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鲤鱼汤对阿霉素肾病大鼠蛋白尿的影响

医学研究杂志 2011年第4期40卷 37-39页

作者：田小剑于俊生郭云良周晓彬吴慧马璇于春荣沈卫青岛大学医学院 266000 青岛大学附属海慈医院青岛大学医学院附属医院威海市文登中心医院

目的观察鲤鱼汤对阿霉素肾病大鼠蛋白尿的治疗作用。方法 SPF级Wistar大鼠50只,经尾静脉分两次注射阿霉素制备肾病综合征模型,检测大鼠阿霉素注射前1周、注射后每3天的12h尿蛋白排泄量并描绘尿蛋白排泄量变化曲线;实验结束后测定大鼠血... 详细信息

目的观察鲤鱼汤对阿霉素肾病大鼠蛋白尿的治疗作用。方法 SPF级Wistar大鼠50只,经尾静脉分两次注射阿霉素制备肾病综合征模型,检测大鼠阿霉素注射前1周、注射后每3天的12h尿蛋白排泄量并描绘尿蛋白排泄量变化曲线;实验结束后测定大鼠血清清蛋白(ALB)、总蛋白(TP)、三酰甘油(TG)、总胆固醇(TCHO)的水平并进行结果分析。结果与正常组比较,模型组12h尿蛋白排泄量、血脂水平明显升高;血清总蛋白、清蛋白水平明显降低。与模型组比较,各治疗组12h尿蛋白排泄量降低,血清清蛋白、总蛋白水平升高。结论鲤鱼汤能降低阿霉素肾病大鼠的尿蛋白排泄量,提高血清蛋白及总蛋白水平。

关键词：鲤鱼汤阿霉素肾病肾病综合征蛋白尿

A Consensus and Incentive Program for Charging Piles Based on Consortium Blockchain

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CSEE Journal of Power and Energy Systems 2018年第4期4卷 452-458页

作者： Qingsu He yu Xu Yong Yan junsheng Wang Qingzhi Han Lili Li State Grid Electronic Commerce Co. LTD.Beijing 100053China State Grid Zhejiang Electric Power Company Hangzhou 310007China

Charging piles are used for charging electric vehicles and are directly accessible to users in an energy internet entrance,while playing an important role in energy ***,each enterprise constructs the center of operation and maintenance of their systems independently,along with their respective APP payment *** results in high operating costs,poor user experience,and low utilization rate of the pile,which limits the promotion and popularization of electric *** overcome this limitation,there is a need for a multi-center,fair,and transparent consortium blockchain,which can conform to the application requirements of a unified payment system and accommodate a range of diverse enterprise charging *** this paper,the design for a consensus and incentive program for consortium blockchain is ***,the application status of blockchain in an energy internet is ***,the logical structure and hierarchical model of the consortium blockchain are ***,multicycle accounting and limiting the amount of accounting nodes in each round is presented to ensure the overhead of consensus remain ***,the accounting incentive mechanism and the bidding encouragement strategy based on“electric beans”are designed.

关键词： Charging pile consortium blockchain energy internet payment solution power profit bean

鲤鱼赤小豆汤对阿霉素肾病大鼠尿蛋白排泄量的影响

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临床医学工程 2011年第2期18卷 165-167页

作者：吴慧于俊生周晓彬郭云良田小剑刘琳沈卫青岛大学医学院山东青岛266021 青岛大学附属海慈医院山东青岛266021 洛阳市第一中医院河南洛阳471002

目的探讨鲤鱼赤小豆汤治疗肾病综合征的作用机制。方法成年健康Wistar大鼠50只,经大鼠尾静脉注射阿霉素制备肾病综合征模型,终点法检测实验大鼠阿霉素注射前1W、注射后每3d的12h尿蛋白排泄量,和治疗3W后血清总蛋白、白蛋白水平。结果鲤... 详细信息

目的探讨鲤鱼赤小豆汤治疗肾病综合征的作用机制。方法成年健康Wistar大鼠50只,经大鼠尾静脉注射阿霉素制备肾病综合征模型,终点法检测实验大鼠阿霉素注射前1W、注射后每3d的12h尿蛋白排泄量,和治疗3W后血清总蛋白、白蛋白水平。结果鲤鱼赤小豆汤组12h尿蛋白排泄量从第9天开始降低,与模型组比较有显著性差异(P<0.01);血清总蛋白和白蛋白水平升高,与模型组比较有显著性差异(P<0.05),鲤鱼赤小豆汤高剂量组显著优于福辛普利组(P<0.05)。结论鲤鱼赤小豆汤高剂量组可以降低肾病综合征模型大鼠尿蛋白排泄量,提高其血清总蛋白和白蛋白水平。

关键词：鲤鱼赤小豆汤阿霉素肾病肾病综合征尿蛋白排泄量

补肾排毒颗粒对维持性血透患者血清抵抗素水平的影响

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中国中医药科技 2016年第3期23卷 255-256页

作者：王福荣王丽华宋洁妮李平海李淑秀于俊生青岛市海慈医疗集团 91286部队门诊部

目的:探讨补肾排毒颗粒对维持性血透患者血清抵抗素水平的影响。方法:选择透析3个月以上的维持性血透患者90例,随机分为3组,常规透析组、补肾排毒颗粒组、立普妥组,每组30例;健康体检的20人作正常对照组。各组分别于服药前、服药4、8、1... 详细信息

目的:探讨补肾排毒颗粒对维持性血透患者血清抵抗素水平的影响。方法:选择透析3个月以上的维持性血透患者90例,随机分为3组,常规透析组、补肾排毒颗粒组、立普妥组,每组30例;健康体检的20人作正常对照组。各组分别于服药前、服药4、8、12 W后空腹采血,免疫比浊法测定血清抵抗素(resistin)水平。结果:各透析组患者治疗前血清抵抗素水平均明显高于正常健康组,差异具显著统计学意义(P0.05)。结论:补肾排毒颗粒可以明显改善维持性血透患者血清抵抗素水平。

关键词：肾透析 @补肾排毒颗粒 @血清抵抗素人类

Multi-phase-field simulation of austenite peritectic solidification based on a ferrite grain

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Chinese Physics B 2021年第1期30卷 572-577页

作者： Chao Yang Jing Wang junsheng Wang yu Liu Guomin Han Haifeng Song Houbing Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Software Center for High Performance Numerical Simulation China Academy of Engineering PhysicsBeijing 100088China

A multi-phase-field model is implemented to investigate the peritectic solidification of Fe-C alloy. The nucleation mode of austenite is based on the local driving force, and two different thicknesses of the primary austenite on the surface of the ferrite equiaxed crystal grain are used as the initial conditions. The simulation shows the multiple interactions of ferrite, austenite, and liquid phases, and the effects of carbon diffusion, which presents the non-equilibrium dynamic process during Fe-C peritectic solidification at the mesoscopic scale. This work not only reveals the influence of the austenite nucleation position, but also clarifies the formation mechanism of liquid phase channels and molten pools. Therefore, the present study contributes to the understanding of the micro-morphology and micro-segregation evolution mechanisms of Fe-C alloy during peritectic solidification.

关键词： multi-phase-field simulation morphology evolution peritectic solidification carbon diffusion Fe-C alloy

BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis

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Journal of Integrative Plant Biology 2022年第6期64卷 1264-1280页

作者： Jinping Deng Lingyao Kong Yinhua Zhu Dan Pei Xuexue Chen yu Wang junsheng Qi Chunpeng Song Shuhua Yang Zhizhong Gong State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China College of Life Sciences Qingdao UniversityQingdao 266071China Collaborative Innovation Center of Crop Stress Biology Institute of Plant Stress BiologyHenan UniversityKaifeng 475001HenanChina Institute of Life Science and Green Development School of Life SciencesHebei UniversityBaoding 071002China

The mechanisms that balance plant growth and stress responses are poorly understood, but they appear to involve abscisic acid(ABA) signaling mediated by protein kinases. Here, to explore these mechanisms, we examined the responses of Arabidopsis thaliana protein kinase mutants to ABA treatment. We found that mutants of BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1(BAK1) were hypersensitive to the effects of ABA on both seed germination and primary root growth. The kinase OPEN STOMATA 1(OST1) was more highly activated by ABA in bak1 mutant than the wild type. BAK1 was not activated by ABA treatment in the dominant negative mutant abi1-1 or the pyr1 pyl4 pyl5 pyl8 quadruple mutant, but it was more highly activated by this treatment in the abi1-2 abi2-2 hab1-1 loss-of-function triple mutant than the wild type. BAK1 phosphorylates OST1 T146 and inhibits its activity. Genetic analyses suggested that BAK1 acts at or upstream of core components in the ABA signaling pathway, including PYLs, PP2 Cs,and Sn RK2 s, during seed germination and primary root growth. Although the upstream brassinosteroid(BR) signaling components BAK1 and BR INSENSITIVE 1(BRI1) positively regulate ABAinduced stomatal closure, mutations affecting downstream components of BR signaling, including BRASSINOSTEROID-SIGNALING KINASEs(BSKs)and BRASSINOSTEROID-INSENSITIVE 2(BIN2), did not affect ABA-mediated stomatal movement. Thus,our study uncovered an important role of BAK1 in negatively regulating ABA signaling during seed germination and primary root growth, but positively modulating ABA-induced stomatal closure, thus optimizing the plant growth under drought stress.

关键词： abscisic acid BAK1 primary root growth stomatai closure

Arabidopsis U-box E3 ubiquitin ligase PUB11 negatively regulates drought tolerance by degrading the receptor-like protein kinases LRR1 and KIN7

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Journal of Integrative Plant Biology 2021年第3期63卷 494-509页

作者： Xuexue Chen Tingting Wang Amin Ur Rehman yu Wang junsheng Qi Zhen Li Chunpeng Song Baoshan Wang Shuhua Yang Zhizhong Gong State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Collaborative Innovation Center of Crop Stress Biology Institute of Plant Stress BiologyHenan UniversityKaifeng 475001China Key Lab of Plant Stress Research College of Life ScienceShandong Normal UniversityJi'nan 250000China School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 100193China

Both plant receptor-like protein kinases(RLKs)and ubiquitin-mediated proteolysis play crucial roles in plant responses to drought ***,the mechanism by which E3 ubiquitin ligases modulate RLKs is poorly *** this study,we showed that Arabidopsis PLANT U-BOX PROTEIN 11(PUB11),an E3 ubiquitin ligase,negatively regulates abscisic acid(ABA)-mediated drought ***11 interacts with and ubiquitinates two receptor-like protein kinases,LEUCINE RICH REPEAT PROTEIN 1(LRR1)and KINASE 7(KIN7),and mediates their degradation during plant responses to drought stress in vitro and in ***11 mutants were more tolerant,whereas Irr1 and kin7 mutants were more sensitive,to drought stress than the wild *** analyses show that the pub11 Irr1 kin7 triple mutant exhibited similar drought sensitivity as the Irr1 kin7 double mutant,placing PUB11 upstream of the two *** acid and drought treatment promoted the accumulation of PUB11,which likely accelerates LRR1 and KIN7 ***,our results reveal that PUB11 negatively regulates plant responses to drought stress by destabilizing the LRR1 and KIN7 RLKs.

关键词： abscisic acid drought response E3 ligase receptor-like kinase ubiquitination

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红枣甘草复合果酒加工工艺的研究

现代食品 2020年第16期5卷 113-118页

作者：刘飞阿曼古丽高旭升崔凤雅任道博余俊生阿卜杜外力·艾萨喀什大学生命与地理科学学院新疆喀什844000

为制作出一种天然、健康、低酒精度、高营养的发酵型红枣甘草复合果酒,本文以新疆甘草、红枣为主要原料,通过设置单因素对比实验及L9(3^4)正交优化实验,以感官评分为指标,得出了制作红枣甘草复合果酒的最佳工艺:焦亚硫酸钾添加量为70 mg... 详细信息

为制作出一种天然、健康、低酒精度、高营养的发酵型红枣甘草复合果酒,本文以新疆甘草、红枣为主要原料,通过设置单因素对比实验及L9(3^4)正交优化实验,以感官评分为指标,得出了制作红枣甘草复合果酒的最佳工艺:焦亚硫酸钾添加量为70 mg·L^-1,酿酒酵母添加量为0.4 g·L^-1,主发酵时间7 d,主发酵温度为25℃,陈酿50 d,此时制得的复合果酒感官品质最优,且成品红枣甘草复合果酒的部分理化指标均符合果酒的相关国家标准。

关键词：红枣甘草果酒发酵工艺

RAF22,ABI1 and OST1 form a dynamic interactive network that optimizes plant growth and responses to drought stress in Arabidopsis

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Molecular Plant 2022年第7期15卷 1192-1210页

作者： Zhihui Sun Zhenkai Feng Yanglin Ding yuanpeng Qi Shan Jiang Zhen Li yu Wang junsheng Qi Chunpeng Song Shuhua Yang Zhizhong Gong State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Collaborative Innovation Center of Crop Stress Biology Institute of Plant Stress BiologyHenan UniversityKaifeng 475001China School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 100193China

Plants adapt to their ever-changing environment via positive and negative signals induced by environmental *** stress,for instance,induces accumulation of the plant hormone abscisic acid(ABA),triggering ABA signal ***,the molecular mechanisms for switching between plant growth promotion and stress response remain poorly *** we report that RAF(rapidly accelerated fibrosarcoma)-LIKE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 22(RAF22)in Arabidopsis tha/iana physically interacts with ABA INSENSITIVE 1(ABl1)and phosphorylates ABl1 at Ser416 residue to enhance its phosphatase ***,ABl1 can also enhance the activity of RAF22 through dephosphorylation,reciprocally inhibiting ABA signaling and promoting the maintenance of plant growth under normal *** drought stress,however,the ASA-activated OPEN STOMATA1(OST1)phosphorylates the Ser81 residue of RAF22 and inhibits its kinase activity,restraining its enhancement of ABl1 *** together,our study reveals that RAF22,ABl1,and OST1 form a dynamic regulatory network that plays crucial roles in optimizing plant growth and environmental adaptation under drought stress.

关键词： ABA signaling RAF22 ABl1 OST1 phosphorylation