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A Spatiotemporal Interactive Processing Bias Correction Method for Operational Ocean Wave Forecasts

Journal of Ocean University of China 2022年第2期21卷 277-290页

作者： AI Bo yu mengchao GUO Jingtian ZHANG Wei JIANG Tao LIU Aichao WEN Lianjie LI Wenbo College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China North China Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266100China 391033 Troops People’s Liberation Army of ChinaQingdao 266000China

Numerical models and correct predictions are important for marine forecasting,but the forecasting results are often unable to satisfy the requirements of operational wave forecasting.Because bias between the predictions of numerical models and the actual sea state has been observed,predictions can only be released after correction by forecasters.This paper proposes a spati-otemporal interactive processing bias correction method to correct numerical prediction fields applied to the production and release of operational ocean wave forecasting products.The proposed method combines the advantages of numerical models and Forecast Discussion;specifically,it integrates subjective and objective information to achieve interactive spatiotemporal correc-tions for numerical prediction.The method corrects the single-time numerical prediction field in space by spatial interpolation and sub-zone numerical analyses using numerical model grid data in combination with real-time observations and the artificial judg-ment of forecasters to achieve numerical prediction accuracy.The difference between the original numerical prediction field and the spatial correction field is interpolated to an adjacent time series by successive correction analysis,thereby achieving highly efficient correction for multi-time forecasting fields.In this paper,the significant wave height forecasts from the European Centre for Medium-Range Weather Forecasts are used as background field for forecasting correction and analysis.Results indicate that the proposed method has good application potential for the bias correction of numerical predictions under different sea states.The method takes into account spatial correlations for the numerical prediction field and the time series development of the numerical model to correct numerical predictions efficiently.

关键词： numerical models ocean wave forecasts spatial interpolation time series interpolation successive correction

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NIPS法疏水PVDF膜的结构与性能调控研究进展

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膜科学与技术 2024年第1期44卷 147-156,178页

作者：徐小洁于孟超王钰王涛冯英楠赵之平北京理工大学化学与化工学院北京102488

非溶剂致相分离法(NIPS)是制备多孔有机膜一种高效工艺手段,其过程中涉及的热力学与动力学因素对于疏水多孔膜的成膜结构与性质起着至关重要的决定性作用.为此,本文以常用疏水膜制备原材料聚偏氟乙烯(PVDF)为研究对象,系统阐述采用传统... 详细信息

非溶剂致相分离法(NIPS)是制备多孔有机膜一种高效工艺手段,其过程中涉及的热力学与动力学因素对于疏水多孔膜的成膜结构与性质起着至关重要的决定性作用.为此,本文以常用疏水膜制备原材料聚偏氟乙烯(PVDF)为研究对象,系统阐述采用传统浸没沉淀相转化法和新兴喷雾辅助相转化法两种NIPS制膜工艺路线对PVDF疏水膜微纳结构的影响及其内在成膜机理,旨在通过明晰制膜过程中影响因素对成膜疏水性、孔结构参数的作用规律,为疏水膜的可控制备提供理论指导与技术支持.

关键词：疏水有机膜非溶剂致相转化法喷雾辅助相转化法膜蒸馏

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幽门螺杆菌毒力因子CagA的基因表达调控机制研究进展

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医学分子生物学杂志 2024年第2期21卷 171-175页

作者：王萌萌余梦超王莉莉赵振宇董全江青岛市市立医院中心实验室山东省青岛市266000 山东第二医科大学临床医学院山东省潍坊市261000 大连医科大学研究生院辽宁省大连市116000

全球约有一半人口感染了幽门螺杆菌(Helicobacter pylori,H.pylori),特别是发展中国家的感染率极高。目前,幽门螺杆菌感染已被列为胃癌发生的高危因素。幽门螺杆菌感染的致病机制被认为与环境因素、宿主易感性和细菌毒力等因素之间复杂... 详细信息

全球约有一半人口感染了幽门螺杆菌(Helicobacter pylori,H.pylori),特别是发展中国家的感染率极高。目前,幽门螺杆菌感染已被列为胃癌发生的高危因素。幽门螺杆菌感染的致病机制被认为与环境因素、宿主易感性和细菌毒力等因素之间复杂的相互作用有关。文章主要对幽门螺杆菌毒力因子细胞毒素相关基因(cytotoxin-associated gene A,cagA)表达调控的分子机制进行综述,以便更好地理解cagA的致病性,为今后预防和治疗由幽门螺杆菌所引起的疾病提供理论参考。

关键词：幽门螺杆菌 cagA 调控机制

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毒力基因序列变异对幽门螺杆菌毒力的影响

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胃肠病学和肝病学杂志 2024年第4期33卷 473-477页

作者：王萌萌梁淑贞余梦超王莉莉王啸宇董全江山东第二医科大学临床医学院山东潍坊261000 青岛市市立医院中心实验室

幽门螺杆菌(Helicobacter pylori,H.pylori)是一种常见细菌,H.pylori感染已经被证实为胃癌的高危因素。世界上约50%人口感染了H.pylori。然而,最终只有2%~3%的H.pylori感染者会患上胃癌。不同的疾病结局是由细菌、宿主和环境因素之间复... 详细信息

幽门螺杆菌(Helicobacter pylori,H.pylori)是一种常见细菌,H.pylori感染已经被证实为胃癌的高危因素。世界上约50%人口感染了H.pylori。然而,最终只有2%~3%的H.pylori感染者会患上胃癌。不同的疾病结局是由细菌、宿主和环境因素之间复杂的相互作用所介导的。过去20年里,通过对宿主和细菌因素的研究,提高了对H.pylori发病机制的认识。这些研究包括确定不同的毒力因子序列变异对H.pylori致病的影响及其与不同疾病结局的关联,特别是细菌黏附素、细胞毒素和空泡毒素等。

