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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang wei chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen huirun chen Jinhui chen Ji-yuan chen Kai chen Mali chen mingjun chen mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen ying chen yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue deng wei-Tian deng Zhi deng Ziyan deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

A comparison of stellar atmospheric parameters from the LAMOST and APOGEE datasets

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Research in Astronomy and Astrophysics 2015年第8期15卷 1125-1136页

作者： yu-qin chen Gang Zhao chao Liu Jing Ren yun-Peng Jia Jing-Kun Zhao A-Li Luo yue Wu Yong Zhang Yong-hui Hou yue-Fei wang ming yang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

We have compared stellar parameters, including temperature, gravity and metallicity, for common stars in the LAMOST DR2 and SDSS DR12/APOGEE datasets. It is found that the LAMOST dataset provides a more well-defined red clump feature than the APOGEE dataset in the Teff versus log g diagram. With this advantage, we have separated red clump stars from red giant stars, and attempt to establish calibrations between the two datasets for the two groups of stars. The results show that there is a good consistency in temperature with a calibration close to the one-to-one line, and we can establish a satisfactory metallicity calibration of[Fe/H]APOGEE= 1.18[Fe/H]LAMOST ＋ 0.11 with a scatter of ～ 0.08 dex for both the red clump and red giant branch samples. For gravity, there is no correlation for red clump stars between the two datasets, and scatters around the calibrations of red giant stars are substantial. We found two main sources of scatter in log g for red giant stars. One is a group of stars with 0.00253 × Teff- 8.67 〈 log g 〈 2.6 located in the forbidden region, and the other is the contaminated red clump stars, which could be picked out from the unmatched region where stellar metallicity is not consistent with position in the Teff versus log g diagram. After excluding stars in these two regions,we have established two calibrations for red giant stars, log g APOGEE = 0.000615 ×Teff,LAMOST＋ 0.697 × log g LAMOST- 2.208（σ = 0.150） for [Fe/H] 〉-1 and log gAPOGEE= 0.000874×Teff,LAMOST＋0.588×log g LAMOST-3.117（σ = 0.167）for [Fe/H] 〈-1. The calibrations are valid for stars with Teff = 3800- 5400 K and log g = 0- 3.8 dex, and are useful in work aiming to combine the LAMOST and APOGEE datasets in a future study. In addition, we find that an SVM method based on asteroseismic log g is a good way to greatly improve the accuracy of gravity for these two regions, at least in the LAMOST dataset.

关键词： stars: late type—stars: fundamental parameters—stars: atmospheres—stars: abundances

Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer

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World Journal of Gastroenterology 2017年第11期23卷 2012-2022页

作者： yu-qin Sun Jian-wei Xie Hong-Teng Xie Peng-chen chen Xiu-Li Zhang chao-hui Zheng Ping Li Jia-Bin wang Jian-Xian Lin Long-Long Cao Chang-ming Huang yao Lin College of Life Sciences Fujian Normal University Department of Gastric Surgery Fujian Medical University Union Hospital

AIM To evaluate the predictive value of the expression of chromosomal maintenance(CRM)1 and cyclindependent kinase(CDK)5 in gastric cancer(GC) patients after *** A total of 240 GC patients who received standard gastrectomy were enrolled in the study. The expression level of CRM1 and CDK5 was detected by immunohistochemistry. The correlations between CRM1 and CDK5 expression and clinicopathological factors were explored. Univariate and multivariate survival analyses were used to identify prognostic factors for GC. Receiver operating characteristic analysis was used to compare the accuracy of the prediction of clinical outcome by the parameters. RESULTS The expression of CRM1 was significantly related to size of primary tumor(P = 0.005), Borrmann type(P = 0.006), degree of differentiation(P = 0.004), depth of invasion(P = 0.008), lymph node metastasis(P = 0.013), TNM stage(P = 0.002) and distant metastasis(P = 0.015). The expression of CDK5 was significantly related to sex(P = 0.048) and Lauren's classification(P = 0.011). Multivariate Cox regression analysis identified that CRM1 and CDK5 co-expression status was an independent prognostic factor for overall survival(OS) of patients with GC. Integration of CRM1 and CDK5 expression could provide additional prognostic value for OS compared with CRM1 or CDK5 expression alone(P = 0.001).CONCLUSION CRM1 and CDK5 co-expression was an independent prognostic factors for GC. Combined CRM1 and CDK5 expression could provide a prognostic model for OS of GC.

