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Fabrication and Evaluation of Porous Keratin/chitosan(KCS) Scaffolds for Effectively Accelerating Wound Healing

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Biomedical and Environmental Sciences 2015年第3期28卷 178-189页

作者： TAN Hong Bo WANG fu You DING Wei ZHANG Ying DING Jing CAI Di Xin yu kai fu YANG Jun YANG Liu XU Yong Qing Department of Orthopedics Kunming General Hospital of Chinese People's Liberation Army Center for Joint Surgery Southwest HospitalThe Third Military Medical University Department of Clinical Laboratory Kunming General HospitalChinese People's Liberation Army

Objective To develop a dressing with desired antibacterial activity, good water maintaining ability and mechanical properties for wound healing and skin regeneration. Methods The chitosan with different concentrations were added in keratin solution to form porous keratin/chitosan（KCS） scaffolds. The morphological characteristics, chemical composition, wettability, porosity, swelling ratio and degradation of the scaffolds were evaluated. The antibacterial activity was tested by using S. aureus and E. coli suspension for 2 h. And L929 fibroblast cells culture was used to evaluate the cytotoxicity of the KCS scaffolds. Results The adding of chitosan could increase the hydrophobicity, decrease porosity, swelling ratio and degradation rate of the KCS porous scaffolds. Mechanical properties of KCS scaffolds could be enhanced and well adjusted by chitosan. KCS scaffolds could obviously decrease bacteria number. The proliferation of fibroblast cells in porous KCS patch increased firstly and then decreased with the increase of chitosan concentration. It was appropriate to add 400 μg/m L chitosan to form porous KCS scaffold for achieving best cell attachment and proliferation compared with other samples. Conclusion The porous KCS scaffold may be used as implanted scaffold materials for promoting wound healing and skin regeneration.

关键词： Keratin Chitosan Porous scaffold Wound healing Skin regeneration

港铁车轮与60E1钢轨单向伸缩调节器的接触分析

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科技和产业 2021年第5期21卷 330-334页

作者：于开福中铁山桥集团有限公司河北秦皇岛066205

为了提升乘车体验以及运输效率,对钢轨一体化的要求逐渐提高。钢轨伸缩调节器技术的应用与发展在解决钢轨一体化中卓有成效,但调节器成为线路的薄弱环节,使铁路病害的发生概率增加,增大了铁路维护工作量。针对港铁车轮与钢轨单向伸缩调... 详细信息

为了提升乘车体验以及运输效率,对钢轨一体化的要求逐渐提高。钢轨伸缩调节器技术的应用与发展在解决钢轨一体化中卓有成效,但调节器成为线路的薄弱环节,使铁路病害的发生概率增加,增大了铁路维护工作量。针对港铁车轮与钢轨单向伸缩调节器的接触状况,利用软件建立港铁车轮与60E1钢轨单向伸缩调节器的三维接触有限元模型,并进行计算,分析不同轴重、横移量下的接触斑、等效应力等的变化情况。得出以下结论:在港铁车轮与60E1钢轨单向伸缩调节器的接触系统中,不同横移量时,接触斑变化较大,轴重越大接触斑面积越大;最大等效应力值集中分布在接触斑中心以下1~4 mm的钢轨内部,等效塑性应变分布规律与等效应力分布一致;最大等效应力与等效塑性应变随轴重的改变有相同的变化规律,即在对中位置和18 t轴重时拥有最大值,合理地安排轴重将有助于减缓轮轨的磨耗。

关键词：港铁车轮单向伸缩调节器有限元分析轮轨接触

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基于L1范数的特征提取算法研究

兰州文理学院学报（自然科学版） 2017年第5期31卷 83-88页

作者：谢玉凯卢桂馥安徽工程大学计算机与信息学院安徽芜湖241000

基于L1范数的特征提取算法因其识别率高的优点,使图像识别能力有了显著的提升,在图像识别领域有着重要的应用.本文对L1范数特征提取方法的发展历程进行了分析,讨论了基于L1范数PCA、LDA及它们对应的各种改进型的研究现状,通过人脸数据... 详细信息

基于L1范数的特征提取算法因其识别率高的优点,使图像识别能力有了显著的提升,在图像识别领域有着重要的应用.本文对L1范数特征提取方法的发展历程进行了分析,讨论了基于L1范数PCA、LDA及它们对应的各种改进型的研究现状,通过人脸数据库实验测试了相关L1范数算法的识别性能优劣.最后对各种方法的应用前景做了展望.

关键词：特征抽取图像识别 L1范数降维

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong fu Dian yu Jane Howe kaiwen Chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-yu Wang Ka Lu Ju-Song Yang fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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HPLC法同时测定强阳保肾丸中淫羊藿苷和补骨脂素的含量

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沈阳药科大学学报 2010年第7期27卷 555-558,569页

作者：葛洁于凯付永慧熊志立李发美沈阳药科大学药学院辽宁沈阳110016

目的建立HPLC法同时测定强阳保肾丸中淫羊藿苷和补骨脂素含量的方法。方法采用Phenomen kromasil C18色谱柱（250 mm×4.6 mm,5μm）,以乙腈-体积分数为0.05%的磷酸溶液（体积比为25∶75）进行等度洗脱,检测波长：270 nm,柱温：30℃,流... 详细信息

目的建立HPLC法同时测定强阳保肾丸中淫羊藿苷和补骨脂素含量的方法。方法采用Phenomen kromasil C18色谱柱（250 mm×4.6 mm,5μm）,以乙腈-体积分数为0.05%的磷酸溶液（体积比为25∶75）进行等度洗脱,检测波长：270 nm,柱温：30℃,流速：1.0 ***-1。结果淫羊藿苷质量浓度在0.509~20.400 mg.L-1（r=1.000）内、补骨脂素质量浓度在0.416~16.600 mg.L-1（r=0.9999）内与峰面积呈良好的线性关系;淫羊藿苷、补骨脂素的回收率分别为99.0%、101.0%,RSD分别为1.5%、1.6%。结论所建立的定量方法适用于强阳保肾丸中淫羊藿苷和补骨脂素的含量测定。

关键词：强阳保肾丸高效液相色谱法淫羊藿苷补骨脂素

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance