the energy dissipation was characterized by AE sources and energy distribution,utilizing our selfdeveloped AE analysis program(RockAE).(2)The accumulated AE energy,an index representing energy dissipation,across the AE-depicted microcrack zone followed the normal distribution model(the mean and variance relate to the real fracture path and the microcrack zone width).This result implies that the nucleation and coalescence of massive cracks(i.e.,real fracture generation process)are supposed to follow a normal distribution.(3)Then,we obtained the real fracture extension path by joining the peak positions of the AE energy normal distribution curve at different cross-sections of the microcrack ***,we distinguished between the microcrack zone and the concealed real fracture within *** deviation was validated as slight as 1–3 mm.

关键词： GeoEnergy exploitation Rock fracture Fracture identification Acoustic emission AE energy analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

State and parameter identification of linearized water wave equation via adjoint method

引用

Science China(Information Sciences) 2024年

作者： yang yu Cheng-Zhong XU Hai-Long PEI Jinpeng yu School of Automation Qingdao University LAGEP Batiment CPE University Claude Bernard-Lyon 1 School of Automation Science and Engineering Key Laboratory of Autonomous Systems and Networked ControlMinistry of Education Guangdong Engineering Technology Research Center of Unmanned Aerial Vehicle SystemSouth China University of Technology

In this paper, we focus on the state and parameter identification problem of a hydrodynamical system. This system is modeled as a linearized water wave equation(LWWE), a hyperbolic state-space model coupled with a Laplace equation. We assume that the wave elevation at two distinct points is the only measurement of water waves. We show that the state and water depth can be reconstructed from this point measurement records. The identification problem is recast as an optimization problem over an infinitedimensional space. We propose the adjoint method-based identification algorithm to generate an estimated state and water depth. We then performed a numerical simulation to show the effectiveness of our designed algorithm by comparing it with existing studies.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Experience of humanistic nursing in hemodialysis nursing for patients with diabetic kidney disease

引用

World Journal of Diabetes 2024年第2期15卷 186-195页

作者： Xiao-Ying Chai Xiao-Yan Bao Ying Dai Xing-Xing Dai yu Zhang yu-Ling yang Department of Nephrology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Hemodialysis The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a prevalent complication of diabetes that often requires hemodialysis for *** the field of nursing,there is a growing recognition of the importance of humanistic care,which focuses on the holistic needs of patients,including their emotional,psychological,and social ***,the application of humanistic nursing in the context of hemodialysis for DKD patients remains relatively *** To explore the experience of humanistic nursing in hemodialysis nursing for DKD *** Ninety-six DKD patients treated with hemodialysis from March 2020 to June 2022 were included in the study and divided into the control cluster(48 cases)and the study cluster(48 cases)according to different nursing methods;the control cluster was given routine nursing and the study cluster was given humanized *** variances of negative emotion mark,blood glucose,renal function,the incidence of complications,life mark and nursing satisfaction before and after nur-sing were contrasted between the two *** No significant difference in negative emotion markers between the two clusters were observed before nursing(P>0.05),and the negative emotion markers of the two clusters decreased after *** Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale markers were lower in the study cluster than the control *** healing rate of patients in the study cluster was significantly higher than the control cluster(97.92%vs 85.42%,P0.05).However,after nursing,blood urea nitrogen and serum creatinine(SCr)levels in the study cluster were lower than those in the control cluster(P<0.05).The incidence rate of complications was significantly lower in the study group compared to the control cluster(6.25%vs 20.83%,P<0.05).There was no significant difference in the life markers between the two clusters be

关键词： Diabetic kidney disease Hemodialysis Humanistic nursing Incidence of complication Effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：