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A novel core-shell rifampicin/isoniazid electrospun nanofiber membrane for long time drug dissolution

Engineered Regeneration 2022年第1期3卷 73-79页

作者： Chenxi Li yueqi Liu Ming Wei Jun Liu xiaomin yu Ping Hu Yong Liu Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China College of Mechanical and Electric Engineering Beijing University of Chemical TechnologyBeijing 100029China Department of Infectious Disease and Clinical Microbiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Rifampicin(RIF)and isoniazid(INH)are commonly applied jointly in clinical to improve the treatment efficacy of *** to the metabolism of the kidneys,most of RIF and INH would be excreted by human bodies after reaching a high drug concentration,which causes serious waste of drugs and does harm to our *** this study,polylactic acid(PLLA)was chosen as the carrier to prepare core-shell drug-loaded nanofibers with RIF in the shell and INH in the core by coaxial *** results showed that the average diameter of the core-shell drug-loaded fibers with an obvious core-shell structure was about 650 *** of RIF and INH in the fibers became amorphous;the rest maintained *** combination of PLLA and RIF made the fibers obvious hydrophobic and exhibited a slowly phased sustained-dissolve property during in vitro dissolution *** in vitro antibacterial experiments confirmed that the core-shell drug-loaded nanofibers had a favorite inhibitory effect on Staphylococcus aureus,which endowed practical medical value to the *** core-shell drug-loaded nanofibers effectively separated RIF and INH,preventing the degradation of RIF caused by the direct contact of the two *** slow-dissolve characteristics can maintain a relatively stable drug concentration and avoid the damage to the human body caused by the quick dissolve and rapid metabolism of *** combination with coaxial electrospinning fills the gap in the core-shell system with two drugs and has great significance in the future.

关键词： Dual drug delivery Core-shell structure Coaxial electrospinning Phased sustained-dissolve Staphylococcus aureus

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基于改进图像增强及CNN的复杂环境车牌识别算法

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计算机科学 2024年第S1期51卷 562-568页

作者：杨秀璋武帅任天舒廖文婧项美玉于小民刘建义陈登建贵州财经大学信息学院贵阳550025 贵州财经大学大数据应用与经济学院(贵阳大数据金融学院) 贵阳550025 贵州财经大学贵州省经济系统仿真重点实验室贵阳550025

传统图像识别和深度学习模型较难检测复杂环境下的车牌,其场景适用性和精确率较低,从而严重威胁交通安全,影响智慧交通发展。基于此,文中提出了一种基于改进图像增强及CNN的复杂环境车牌识别算法。首先,结合目标图像的平均灰度值,利用AC... 详细信息

传统图像识别和深度学习模型较难检测复杂环境下的车牌,其场景适用性和精确率较低,从而严重威胁交通安全,影响智慧交通发展。基于此,文中提出了一种基于改进图像增强及CNN的复杂环境车牌识别算法。首先,结合目标图像的平均灰度值,利用ACE算法和暗通道先验去雾算法对复杂环境下的车牌数据集进行图像增强;然后提出了一种融合色彩关键特征和波峰关键特征的车牌区域定位算法,通过8个核心步骤有效定位复杂环境下车牌的区域;最后构建五层卷积神经网络的模型,以实现车牌字符识别。实验结果表明,所提算法能有效识别复杂环境下行驶车辆的车牌,该算法在复杂环境车牌区域定位的精确率为86.04%,召回率为82.60%,F 1值为84.29%,其F 1值比传统图像处理算法提升了47.29%,比SSD算法提升了24.73%,比YOLO算法提升了26.37%,比YOLOv3提升了17.15%。同时,所提方法的时间复杂度较低,属于一种轻量级的车牌识别方法,能消除噪声并实现车牌字符识别,具有一定的应用前景和实用价值,也将为智慧交通的研究提供理论基础。

关键词：车牌识别图像增强深度学习复杂环境智慧交通

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贵州省省级水网建设研究

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黑龙江水利科技 2024年第2期52卷 137-140页

作者：余晓敏冯楚桥杨荣芳郝志斌贵州省水利水电勘测设计研究院有限公司贵阳550002

水网作为贵州基础设施建设的六网之一,对保障贵州水安全具有重要意义。根据国家支持贵州在新时代西部大开发上闯新路的新形势,按照水利部关于加快推进省级水网建设的新要求,立足贵州水网建设基础和短板,提出贵州省水网的总体布局,以期... 详细信息

