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New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus

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Chinese Journal of Natural Medicines 2023年第7期21卷 551-560页

作者： CAO Xinxin WANG Xinxin ZHANG yu XU Defeng SONG Xiuqing yu jinhai BAO Jie ZHANG Junsheng ZHANG Hua School of Biological Science and Technology University of JinanJinan 250022China

Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus,led to the separation of 18 labdane type diterpenoids(1-18).Through comprehensive spectroscopic analyses and quantum chemical calculations,these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones(1-6),two new(7 and 8)and six known(13-18)interesting 6,5,5-di-spirocyclic ones,a new rare 14,15-dinor derivative(9),and three new ones incorporating a y-lactone unit(10-12).An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way,comparable to the reference drug N-acetylcysteine.

关键词： Leonurus japonicus Labdane Diterpenoid Neuroprotective activity

Recovery of the gravity field from GOCE data by using the invariants of gradient tensor

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Science China Earth Sciences 2013年第9期56卷 1193-1199页

作者： yu jinhai WAN Xiaoyun Key Laboratory of Computational Geodynamics Chinese Academy of Sciences College of Earth Science Graduate University of Chinese Academy of Sciences

The gravity field models GUCAS_EGM and GUCAS_EGM_DL are established from GOCE data (GOCE Level 2 Products from Nov. 1 to Dec. 31, 2009) based on the method of the invariants of the gravity gradient tensor, where GUCAS_EGM is derived after GOCE gravity gradient data are filtered with FIR, and GUCAS_EGM_DL is computed with an additional Durbin-Levison arithmetic apart from FIR. Since this method, different from current programs dealing with GOCE data, is introduced for the first time, some new problems are required to be discussed in advance; for example, how to filter GOCE gravity gradient data, how to compute the invariants of the gradient tensor, and how to deal with the pole gap and so on. In addition, by comparing our models with ones recommended by ESA, it can be seen that the variations of GUCAS_EGM and the models recommended by ESA to EGM08 are almost equivalent, and the variation of GUCAS_EGM_DL to EGM08 is obviously less than ones of the recommended models.

关键词：重力梯度张量 GOCE 重力场不变量恢复使用数据处理磁极间隙 FIR

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甲状腺相关眼病潜在治疗靶点的研究现状

中华眼科杂志 2024年第3期60卷 282-288页

作者：余进海王耀华廖洪斐南昌大学江西医学院眼视光学院南昌330006南昌大学附属眼科医院、江西省眼科疾病临床医学研究中心、江西省眼科学与视觉科学研究所、江西省眼科学重点实验室南昌330006 南昌大学附属眼科医院、江西省眼科疾病临床医学研究中心、江西省眼科学与视觉科学研究所、江西省眼科学重点实验室南昌330006

甲状腺相关眼病(TAO)是一种影响视功能和容貌的自身免疫性眼病,包括炎性反应、氧化应激、脂肪生成、纤维化等眼眶组织病理性重塑过程。目前临床一线治疗方案并不能对所有患者产生疗效。本文针对近年国内外关于TAO潜在治疗靶点的研究进... 详细信息

甲状腺相关眼病(TAO)是一种影响视功能和容貌的自身免疫性眼病,包括炎性反应、氧化应激、脂肪生成、纤维化等眼眶组织病理性重塑过程。目前临床一线治疗方案并不能对所有患者产生疗效。本文针对近年国内外关于TAO潜在治疗靶点的研究进行总结,包括受体蛋白靶点、免疫细胞靶点、脂肪抑制靶点、抗纤维化靶点、转录因子靶点、代谢调节酶靶点,涉及非天然化合物和天然化合物,以期为临床科研工作者在TAO治疗研究方向方面提供借鉴和思路,促进新型治疗药物应用于临床。

关键词： Graves眼病临床方案临床研究

The age and tectonic environment of the rhyolitic rocks on the western side of Wuyi Mountain,South China

