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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng wu Mei-yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang Hong-Lei Wang yue-Ze Wang hui-hui You Hong-wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

雨洪水回灌不同渗流状态下微生物迁移沉积特征

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中国环境科学 2025年第1期45卷 487-499页

作者：武宇辉杨悦锁路莹闫子晗王茜丹石敏吉林大学地下水资源与环境教育部重点实验室吉林长春130021 生态环境部华南环境科学研究所广东广州510535 南京大学地球科学与工程学院水科学系表生地球化学教育部重点实验室江苏南京210023 南方科技大学环境科学与工程学院广东深圳518005

针对雨洪水人工回灌特有的水动力和水环境条件,通过系列一维渗流模拟试验,系统分析不同饱和度、酸碱环境、离子强度和回灌速度等渗流状态下堵塞模式微生物在多孔介质内的迁移沉积特征,进而明确不同渗流状态下多孔介质内部微生物堵塞发... 详细信息

针对雨洪水人工回灌特有的水动力和水环境条件,通过系列一维渗流模拟试验,系统分析不同饱和度、酸碱环境、离子强度和回灌速度等渗流状态下堵塞模式微生物在多孔介质内的迁移沉积特征,进而明确不同渗流状态下多孔介质内部微生物堵塞发展状况,同时通过DLVO理论计算揭示不同酸碱环境和离子强度下微生物运移过程中主控作用力.结果显示,当介质饱和度降低、介质内pH值下降、回灌水离子强度增加或回灌流速降低时,堵塞微生物迁移均会变慢,在介质上的沉积增加且层间沉积非均匀程度降低,导致介质内部更易形成生物堵塞.饱和度介于60%~80%、pH值介于7.5~8.5或离子强度介于1~5mmol/L范围内时,分别改变饱和度、pH值或者离子强度,对微生物迁移的影响较弱.渗流速度在0.5~1mL/min范围内,非饱和条件会削弱流速变化对菌体迁移沉积的影响.不同酸碱环境和离子强度下,饱和与非饱和介质中微生物运移主控作用力分别为静电作用力和毛细管作用力.

关键词：堵塞微生物迁移沉积渗流状态雨洪水回灌生物堵塞

PandaX-xT——A deep underground multi-ten-tonne liquid xenon observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 105-120页

作者： Abdusalam Abdukerim Zihao Bo wei Chen Xun Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Linhui Gu Xunan Guo Xuyuan Guo Zhichao Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang junting Huang Zhou Huang Ruquan Hou yu Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong Lu Xiaoying Lu Lingyin Luo yunyang Luo Wenbo Ma yugang Ma yajun Mao yue Meng Xuyang Ning binyu Pang Ningchun Qi Zhicheng qian Xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang wei Wang Xiuli Wang Xu Wang Zhou Wang yuehuan wei Mengmeng wu weihao wu yuan wu Mengjiao Xiao Xiang Xiao binbin yan Xiyu yan Yong yang Chunxu yu Ying yuan Zhe yuan Youhui yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang wei Zhang yang Zhang Yingxin Zhang yuanyuan Zhang Li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou yubo Zhou Zhizhen Zhou New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinesen Academy of SciencesHuizhou 516000China yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China School of Physics Nankai UniversityTianjin 300071China SJTU Paris Elite I

We propose a major upgrade to the existing PandaX-4T experiment at the China Jinping Underground *** new experiment,PandaX-xT,will be a multi-ten-tonne liquid xenon,ultra-low background,and general-purpose *** full-scaled PandaX-xT contains a 43-t liquid xenon active *** an experiment will significantly advance our fundamental understanding of particle physics and *** sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits,approaching the so-called“neutrino floor”for a dark matter mass above 10 GeV/c^(2),providing a key test to the Weakly Interacting Massive Particle *** searching for the neutrinoless double beta decay of^(136)Xe isotope in the detector,the effective Majorana neutrino mass can be measured to a 10-41 meV/c^(2) sensitivity,providing a key test to the Dirac/Majorana nature of *** neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level,opening up new windows of *** on the findings,PandaX-xT will seek the next stage upgrade utilizing isotopic separation of natural xenon.

关键词： dark matter neutrino less double beta decay astrophysical neutrinos liquid xenon

Lakes in the Qinghai-Tibet Plateau are conducive to regional permafrost development

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Journal of Mountain Science 2023年第3期20卷 738-749页

作者： XIE Chang-wei yang Gui-qian WANG wu ZHANG yu-xin LIU Wen-hui LIU Guang-yue wu Ji-chun PANG qiang-qiang Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryosphere SciencesNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 101408China Department of Geological Engineering Qinghai UniversityXining 810016China

The Qinghai-Tibet Plateau(QTP)possesses the largest areas of permafrost in the midand low latitude regions on the earth and many large lakes in the permafrost *** on a comprehensive investigation around certain typical lakes,this study found that although the presence of lakes formed different ranges of unfrozen zones in permafrost,the heating effect of lake water on surrounding permafrost is limited to a small *** temperature of permafrost around the lake is closely related to the distance to the lake and the ice content of the *** lakes are ice-rich permafrost zones and permafrost temperature in this area is significantly lower than that far away from the lake,which indicates that the existence of lakes in the QTP has special effect on the permafrost *** on the monitoring results,this study presents the typical distribution pattern of the permafrost around large lakes and discusses the reasons for the distribution *** to the huge area of lakes and the significant impact of lakes on permafrost distribution,it is suggested to re-estimate the total permafrost area and underground ice storage in the QTP.