关键词： Gastric cancer CRM1 CDK5 Prognosis

Traditional Chinese medicine nursing protocols for COVID-19

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Journal of Integrative Nursing 2020年第2期2卷 40-49页

作者： Mei‑Zhen LIN Qiao‑Mei WU yu LIU Zhong‑De ZHANG Gang‑Yi PENG Chang‑Xiu WAN Xiao‑Pan wang ying‑Rui MA Ping XIONG hui‑chao chen Qiu‑ying deng Li‑Li deng Ding‑Rong QIU Lin wei Jiu‑Hong YOU yang‑chen LIU Guang‑qing ZHANG Li‑Xia KOU ming‑ming XU yu‑Mei chen yin‑qin ZHONG Xiao‑qin LU Han‑Jiao LIU Jin ZHOU Hong YE Xiao‑Zhen GONG Shi‑Miao LUO Xi‑yan HU Nursing Department Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouChina Hospital Office Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouChina Health Commission of Guangdong Province GuangzhouChina Nursing Department Hubei Provincial Hospital of Traditional Chinese MedicineWuhanChina Nursing Department Hubei Provincial Hospital of Integrated Traditional Chinese and Western MedicineWuhanChina Nursing Department Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyangChina Nursing Department Nanchang Ninth HospitalNanchangChina Hospital Office Nursing DepartmentSouthern Hospital of Southern Medical UniversityGuangzhouChina Nursing Department Guangdong Provincial Second Traditional Chinese Medicine HospitalGuangzhouChina Nursing Department Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Nursing Department Foshan Traditional Chinese Medicine HospitalFoshanChina Nursing Department Shenzhen Hospital of Guangzhou University of Traditional Chinese MedicineShenzhenChina Nursing Department Dongguan Traditional Chinese Medicine HospitalDongguanChina Nursing Department Shenzhen Bao’an Traditional Chinese Medicine HospitalShenzhenChina Nursing Department Southern Medical University Hospital of Integrated Traditional Chinese and Western MedicineGuangzhouChina

In order to facilitate nurses to understand the key points of COVID‑19’s common syndromes,master the key points of nursing with syndrome differentiation,use the advantages of traditional Chinese medicine(TCM)nursing characteristics,standardize TCM nursing behavior,and improve the TCM nursing effect,through the search of relevant information,combined with the clinical practice experience of more than 1 month of front‑line anti‑epidemic nursing staff,the TCM nursing protocols for COVID‑19(draft)were *** four rounds of expert consultation and discussion,and 15 times of collation and revision,the final version of TCM nursing protocols for COVID‑19 was *** TCM nursing protocols for COVID‑19 include the following five parts:key points of common syndromes,nursing for common symptoms/syndromes,TCM special nursing,healthy guidance,and difficulties in nursing;it is scientific and practical,and can provide clinical guidance for nursing of patients with COVID‑19.

关键词： COVID-19 nursing protocol traditional Chinese medicine

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai deng Xiao-wei Liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan chen Jian-Jun chen Kun-Xin chen Li chen Xue-Lei chen Xiao-yan chen ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li yan Li yin-Bi Li Ye-Ping Li yuan liang Chien-cheng Lin chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu yu Luo yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-yin Shen Huo-ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-qing wang Xia wang ya-Nan wang You wang yue-Fei wang You-Fen wang Peng wei ming-Zhi wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang hui-qin yang ming yang Zheng-Qiu yao Yong yu hui yuan Hai-Bo yuan Hai-Long yuan wei-Min yuan chao Zhai En-Peng Zhang Hua-wei Zhang Jian-Nan Zhang Li-Pin Zhang wei Zhang Yong Zhang yan-Xia Zhang Zheng-chao Zhang ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： ling-Long Tang yu-Pei chen Chuan-Ben chen ming-yuan chen Nian-Yong chen Xiao-Zhong chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He chao-Su Hu De-sheng Hu Guang-yuan Hu Hao Jiang wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong qin liang-Fang Shen ying Sun Pei-Guo wang Ren-Sheng wang Ruo-Zheng wang Xiao-Shen wang ying wang hui Wu yun-Fei Xia Shao-Wen Xiao Kun-yu yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China Department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li wei Dong yu-Qi Liu yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin chen yang-Gan wang Hai-Rong wang qin yu Jing He Yi-Lin Mao Xiao-Fang Bin yue deng yu-Dan Tian qing-Hua Han Da-Jin Liu Li-qin Duan ming-Jun Zhao Cui-ying Zhang Hai-ying Dai Ze-Hua Li ying Xiao You-Zhi Hu Xiao-yu Huang Kun Xing Xin Jiang chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang ying yang yao-Rong Dong Lei Zhang Guang Fu ying Li Shu-wei Huang Li-Ping Dou Lan-Jun Sun ying-Qiang Zhao Jie Li yun Xia Jun Liu Fan Liu Wen-Jin He ying Li Jian-Cong Tan yang Lin ya-Bin Zhou Jian-Fei yang Guo-qing Ma hui-Jun chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin ya-Nan yu Hai-Xia dang Bing Li Fei Teng wang-Min Qiao Xiao-Long Zhu Bing-wei chen Qi-Guang chen Chun-Ti Shen Yong-yan wang yun-Dai chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates