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Science China Earth Sciences 2008年第8期51卷 1053-1063页

作者： SHU LiangShu DENG Ping yu jinhai WANG YanBin JIANG ShaoYong State Key Laboratory for Mineral Deposits Research Department of Earth SciencesNanjing UniversityNanjing 210093China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Center of Iron-Probe in Beijing Beijing 100037China

During the geological survey of the metamorphic rocks in Xingning-Wuhua region on the western side of Wuyi Mountain, South China, we discovered the Neoproterozoic rhyolite and rhyolitic greywacke for the first time that outcrop in the Proterozoic metamorphic rocks near Jingnan Town of Xingning County, eastern Guangdong Province. A systematic research on petrology, geochemistry and geochronology of rhyolitic rocks was conducted to understand their tectonic setting and formation age. The Jingnan rhyolite is interbedded with a coeval greywacke, with a total thickness of 60 m; both rhyolite and greywacke display a similar folding and metamorphic pattern. Meta-rhyolite consists of groundmass and phenocrystals including sanidine, orthoclase, and quartz with distinct undulose extinction; the groundmass has been recrystallized into fine-grain feldspar, quartz and sericite aggregation. Meta-greywacke is composed of crystallinoclastic grains (sanidine, orthoclase, quartz and oligoclase) and clay groundmass. Zircon grains used for the SHRIMP U-Pb analysis are light brown-colored and euhedral or subeuhedral. Dating data suggest two age groups; eight grains of magmatype zircon with an idiomorphic form yield an age of 972±8 Ma, and the other seven weakly corroded grains of zircon with euhedral to subeuhedral shape construct an average age of 1097±11 Ma, which were captured from older rocks by an uplifting magma, implying that a late Mesoproterozoic basement exists in the Nanling region. In addition, one Paleoproterozoic age, 2035±11 Ma, is obtained from a rounded detrital zircon, indicating that a Paleoproterozoic thermal event took place in the South China. Geochemically, the Jingnan rhyolitic rocks are characterized by high K2O content, intermediate Al2O3 content, with the ACNK value 0.98―1.11, and belonging to high-K alkaline series. They are rich in ΣREE, Rb, Th and Ce, depleted in Ba, Sr, Eu, Ti, P and Nb-Ta, and with moderate negative Eu and Sr anomalies. These features indicate that the Jingnan volcanic rocks have an af

关键词： rhyolite calc-alkaline series early stage of Neoproterozoic western Wuyi Mountain South China

Jurassic sedimentary features and tectonic settings of southeastern China

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Science China Earth Sciences 2009年第12期52卷 1969-1978页

作者： SHU LiangShu WANG Yan SHA JinGeng JIANG ShaoYong yu jinhai WANG YanBin State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing 210093China LPS Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Liaohe Oilfield Company PetroChinaPanjin 124010China Beijing SHRIMP Center Chinese Academy of Geological SciencesBeijing 100037China

Two types of the Jurassic basins are distinguished in SE China based on their geodynamic features: the Late Triassic-Early Jurassic post-orogenic basins and the Middle Jurassic intra-continental extensional basins. The Lower Jurassic sequence shows a change from coarseto fine-grained accumulation, suggesting a gradually deepening depositional environment from river to shore-lake and to deep-water lake. In contrast, the Middle Jurassic accumulation was changed from claystone to conglomerate along the coastal provinces in SE China, indicative of an initial crustal uplift. The Wuyi Mountains have been a paleogeograghic separating zone since the Middle Jurassic. The Late Jurassic strata are absent in most areas of SE China. A large-scale bimodal intra-continental rift-type volcanism occurred during the Middle Jurassic along a 40-60 km wide and 200 km long area in western Fujian and southern Jiangxi provinces, which is most likely the strongest volcanism in SE China since the Cambrian. The SHRIMP zircon U-Pb analyses on the rhyolite from the Dongkeng basin in the southern Jiangxi area yield a concord U-Pb age of 160±0.5 Ma, providing an upper age limit for the bimodal volcanic eruption. The analyses of the basin features indicate a change of the depositional environment during the interval from Middle Triassic to Late Triassic from a shallow-sea to an intra-continent in SE China in response to the strong collision between the Yangtze and North China Blocks. Sedimentary structures record a southward direction of Early Jurassic paleo-currents, reflecting that their source areas were to the north side. We propose that the Wuyi region was uplifted as early as Middle Jurassic, followed by a wide E-W-trending extended depression and bimodal volcanism in the western foot of the Wuyi Mountains. Presumably the uplift of the Wuyi domain changed the Middle Jurassic paleo geographic outline and formed the transformational tectonic regime from compression to extension as a tectonic response to the Pacific plate subduction.

