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丹篓片联合阿托伐他汀钙片对痰瘀互结证稳定性心绞痛患者的临床疗效

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中成药 2024年第4期46卷 1168-1172页

作者：王梦豪张晓丹杨慰余思思蔡艳李家英上海中医药大学附属第七人民医院传统医学示范中心上海200137

目的考察丹篓片联合阿托伐他汀钙片对痰瘀互结证稳定性心绞痛患者的临床疗效。方法 80例患者随机分为对照组和观察组,每组40例,对照组给予阿托伐他汀钙片,观察组在对照组基础上加用丹篓片,疗程8周。检测临床疗效、中医证候评分、血管... 详细信息

目的考察丹篓片联合阿托伐他汀钙片对痰瘀互结证稳定性心绞痛患者的临床疗效。方法 80例患者随机分为对照组和观察组,每组40例,对照组给予阿托伐他汀钙片,观察组在对照组基础上加用丹篓片,疗程8周。检测临床疗效、中医证候评分、血管内皮功能指标(NO、VEGF、ET-1)、血脂相关指标(TC、TG、HDL-C、LDL-C、脂蛋白a、ApoB/A1)、24 h动态心电图指标(缺血发作次数、最长持续时间、心脏缺血总负荷)、SAQ评分、安全性指标(AST、ALT、Scr、BUN)变化。结果观察组总有效率高于对照组(P0.05)。结论丹篓片联合阿托伐他汀钙片可安全有效地改善痰瘀互结证稳定性心绞痛患者心肌缺血程度、临床症状,调节血脂,减轻血管内皮损伤。

关键词：丹篓片阿托伐他汀钙片稳定性心绞痛痰瘀互结

轻度认知障碍进展为阿尔兹海默症风险因素的Meta分析

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实用临床医学（江西） 2024年第4期25卷 80-88页

作者：喻思思罗拯钟清玲江西中医药大学护理学院南昌大学第一附属医院神经内科南昌330004 南昌大学第一附属医院护理学院南昌330004

目的系统评价轻度认知障碍(MCI)进展为阿尔兹海默症(AD)的风险因素,为早期干预提供参考依据。方法计算机检索国内外6大数据库有关MCI患者进展为AD影响因素的文献,检索时间从建库至2022年12月,由2名研究者单独进行文献筛选及数据提取,采... 详细信息

目的系统评价轻度认知障碍(MCI)进展为阿尔兹海默症(AD)的风险因素,为早期干预提供参考依据。方法计算机检索国内外6大数据库有关MCI患者进展为AD影响因素的文献,检索时间从建库至2022年12月,由2名研究者单独进行文献筛选及数据提取,采用Stata SE12.0软件进行数据分析。结果最终纳入文献35篇,共10985例MCI患者,提取风险因素13个。Meta分析结果显示:MCI患者AD的患病率为32%,其中年龄(RR=1.07,95%CI:1.02~1.13)、性别(RR=1.50,95%CI:1.33~1.68)、抑郁(RR=1.23,95%CI:1.02~1.48)、高血压(RR=1.45,95%CI:1.04~2.03)、糖尿病(RR=1.92,95%CI:1.44~2.56)、脑血管疾病(RR=1.78,95%CI:1.18~2.69)、携带ApoE基因(RR=1.77,95%CI:1.56~2.01)是MCI进展为AD的危险因素(P<0.05)。结论MCI患者转化为AD的风险较高,且影响因素较多,应早期进行筛查与干预,以降低AD的发生率。

关键词：轻度认知障碍阿尔兹海默症风险因素 Meta分析

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Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： si-yu Tang Liang Zheng Xiao-Ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculatio... 详细信息

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|sions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

Weakly Compact Sets and Riesz Representation Theorem in Musielak Sequence Spaces

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Acta Mathematica sinica,English Series 2024年第2期40卷 467-484页

作者： Wan Zhong GONG si yu SHI Zhong Rui SHI Department of Mathematics Anhui Normal UniversityWuhu 241000P.R.China Smeal College of Business Pennsylvania State UniversityUniversity ParkPennsylwania 16802USA Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

In this work,we give some criteria of the weakly compact sets and a representation theorem of Riesz's type in Musielak sequence spaces using the ideas and techniques of sequence spaces and Musielak ***,as an immediate consequence of the criteria considered in this paper,the criteria of the weakly compact sets of Orlicz sequence spaces are deduced.

关键词： Compact set weak topology Banach space dual space Musielak sequence spaces

Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

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World Journal of Gastroenterology 2024年第5期30卷 512-515页

作者： Jun-Min Song si-yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of Gastroenterology by Zhou et *** authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease *** notable strengths,it is crucial to address potential ***,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with ***,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of *** cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 ***,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various ***,the impact of nonrandom exclusion on relapse outcomes should be carefully *** conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP *** foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological *** this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

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Journal of Iron and Steel Research International 2024年第2期31卷 488-500页

作者： Tao-long Xu si-han Guo Gong-zhen He Hao-yu Han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina sichuan East Gas Transmission Sales Center of sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel *** on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constant-temperature and constant-pressure relaxation were performed under NPT(the isothermal–isobaric)*** mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in *** addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics

Extreme value theory applied to the auroral electrojet indices

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Earth and Planetary Physics 2024年第2期8卷 375-381页

作者： si Chen Hong yuan Yong Wei Guang Yang FengZheng yu Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The study of extreme weather and space events has gained paramount importance in modern society owing to rapid advances in high *** and describing exceptional occurrences plays a crucial role in making decisive assessments of their potential impact on technical,economic,and social aspects in various *** research focuses on analyzing the hourly values of the auroral electrojet(AE)geomagnetic index from 1957 to 2019 by using the peak over threshold method in extreme value *** fitting the generalized Pareto distribution to extreme AE values,shape parameter indices were derived,revealing negative values that establish an upper bound for this time ***,it became evident that the AE values had reached a plateau,suggesting that extreme events exceeding the established upper limit are *** a result,although the need for diligent precautions to mitigate the consequences of such extreme events persists,surpassing the upper limit of AE values becomes increasingly *** is also possible to observe an aurora in the middle-and low-latitude regions during the maximum period of the AE index.

关键词： auroral electrojet indices extreme value theory extreme events

Analytical Solution and simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action

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China Ocean Engineering 2024年第1期38卷 54-67页

作者： WANG Pi-guang Lyu si-yu QU Yang ZHAO Mi DU Xiu-li State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of Tech-nologyBeijing 100124China

This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water *** governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible *** governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary *** analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite *** main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion *** added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering *** calculation results show that the simplified formulas are in good agreement with the analytical solutions.

关键词： earthquake hydrodynamic pressure truncated cylinder added mass simplified formula

Gut microbiota and female health

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World Journal of Gastroenterology 2024年第12期30卷 1655-1662页

作者： Meng-Yao Wang Li-Xuan Sang si-yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Endoscopic CenterEngineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological *** advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer *** this,there has been limited discussion on the underlying *** editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite *** focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.

关键词： Gut microbiota Female health Estrogen Polycystic ovarian syndrome Endometriosis