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Science China(Technological Sciences) 2011年第9期54卷 2421-2428页

作者： XU ShiLang yu wenting SONG ShiDe College of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China The 3rd Railway Survey and Design Institute Tianjin 300251 China State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

Carbon/glass fiber hybrid textile reinforced concrete is a relatively new composite material with good mechanical capacity and excellent electrical *** small-scale slab heating experiments and numerical simulation are presented in this *** variation curves obtained during heating indicate the effects of environmental temperature,heat-conducting layer thickness and electric heating *** of temperature rising between the situations with and without thermal isolation layer is given as *** results indicate that the textile can form a good conductive heating network and generate enough heat to raise the temperature in the concrete when connected to a power supply,while the resistance of the slab remains stable during the *** results are in good accordance with the *** time snow-melting experiment was conducted to verify the feasibility of *** electrothermal properties of textile can be utilized for deicing and snow melting in a safe,environmentally friendly and efficient way.

关键词： carbon/glass fiber hybrid textile reinforced concrete numerical simulation electrothermal properties deicing and snowmelting

Preparation of biomimetic gene hydrogel via polymerase chain reaction for cell-free protein expression

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Science China Chemistry 2020年第1期63卷 99-106页

作者： Feng Li wenting yu Xue Zhang Xiaocui Guo Xihan Xu Xiaolei Sun Dayong Yang Frontier Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University

Deoxyribonucleic acid(DNA)hydrogels,a three-dimensional(3 D)network made from DNA chains,have attracted great attention because of its molecular programmability,excellent biocompatibility and wide biomedical *** of hydrogel incorporating genetic function is still a challenge because of the limitations in available preparation ***,we develop a polymerase chain reaction(PCR)based strategy to construct gene integrated hydrogel to mimic the biofunction of nucleus *** primers were chemically modified by methacrylamide,which were used as modular primers in PCR to hybridize with template plasmid DNA,yielding methacrylamide functionalized gene(Acry-gene).Afterwards,Acry-gene was chemically cross-linked and compressed via free radical polymerization of terminal group methacrylamide to form a threedimensional gene network,namely gene *** gene hydrogel retained the genetic function and expressed protein successfully in a cell free protein expression *** work provides a general approach for the construction of biofunctional gene hydrogel which mimics bioprocesses,showing great potential in biomedicine and biomimetic fields.

关键词： hydrogel DNA polymerase chain reaction free radical polymerization biomimetic materials

Modulation Effects of the 3D Strain Microenvironment on Characteristics of Mesenchymal Stem Cell-Derived Exosomes

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医用生物力学 2019年第A1期34卷 128-129页

作者： yufei Ma wenting yu Feng Xu School of Life Science and Technology Xi’an Jiaotong UniversityXi’an710049China Stomatological Hospital College of MedicineXi’an Jiaotong UniversityXi’an710004China

It is necessary to investigate the characteristics of Mesenchymal stem cells(MSCs)derived exosomes,and especially their application in tissue *** studies have shown that inflammatory stimulation enhanced the secretion of MSC-derived exosomes with stronger anti-inflammatory protein,cytokine profiles,and functional RNA via altering COX2/PGE2 ***,accumulating evidence has also revealed that biophysical cues(especially biomechanical cues)in cell microenvironment have significant effects not only on cells but also on their *** has been reported that applying bi-axial strain to MSCs induces formation of a stiffer cytoskeleton through mTORC2 signaling,which biases against adipogenic differentiation and toward *** the same time,For example,dimensionality,composition and stiffness of the extracellular matrix(ECM)has been proved to affect the size and composition of exosomes secreted by cancer ***,the effects of biomechanical cues in the three-dimensional(3D)microenvironment on stem cell-derived exosomes remains to be ***,it is important to understand the roles of 3D cell mechanical microenvironment in regulating the characteristics of stem cell-derived exosomes and develop more efficient approaches to enhance their *** study aimed to explore the changes in characteristics of exosomes secreted by MSCs in periodontium in response to the matrix strain in *** ligament stem cells(PDLSCs)were cultured in a 3D strain microenvironment engineered with microscale magnetically stretched collagen *** morphology,particle distribution,marker protein expression of PDLSC-derived exosomes were *** the pro-osteogenic property of exosomes was evaluated by assessing cell viability,proliferation,migration and osteogenic differentiation of target cells,for instance human bone marrow mesenchymal stem cells(hBMSCs).Detailed characterizations revealed that PDLSC-derived exosome

