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Application analysis of empirical mode decomposition and phase space reconstruction in dam time-varying characteristic

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Science china(Technological Sciences) 2010年第6期53卷 1711-1716页

作者： zhang ZhiJun1,2,3,GU ChongShi1,2.bao tengfei1,2,zhang lan1,2.& yu hong1,2.1 state key laboratory of hydrology-water resources and hydraulic engineering,hohai university,nanjing 2.0098,china 2 National engineering Research Center of water resources Efficient Utilization and engineering Safety,hohai university,nanjing 2.0098,china 3 Department of Civil,Environmental and Geomatic engineering,Swiss Federal Institute of Technology,Zurich 8093,Switzerland state key laboratory of hydrology-water resources and hydraulic engineering Hohai University Nanjing China National engineering Research Center of water resources Efficient Utilization and engineering Safety Hohai University Nanjing China Department of Civil Environmental and Geomatic Engineering Swiss Federal Institute of Technology Zurich Switzerland

In view of some courses of the time-varying characteristics processing in the analysis of dam deformation,the paper proposes a new method to analyze the dam time-varying characteristic based on the empirical mode decomposition and phase space reconstruction *** of all,to reduce the influences on the traditional statistical model from human factors and assure the analysis accuracy,response variables of the time-varying characteristic are obtained by the way of the empirical mode decomposition;and then,a phase plane of those variables is reconstructed to investigate their processing *** methods have already been applied to an actual project and the results showed that data interpretation with the assists of empirical mode decomposition and phase space reconstruction is effective in analyzing the perturbations of response variables,explicit in reflecting the entire development process,and valid for obtaining the evolution rules of the time-varying *** methodology is a powerful technical support for people to further master the rules of dam operation.

关键词： dam safety monitoring dam time-varying characteristic empirical mode decomposition phase space reconstruction

Integration of gut microbiota and metabolomics analysis to unravel the neuroprotective effects of Hydroxy-α-sanshool on Alzheimer's Disease

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Food Science and Human Wellness 2024年

作者： Ruo-lan Li Wen-Wen Chen hong zhang Qi Liang Ling-yu Wang Wei Peng Chun-Jie wu state key laboratory of Southwestern Chinese Medicine resources， School of Pharmacy， Chengdu university of Traditional Chinese Medicine Institute of Innovation， Chengdu university of Traditional Chinese Medicine Sichuan Cancer Hospital and Institute， School of Medicine， university of Electronic Science and Technology of china Chengdu Women's and Children's Central Hospital， School of Medicine， university of Electronic Science and Technology of china Meishan Hospital of TCM， Meishan Hospital Affiliated to Chengdu university of Traditional Chinese Medicine

Alzheimer's disease （AD） is a common neurodegenerative disease， and oxidative stress induced by Aβ deposition is the key cause of neuronal apoptosis in AD patient. Hydroxy-α-sanshool （HAS） is the predominant flavour substances in the pericarp of Zanthoxylum bungeanum Maxim. （Rutaceae family）， which is a known condiment food and herbal medicine in china. We attempt to comprehensively elucidate the pathway and related mechanisms of HAS therapy on AD through in vivo and in vitro experiments. The results showed that HAS could inhibit cell apoptosis， suppress the reactive oxygen species （ROS）， and increase the antioxidative enzymes in Aβ1-42induced HT22 cells. In vivo， HAS attenuated the learning and memory impairment in senescence-accelerated mouse prone 8 （SAMP8） mice， and protected neuronal cells in hippocampus. Interestingly， the 16S rRNA gene sequencing results showed HAS could restore the richness and diversity of the intestinal microbiota， reduce the abundance of Lactobacillus， and increase the abundance of Bateroides and Parabacteroides. Moreover， the contents of 10 metabolites were significantly changed after HAS treatment， which was beneficial to treat AD. In conclusion， HAS could inhibit apoptosis in nerve cells by attenuating Aβ induced oxidative stress level， while it can also influence the metabolic pathways and affect the gut microbiota composition of AD mice.