水网作为贵州基础设施建设的六网之一,对保障贵州水安全具有重要意义。根据国家支持贵州在新时代西部大开发上闯新路的新形势,按照水利部关于加快推进省级水网建设的新要求,立足贵州水网建设基础和短板,提出贵州省水网的总体布局,以期高质量推动贵州水网建设。

关键词：省级水网水安全保障高质量发展贵州省

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基于变步长凸组合LMS自适应滤波高原动态血氧检测系统设计

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成都信息工程大学学报 2024年第2期39卷 142-147页

作者：冯东余小敏张益林蓝梓豪米维郭明跃成都信息工程大学物理场生物效应及仪器四川省高校重点实验室四川成都610225 九寨沟县林业和草原生态旅游开发中心四川九寨沟623400

针对基于光电检测方法的血氧仪只能在静止状态下测试血氧饱和度(血氧)的问题,提出一种基于变步长凸组合LMS自适应滤波动态血氧检测方法。方法对原始光电描记脉搏波信号经预处理后,通过固步长与变步长LMS自适应算法组合,以三轴加速度计... 详细信息

针对基于光电检测方法的血氧仪只能在静止状态下测试血氧饱和度(血氧)的问题,提出一种基于变步长凸组合LMS自适应滤波动态血氧检测方法。方法对原始光电描记脉搏波信号经预处理后,通过固步长与变步长LMS自适应算法组合,以三轴加速度计采集信号作为运动噪声参考信号,获得理想脉搏波信号再准确计算血氧值。在此基础上,开发了一套基于物联网的穿戴式高原血氧检测系统,经过模拟正常行走及在不同海拔条件下测试,最大误差不超过4%,验证了算法的有效性和准确性。结果显示,基于物联网的血氧监测系统对于高原旅游中高原反应的实时监测与提醒具有实际意义。

关键词：血氧饱和度光电容积脉搏波变步长凸组合LMS自适应滤波高原反应物联网

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星状神经节阻滞对鼻内窥镜手术患者术后睡眠障碍的影响

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江苏医药 2024年第8期50卷 799-802,806页

作者：贺晨晨散小虎刘海英喻晓敏杨进国国药东风总医院麻醉科湖北十堰442000 国药东风总医院疼痛科湖北十堰442000

目的探讨星状神经节阻滞(SGB)对鼻内窥镜手术患者术后睡眠障碍的影响。方法择期全麻行鼻内窥镜手术患者58例,随机分为两组,每组29例。麻醉诱导前30 min,观察组行超声引导下SGB,对照组不行SGB。比较两组术前1 d以及术后1、3、5 d匹兹堡... 详细信息

目的探讨星状神经节阻滞(SGB)对鼻内窥镜手术患者术后睡眠障碍的影响。方法择期全麻行鼻内窥镜手术患者58例,随机分为两组,每组29例。麻醉诱导前30 min,观察组行超声引导下SGB,对照组不行SGB。比较两组术前1 d以及术后1、3、5 d匹兹堡睡眠指数(PSQI)评分。记录两组术后1 d的夜间总睡眠时间、睡眠效率和清醒次数。术后24 h评估VAS疼痛评分。观察SGB相关并发症,并记录术后24 h内需要补救镇痛的例数。结果与对照组比较,观察组术后1 d的夜间总睡眠时间延长,睡眠效率提高,夜间睡眠过程中清醒次数减少(P0.05)。结论SGB可有效改善鼻内窥镜手术患者术后睡眠质量,减轻术后疼痛。

关键词：星状神经节阻滞鼻内窥镜手术睡眠障碍

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Synthesis and microwave absorption performance of heat-treated RF/SiO_(2)aerogels

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Defence Technology（防务技术） 2024年第4期34卷 177-186页

作者： Xinli Ye Hao yu Kai Zheng Shan Li xiaomin Ma Bangxiao Mao Junxiong Zhang School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072PR China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057PR China Yangtze River Delta Research Institute of Northwestern Polytechnical University Suzhou 215400PR China National Equipment New Material&Technology(Jiangsu)Co. LtdSuzhou 215400PR China Beijing Xinfeng Aerospace Equipment Co. LtdBeijing 100854PR China School of Textile and Clothing Nantong UniversityNantong 226019PR China

