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Robust optical mode converter based on topological waveguide arrays

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Chinese Physics B 2024年第6期33卷 197-203页

作者：徐宇翔唐文剑姜力炜吴德兴王恒许冰聪陈林 Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Optical mode converters are essential for enhancing the capacity of optical communication systems. However, fabrication errors restrict the further improvement of conventional mode converters. To address this challenge, we have designed an on-chip TE0–TE1mode converter based on topologically protected waveguide arrays. The simulation results demonstrate that the converter exhibits a mode coupling efficiency of 93.5% near 1550 nm and can tolerate a relative fabrication error of 30%. Our design approach can be extended to enhance the robustness for other integrated photonic devices, beneficial for future development of optical network systems.

关键词： on-chip integrated photonic devices topological photonics mode converter robustness

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2024年

作者： Jinliang Wang Wenyong Zhou yu xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular Oncology Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers, the non-squamous and squamous subtypes （nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology, and potential genomic correlates affecting responses to immune checkpoint inhibitor （ICI）-based treatments. In our inhouse training cohort （n=85）, the presence of the LRP1B deleterious mutation （LRP1B-del） was associated with longer and shorter progression-free survival （PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs, respectively (Pinteraction=0.008). These results were validated using a larger public ICI cohort (n=208, Pinteraction<0.001). Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs （P=0.040） and sqNSCLCs （P=0.014）, respectively. In the POPLAR/OAK cohort, nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel (hazard ratio （HR）=0.70, P=0.046), whereas this benefit was negligible in those without LRP1B-del （HR=1.05, P=0.64）. Conversely, sqNSCLCs without LRP1Bdel benefited more from atezolizumab （HR=0.60, P=0.002） than those with LRP1B-del （HR=1.30, P=0.31）. Consistent results were observed in the in-house CHOICE-01 cohort, in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone (Pinteraction=0.008). This multi-cohort study delineates the antithetical impacts of LRP1Bdel in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy alone. Our findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs, emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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不确定非线性离散系统指令滤波事件触发控制

控制理论与应用 2024年第5期41卷 839-846页

作者：徐雨梦于金鹏林崇于海生青岛大学自动化学院山东青岛266071 山东省工业控制重点实验室山东青岛266071

本文提出了考虑输入饱和的一类不确定非线性离散系统的事件触发指令滤波控制方法.采用指令滤波控制技术解决了传统反步法存在的“因果矛盾”问题,引入补偿机制提高了系统的控制精度;利用事件触发机制能够避免自适应律和控制律的频繁更新... 详细信息

本文提出了考虑输入饱和的一类不确定非线性离散系统的事件触发指令滤波控制方法.采用指令滤波控制技术解决了传统反步法存在的“因果矛盾”问题,引入补偿机制提高了系统的控制精度;利用事件触发机制能够避免自适应律和控制律的频繁更新,降低了计算负担,提高了资源利用率;运用模糊逻辑系统逼近系统中未知的非线性函数;结合李雅普诺夫稳定性理论,验证了提出的控制方案能够保证跟踪误差收敛到原点小的邻域内以及闭环系统的所有信号有界.仿真结果表明,本文提出的控制方法具有较强的鲁棒性及较好的跟踪性能.

关键词：指令滤波反步事件触发机制模糊逻辑系统输入饱和离散

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薄膜微盘激射性质

物理学报 2024年第8期73卷 105-114页

作者：徐宇轩姚泰宇邓莉陈诗枚徐辰尧唐文轩华东师范大学物理与电子科学学院上海200241

基于半导体变形微腔的定向激射效应,在各向同性薄膜中制备变形微腔,将为多功能、高集成光子有源芯片提供新的解决方案.利用二维波动光学理论,以Z切向掺饵铌酸锂薄膜蚶线形微盘中的TE20,1模式为例,分析了不同变形因子ε微盘的模式分布、... 详细信息