关键词： Heating effect So1il water content Permafrost distribution Lakes Qinghai-Tibet Plateau

Percutaneous fixation of neonatal humeral physeal fracture: A case report and review of the literature

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World Journal of Clinical Cases 2020年第19期8卷 4535-4543页

作者： wei Tan Fu-Hua Wang Jing-hui yao wei-Ping wu Yi-bin Li yue-Lun Ji yue-Peng qian Department of Pediatric Orthopedics The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina The First School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Orthopaedics and Traumatology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Neonatal distal humeral physeal fractures are rare and difficult to ***,missed diagnoses and delayed healing are *** studies have reported surgical treatment,because a callus may develop at the fracture site 5 d after the fracture,resulting in difficult reduction,and reduction of the limb may cause further physeal *** surgical challenges include the provision of adequate anesthesia and complexity of the ***,without appropriate reduction and fixation,a varus elbow deformity may *** reduction and percutaneous pin fixation are ideal treatment *** SUMMARY A 4-day-old neonate with left elbow pain accompanied by limited movement for 4 d was admitted,and diagnosed with delayed physeal fracture of the distal humerus based on physical examination,ultrasonography,and magnetic resonance *** patient was treated by manual reduction combined with percutaneous pin fixation under ***,the reduction was *** upper limbs could have been lifted and the fingers could have been moved freely on the second day after the *** The techniques of manual reduction and percutaneous pin fixation,to treat neonatal distal humeral physeal fractures,are safe and reliable.

关键词： Physeal fracture of the distal humerus Manual reduction Percutaneous pin fixation Neonate Case report

Dynamic changes in lakes in the Hoh Xil region before and after the 2011 outburst of Zonag Lake

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Journal of Mountain Science 2019年第5期16卷 1098-1110页

作者： LIU Wen-hui XIE Chang-wei ZHAO Lin wu Tong-hua WANG wu ZHANG yu-xin yang Gui-qian ZHU Xiao-fan yue Guang-yang Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryosphere Sciences Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences University of Chinese Academy of Sciences

Zonag, Kusai, Hedin Noel and yanhu Lakes are independent inland lakes in the Hoh Xil region on the Qinghai-Tibet Plateau. In September2011, Zonag Lake burst after the water level had increased for many years. Floods flowed through Kusai and Hedin Noel Lakes into yanhu Lake; since then, the four small endorheic catchments merged into one larger catchment. This hydrological process caused the rapid shrinkage of Zonag Lake and continuous expansion of yanhu Lake. In this study,based on satellite images, meteorological data and field investigations, we examined the dynamic changes in the four lakes and analyzed the influencing factors. The results showed that before 2011, the trends in the four lake areas were similar and displayed several stages. The change in the area of Zonag Lake corresponded well to the change in annual precipitation(AP), but the magnitude of the change was less than that of a non-glacier-fed lake. Although increased precipitation was the dominant factor that caused Zonag Lake to expand, increased glacier melting and permafrost thawing due to climate warming also had significant effects. After the 2011 outburst of Zonag Lake, due to the increasing AP and accelerating glacier melting, the increases in water volume of the three lakes were absorbed by yanhu Lake, and yanhu Lake expanded considerably. According to the rapid growth rates in water level and lake area, yanhu Lake is likely to burst in 1-2 years.

关键词： Dynamic change Lake areas Influencing factors Glacier change Permafrost thawing Zonag Lake

Autoimmune enteropathy and primary biliary cholangitis after proctocolectomy for ulcerative colitis:A case report and review of the literature

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World Journal of Gastroenterology 2021年第29期27卷 4929-4938页

作者： Qing-yang Zhou wei-Xun Zhou Xi-yu Sun bin wu wei-yang Zheng yue Li Jia-Ming qian Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Autoimmune enteropathy(AIE)and primary biliary cholangitis(PBC)are both immune-mediated *** or PBC complicated with ulcerative colitis(UC)are *** are no cases of AIE and PBC diagnosed after proctocolectomy for UC reported before,and the pathogenesis of these comorbidities has not been *** SUMMARY A middle-aged woman diagnosed with UC underwent subtotal colectomy and ileostomy due to the steroid-resistant refractory disease,and a restorative proctectomy with ileal pouch-anal anastomosis and proximal neoileostomy was postponed due to active residual rectal inflammation in January 2016.A few months after the neoileostomy,she began to suffer from recurrent episodes of watery *** was diagnosed with postcolectomy enteritis and stoma closure acquired a good therapeutic ***,her symptoms of diarrhea relapsed in 2019,with different histological features of endoscopic biopsies compared with 2016,which showed apoptotic bodies,a lack of goblet and Paneth cells,and villous blunting.A diagnosis of AIE was established,and the patient’s stool volume decreased dramatically with the treatment of methylprednisolone 60 mg/d for 1 wk and tacrolimus 3 mg/d for 4 ***,her constantly evaluated cholestatic enzymes and high titers of antimitochondrial antibodies indicated the diagnosis of PBC,and treatment with ursodeoxycholic acid(16 mg/kg per day)achieved satisfactory *** Some immune-mediated diseases may be promoted by operation due to microbial alterations in UC *** follow-up is essential for UC patients with postoperative complications.