关键词：幽门螺杆菌毒力基因序列变异胃癌

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Cold-induced retrotransposition of fish LINEs

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Journal of Genetics and Genomics 2017年第8期44卷 385-394页

作者： Shue Chen mengchao yu Xu Chu Wenhao Li Xiujuan Yin Liangbiao Chen Key Laboratory of Aquaculture Resources and Utilization Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201206China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Classes of retrotransposons constitute a large portion of metazoan genome. There have been cases re- ported that genomic abundance of retrotransposons is correlated with the severity of low environmental temperatures. However, the molecular mechanisms underlying such correlation are unknown. We show here by cell transfection assays that retrotransposition （RTP） of a long interspersed nuclear element （LINE） from an Antarctic nototbenioid fish Dissostichus mawsoni （droLl） could be activated by low temperature exposure, causing increased dmLl copies in the host cell genome. The cold-induced droll propagation was demonstrated to be mediated by the mitogen-activated protein kinases （MAPK）]p38 signaling pathway, which is activated by accumulation of reactive oxygen species （ROS） in cold-stressed conditions. Surprisingly, droLl transfected cells showed an increase in the number of viable cells after prolonged cold exposures than non-transfected cells. Features of cold inducibility of dmLl were reca- pitulated in LINEs of zebrafish origin both in cultured cell lines and tissues, suggesting existence of a common cold-induced LINE amplification in fishes. The findings reveal an important function of LINEs in temperature adaptation and provid insights into the MAPK/p38 stress responsive pathway that shapes LINE composition in fishes facing cold stresses. Copyright 2017, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

关键词： RetrotransposonROSp38Cold adaptationLINE amplification

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Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li Kang Yang Chenpeng Xi mengchao Li Borong Li Gui Xu yuanbin Xiao Xiancai Cui Zhiliang Liu Lingyun Li Yan yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal batteries.In this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal anode.The polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional theory.The organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

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Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2017年第6期8卷 455-466页

作者： yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang mengchao yu Zhicong Liao Yong Zhou Chen-yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for Micro-RNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University Nanjing 210046 China The Second Department of Medical Oncology Linyi Tumor Hospital Linyi 276000 China Department of Cardio-Thoracic Surgery Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing Universityand Nanjing Multi-Center Biobank Nanjing 210008 China

MTUS1 （microtubule-associated tumor suppressor 1） has been identified that can function as a tumor sup- pressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b （miR-19a/b） promote prolifer- ation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell prolif- eration and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was experimentally affirmed by cell transfection assay and luciferase reporter assay. Finally, miR-19a/b were shown to cooperatively repress MTUS1 expression and synergistically regulate MTUS1 expression to pro- mote lung cancer cell proliferation and migration. In conclusion, our findings have provided the first cluesregarding the roles of miR-19a/b, which appear to func- tion as oncomirs in lung cancer by downregulating MTUSI.

关键词： microRNA MTUS1 miR-19a/b,lung cancer proliferation migration

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miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ

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Protein & Cell 2016年第10期7卷 722-734页

作者： Yanqing Liu Uzair-ur-Rehman yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu mengchao yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-yu Zhang Feng Zhi Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry for Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University 163 Xianlin Road Nanjing 210046 China Modern Medical Research Center Third Affiliated Hospital of Soochow University 185 Juqian Road Changzhou 213003 China Department of Gastrointestinal Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan Road Nanjing 210008 China

Programmed cell death 4 （PDCD4） is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer （CRC）. During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and conse- quently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken toge- ther, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.

关键词： microRNA colorectal cancer miR-181b,PDCD4

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基于多模型平差接力的长时序风暴增水预测方法

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海洋预报 2023年第2期40卷 32-44页

作者：杨彬艾波商杰刘清容于梦超山东科技大学测绘与空间信息学院山东青岛266590 自然资源部北海预报减灾中心山东青岛266061

利用神经网络模型预测未来风暴增水时,预测精度会随预测时序的延伸不断降低。基于长短期记忆(Long Short-Term Memory)神经网络模型,以风速、风向、气压和前时序的风暴增水数据作为模型输入,利用多个模型接力预测风暴增水时间序列,减小... 详细信息

利用神经网络模型预测未来风暴增水时,预测精度会随预测时序的延伸不断降低。基于长短期记忆(Long Short-Term Memory)神经网络模型,以风速、风向、气压和前时序的风暴增水数据作为模型输入,利用多个模型接力预测风暴增水时间序列,减小误差随模型的迭代累积,建立基于多模型平差接力的长时序风暴增水预测方法。对比不同地点和不同台风下的风暴增水预测分析结果,模型在渤黄海北部区域每月的均方根误差为4~7 cm,在黄海中部区域可控制在10 cm以内,能够较准确预测未来24 h的风暴增水。

关键词：风暴增水长短期记忆神经网络时间序列预测多模型平差接力

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连续流动分析法在某河挥发酚监测中的应用

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当代化工研究 2023年第8期 77-79页

作者：吴晴马添翼俞梦超江苏常睿环境科技有限公司江苏215500

本文采用流动注射法对河流流域不同剖面中的挥发性酚类物质进行测定,采用加标法、重复法、并行测定等质量控制手段,确保测定结果的可靠、准确。在对河道近几年来不同剖面挥发性物质进行研究的基础上,对该河水体中挥发性物质的变化特征... 详细信息

本文采用流动注射法对河流流域不同剖面中的挥发性酚类物质进行测定,采用加标法、重复法、并行测定等质量控制手段,确保测定结果的可靠、准确。在对河道近几年来不同剖面挥发性物质进行研究的基础上,对该河水体中挥发性物质的变化特征及其成因进行研究。

关键词：连续流动分析法某河挥发酚监测应用分析

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