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Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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Journal of Traditional Chinese Medicine 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi yu tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing GUAN Qian CHEN Lulu HU Hui School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102401China Department of Acupuncture-Moxibustion Beijing Massage HospitalBeijing 100035China Department of Acupuncture-Moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant ***:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and *** fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,*** modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 *** the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the *** plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics ***:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and *** differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina *** primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic ***:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action poss

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine Tuina therapy

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 10-18页

作者： Hourong Wang Zhifeng Liu tianyuan yu Yingqi Zhang Yi Jiao Di Liu Yajing Xu Qian Guan Mengqian Lu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal *** this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal *** found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological ***,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

关键词： Traditional Chinese medicine External therapy Intestinal flora Digestive diseases Neurological diseases Acupoint Mechanism

于天源治疗神经根型颈椎病的推拿辨证及治则治法

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辽宁中医杂志 2022年第8期49卷 49-51页

作者：耿楠于天源北京中医药大学东方医院推拿科北京100078 北京中医药大学北京100029

颈椎病分为颈型、神经根型、椎动脉型、脊髓型、交感型和混合型6种类型,其中神经根型颈椎病是常见的颈椎病类型之一,表现为颈项部肌肉僵硬、酸痛,活动受限,常出现上肢麻木疼痛波及至手指。临床应用推拿手法治疗疾病时,须提出与推拿临床... 详细信息

颈椎病分为颈型、神经根型、椎动脉型、脊髓型、交感型和混合型6种类型,其中神经根型颈椎病是常见的颈椎病类型之一,表现为颈项部肌肉僵硬、酸痛,活动受限,常出现上肢麻木疼痛波及至手指。临床应用推拿手法治疗疾病时,须提出与推拿临床实践相应的治则治法,即在临床辨证的前提下提出相应治疗原则,施用相应推拿治法。其中治则是治疗疾病时须遵循的法则,是用以指导治疗方法的总则;而治法是在治则的指导下制定的治疗疾病的具体方法,它从属于治则,通常是多项治则联合多项治法同时使用。该文结合临床,阐述了于天源教授对推拿手法治疗神经根型颈椎病在临床辨证及治则治法的运用经验,在临床治疗中于天源教授运用推拿手法治疗神经根型颈椎病遵循以伤科辨证为主的原则,总结主要治则治法包括:强则松之、塞则通之、凝则动之、乱则复之、收则散之,并与同学科系列教材治疗本病的治则治法进行对比分析,强调推拿治疗需辨证论治,且以伤科辨证为主。

关键词：神经根型颈椎病于天源推拿辨证治则治法

Effect of pediatric tuina on hypothalamic metabolites in young rabbits using liquid chromatography-mass spectrometry

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 188-196页

作者： Zhifeng Liu Yi Jiao tianyuan yu Yingqi Zhang Di Liu Hourong Wang Yajing Xu Qian Guan Taotao Lv Jian Shu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Department of Acupuncture Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Shu Acupuncture Clinic FayettevilleNY13066USA

Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric ***: A total of 30 young rabbits were randomly assigned into three groups: the normal group, the model group, and the tuina group. Both the model group and the tuina group were injected intravenously with LPS. “Six antipyretic manipulations”(pushing Tianmen, pushing Kangong, kneading Taiyang,kneading Erhougaogu, clearing Tianheshui, and pushing Jizhu) were administered 1 h after the LPS injection in the tuina group. The rectal temperatures of the young rabbits were monitored during the experiment to explore the antipyretic effect. Three hours after the injection, the content of interleukin-1β(IL-1β), tumor necrosis factor(TNF)-a, and prostaglandin E;(PGE;) in the serum was detected. In addition, liquid chromatography-mass spectrometry(LC-MS) was used for the hypothalamus ***: Compared with the model group, the rectal temperature of the tuina group was decreased at 2 h and 3 h after the LPS injection(P =.04, P =.03, respectively), and the content of IL-1β, TNF-a, and PGE2was decreased(P =.03, P =.003, and P =.008, respectively). The metabolomics results showed that there were 23 potential biomarkers after the tuina intervention, enriching 27 pathways. Lipid metabolites,especially glycerophospholipids, were a majority of the altered metabolites. The primary metabolic pathways affected by tuina included the arachidonic acid metabolism, the GABAergic synapse, D-glutamine and D-glutamate metabolism, and the glutamatergic ***: Pediatric tuina reduced the temperature of the febrile rabbits and downregulated the expression of IL-1β, TNF-a, and PGE2, and the antipyretic mechanism may be related to changes in metabolites and metabolic pathways in the hypothalamus.