关键词： Modulation Effects the 3D Strain Microenvironment Characteristics Mesenchymal Stem Cell-Derived Exosomes

Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking

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Chemical Research in Chinese Universities 2020年第5期36卷 962-969页

作者： yu wenting XUE Bin ZHU Zhenshu SHEN Ziqin QIN Meng WANG Wei CAO Yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostnictureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China Shenzhen Research Institute of Nanjing University Shenzhen 518057P.R.China International Center Nanjing Foreign Language SchoolNanjing210000P.R.China

Injectable hydrogels are ideal biomaterials tor delivering cells,growth tactors and dmgs specifically to localized lesions and subsequent controlled *** factors can a fleet the efficacy of injectable *** avoid potential damage to encapsulated cells or dmgs,injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly refonn after ***,dynamic hydrogels are often mechanically weak,leading to the leakage of encapsulated cells or *** we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand *** showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not atlected by the fonnation of multivalent ***,the mechanical stability of the hydrogels was significantly improved due to the increased themiodynamic stability of the *** turthcr showed that the drug release rates were slowed down by the formation of multivalent *** results highlight the importance of ligand valency to themechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels.

关键词： Peptide-ion coordination Ligand cooperativity Tnjectable hydrogek Mechanical response

Regional and Sectoral Patterns and Determinants of Comparative Advantage in China

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2017年第1期12卷 7-36页

作者： William Charles Sawyer Kiril Tochkov wenting yu Department of Economics Texas Christian University Fort Worth Texas 76129 USA Tepper School of Business Carnegie Mellon University Pittsburgh PA 15213 USA

China＇s export performance is marked by large regional disparities which affect trade patterns at the national level. This paper uses data from input-output tables to estimate the comparative advantage of Chinese provinces in the three main economic sectors over the period 1992-2007. In contrast to existing studies, we include the services sector in the analysis and construct not only indices of revealed comparative advantage for overall trade, but also bilateral indices for interprovincial trade. The results indicate that West and Central China have a comparative advantage in agriculture/mining, coastal provinces in manufacturing, and metropolitan provinces in services. However, interprovincial trade exhibits a more complex pattern. Regression analysis identifies labor endowments as the key determinant of comparative advantage in total trade, while physical capital is the driving force in domestic trade. Human capital and government spending have a positive effect, whereas industrial loans and taxes, along with provincial trade barriers, impair comparative advantage.

关键词： comparative advantage trade sectors regional disparities China

Insight into the Urea Binding and K166R Mutation Stabilizing Mechanism of TIpB： Molecular Dynamics and Principal Component Analysis Study

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Chemical Research in Chinese Universities 2014年第6期30卷 1011-1017页

作者： WU yunjian ZHENG Qingchuan XU yu CHU wenting CUI Yinglu WANG Yan ZHANG Hongxing State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130021 P R. China

Chemoreceptor TlpB（Tlp=transducer-like protein）, which has been demonstrated to respond to pH sensing function, is crucial for the survival ofHelicobacterpylori（H, pylori） in host stomach. Urea was proposed to be essen- tial for TlpB＇s pH sensing function via binding with the Per-ARNT-Sim（PAS） domain of TlpB. Additionally, KI66R mutation of the TlpB protein has also been proven to have a similar effect on TlpB pH sensing as urea binding. Al- though X-ray crystallographic studies have been carried out for urea-bound Tlpl3, the molecular mechanism for the stabilization of TIpB induced by urea binding and K166R mutation remains to be elucidated. In this study, molecular dynamics simulations combined with principal component analysis（PCA） for the simulation results were used to gain an insight into the molecular mechanism of the stabilization of urea on TlpB protein. The formed H-bonds and salt-bridges surrounding Aspll4, which were induced by both urea binding and K166R mutation of TIpB, were im- portant to the stabilization of TlpB by urea. The similarity between the urea binding and K166R mutation as well as their differences in effect has been explicitly demonstrated with computer simulations at atomic-level. The findings may Dave the wav for the further researches of TlpB.