关键词： sedimentary features paleo-geographic framework tectonic transformation SHRIMP U-Pb dating Jurassic southeastern China

Composition variations of the Sinian-Cambrian sedimentary rocks in Hunan and Guangxi and their tectonic significance

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Science China Earth Sciences 2013年第11期56卷 1899-1917页

作者： WANG PengMing yu jinhai SUN Tao SHI yu CHEN PeiRong ZHAO KuiDong CHEN WeiFeng LIU Qian State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University

This paper reports the geochemical and zircon U-Pb dating data of the Sinian to Cambrian low-grade metamorphic rocks in the Miaoer Mountain area,Guangxi and the Jinjiling area,Hunan Province.Petrographic and geochemical features indicate that protoliths of these metamorphic rocks are clastic sedimentary rocks with medium weathering,which were formed in the passive continental margin.Geochemistry and zircon U-Pb ages indicate that the Sinian and Cambrian sedimentary rocks in the Jinjiling area have similar detritus components,which are characterized by abundant Grenvillian detrital zircons,suggesting a close affinity with the Cathaysia Block.The Cambrian sedimentary rocks in the Miaoer Mountain area have similar geochemistry and zircon geochronology to those in the Jinjiling area,showing an affinity with the Cathaysia Block.However,the Sinian sedimentary rocks in the Miaoer Mountain area show different geochemical features from the Cambrian sedimentary rocks and those in the Jinjiling area,and are characterized by abundant 840–700 Ma detrital zircons and less^2.0 Ga ones,showing a close affinity with the Yangtze Block.These variations suggest that the Jinjiling area continuously accepted the fragments from the Cathaysia from the Sinian to the Cambrian,whereas the provenance of the Miaoer Mountain sedimentary basin changed from the Yangtze Block to the Cathaysia Block during this interval.This change implies a tectonic movement,which caused the further sinking of the basin in the Miaoer Mountain area and northwestward transferring of the basin center before the Middle Cambrian,so that the Miaoer Mountain basin received the detritus from the Cathaysia Block in the Middle Cambrian.This fact also proves that the Yangtze and Cathaysia blocks have converged at least in Middle Cambrian,and the southwestern boundary between them is located between the Miaoer Mountain and Jinjiling areas.

关键词：碎屑沉积岩震旦系寒武纪湖南省组成变化构造意义广西地球化学特征

含氟流体助熔华南基底片麻岩的实验研究:对稀土成矿花岗岩成因的制约

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大地构造与成矿学 2024年第2期48卷 213-231页

作者：李嘉豪丁兴刘军锋于津海中国科学院广州地球化学研究所同位素地球化学国家重点实验室广东广州510640 长安大学地球科学与资源学院陕西西安710064 中国科学院深地科学卓越创新中心广东广州510640 南京大学地球科学与工程学院江苏南京210023

为了明确含氟流体对花岗岩源区岩浆过程中稀土元素地球化学行为的影响,本文采用华南代表性的高稀土片麻岩和低稀土片麻岩作为初始物质,与~4%的流体(纯水、1.5 mol/L HF、1.0 mol/L NaF)在0.8 GPa、1000℃的条件下开展了流体助熔的部分... 详细信息

为了明确含氟流体对花岗岩源区岩浆过程中稀土元素地球化学行为的影响,本文采用华南代表性的高稀土片麻岩和低稀土片麻岩作为初始物质,与~4%的流体(纯水、1.5 mol/L HF、1.0 mol/L NaF)在0.8 GPa、1000℃的条件下开展了流体助熔的部分熔融实验。实验结果表明,所有片麻岩的熔融程度达到40%以上,残余矿物组合主要为斜长石+石英+斜方辉石±单斜辉石+钛铁矿+磷灰石±黑云母。部分熔融产生的熔体的成分主要为花岗闪长质‒花岗质,总体具有高氟(0.11%~0.27%)、高水(0.38%~1.86%)和A2型花岗岩的特征;其中,高稀土片麻岩部分熔融形成的熔体为钾玄质和准铝质,而低稀土片麻岩熔融形成的熔体偏高钾钙碱性和强过铝质。在微量元素蛛网图上,两者均表现为富集K、Rb、Th、Ce、Sm、Y、Yb等元素,亏损Ba、Nb、Ta、Zr、Hf、Ti等元素;稀土元素配分曲线则表现为右倾、负Eu异常的特征。相对于原岩,含氟流体助熔会强化熔体中Si、K、Na、Rb、Sr、Ba、Th、U、LREE和F的富集,并增加熔体的La_(N)/Yb_(N)值。同时,实验也证实片麻岩部分熔融形成的熔体的稀土元素含量主要受原岩控制,高稀土片麻岩更易于熔出稀土元素初始富集的熔体;相对于原岩,各类流体助熔均会造成稀土元素在熔体中不同程度的富集,其中,含HF流体助熔最高可富集稀土46%~49%(近1.5倍富集)。我们因此认为在华南LREE型和HREE型成矿花岗岩形成过程中,含F流体发挥重要的作用。此外,本文也提出了一种新的A2型花岗岩形成机制,即含F流体助熔地壳基底岩石,这很好地解释了华南晚中生代大规模分布的与稀土、稀有金属及氟成矿相关的陆内A2型花岗岩的形成。

关键词：部分熔融流体助熔含氟流体稀土元素花岗岩片麻岩

Paleoproterozoic basement beneath the southern Jiangxi Province:Evidence from U-Pb ages and Lu-Hf isotopes in zircons from the Doushui lamprophyre

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Chinese Science Bulletin 2009年第9期54卷 1555-1563页

作者： yu jinhai WANG LiJuan O'REILLY S Y SHU LiangShu SUN Tao State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University Nanjing 210093 China GEMOC National Key Centre Department of Earth and Planetary Science Macquarie University Sydney NSW 2109 Australia

这篇论文论述侵入的煌斑岩的 geochemical 分析在 Shangyou 县的古苏格兰的 Doushui 花岗石身体，南部的江西省。U-Pb 标明日期和 Hf 同位素分析特别从它为锆石被执行。Petrological 和 geochemical 特征证明煌斑岩属于 high-K，弱碱的... 详细信息