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Dalbergia odorifera Essential Oil Protects against Myocardial Ischemia through Upregulating Nrf2 and Inhibiting Caspase Signaling Pathways in Isoproterenol-Induced Rats

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 338-347页

作者： Can-hong Wang bao Gong Hui Meng yu-lan wu Xiang-Sheng Zhao Jian-He Wei Hainan Provincial key laboratory of resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina key laboratory of state Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina key laboratory of Bioactive Substances and resources Utilization of Chinese Herbal Medicine Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Ministry of Education and National engineering laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular *** study aimed to determine the potential myocardial protective effect and possible mechanism of action of *** ife ra essential oil(DOEO).Materials and Methods:The essential oil of *** was extracted by *** cardioprotective effects of DOEO were examined by histopathological observation,myocardial enzyme detection,peroxidation,anti-oxidant level detection,and related protein *** compounds in the blood were identified by gas chromatography-mass ***:These results showed that DOEO had significant myocardial cell protection,with IC50 values ranging from 17.64 to 24.78μg/mL in *** to the myocardial ischemia group,the DOEO pretreatment groups had lower levels of myocardial injury,creatinine kinase,lactate dehydrogenase,alanine transaminase,aspartate transaminase,hydrogen peroxide,and nitric oxide,and higher levels of glutathione and superoxide *** addition,DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase *** r,immunohistochemical e xperiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2(Nrf2)and heme oxygenase-1(HO-1)and reduced the expression of apoptotic caspases,including caspase 3 and caspase *** main components of the blood were transnerolidol and nerolidol ***,the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor-antioxidant response element(Nrf2-ARE)and caspase *** has a therapeutic effect on MI by inhibiting the oxidant and apoptotic ***:*** may be a potential candidate drug for treating myocardial ischemic injury.

关键词： Anti-apoptosis Anti-oxidation Dalbergia odorifera essential oil Isoproterenol Myocardial ischemia

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甘蔗与斑茅杂交染色体组构成特征研究

作物学报 2024年第3期50卷 633-644页

作者：薛丽李心怡黄勇泰欧财篮吴小青余泽怀崔泽田张木清邓祖湖余凡亚热带农业生物资源保护与利用国家重点实验室/广西甘蔗生物学重点实验室/广西大学农学院广西南宁530004 福建农林大学农学院国家甘蔗工程技术研究中心福建福州350002

斑茅是甘蔗重要的野生种质资源,渗入斑茅血缘来提高甘蔗抗性是目前甘蔗育种的重要途径之一。对甘蔗与斑茅杂交后代进行染色体分型有利于高效利用斑茅的各种优异性状。本研究利用斑茅特异引物鉴定斑茅与甘蔗杂交高世代材料的真实性,通过... 详细信息

斑茅是甘蔗重要的野生种质资源,渗入斑茅血缘来提高甘蔗抗性是目前甘蔗育种的重要途径之一。对甘蔗与斑茅杂交后代进行染色体分型有利于高效利用斑茅的各种优异性状。本研究利用斑茅特异引物鉴定斑茅与甘蔗杂交高世代材料的真实性,通过荧光原位杂交对甘蔗与斑茅染色体进行分型,以探究斑茅和甘蔗染色体在子代中的遗传与分离,并分析其染色体组结构特征。结果表明,杂交群体中有30份为斑茅的真实后代,包含斑茅染色体从1~10条不等,说明其后代群体基本服从n+n的遗传方式,占整个真实后代群体的60%。斑茅与甘蔗发生染色体水平的重组约16.67%,并且斑茅与不同血缘甘蔗重组的概率趋近一致。割手密种特异探针共定位结果表明,斑茅血缘的渗入降低了近现代栽培甘蔗种中热带种血缘与重组血缘的占比,并同时提高了割手密血缘的比例。本研究分析的甘蔗与斑茅杂交后代中不同血缘染色体组的遗传及结构特点,为提高斑茅种质资源在甘蔗育种中的开发利用提供了细胞遗传学基础。

关键词：甘蔗斑茅荧光原位杂交染色体遗传

Enrichment of Ni-Mo-V via pyrometallurgical reduction from spent hydrogenation catalysts and the multi-reaction mechanism

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稀有金属:英文版 2023年第8期42卷 2700-2712页

作者： Zhi-Sheng Shi yun-Ji Ding Xi-Ping Yin Bo Liu Han-Lin Shen Bo-yu wu bao-Huai Zhao Feng-lan Han Christian Ekberg Shen-Gen zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China Institute of engineering Technology SINOPEC Catalyst Co.Ltd.Beijing 101111China School of Material Science and engineering North Minzu UniversityYinchuan 750021China Nuclear Chemistry and Industrial Material Recycling Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGothenburg 41296Sweden