基于半导体变形微腔的定向激射效应,在各向同性薄膜中制备变形微腔,将为多功能、高集成光子有源芯片提供新的解决方案.利用二维波动光学理论,以Z切向掺饵铌酸锂薄膜蚶线形微盘中的TE20,1模式为例,分析了不同变形因子ε微盘的模式分布、品质因子Q、定向激射效果D以及庞加莱截面图.理论模拟结果显示,微盘变形过程中微盘周长与谐振波长的比值近似为一定值.当ε大于0.24时,微盘具有较好的单向激射性,Q值大于10^(5);当ε变形因子大于0.4时,庞加莱截面图几乎被混沌海区域占据,Q值低于10^(3).因此,薄膜蚶线形微盘变形因子ε在0.24—0.4之间时,微盘不仅具有高的品质因子(Q值为10^(3)—10^(5)),激射方向性也较高(D值为6.45—8.32).

关键词：蚶线形微盘模式分布品质因子定向激射

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su xuefeng yu Li Yan Guijun Qin xulei Tang Gang Chen Min xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu yuhong Chen Jieli Lu Weiqing Wang Guang Ning yu xu yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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江西德安彭山矿田遥感找矿预测研究

岩石矿物学杂志 2024年第4期43卷 973-981页

作者：谭荣徐裕敏徐先宇王天晨余振东江西省地质局第三地质大队江西九江332100

矿田找矿预测过程中受基础地质大数据的影响较大,导致其应用于地质复杂区域时筛选结果的准确性较差,为此研究了江西省德安县彭山矿田遥感找矿预测方法。以下鞭山锡矿区作为彭山地区的典型矿田,分析了其地质特征与成矿规律,依据分析结果... 详细信息

矿田找矿预测过程中受基础地质大数据的影响较大,导致其应用于地质复杂区域时筛选结果的准确性较差,为此研究了江西省德安县彭山矿田遥感找矿预测方法。以下鞭山锡矿区作为彭山地区的典型矿田,分析了其地质特征与成矿规律,依据分析结果再结合遥感技术,获得遥感找矿要素与遥感蚀变信息,建立遥感综合信息找矿靶区预测模型,得到彭山地区找矿靶区定量预测结果输出。预测结果显示,研究区共定量预测出3个典型找矿靶区,分别位于该区的西北侧、西侧及东侧区域,主要具环形与条带状构造,构造发育方向主要为东北向、西北向及近南北向,所提取到的遥感蚀变信息主要有碳酸盐化、绿帘石化、绿泥石化、绢云母化、高岭土化及铁染,3个靶区均具有较好的成矿条件;野外实际查证证实3个靶区中存在高岭土化、铁染及碳酸盐化等蚀变发育,且蚀变岩块中Cu与Au的含量较高,预测结果得到证实,可为该区域的找矿勘探提供可靠的参考依据。

关键词：德安县彭山矿田地质成矿规律找矿靶区遥感技术蚀变信息

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乡村振兴战略背景下促进农民增收的个性化研究——以盐城市芦蒲镇为例

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中国农机化学报 2024年第7期45卷 310-315页

作者：徐雨赵闰许永刚农业农村部南京农业机械化研究所南京市210014 常州市武进区农业农村局江苏常州213100

乡村振兴战略的实施对农民致富增收提出更高的要求,针对农民收入低下难以增收的问题展开讨论,探究制定因地制宜的增收策略,来明确农民致富增收途径。通过分析盐城市芦蒲镇农民收入的特点,梳理当下通过发展高效附加值农业、培植能人经济... 详细信息

乡村振兴战略的实施对农民致富增收提出更高的要求,针对农民收入低下难以增收的问题展开讨论,探究制定因地制宜的增收策略,来明确农民致富增收途径。通过分析盐城市芦蒲镇农民收入的特点,梳理当下通过发展高效附加值农业、培植能人经济、建设高标准农田和培养优秀的领路人等促进农民增收措施方面进行调查研究。在本地区工商业经济基础薄弱和高效农业发展程度受制约的情况下,通过明确乡村振兴发展主线、落实优势自然资源举措、锚定产业目标、建强干部队伍建设等方面来客观提出促进农民增收的策略,为实施乡村振兴战略中农民增收提供思路和理论支撑。

关键词：农民增收乡村振兴高标准农田队伍建设策略

A Transformer-Assisted Cascade Learning Network for Choroidal Vessel Segmentation

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Journal of Computer Science & Technology 2024年第2期39卷 286-304页

作者：温阳吴依林毕磊石武祯刘潇骁许毓鹏许迅曹文明冯大淦 Guangdong Provincial Key Laboratory of Intelligent Information Processing School of Electronics and Information EngineeringShenzhen UniversityShenzhen 518060China Institute of Translational Medicine Shanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China School of Information Technologies The University of SydneySydney 2006Australia

As a highly vascular eye part,the choroid is crucial in various eye disease ***,limited research has focused on the inner structure of the choroid due to the challenges in obtaining sufficient accurate label data,particularly for the choroidal ***,the existing direct choroidal vessel segmentation methods for the intelligent diagnosis of vascular assisted ophthalmic diseases are still unsatisfactory due to noise data,while the synergistic segmentation methods compromise vessel segmentation performance for the choroid layer segmentation *** cascaded structures grapple with error propagation during *** address these challenges,we propose a cascade learning segmentation method for the inner vessel structures of the choroid in this ***,we propose TransformerAssisted Cascade Learning Network(TACLNet)for choroidal vessel segmentation,which comprises a two-stage training strategy:pre-training for choroid layer segmentation and joint training for choroid layer and choroidal vessel *** also enhance the skip connection structures by introducing a multi-scale subtraction connection module designated as MSC,capturing differential and detailed information ***,we implement an auxiliary Transformer branch named ATB to integrate global features into the segmentation *** results exhibit that our method achieves the state-of-the-art performance for choroidal vessel ***,we further validate the significant superiority of the proposed method for retinal fluid segmentation in optical coherence tomography(OCT)scans on a publicly available *** these fully prove that our TACLNet contributes to the advancement of choroidal vessel segmentation and is of great significance for ophthalmic research and clinical application.

关键词： choroidal vessel segmentation optical coherence tomography(OCT) Transformer-assisted cascade learning retinal fluid segmentation multi-scale feature extraction

Physical mechanism of oxygen diffusion in the formation of Ga_(2)O_(3) Ohmic contacts

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Chinese Physics B 2024年第1期33卷 653-659页

作者：徐宿雨于淼袁东阳彭博元磊张玉明贾仁需 Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi'an 710071China The 13 th Research Institute China Electronics Technology Group Corporation Shijiazhuang 050051China

The formation of low-resistance Ohmic contacts in Ga_(2)O_(3) is crucial for high-performance electronic devices. Conventionally, a titanium/gold(Ti/Au) electrode is rapidly annealed to achieve Ohmic contacts, resulting in mutual diffusion of atoms at the interface. However, the specific role of diffusing elements in Ohmic contact formation remains *** this work, we investigate the contribution of oxygen atom diffusion to the formation of Ohmic contacts in Ga_(2)O_(3). We prepare a Ti/Au electrode on a single crystal substrate and conduct a series of electrical and structural *** density functional theory, we construct a model of the interface and calculate the charge density, partial density of states, planar electrostatic potential energy, and I–V characteristics. Our results demonstrate that the oxygen atom diffusion effectively reduces the interface barrier, leading to low-resistance Ohmic contacts in Ga_(2)O_(3). These findings provide valuable insights into the underlying mechanisms of Ohmic contact formation and highlight the importance of considering the oxygen atom diffusion in the design of Ga_(2)O_(3)-based electronic devices.

关键词： Ga_(2)O_(3) Ohmic contacts oxygen diffusion density functional theory