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L-Type Calcium Channel Modulates Low-Intensity Pulsed Ultrasound-Induced Excitation in Cultured Hippocampal Neurons

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Neuroscience Bulletin 2024年第7期40卷 921-936页

作者： Wen-Yong Fan Yi-ming chen Yi-Fan Wang yu-qi Wang Jia-qi Hu Wen-Xu Tang Yi Feng qian cheng Lei xue State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain science Fudan UniversityShanghai 200433China Department of Physiology and Neurobiology School of Life SciencesFudan UniversityShanghai 200438China Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji UniversityShanghai 200070China Center for Rehabilitation Medicine Department of Pain ManagementZhejiang Provincial People's HospitalAffliated People's HospitalHangzhou Medical CollegeHangzhou 310014China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Shanghai Research Institute for Intelligent Autonomous systems Tongji UniversityShanghai 201210China Research Institute of Intelligent Complex systems Fudan UniversityShanghai 200433China

As a noninvasive technique,ultrasound stimulation is known to modulate neuronal activity both in vitro and in *** latest explanation of this phenomenon is that the acoustic wave can activate the ion channels and further impact the electrophysiological properties of targeted ***,the underlying mechanism of low-intensity pulsed ultrasound(LIPUS)-induced neuro-modulation effects is still ***,we characterize the excitatory effects of LIPUS on spontaneous activity and the intracellular Ca^(2+)homeostasis in cultured hippocampal *** whole-cell patch clamp recording,we found that 15 min of 1-MHz LIPUS boosts the frequency of both spontaneous action potentials and spontaneous excitatory synaptic currents(sEPSCs)and also increases the amplitude of sEPSCs in hippocampal *** phenomenon lasts for>10 min after LIPUS *** with Ca^(2+)imaging,we clarified that LIPUS increases the[Ca^(2+)]cyto level by facilitating L-type Ca^(2+)channels(LTCCs).In addition,due to the[Ca^(2+)]cyto elevation by LIPUS exposure,the Ca^(2+)-dependent CaMKII-CREB pathway can be activated within 30 min to further regulate the gene transcription and protein *** work suggests that LIPUS regulates neuronal activity in a Ca^(2+)-dependent manner via *** may also explain the multi-activation effects of LIPUS beyond *** stimulation potentiates spontaneous neuronal activity by increasing Ca^(2+)influx.

关键词： Low-intensity pulsed ultrasound Neuromodulation L-type calcium channel Hippocampal neuron

Enhanced carbon capture with motif-rich amino acid loaded defective robust metal-organic frameworks

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Nano Research 2024年第3期17卷 2004-2010页

作者： qi-Ye Ju Jia-Jia Zheng Li Xu Hai-Yan Jiang Zi-qian xue Lu Bai Yang-Yang Guo ming-Shui Yao Ting-yu Zhu State Key Laboratory of Multi-phase Complex systems CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100190China School of Rare Earths University of Science and Technology of ChinaHefei 230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China Institute for Integrated Cell-Material sciences Kyoto UniversityInstitute for Advanced StudyKyoto UniversityYoshidaUshinomiya-choSakyokuKyoto 606-8501Japan

The use of metal-organic frameworks(MOFs)as solid adsorption materials for carbon capture is promising,but achieving efficient and reversible adsorption with a balance of capacity and selectivity for carbon dioxide(CO_(2))over N_(2) remains a *** take full advantage of the strong channel traffic and robustness of MOFs with relatively small pores,it is highly necessary to employ a defect-engineering strategy to construct a broader channel structure that can facilitate the loading of functional motif-rich amino acids(AAs).This strategy can greatly enhance the CO_(2) adsorption performance of *** this study,motif-rich amino acids are loaded into the defective and robust porous frameworks via combined defect-engineering and post-synthetic *** defective Zr/Hf-MOF-808s modified with AAs,especially for the 18 mol%4-nitroisophthalic acid,generated defective products allowing for the loading of L-serine(L-Ser).This modification resulted in a significant improvement in both the adsorption capacity(248%improvement at 298 K,100 kPa)and the selectivity of CO_(2)/N_(2) using the ideal adsorbed solution theory(IAST),with the selectivity increasing to 120.55 and 38.27 at 15 and 100 kPa,respectively,while maintaining good cycling *** functional theory(DFT)simulation,CO_(2) temperature-programmed desorption(CO_(2)-TPD),and in situ Fourier transform infrared spectroscopy(FTIR)were further employed to have a better understanding of the enhanced CO_(2) adsorption ***,unlike the AAs loaded pristine MOF-808s that showed the best CO_(2) adsorption capacity with the loading of short and small glycine(Gly),the broadened channel size in our work enables the loading of functional motif-rich L-serine,which brings more active binding sites,improving CO_(2) adsorption.