关键词： TlpB Per-ARNT-Sim(PAS) domain Molecular dynamics simulation Principal component analysis

Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis

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Bioactive Materials 2022年第9期7卷 409-425页

作者： Delong Jiao Jing Wang wenting yu Ke Zhang Ning Zhang Lingyan Cao Xinquan Jiang yuxing Bai Institute of Dental Research Beijing Stomatological Hospital&School of StomatologyCapital Medical UniversityBeijing100050China Department of Orthodontics Beijing Stomatological Hospital&School of StomatologyCapital Medical UniversityBeijing100050China Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai200011China

We has synthesized the biocompatible gelatin reduced graphene oxide(GOG)in previous research,and in this study we would further evaluate its effects on bone remodeling in the aspects of osteoclastogenesis and angiogenesis so as to verify its impact on accelerating orthodontic tooth *** mouse orthodontic tooth movement(OTM)model tests in vivo showed that the tooth movement was accelerated in the GOG local injection group with more osteoclastic bone resorption and neovascularization compared with the PBS injection *** analysis on the degradation of GOG in bone marrow stromal stem cells(BMSCs)illustrated its good biocompatibility in vitro and the accumulation of GOG in spleen after local injection of GOG around the teeth in OTM model in vivo also didn’t influence the survival and life of *** co-culture of BMSCs with hematopoietic stem cells(HSCs)or human umbilical vein endothelial cells(HUVECs)in transwell chamber systems were constructed to test the effects of GOG stimulated BMSCs on osteoclastogenesis and angiogenesis in *** the GOG stimulated BMSCs co-culture in upper chamber of transwell,the HSCs in lower chamber manifested the enhanced ***,the co-culture of GOG stimulated BMSCs with HUVECs showed a promotive effect on the angiogenic ability of *** mechanism analysis on the biofunctions of the GOG stimulated BMSCs illustrated the important regulatory effects of PERK pathway on osteoclastogenesis and *** the results showed the biosecurity of GOG and the biological functions of GOG stimulated BMSCs in accelerating bone remodeling and tooth movement.

关键词： Bone remodeling Reduced graphene oxide Angiogenesis Osteoclastogenesis Orthodontic tooth movement

Social bookmarking behaviors of college students:A survey of Wuhan University Library users

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Chinese Journal of Library and Information Science 2013年第3期6卷 15-30页

作者： Dan WU Xiaomei XU wenting yu School of Information Management Wuhan University

Purpose:To have a better understanding of library users' social bookmarking behaviors,we conducted a survey of college students to examine how much attention they have paid to social bookmarking results,their social bookmarking motivations and behaviors on book sharing sites and in their library's OPAC,and their expectations to their library's social bookmarking ***/methodology/approach:A questionnaire survey was conducted to investigate social bookmarking behaviors and motivations of users of Wuhan University Library(WUL) on book sharing sites and in WUL's OPAC.A total of 700 questionnaires were distributed and357 valid questionnaires were *** was used for data ***:The results revealed that there were differences between users' social bookmarking behaviors on book sharing sites and in the Library's *** preferred to use tags than add tags on book sharing *** main tagging motivation on book sharing sites was for meeting users' specific needs such as collection management and book *** for the Library,the lack of publicity and promotion of the social bookmarking service led to insufficient use of the Library's *** to a lack of knowledge of the social bookmarking service,users did not care about the lectures or publicity campaigns about the Library's social bookmarking *** limitations:Because social bookmarking was not common among WUL users,and the questionnaires could be handed out to a limited number of people,it was hard to describe users' social bookmarking behaviors in the Library's OPAC by investigating a sample of 357Library users,and therefore we only investigated users' social bookmarking behaviors on the book sharing *** implications:The survey results provide insights into library users' social bookmarking behaviors and *** study will help academic libraries improve their social bookmarking ***/value:In spite of growing popularity of s