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Virologica Sinica 2021年第5期36卷 879-889页

作者： yan-Feng yao Ze-Jun wang Ren-Di Jiang Xue Hu Hua-Jun Zhang Yi-Wu Zhou Ge Gao ying chen yun Peng Mei-qin Liu ya-Nan Zhang Juan Min Jia Lu Xiao-Xiao Gao Jing Guo cheng Peng Xu-Rui Shen Qian Li Kai Zhao lian yang Xin Wan Bo Zhang Wen-hui wang Jia Wu Peng Zhou Xing-Lou yang Shuo Shen chao Shan Zhi-ming yuan Zheng-Li Shi Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of Biological Products Co.Ltd Jiangxia DistrictWuhan 430024China University of Chinese Academy of Sciences Beijing 100049China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430074China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so ***,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative *** is the most effective approach to eradicate a *** tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human *** we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human *** data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested *** addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in *** results warranted positive outcomes in future clinical trials in humans.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Inactivated vaccine Transgenic mouse Non-human primate

Quantum interference with independent single-photon sources over 300 km fiber

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Advanced Photonics 2022年第6期4卷 64-70页

作者： Xiang You ming-yang Zheng Si chen Run-Ze Liu Jian qin Mo-Chi Xu Zheng-Xuan Ge Tung-Hsun Chung yu-Kun Qiao yang-Fan Jiang Han-Sen Zhong ming-cheng chen hui wang yu-ming He Xiu-Ping Xie Hao Li Li-Xing You Christian Schneider Juan yin Teng-yun chen Mohamed Benyouce Yong-Heng Huo Sven Höfling Qiang Zhang chao-yang Lu Jian-wei Pan University of Science and Technology of China School of Cyberspace SecurityHefeiChina University of Science and Technology of China Hefei National Laboratory for Physical Sciences at MicroscaleDepartment of Modern PhysicsHefeiChina University of Science and Technology of China CAS Centre for Excellence in Quantum Information and Quantum PhysicsShanghaiChina Jinan Institute of Quantum Technology JinanChina Chinese Academy of Sciences Shanghai Institute of Microsystem and Information Technology(SIMIT)State Key Laboratory of Functional Materials for InformaticsShanghaiChina Universitat Würzburg Technische PhysikPhysikalisches Instität and Wilhelm Conrad Röntgen-Center for Complex Material SystemsWürzburgGermany University of Oldenburg Institute of PhysicsOldenburgGermany University of Kassel Institute of Nanostructure Technologies and AnalyticsCINSaTKasselGermany Nyu-ECNU Institute of Physics at Nyu Shanghai ShanghaiChina

In the quest to realize a scalable quantum network,semiconductor quantum dots(QDs)offer distinct advantages,including high single-photon efficiency and indistinguishability,high repetition rate(tens of gigahertz with Purcell enhancement),interconnectivity with spin qubits,and a scalable on-chip ***,in the past two decades,the visibility of quantum interference between independent QDs rarely went beyond the classical limit of 50%,and the distances were limited from a few meters to ***,we report quantum interference between two single photons from independent QDs separated by a 302 km optical *** single photons are generated from resonantly driven single QDs deterministically coupled to *** frequency conversions are used to eliminate the QD inhomogeneity and shift the emission wavelength to the telecommunication *** observed interference visibility is 0.670.02(0.930.04)without(with)temporal *** improvements can further extend the distance to∼600 *** work represents a key step to long-distance solid-state quantum networks.

关键词： quantum networks quantum dots solid-state single-photon sources quantum frequency conversion quantum interference