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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG yun HE Ying LU Xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG Xue Yong MA Hong Xia yu peng cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina Qingdao chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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基于激光雷达扫描的观览车摆角测量方法

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激光与红外 2024年第7期54卷 1045-1052页

作者：余鹏程熊芝董佳乐黄荔生胡诚湖北工业大学机械工程学院湖北武汉430068 湖北省现代制造质量工程重点实验室湖北武汉430068 江西省检验检测认证总院特种设备检验检测研究院江西南昌330029 江西省检验检测认证总院特种设备检验检测研究院鹰潭检测分院江西鹰潭335000

针对现有的倾角仪在测量大型观览车最大摆角时存在的安装复杂、测量效率低下问题,本文提出了一种结合特征滤波与投影转换的摆角测量方法。该方法综合使用激光雷达与监控相机的数据,实现对大型观览车摆角的非接触式精确测量。首先,通过... 详细信息

针对现有的倾角仪在测量大型观览车最大摆角时存在的安装复杂、测量效率低下问题,本文提出了一种结合特征滤波与投影转换的摆角测量方法。该方法综合使用激光雷达与监控相机的数据,实现对大型观览车摆角的非接触式精确测量。首先,通过方向特征滤波器选取摆臂部分的点云;接着,利用形状特征滤波器移除不规则形状的点云;然后,将这些点云投影至二维平面,并用最小二乘法拟合边缘直线来解算摆角。最后,通过等比例模型实验得到该方法角度测量平均误差绝对值为0.29°,最大误差绝对值为0.45°。实验结果表明,该方法能有效提升大型观览车摆角的测量效率并确保测量精度。

关键词：激光点云观览车特征滤波投影变换摆角测量

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基于GIS的合肥市中心城区医疗服务空间可达性研究

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河南城建学院学报 2024年第3期33卷 65-71,97页

作者：谢鹏黄云峰于鹏诚安徽理工大学土木建筑学院安徽淮南232001

城市医疗设施资源配置和卫生服务的均衡性对居民生活质量的提升至关重要。以合肥市中心城区为例,运用地理信息系统(GIS)技术,采用多种出行模式下的改进潜能模型法,结合基尼系数和四象限筛选等方法,对不同时间阈值下的城市医疗设施的可... 详细信息

城市医疗设施资源配置和卫生服务的均衡性对居民生活质量的提升至关重要。以合肥市中心城区为例,运用地理信息系统(GIS)技术,采用多种出行模式下的改进潜能模型法,结合基尼系数和四象限筛选等方法,对不同时间阈值下的城市医疗设施的可达性及均衡性进行综合评价,提出了优化合肥市中心城区医疗服务空间的建议。结果显示:合肥市中心城区医疗设施空间可达性差异明显,整体上呈现中心紧密、四周松散的空间特征;通过识别分析可达性较低的区域,建议改善杏林街道社区卫生服务中心,改善后可达性和服务效率明显提升。

关键词：医疗设施 GIS 改进潜能模型空间可达性优化选址

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数据驱动的公路典型风险场景聚类与特征分析

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科学技术与工程 2024年第8期24卷 3426-3433页

作者：胡伟超陈艳艳于鹏程于士杰牛世峰北京工业大学城市交通学院北京100124 公安部道路交通安全研究中心北京100062 长安大学汽车学院西安710064

为了明晰公路交通中典型风险场景,提高公路测试场景构建和公路安全分析的针对性和指导性。收集不同区域代表性省份5年约60000条公路交通事故数据作为数据源,筛选确定关键分类变量,分别针对7类典型公路路段和路口开展典型交通冲突形式聚... 详细信息

为了明晰公路交通中典型风险场景,提高公路测试场景构建和公路安全分析的针对性和指导性。收集不同区域代表性省份5年约60000条公路交通事故数据作为数据源,筛选确定关键分类变量,分别针对7类典型公路路段和路口开展典型交通冲突形式聚类分析,共获取16类典型风险场景,然后构建场景风险特征表征参数,针对典型风险场景的风险特征进行对比分析,进而深入分析道路和环境因素对场景事故数量和发生事故严重程度的影响特征。结果表明:路表情况、防护设施类型、交通信号方式、照明条件、天气和能见度等因素都对部分场景的风险度有较大影响,路面状况因素对场景风险度影响不大。

关键词：交通安全风险特征 K均值聚类公路典型风险场景

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A New Proof of Superclose of a Crouzeix-Raviart Type Finite Element for Second Order Elliptic Equation

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Chinese Quarterly Journal of Mathematics 2007年第4期22卷 627-632页

作者： peng yu-cheng SHI Dong-yang Department of Mathematics Xinyang Normal University Xinyang 464000 China Department of Mathematics Zhengzhou University Zhengzhou 450052 China

In this paper, a new proof of superclose of a Crouzeix-Raviart type finite element is given for second order elliptic boundary value problem by Bramble-Hilbert lemma on anisotropic meshes.