关键词： Fever Pediatric tuina Metabolomics Liquid chromatography coupled with mass spectrometry Hypothalamus Interleukin-1b Tumor necrosis factor-a Prostaglandin E_(2)

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论缺盆经脉交会及其临床意义

北京中医药大学学报 1999年第4期22卷 77-78页

作者：于天源北京中医药大学针灸推拿系

缺盆既是一个中医的解剖部位，也是一个穴位名称。作为解剖部位是指锁骨上窝，作为穴位定位于：锁骨上窝中点下缘，距前正中线４寸。本穴从古至今都认为是足阳明胃经的穴位。笔者认为缺盆穴处相交会的经脉、经别、经筋较多，应视其为交... 详细信息

缺盆既是一个中医的解剖部位，也是一个穴位名称。作为解剖部位是指锁骨上窝，作为穴位定位于：锁骨上窝中点下缘，距前正中线４寸。本穴从古至今都认为是足阳明胃经的穴位。笔者认为缺盆穴处相交会的经脉、经别、经筋较多，应视其为交会穴。其意义不是简单地增加一个交会...

关键词：针灸腧穴缺盆交会穴穴位

Applying RNA sequencing technology to explore repair mechanism of Tuina on gastrocnemius muscle in sciatic nerve injury rats

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Chinese Medical Journal 2022年第19期135卷 2378-2379页

作者： Taotao Lyu Zhifeng Liu tianyuan yu Mengqian Lu Yingqi Zhang Yi Jiao Hourong Wang Yajing Xu Qian Guan School of Acupuncture Moxibustion and TuinaBejing University of Chinese MedicineBeijing 100029China Tuina Research Center of Beijing University of Chinese Medicine Bejing 100029China

To the Editor:Peripheral nerve injury(PNI)refers to the injury of the peripheral nerve plexus,nerve trunk,or its branches undertheaction of *** muscle-derived cells servea strong secretory,function while they can differentiate into Schwann cell-like cells or other ceil types,so that it can,effectively promote regeneration'of peripheral *** some specific acupuncture points with mild mechanical stimulation on the surface can have a positive effect on nerve repair.2i Tuina helps relieve symptoms such as muscle spasms and pain caused by nerve *** are three points belonging to the Bladder meridian of foot Taiyang(BL)and the Gallbladder meridian of foot Shaoyang(GB),which usually are selected to carry out *** to the anatomical nerve position,Yinmen(BL37)is on the sciatic nerve trunk,Chengshan(BL57)is on the tibial nerve,and Yanglingquan(GB34)is on the common peroneal nerve;meanwhile,the three points are on the sciatic nerve or its *** three points are on the biceps femoris,gastrocnemius,and tibial anterior muscles.

关键词： meridian gastro acupuncture

基于局部敏感哈希算法和神经网络学习的跨媒体检索方法

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国防科技大学学报 2018年第1期40卷 93-98页

作者：白亮贾玉华王昊冉谢毓湘于天元国防科技大学系统工程学院湖南长沙410073

为了提高跨媒体检索的效率,可行的方法是降低数据集中不相关内容的比例。采用局部敏感哈希算法将图像数据映射到汉明空间并利用神经网络学习将文本数据映射到汉明空间的哈希函数,提出一种可以显著提高数据集中相关文件比例的高效跨媒体... 详细信息

为了提高跨媒体检索的效率,可行的方法是降低数据集中不相关内容的比例。采用局部敏感哈希算法将图像数据映射到汉明空间并利用神经网络学习将文本数据映射到汉明空间的哈希函数,提出一种可以显著提高数据集中相关文件比例的高效跨媒体检索方法。实验结果表明,提出的方法能够有效去除数据集中的不相关内容,相对于已有的跨媒体检索方法,其有效提高了检索效率与准确率。

关键词：跨媒体检索神经网络算法局部敏感哈希算法多模态数据索引

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小议住宅设计

黑龙江冶金 2014年第3期34卷 58-60页

作者：于天媛上海拓方建筑设计事务所上海200433

本文总结了现在居住小区规划设计及单体设计中遇到的一些问题及解决办法,对如何做好舒适、安全、经济的住宅设计为具有一定的参考价值。

关键词：住宅设计总体规划建筑风格成本控制

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初中物理教学中推理能力培养的实践研究构架

科教导刊 2021年第10期 149-151页

作者：俞天元甘肃省武威市凉州区中等职业专业学校甘肃式威733000

物理学是一门研究客观世界内在规律的学科,物理学比较抽象、深奥,与初中生的日常生活存在着一定的距离。因此,初中物理教师需要着重提升学生的抽象思维、培养学生的推理能力,继而引导学生掌握物理知识,切实提高学生的物理素养。本文将... 详细信息

物理学是一门研究客观世界内在规律的学科,物理学比较抽象、深奥,与初中生的日常生活存在着一定的距离。因此,初中物理教师需要着重提升学生的抽象思维、培养学生的推理能力,继而引导学生掌握物理知识,切实提高学生的物理素养。本文将就如何在初中物理教学中培养学生的推理能力展开研究,希望本文可以帮助各地、各初中学校的物理教师改善物理教学。

关键词：初中物理教学学生推理能力