这篇论文论述侵入的煌斑岩的 geochemical 分析在 Shangyou 县的古苏格兰的 Doushui 花岗石身体，南部的江西省。U-Pb 标明日期和 Hf 同位素分析特别从它为锆石被执行。Petrological 和 geochemical 特征证明煌斑岩属于 high-K，弱碱的辉石黑云母煌斑岩。它被 Mg #(0.74 ) ， Ni (253 μg/g ) 和 Cr (893 μg/g ) 满足的高度描绘，并且也在不兼容的元素充实，例如 REE， Rb， Sr， Ba 和 K。它的原语融化，这被建议可能由 non-crust-derived 源于充实的披风 metasomatized 代理人。在煌斑岩标明日期锆石的结果的形态学和 LAM-ICPMS 显示他们是从深外壳的岩石捕获的 xenocrysts。在 ∼1.86 Ga 形成的大多数 xenocrystic 锆石，和在不同 Phanerozoic 时期的一些。Paleoproterozoic 锆石具有 magmatic 起源并且有类似的 176Hf/177 Hf 和 176Lu/177 Hf 比率，显示他们可能从一样的火的地下室岩石。年龄和从这地下室岩石的锆石的 Hf 同位素作文类似于在南部的浙江省的 Paleoproterozoic Danzhu 花岗石的那些，但是极其与 Nanling 地下室区分开来，建议学习区域可能是一向西在东方卡赛西亚·布洛克的 Paleoproterozoic Wuyishan 岩层的延期部分。这些 Paleoproterozoic 锆石有低 Hf 同位素作文，外壳的来源特征。这些锆石的 Hf 模型年龄和在他们以内的更旧的继承核心的存在，结合了可得到的其它数据由以前的研究报导了，建议 Paleoproterozoic 岩浆的来源是 Neoarchaean 外壳，在 Wuyishan 岩层暗示更旧的地下室的存在。U-Pb 年龄和五 Phanerozoic 锆石的 Hf 同位素显示那个 Paleoproterozoic 地下室经历了多重做的发生在古苏格兰， Indosinian 和早 Yanshanian 分别地。古苏格兰的 magmatism 也涉及少年外壳重做。

关键词：模式年龄铪同位素地下室江西省锆石 Pb 地球化学分析地壳岩石

Finding of ancient materials in Cathaysia and implication for the formation of Precambrian crust

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Chinese Science Bulletin 2007年第1期52卷 13-22页

作者： yu jinhai Y S O'REILLY WANG LiJuan W L GRIFFIN JIANG ShaoYong WANG RuCheng XU XiSheng State Key Laboratory for Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing 210093 China GEMOC ARC National Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney N.S.W. 2109

在 Nanxiongarea 从帕拉片麻岩为 56 由岩屑形成的锆石标明日期的 U-Pb，北广东省，显示在 Cathaysiahinterland 的最近的 Neoproterozoic 沉积由众多的 Grenvillian 和 Neoarchaean 组成碎屑状的材料，以及 someMesoproterozoic 岩屑... 详细信息

在 Nanxiongarea 从帕拉片麻岩为 56 由岩屑形成的锆石标明日期的 U-Pb，北广东省，显示在 Cathaysiahinterland 的最近的 Neoproterozoic 沉积由众多的 Grenvillian 和 Neoarchaean 组成碎屑状的材料，以及 someMesoproterozoic 岩屑。次要的 Paleoarchaean (3.76 Ga ) 和 Mesoarchaean (3.0—3.2 Ga ) 锆石，是在华南的最旧的锆石，第一也在沉积被发现，建议卡赛西亚·布洛克可以包含很旧的材料。thirty-sevenzircons 的 Hf 同位素作文表明这些碎屑状的材料有不同起源。次要的锆石从产生从的岩浆结晶相对少年外壳，当大多数锆石的父母岩浆从古老的外壳被导出时。U-Pb 标明日期和这些锆石的 Hf 同位素分析的集成建议在 Cathaysia 块的少年外壳的产生主要发生在 2.5 点—2.6Ga。Mesoarchaean (3.0—3.3 Ga ) ，迟了的 Paleoproterozoic (～ 1 .8 Ga ) 和 Paleoarchaean (～ 3 .7 Ga ) 可以也是外壳的生长的重要事件。Grenvillian magmatism 是极其强烈的，但是它主要涉及与少年外壳的很少形成古老的外壳的部件再循环。～ 2 .1 Ga Hf 模型年龄的 Themarked 存在和有结晶化的锆石的缺席在～ 2 .1 Ga 变老建议许多锆石的父母岩浆可能从由 Neoarchaean 和迟了的 Paleoproterozoic 材料组成的混合来源被导出。

关键词：前寒武纪地层历史地理地理研究