Spent hydrogenation catalysts are important secondary resources due to richness in the valuable metals of Ni,Mo and *** of valuable metals from spent catalysts has high economic value and environmental benefits since they are hazardous wastes as *** recycling processes including hydrometallurgical leaching and soda roasting-leaching have disadvantages such as generating large amounts of wastewater,long process,and low recovery efficiency of valuable ***,this paper proposed synergistic enrichment of Ni,Mo and V via pyrometallurgical reduction at 1400-1500℃.The melting temperature and viscosity of slag were reduced through slag designing by software FactSage *** phase diagram of Al_(2)O_(3)-Cap-SiO_(2)-Na_(2)O-B_(2)O_(3)was drawn,and low-temperature region(≤1300℃)was selected as target slag ***,Mo,and V can be collaborative captured and recovered through the mutual solubility at molten *** the melting temperature and the amount of CaO,Na_(2)O and C were conducive to improving the metals recovery *** kilogram-scale experiments were carried out,and the recovery efficiencies of Ni,Mo and V were 98.3%,95.3%and 97.9%under optimized conditions:at 1500℃,with the basicity of 1.0,13.1 wt%SiO_(2),7.0 wt%B_(2)O_(3),7.7 wt%Na_(2)O and 20.0wt%*** distribution behavior of valuable metals was clarified by investigating the melting process of slag and the reduction in valuable *** was preferentially reduced and acted as a capturing agent,which captured other metals to form NiMoV alloys.

关键词： Spent hydrogenation catalysts(SHC) Pyrometallurgical reduction Slag design Enrichment Settlement

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： Xiao-Dong Song Fei Yang Hua-Yong wu Jing zhang De-Cheng Li Feng Liu yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-yu Long Ying Lu yue-yu Sui Qiu-Bing Wang Ke-Ning wu Feng-Rong zhang Ming-Kui zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang yuan Yang-Zhu zhang Jun-Ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen yun-Zhong Dong Chun-lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng Wang Tian-Wei Wang Xiang-Hua Wei hong-Qi wu Xia Zhao Qing Zhou Gan-Lin zhang state key laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of resources and Environment Huazhong Agricultural University Institute of Agricultural resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of land and Environment Shenyang Agricultural University School of land Science and Technology China University of Geosciences College of land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural resources and Environment Northwest A & F University College of resources and Environment Southwest University College of resources Sichuan Agricultural University College of resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and resources Research Shanxi Academy of Agricultural Sciences College of resources and Environment Henan Agricultural University College of resources and Environment China Agricultural University College of resources and Environmental Sciences Nanjing Agricultural University College of resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2.10 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across china(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： china soil inorganic carbon stocks global change carbonate soil acidification

Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in china

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 176-186页

作者： Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-yu Shao Run-Fa bao Yi-Jun Shu Xu-An Wang Wen-Guang wu Xiang-Song wu Mao-lan Li hong Cao Kun-Hua Wang hong-yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu yun-Fu Cui Zai-Yang zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi zhang Chang Liu Wan-Yee Lau Ying-Bin Liu Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai key laboratory of Biliary Tract Disease Research Shanghai 200092China Department of Biliary-Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China state key laboratory for Oncogenes and Related Genes Shanghai 200127China Department of General Surgery Shanxi Provincial Cancer HospitalTaiyuan 030013Shanxi ProvinceChina Department of GI Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastrointestinal and Hernia Surgery The First Affiliated Hospital of Kunming Medical UniversityKunming 650031Yunnan ProvinceChina Department of Hepatobiliary Surgery Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina Department of General Surgery Taizhou Municipal HospitalTaizhou 318000Jiangsu ProvinceChina Department of Hepatobiliary Surgery Wuxi Second People's HospitalWuxi 214002Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Biliary Tract Surgery Second Military Medical UniversitySecondary Military Medical UniversityShanghai 200438China Department of General Surgery Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Department of General Surgery Shaoxing Second HospitalShaoxing 312000Zhejiang ProvinceChina Department of HPB Surgery Changzhou No.2 People’s HospitalChangzhou 213003Jiangsu ProvinceChina Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbin 150009Heilongjiang ProvinceChina Department of Hepatobiliary Surgery Shengjing Hospital of China Medical UniversityShenyang 1

BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of *** To investigate whether RL can improve the prognosis of patients with T1b *** We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2.16 at 24 hospitals in 13 provinces in *** logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch *** investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did *** Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch ***(9.1%)patients in the Ch+RL group had lymph node *** 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent ***+Ch showed no improvement in prognosis in T1b GBC *** recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC *** Ch+RL should be advised in T1b GBC.

关键词： Gallbladder cancer Lymphadenectomy Hepatectomy Staging Prognosis Surgery

Lipid rafts mediates ATP-induced endocytosis,signal transduction and retrograde transport of P2X3 receptor

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Lipid rafts mediates ATP-induced endocytosis,signal transduc...