关键词： Crouzeix-Raviaxt type finite element superclose anisotropic meshes

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Permanent displacement models of earthquake-induced landslides considering near-fault pulse-like ground motions

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Journal of Mountain Science 2019年第6期16卷 1244-1265页

作者： ZHANG Ying-bin XIANG Chen-lin CHEN Yan-long cheng Qian-gong XIAO Li yu peng-cheng CHANG Zhi-wang Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining&TechnologyXuzhou 221116China Department of Geotechnical Engineering School of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China

The permanent displacement of seismic slopes can be regarded as an effective criterion for stability estimation. This paper studied the characteristics of permanent displacements induced by velocity pulse-like ground motions and developed an empirical model to readily evaluate the stability of seismic slopes in a near-fault region. We identified 264 velocity pulse-like ground motions from the Next Generation Attenuation(NGA) database using the latest improved energy-based approach. All selected ground motions were rotated to the orientation of the strongest observed pulse for considering the directivity of the pulse effect, so that the most dangerous condition for slopes was considered. The results show the velocity pulse-like ground motions have a much more significant effect on permanent displacement of slopes than non-pulse-like ground motions. A regression model based on a function of peak ground velocity(PGV), peak ground acceleration(PGA) and critical acceleration(ac), was generated. A significant difference was found by comparing the presented model with classical models from literatures. This model can be used to evaluate the seismic slope stability considering the effects of nearfault pulse-like characteristics.

关键词： Seismic slope Permanent displacement Pulse effect Earthquake-induced landslides Near-fault

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NUMERICAL RESEARCH ON WATER GUIDE BEARING OF HYDRO-GENERATOR UNIT USING FINITE VOLUME METHOD

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Journal of Hydrodynamics 2007年第5期19卷 635-642页

作者： peng yu-cheng CHEN Xi-yang ZHANG Ke-wei HOU Guo-xiang School of Energy and Power. Engineering Huazhong University of Science and Technology Wuhan 430074 China School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

With the consideration of the geometry of tilting pad journal bearing, a new form of the Reynolds equation was derived in this article. The film thickness, the squeeze motion of the journal and the rotation motion of the pad were explicitly contained in the equation. Based on this equation, together with the equilibrium equation of pad pivot, the water guide bearing used in the Gezhouba 10 F hydro-generator unit was numerically researched. The new Reynolds equation for the lubricating film was solved using Finite Volume （FV） discretization, Successive Over-Relaxation （SOR） iteration method and C＋＋ code are included. According to the numerical solution, and the stability of the film and the influences of the film thickness, the journal squeeze effect and the pad rotation effect on film force were discussed. The results indicate that the squeeze effect can not be neglected, although the rotation effect is negligible for both low-speed and high-speed bearings, so the computing time could be greatly reduced.

关键词： hydro-generator unit Reynolds equation,tilting pad journal bearing Finite Volume (FV) method

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Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： Xing-yu Chen Lin cheng cheng-yang Hu yu-peng Zhang Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

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Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research International 2024年第6期31卷 1344-1354页

作者： peng-bo Liu Shu-sen cheng yu-qing Xue Xiao-man cheng Zhao Liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

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Multi-objective optimization and evaluation of supercritical CO_(2) Brayton cycle for nuclear power generation

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Nuclear Science and Techniques 2024年第2期35卷 183-209页

作者： Guo-peng yu Yong-Feng cheng Na Zhang Ping-Jian Ming Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle *** models of four Brayton cycle layouts are developed in this study for different reactors to reduce the cost and increase the thermohydraulic performance of nuclear power generation to promote the commercialization of nuclear *** analysis,multi-objective optimizations,and four decision-making methods are applied to obtain each Brayton scheme’s optimal thermohydraulic and economic *** show that for the same design thermal power scale of reactors,the higher the core’s exit temperature,the better the Brayton cycle’s thermo-economic *** the four-cycle layouts,the recompression cycle(RC)has the best overall performance,followed by the simple recuperation cycle(SR)and the intercooling cycle(IC),and the worst is the reheating cycle(RH).However,RH has the lowest total cost of investment(C_(tot))of$1619.85 million,and IC has the lowest levelized cost of energy(LCOE)of 0.012$/(kWh).The nuclear Brayton cycle system’s overall performance has been improved due to *** performance of the molten salt reactor combined with the intercooling cycle(MSR-IC)scheme has the greatest improvement,with the net output power(W_(net)),thermal efficiencyη_(t),and exergy efficiency(η_(e))improved by 8.58%,8.58%,and 11.21%,*** performance of the lead-cooled fast reactor combined with the simple recuperation cycle scheme was optimized to increase C_(tot) by 27.78%.In comparison,the internal rate of return(IRR)increased by only 7.8%,which is not friendly to investors with limited *** the nuclear Brayton cycle,the molten salt reactor combined with the recompression cycle scheme should receive priority,and the gas-cooled fast reactor combined with the reheating cycle scheme should be considered carefully.

关键词： Supercritical CO_(2)Brayton cycle Nuclear power generation Thermo-economic analysis Multi-objective optimization Decision-making methods

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