关键词： carbon capture and storage metal-organic framework(MOF) amino acids(AAs) defect-engineering motif-rich

Optical colorimetric LiTaO_(3)wafers for highprecision lithography on frequency control of SAW devices

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Photonics Research 2024年第2期12卷 341-349页

作者： ming hui FANG YINONG XIE FANGqi xue ZHILIN WU JUN SHI SHENG yu YANG YILIN LIU ZHIHUANG LIU HSIN CHI WANG FAJUN LI qiNG HUO LIU JINFENG ZHU School of Electronic science and engineering Xiamen UniversityXiamen 361005China Quanzhou San’an Integrated Circuit Co. Ltd.Quanzhou 362300China Eastern Institute of technology Ningbo 315200China

Surface acoustic wave(SAW)resonators based on lithium tantalate(LT,LiTaO_(3))wafers are crucial elements of mobile communication *** use of intrinsic LT wafers typically brings about low fabrication accuracy of SAW resonators due to strong UV reflection in the lithography *** hinders their resonance frequency control seriously in industrial *** doping and chemical reduction could be applied to decrease the UV reflection of LT wafers for high lithographic ***,conventional methods fail to provide a fast and nondestructive approach to identify the UV performance of standard single-side polished LT wafers for highprecision frequency ***,we propose a convenient on-line sensing scheme based on the colorimetry of reduced Fe-doped LT wafers and build up an automatic testing system for industrial *** levels of Fe doping and chemical reduction are evaluated by the lightness and color difference of LT-based *** correlation between the wafer visible colorimetry and UV reflection is established to refine the lithography process and specifically manipulate the frequency performance of SAW *** study provides a powerful tool for the fabrication control of SAW resonators and will inspire more applications on sophisticated devices of mobile communication.

关键词： lithography doping wafer

Preoperative serum cortisone levels are associated with cognition in preschool‑aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

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World Journal of Pediatrics 2024年第2期20卷 173-184页

作者： Si-yu Ma yu-Ting Liu yue-Shuang Cun qiang Wang ming-Cui Fu Ke-De Wu Xin-yu Cai Shu-Ting cheng Nishant Patel Min Da Liang Hu Zhuoga Deqin xue-Jun Kang ming Yang Xu-ming Mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Radiology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Key Laboratory of Child Development and Learning science Research Center For Learning ScienceSchool of Biological Sciences&Medical EngineeringMinistry of EducationSoutheast UniversityNanjing 210096China Medical School of Nanjing university Nanjing 210093China

Background Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart *** with TOF would be confronted with neurological impairment across their *** study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with *** We used mass spectrometry(MS)technology to assess the levels of serum metabolites,Wechsler preschool and primary scale of intelligence-Fourth edition(WPPSI-Ⅳ)index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging(MRI)to detect cortical morphological *** Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal ***,preoperative SpO_(2) was negatively correlated with levels of serum cortisone after adjusting for all ***,after intervening levels of cortisone in chronic hypoxic model mice,total brain volumes were reduced at both postnatal(P)11.5 and P30 *** Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with *** study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

关键词： Cognition Cortisone MRI Neurodevelopment Tetralogy of Fallot

Risk assessment of coastal flooding disaster by storm surge based on Elevation-Area method and hydrodynamic models:Taking Bohai Bay as an example

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china Geology 2024年第3期7卷 494-504页

作者： Fu Wang xue-zheng Liu Yong Li Heng yu ming-zheng Wen yun-zhuang Hu Tianjin Center(North china Center of Geoscience Innovation) China Geological SurveyTianjin 300170China Key Laboratory of Coast Geo-Environment China Geological SurveyTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China Hebei university of Environmental engineering Qinhuangdao 066102China Hebei engineering Research Center for Ecological Restoration of seaward Rivers and Coastal Waters Qinhuangdao 066102China Department of Earth and Environment Boston UniversityBoston 02215USA

The future inundation by storm surge on coastal areas are currently *** increasing global sealevel due to climate change,the coastal flooding by storm surge is more and more frequently,especially in coastal lowland with land ***,the risk assessment of such inundation for these areas is of great significance for the sustainable socio-economic *** this paper,the authors use Elevation-Area method and Regional Ocean Model System(ROMS)model to assess the risk of the inundation of Bohai Bay by storm *** simulation results of Elevation-Area method show that either a 50-year or 100-year storm surge can inundate coastal areas exceeding 8000 km^(2);the numerical simulation results based on hydrodynamics,considering ground friction and duration of the storm surge high water,show that a 50-year or 100-year storm surge can only inundate an area of over 2000 km^(2),which is far less than 8000 km^(2);while,when taking into account the land subsidence and sea level rise,the very inundation range will rapidly increase by 2050 and *** storm surge will greatly impact the coastal area within about 10-30 km of the Bohai Bay,in where almost all major coastal projects are *** prompt response to flood disaster due to storm surge is urgently needed,for which five suggestions have been proposed based on the geological background of Bohai *** study may offer insight into the development of the response and adaptive plans for flooding disasters caused by storm surge.