The well-designed composite with satisfactory electromagnetic microwave absorption at high temperatures remains a serious ***,we fabricated a resorcinol-formaldehyde/silica dioxide composite aerogel(RF/SiO_(2))with a three-dimensional network structure using sol-gel,atmospheric pressure drying technique as well as heat-treated processes to achieve enhanced microwave absorption capabilities in the low frequency *** pristine RF/SiO_(2)aerogel presented a typical micropores structure with a surface area,porous volume,and density of 146.82 m^(2)/g,62.40%,and 0.28 cm^(3)/g,***,the RF/SiO_(2)aerogel showed an effective absorption bandwidth of 3.56 GHz and a minimum reflection loss value of-46.10 d B at 2.25 mm after being heat-treated at 1500°C,while the maximum effective absorption bandwidth was 3.60 GHz at 2.30 *** intricate three-dimensional networks possessed remarkable impedance matching,multiple attenuation mechanisms,interfacial polarization,and dielectric loss,which were attributed to the exceptional ability to absorb electromagnetic *** offered a fresh approach to creating adaptable and effective microwave absorption materials in military defense.

关键词： RF/SiO_(2) Aerogel Heat-treated Microwave absorption

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1例FGAIVS2+1G>T杂合突变导致低异常纤维蛋白原血症的基因突变分析

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温州医科大学学报 2024年第7期54卷 598-602,F0003页

作者：王海坚郑霜余晓敏吴楷雯赵秘胜朱丽青温州市人民医院温州医科大学温州市第三临床学院医学检验中心浙江温州325000 温州医科大学附属第一医院医学检验中心浙江温州325015

目的:对临床发现的1例低异常纤维蛋白原血症进行基因分析,探讨其分子发病机制。方法:选取2023年2月17日因“右肾积水,术前凝血功能异常”就诊于温州市人民医院的男性先证者作为研究对象。PCR扩增该患者FGA、FGB、FGG的外显子及其侧翼序... 详细信息

目的:对临床发现的1例低异常纤维蛋白原血症进行基因分析,探讨其分子发病机制。方法:选取2023年2月17日因“右肾积水,术前凝血功能异常”就诊于温州市人民医院的男性先证者作为研究对象。PCR扩增该患者FGA、FGB、FGG的外显子及其侧翼序列,进行双向测序,明确突变位点。饱和硫酸铵法纯化血浆中纤维蛋白原,进行纤维蛋白原聚集率、凝固率、SDS-PAGE分析;构建包含1-4号外显子的野生型与突变型小基因的pcDNA3.1-载体,转染HEK293T细胞,TRIzol法抽提总mRNA,经过RT-PCR、巢氏PCR、q-PCR验证突变对剪接体功能的影响。结果:先证者Aα链2号内含子IVS2+1G>T(c.180+1G>T)杂合突变,该突变导致先证者纤维蛋白原的聚集最大速率(t=443.069,PT突变变异评级为致病突变。FGAIVS2+1G>T突变导致有42个氨基酸缺失的异常FGA释放入血,但不影响纤维蛋白原的组装与分泌,表现为低异常纤维蛋白原血症。

关键词：低异常纤维蛋白原血症纤维蛋白原基因突变异位转录

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Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

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Journal of Genetics and Genomics 2008年第6期35卷 349-355页

作者： Qibin Luo Qing Zhoub xiaomin yu Hongbin Lin Songnian Hu Jun yu James D. Watson Institute of Genome Sciences Zhejiang University Hangzhou 310008 China Key Laboratory of Genome Information and Sciences Beijing Institute ofGenomics ChineseAcademy of Sciences Beijing 100029 China Graduated School of the Chinese Academy of Sciences Beijing 100049 China

MicroRNAs （miRNAs） are endogenous 22-nt RNAs, which play important regulatory roles by post-transcriptional gene silencing. A computational strategy has been developed for the identification of conserved miRNAs based on features of known metazoan miRNAs in red flour beetle （Tribolium castaneum）, which is regarded as one of the major laboratory models of arthropods. Among 118 putative miRNAs, 47% and 53% of the predicted miRNAs from the red flour beetle are harbored by known protein-coding genes （intronic） and genes located outside （intergenic miRNA）, respectively. There are 31 intronic miRNAs in the same transcriptional orientation as the host genes, which may share RNA polymerase II and spliceosomal machinery with their host genes for their biogenesis. A hypothetical feed-back model has been proposed based on the analysis of the relationship between intronic miRNAs and their host genes in the development of red flour beetle.

