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Unsaturated Creep Behaviors of Weak Intercalated Soils in Soft Rock of Badong Formation

Journal of Mountain Science 2015年第6期12卷 1460-1470页

作者： ZHU Yan-Bo yu hong-ming College of Geology Engineering and Geomatics Chang'an University Faculty of Engineering China University of Geosciences

The cutting slopes in soft rock of redbed appeared in Yichang-Badong highway often suffer from the instability along weak intercalations, so the creep behaviors of weak intercalated soils are crucially important for the stability of cutting slopes. Because the deformation of weak intercalated soils is significantly affected by water content due to the strong water sensitivity, it is necessary to study the influence of matric suction on the creep behaviors of weak intercalated soils. In order to find out the unsaturated creep characters of weak intercalated soils, a GDS unsaturated triaxial apparatus was used. Then the triaxial creep experiments on weak intercalated soil samples under varying matric suction were conducted to obtain the unsaturated creep curves. The results show that the weak intercalated soils have obvious creep behaviors, and the creep strain is in nonlinear relationship with stress and time. When the matric suction is constant, a larger deviator stress will lead to a larger creep strain; When the deviator stress is constant, a smaller matric suction will lead to a larger creep strain. Based on the Mesri creep model, an improved creep model for weak intercalated soils under varying matric suction was established, in which the relationship of stress-strain was expressed with a hyperbolic function, and the relationship of strain-time was expressed with power functions in stages. Then an unsaturated creep model including stress-matric suction-strain-time for weak intercalated soils was established based on the power function relationship between matric suction and Ed(a parameter of the improved creep model). The comparison of the calculated values of creep model and the experimental values shows that the creep behaviors of weak intercalated soils can be predicted by the unsaturated creep model by and large.

关键词： Badong formation Weak intercalated soils Unsaturated creep behaviors Soil triaxial apparatus Creep model

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Studies of Chemical Constituents and Their Antioxidant Activities From Astragalus mongholicus Bunge

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Biomedical and Environmental Sciences 2005年第5期18卷 297-301页

作者： DE-hong yu YONG-ming BAO CHAO-LIANG WEI, LI-JIA AN Department of Environment and Biology Dalian University of Technology Dalian 116024 Liaoning China

To evaluate the antioxidant activities of different chemical constituents from Astragalus mongholicus Bunge and their protection against xanthine （XA）/xanthine oxidase （XO）-induced toxicity in PC12 cells. Methods The compounds of Astragalus mongholicus Bunge were isolated by chromatography and the structures were elucidated on the basis of spectral data interpretation. Their antioxidant activities were detected by 1, 1-diphenyl-2-picrylhydrazyl （DPPH） radical scavenging activities in a cell-free system. Meanwhile, the effects against XA/XO-induced toxicity were assessed using MTT assay in PC12 cells. Results Ten principal constituents were isolated and identified as formononetin （Ⅰ）, ononin （Ⅱ）, calycosin （Ⅲ）, calycosin-7-O-β-D-glucoside （Ⅳ）, 9,10-dimethoxypterocarpan-3-O-β-D-glucoside （Ⅴ）, adenosine （Ⅵ）, pinitol （Ⅶ）, daucosterol （Ⅷ）, β-sitoster （Ⅸ） and saccharose （Ⅹ） from Astragalus mongholicus Bunge. The compounds Ⅰ, Ⅲ, and Ⅳ scavenged DPPH free radicals in vitro. Formononetin and calycosin were found to inhibit XA/XO-induced cell injury significantly, with an estimated EC50 of 50 ng/mL. Conclusion Compound Ⅲ, Ⅵ, and Ⅶ are first reported in this plant. Calycosin exhibits the most potent antioxidant activity both in the cell-free system and in the cell system.