关键词： Storm surge ROMS Elevation-Area method Numerical simulation Land subsidence Flooding disaster Sea level rise Marine geological survey engineering Geological disaster survey engineering Bohai Bay

Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

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Journal of Central South university 2024年第7期31卷 2467-2487页

作者： JIANG Bei WANG ming-zi WANG qi XIN Zhong-xin XING xue-yang DENG yu-song YAO Liang-di State Key Laboratory for Tunnel engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural engineering Shandong UniversityJi􀆳nan 250061China College of Civil engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,china.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour

Observation of spectral lines in the exceptional GRB 221009A

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science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-qiu Zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-chen xue Chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu Wang ming-yu Ge Shu-Xu Yi Li-ming Song Zheng-Hua An Ce Cai Xin-qiao Li Wen-Xi Peng Wen-Jun Tan chen-Wei Wang Xiang-Yang Wen yue Wang Shuo Xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Beijing 100049China yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

Design of tightly linked dual ring antenna and imaging of magnetic field distribution using a diamond fiber probe

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Chinese Physics B 2024年第2期33卷 347-352页

作者：叶青云薛雅文何飞越赵旭彤卞雨辰卢文韬王金旭陈鸿浩夏圣开曾明菁杜关祥 College of Telecommunications and Information engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of science Nanjing University of Posts and TelecommunicationsNanjing 210003China School of Computer science Nanjing University of Posts and TelecommunicationsNanjing 210023China Bell Honors School Nanjing University of Posts and TelecommunicationsNanjing 210023China

A tightly linked dual ring antenna is designed,and it is specifically tailored for uniformly coupling the microwave magnetic field to the nitrogen-vacancy(NV)*** designed antenna operates at a center frequency of about 2.87 GHz,with a bandwidth of around 200 MHz,allowing it to address multiple resonance peaks in the optically detected magnetic resonance(ODMR)spectrum in an external magnetic ***,the antenna generates a fairly uniform magnetic field in a range with a radius of 0.75 *** resolution imaging of the magnetic field distribution on the surface of the antenna is conducted by using a fiber diamond *** also investigate the effect of magnetic field uniformity on the linewidth of ODMR,so as to provide insights into reducing the inhomogeneous broadening of ODMR.

关键词： nitrogen vacancy(NV) microwave(MW)imaging inhomogeneous broadening

Multifunctional catalytic sites regulation of atomic-scale iridium on orthorhombic-CoSe_(2)for high efficiency dual-functional alkaline hydrogen evolution and organic degradation

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Journal of Energy Chemistry 2024年第5期92卷 271-281页

作者： Jingjing Huang chenglin Zhong Yanjie Xia Jia Liu Guizhen Li Chao Yang Jiahong Wang qian Wang Zhenbao Zhang Feng Yan Jianghua Wu yu Deng Zhenjiang Zhou Xingchen He Paul K.Chu Woon-ming Lau xue-Feng yu College of Chemistry and Chemical engineering Linyi UniversityLinyi 276005ShandongChina Shenzhen engineering Center for the Fabrication of Two-Dimensional Atomic Crystals Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093JiangsuChina College of Biosystems engineering and Food science Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

The earth-abundant and high-performance catalysts are crucial for commercial implementation of hydrogen evolution reaction(HER).Herein,a multifunctional site strategy to construct excellent HER catalysts by incorporating iridium(Ir)ions on the atomic scale into orthorhombic-CoSe2(Ir-CoSe_(2))was *** hydrogen evolution activity in alkaline media such as a low overpotential of 48.7 mV at a current density of 10 mA cm^(-2)and better performance than commercial Pt/C catalysts at high current densities were found in the Ir-CoSe_(2) *** the experiments and theoretical calculations,it was revealed that Ir enabled CoSe_(2)to form multifunctional sites to synergistically catalyze alkaline HER by promoting the adsorption and dissociation of H_(2)O(Ir sites)and optimizing the binding energy for H^(*)on Co *** was noticeable that the electrolytic system comprising the Ir-CoSe_(2)electrode not only produced hydrogen efficiently via HER,but also degraded organic pollutants(Methylene blue).The cell voltage of the dual-function electrolytic system was 1.58 V at the benchmark current density of 50 mA cm^(-2),which was significantly lower than the conventional water splitting *** was indicated that this method was a novel strategy for designing advanced HER electrocatalysts by constructing multifunctional catalytic sites for hydrogen production and organic degradation.

关键词： Orthorhombic-CoSe_(2) Multifunctional sites design Hydrogen evolution reaction Synergistically catalyze Methylene blue oxidation