关键词： miRNA host transcript intronic miRNA Tribolium castaneum

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Amphipathicity mediated endocytosis of mesoporous silica nanoparticles with tunable frameworks

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Nano Research 2024年第9期17卷 8350-8359页

作者： Runfeng Lin Tiancong Zhao Liang Chen Minchao Liu Hongyue yu Ruicong Wang Minjia yuan xiaomin Li Dongyuan Zhao Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Shanghai Qiran Biotechnology Co. Ltd.Shanghai 201702China

Due to the amphiphilic nature of phospholipids in the cell membrane,the amphipathicity of the nanomedicine plays a crucial role in the ***,limited biological characterization methods restrict the study of the state of nanoparticles with different amphiphilicities on cell *** understanding of interaction of amphiphilic particle with cell membrane is still ***,by combining the dissipative particle dynamics(DPD)with the framework construction of mesoporous silica nanoparticles(MSNs),we demonstrate the enhanced endocytosis induced by the *** results confirm that the presence of hydrophobic groups on the surface of nanoparticles can disturb the integrity of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)membrane and induce activation of phospholipids to a higher energy level,thereby facilitating the wrapping of *** validate the simulation findings,uniform MSNs with hydrophilic pure silica framework and two types of amphiphilic MSNs with varying hydrophilic organic groups in the framework are rationally synthesized by using different silane *** obtained three kinds of MSNs show similar diameter(~100 nm)and mesopores(~2 nm),but distinct hydrophobicity/hydrophilicity *** phenyl-bridged MSN with a carbon content of 27.1%exhibits enhanced cellular uptake,consistent with the theoretical simulation *** work sheds light on how the surface amphipathicity influences endocytosis through the interaction with cell membrane.

关键词： mesoporous silica nanoparticles mesoporous organosilica endocytosis cell membrane amphipathicity

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Linking coral fluorescence phenotypes to thermal bleaching in the reef-building Galaxea fascicularis from the northern South China Sea

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Marine Life Science & Technology 2024年第1期6卷 155-167页

作者： Sanqiang Gong Jiayuan Liang Gang Li Lijia Xu Yehui Tan Xinqing Zheng Xuejie Jin Kefu yu xiaomin Xia Key Laboratory of Tropical Marine Bio-Resources and Ecology&Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510301China Coral Reef Research Center of China Guangxi UniversityNanning 53004China South China Institute of Environmental Sciences The Ministry of Ecology and Environment of PRCGuangzhou 510530China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Coral fluorescence phenotypes have been suggested as an adaptation to a broad range of environmental conditions,yet the mechanisms linking thermal bleaching tolerance in reef-building coral populations,associated with fluorescence phenotypes due to GFP-like proteins,remains *** this study,the relationship between the thermal sensitivity and phenotypic plasticity of corals was investigated using two phenotypes of Galaxea fascicularis,green and *** results reveal that brown *** was more susceptible to bleaching than green *** when exposed to a higher growth temperature of 32℃.Both phenotypes of *** were associated with the thermotolerant Symbiodiniaceae symbiont,Durusdinium ***,the brown *** showed a significant decrease in Symbiodiniaceae cell density and a significant increase in pathogenic bacteria abundance when the growth temperature was raised from 29 to 32℃.The physiological traits and transcriptomic profiles of Symbiodiniaceae were not notably affected,but there were differences in the transcriptional levels of certain genes between the two phenotype hosts of *** heat stress of 32℃,the gene encoding green fluorescent protein(GFP)-like and chromosome-associated proteins,as well as genes related to oxidative phosphorylation,cell growth and death showed lower transcriptional levels in the brown *** compared to the green ***,the results demonstrate that the green form of *** is better able to tolerate ocean warming and defend against pathogenic bacteria,likely due to higher gene transcription levels and defense ability.

关键词： Fluorescence phenotype Thermal bleaching Microbiome Galaxea fascicularis Ocean warming

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