关键词： Autoimmune enteropathy Primary biliary cholangitis Ulcerative colitis Proctocolectomy Bacterial translocation Case report

Facile Synthesis of High Molecular weight Polypeptides via Fast and Moisture Insensitive Polymerization of a-Amino Acid N-Carboxyanhydrides

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Chinese Journal of Polymer Science 2020年第10期38卷 1131-1140,I0007页

作者： yue Ming wu wei-wei Zhang Rui-Yi Zhou Qi Chen Chen-yu Xie Heng-Xue Xiang bin Sun Mei-Fang Zhu Run-hui Liu State KeyLaboratory of Bioreactor Enginering East China Uniersity of Science and TechnologyShanghai 200237China State Key Laboratory for Modification of Chemical Fibers and Polymer Materals College of Materias Science and EngineringDonghua UniversityShanghai 201620China Key Laboratory of Specally Functional Polymeric Materials and Related Technology(ECUST)Ministry of Education Key Laboratory for Ultrafine Materials of Ministry of EducationResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Polypeptides have been widely utilized in the fields of biomaterials and *** since N-carboxyanhydride(NCA)was reported by Hermann Leuchs in 1906,ring-opening polymerization of NCAS has been extensively used to prepare *** continuous innovations,it is still challenging to synthesize polypeptides in high molecular weight *** address this challenge,we developed KHMDS/NaHMDS initiated fast NCA polymerization that is also moisture tolerant,open-flask amenable and terminal *** NCA polymerization was able to proceed in most common solvents and meet the solubility requirement of variable NCA monomers and corresponding *** can initiate r benzy-L glutamate-N carboxyanhydride(BLG NCA)polymerization in a reaction rate 92 times faster than does hexylamine and 80 times faster than does *** NCA polymerization also demonstrated easy and fast synthesis of gram-scale long chain polypeptides in an open flask.

关键词： NCA polymerization Polypeptide Open vessel Fast polymerization High Mw

Mood symptoms,cognitive function,and changes of brain hemodynamics in patients with COVID-19:A functional near-infrared spectroscopy study

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World Journal of Psychiatry 2025年第3期15卷 193-215页

作者： Wen-Jin Ma Ruo-Chao yuan Zi-yu Peng qian wu Manal Al-Matary hui-Shu yang Peng Cheng Guang-Ju Zhao Chao-Chao Lu yue-Xin Zhang Jia-Kun Hong wei-hui Li Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Research Center of Educational Neuroscience School of Educational ScienceHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Education Hunan Normal UniversityChangsha 410081Hunan ProvinceChina Guigang Medical District of No.923 Hospital PLA Joint Logistics Support ForceGuigang 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Many patients with coronavirus disease 2019(COVID-19)may experience emotional issues and cognitive ***,it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of psychopathological *** remains unclear whether anxiety and depression are caused by stressors or viral *** To use functional near-infrared spectroscopy(fNIRS)to detect cortical hemodynamic changes in patients with COVID-19 and their relationship with mental symptoms(mainly depression and anxiety),to investigate whether COVID-19 causes these changes by affecting brain *** A total of 58 subjects,comprising 29 patients with first acute COVID-19 infection and 29 healthy controls without COVID-19 infection and without anxiety or depression were *** cortical activation during the performance of the verbal fluency test(VFT)and brain connectivity during the resting state(rs)were evaluated by 53-channel *** the COVID-19-infected group,Patient Health Questionnaire-9(PHQ-9)and General Anxiety Disorder-7(GAD-7)were used to assess the emotional state before fNIRS *** For the rs,compared to the uninfected group,the infected group exhibited lower rs functional connectivity(FC)in the dorsolateral prefrontal cortex(DLPFC),which was correlated with both the PHQ score and GAD *** the VFT,the infected group exhibited significantly lower cortical activation than the uninfected group in both Broca-left and ***,the integral value in the DLPFC-L showed a significant negative correlation with the PHQ-9 score during the VFT in the infected *** There were significant differences in the bilateral Broca area and DLPFC between the COVID-19-infected and uninfected groups,which may be the reason why COVID-19 infection impairs cognitive function and language function and leads to psychiatric *** addition,the rsFC in patients with COVID-19 was positively correlated with the severi

关键词： COVID-19 Depression Anxiety Cognitive function Functional near-infrared spectroscopy Verbal fluency test