关键词： Social bookmarking behavior Social bookmark Tagging Rating Academic libraries

Sustainable Development and Tourists’Satisfaction in Historical Districts:Influencing Factors and Features

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Journal of Resources and Ecology 2021年第5期12卷 669-681页

作者： yu wenting ZHU He ZHANG Shuying Beijing Institute of Graphic Communication Beijing 102600China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Determining how to achieve sustainable development and protection of historical districts is a worthwhile research *** a vital way to update urban space,tourism development in historical districts is an effective tool for redistributing urban functions and increasing urban *** paper takes the Insa-dong in South Korea as a case study for the evaluation of tourist satisfaction in historical districts,based on 550 *** questionnaire contains 33 evaluation indicators,and the subjects’subjective judgment and satisfaction with Insa-dong are measured in the form of the Likert *** SPSS to analyze tourists’satisfaction with historical districts,this studyfinds that:(1)The tourist satisfaction evaluation of Insa-dong includes six dimensions in total:"Embodiment of historical elements","The blend of tradition and modernity","Industry distribution and type","Consumer demand","Street layout and function"and"Landscaping".(2)"The blend of tradition and modernity"has the highest weight while"Industry distribution and type"has the lowest one in the analysis of factors influencing overall satisfaction.(3)The analysis of the common factor weights and the common factor satisfaction levels shows that"The blend of tradition and modernity"and"Street layout and function"are the parts that need to be improved."Consumer demand"also has a lot of room for *** research results will be beneficial for enhancing the tourist experiences of historical districts and they provide a theoretical basis and practical experience reference for effective protection and sustainable development of historical districts.

关键词： historical district sustainable development satisfaction Insa-dong South Korea

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时间感知的双塔型自注意力序列推荐模型

计算机科学与探索 2024年第1期18卷 175-188页

作者：余文婷吴云贵州大学公共大数据国家重点实验室贵阳550025 贵州大学计算机科学与技术学院贵阳550025

用户的偏好具有聚合性和漂移性。现有推荐算法在序列建模框架中融合了交互时间相关性的建模,取得了很大的性能改善,但它们在建模时仅考虑了交互的时间间隔,使得它们在捕捉用户偏好的时间动态方面存在局限性。首先,提出了一种新的时间感... 详细信息

用户的偏好具有聚合性和漂移性。现有推荐算法在序列建模框架中融合了交互时间相关性的建模,取得了很大的性能改善,但它们在建模时仅考虑了交互的时间间隔,使得它们在捕捉用户偏好的时间动态方面存在局限性。首先,提出了一种新的时间感知的位置嵌入方法,将时间信息与位置嵌入相结合,帮助模型学习时间层面的项目相关性。随后,在时间感知位置嵌入基础上,提出了时间感知的双塔自注意力序列推荐模型(TiDSA)。TiDSA包含项目级和特征级的自注意力模块,分别从项目和特征两个角度对用户偏好随时间变化的过程进行分析,实现了对时间、项目和特征的统一建模,并且在特征级自注意力模块,设计了多维度的自注意力权重计算方式,从特征维度、项目维度和项目与特征交叉维度充分学习特征之间的相关性。最后,TiDSA将项目级与特征级的信息相融合得到最终的用户偏好表示,并根据该表示为用户提供可靠的推荐结果。四个真实推荐数据集的实验结果表明,TiDSA的性能优于许多先进的基线模型。

关键词：时间感知序列推荐位置嵌入特征级自注意力机制双塔自注意力网络