关键词： Astragalus mongholicus Bunge Constituents Antioxidant PC12 Toxicity

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Cutaneous and systemic plasmacytosis

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Chinese Medical Journal 2012年第22期125卷 4156-4157页

作者： CHENG Ru-hong yu hong LI ming YAO Zhi-rong Shanghai Jiao Tong Univ Dept Dermatol Xinhua Hosp Sch Med Shanghai 200092 Peoples R China

Cutaneous and systemic plasmacytosis （CSP） is a rare condition characterized by a clinical triad of cutaneous lesions, polyclonal hypergammaglobulinemia, and superficial lymphadenopathy. The condition is described primarily in middle-aged Asian patients and particular in Japanese individuals,l A previous study suggest a male ： female ratio of 1 to 0.6, and an age of onset ranging from 20 to 62 years, with both a mean and median age of 37 years.2 Here, we report a Chinese case of CSP, who is the youngest patient of Chinese decent in literature.

关键词： cutaneous and systemic plasmacytosis Chinese

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An improved Mesri creep model for unsaturated weak intercalated soils

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Journal of Central South University 2014年第12期21卷 4677-4681页

作者：祝艳波余宏明 Faculty of Engineering China University of Geosciences College of Geology Engineering and Geomatics Chang’an University

The weak intercalated soils in redbed soft rocks of Badong formation have obvious creep characters. In order to predict the unsaturated creep behaviors of weak intercalated soils, an unsaturated creep model was established based on the unsaturated creep tests of weak intercalated soils by using GDS triaxial apparatus. The results show that the creep behaviors of intercalated soils are apparent and significantly affected by matric suction. Based on this, an empirical Mesri creep model for intercalated soils under varying matric suctions was built. The fitting results show that the parameters Ed and m of this model are in good power relations with matric suction s and stress level Dr, respectively. An improved Mesri creep model was established involving stress-matric suction-strain-time, which is more precise than the Mesri creep model in predicting the unsaturated creep behaviors of weak intercalated soils.

关键词： unsaturated soils creep matric suction improved Mesri model

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Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters

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Acta Pharmacologica Sinica 2007年第8期28卷 1236-1242页

作者： Feng ZHANG~3 yu-hong LI~3 ming-wen FAN~2 Rong JIA Qing-an XU Ji-hua GUO Fei yu Qi-wei TIAN Key Laboratory for Oral Biomedical Engineering of Ministry of Education,School and Hospital of Stomatology,Wuhan University,Wuhan 430079,China Key Laboratory for Oral Biomedical Engineering of Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China

Aim:To evaluate the comparative immunogenicity and protective efficacy of thecytotoxic T-lymphocyte-associated antigen 4(CTLA-4)fusion anti-caries DNAvaccines pGJA-P/VAX1,pGJA-P,and non-fusion anti-caries DNA constructpGLUA-P in *** addition,the ability of CTLA-4 to target pGJA-P/VAX 1-encoding antigen to dendritic cells was tested in ***:All DNAconstructs contain genes encoding the A-P regions of a cell surface protein(PAc)and the glucan binding(GLU)domain of glucosyltransferases(GTFs)of cari-ogenic organism Streptococcus *** dendritic cells were mixed withthe CTLA-4-Ig-GLU-A-P protein expressed by pGJA-P/VAX1-transfected cellsand analyzed by flow *** hamsters were immunized with anti-caries DNA vaccines by intramuscular injection or intranasal *** responses to a representative antigen PAc were assayed by ELISA,andcaries protection was evaluated by Keyes caries ***:A flow cytometricanalysis demonstrated that CTLA-4-Ig-GLU-A-P protein was capable of bind-ing to human dendritic cells,pGJA-P/VAX1 and pGJA-P induced significantlyhigher specific salivary and serum anti-PAc antibody responses than pGLUA-ESignificantly fewer caries lesions were also observed in hamsters immunized withpGJA-P/VAX1 and *** was no significant difference in the anti-PAcantibody level or caries scores between pGJA-P/VAX1 and ***:Antigen encoded by CTLA-4 fusion anti-caries DNA vac-cine pGJA-P/VAX1 could specifically bind to human dendritic cells through theinteraction of CTLA-4 and B7 *** antigen to CTLA-4 has beenproven to greatly enhance the immunogenicity and protective efficacy of anti-caries DNA vaccines.

关键词： DNA vaccines Streptococcus mutans dendritic cells cytotoxic T-lymphocyteassociated antigen 4

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巴东组碎屑土夹层的非饱和蠕变经验模型

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中国公路学报 2016年第4期29卷 22-29页

作者：祝艳波余宏明长安大学地质工程与测绘学院陕西西安710054 中国地质大学(武汉)工程学院湖北武汉430074

为预测基质吸力对巴东组碎屑土夹层蠕变行为的影响,开展其非饱和蠕变经验模型的研究。基于碎屑土夹层的非饱和蠕变试验,尝试改进Singh-Mitchell蠕变模型、Mesri蠕变模型:首先选取幂函数分段描述应变-时间关系曲线的各阶段,拟合模型参数... 详细信息

为预测基质吸力对巴东组碎屑土夹层蠕变行为的影响,开展其非饱和蠕变经验模型的研究。基于碎屑土夹层的非饱和蠕变试验,尝试改进Singh-Mitchell蠕变模型、Mesri蠕变模型:首先选取幂函数分段描述应变-时间关系曲线的各阶段,拟合模型参数与基质吸力关系,建立包含基质吸力的改进Singh-Mitchell蠕变模型、Mesri蠕变模型;其次根据蠕变曲线特点,对应力-应变曲线、应变-时间曲线进行非线性拟合,构建包含基质吸力-应力-应变-时间的非饱和蠕变经验模型;最后对比了3种蠕变模型的预测精度。结果表明:改进的Mesri模型基本能预测碎屑土夹层的蠕变全过程,虽然当偏应力水平增高时,预测值与试验值存在偏差,但其精度基本能够满足工程应用要求;提出的非饱和蠕变模型预测效果一般,改进的Singh-Mitchell模型预测效果最差。

关键词：道路工程非饱和蠕变蠕变模型碎屑土夹层基质吸力

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OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models

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World Journal of Gastroenterology 2008年第30期14卷 4800-4804页

作者： Jun Shi Pin-Kang Wei Shen Zhang Zhi-Feng Qin Jun Li Da-Zhi Sun Yan Xiao Zhi-hong yu Hui-ming Lin Guo-Jing Zheng Xiao-Mei Su Ya-Lin Chen Yan-Fang Liu Ling Xu Department of Traditional Chinese Medicine Shanghai Changzheng Hospital Shanghai 200003 China

AIM： To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique. METHODS： Using OB glue paste technique, orthtopic transplantation models were established by implanting SGC-7901 and NKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed. RESULTS： The success rates of orthotopic transplanration of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%. CONCLUSION： OB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors.

关键词： Gastric tumor Tumor transplantation Disease models Animal Nude mice

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雷达/电子战中的现代隐身技术

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现代雷达 2007年第6期29卷 25-27,67页

作者：余宏明中国船舶重工集团公司723所江苏扬州225001

隐身技术是特征控制技术,通过控制信号特征使目标被武器系统探测更为困难。雷达隐身技术的本质是从不同领域用相应的方法来减少目标反射截面积,从而达到隐身的目的;反之是达到反隐身的目的。概述了隐身和反隐身技术的机理和发展现状,并... 详细信息

隐身技术是特征控制技术,通过控制信号特征使目标被武器系统探测更为困难。雷达隐身技术的本质是从不同领域用相应的方法来减少目标反射截面积,从而达到隐身的目的;反之是达到反隐身的目的。概述了隐身和反隐身技术的机理和发展现状,并从雷达/电子战的角度叙述现代隐身技术的理论依据和发展态势,最终阐述综合电子隐身技术在现代战场中的应用前景。

关键词：隐身技术反隐身技术雷达/电子战综合对抗

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边坡模糊随机可靠性分析的模糊点估计法

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岩土力学 2012年第6期33卷 1795-1800页

作者：王宇贾志刚李晓汪灿余宏明中国地质大学(武汉)工程学院武汉430074 中国科学院地质与地球物理研究所北京100029 中国科学院研究生院北京100049

在统计矩点估计法和模糊随机理论的基础之上,提出边坡工程模糊随机可靠性分析的模糊点估计法,将边坡稳定性极限状态方程由模糊随机集向普通随机集转化,然后利用点估计法求解边坡的可靠度指标。鉴于岩土体物理力学参数的近似分布类型,采... 详细信息

在统计矩点估计法和模糊随机理论的基础之上,提出边坡工程模糊随机可靠性分析的模糊点估计法,将边坡稳定性极限状态方程由模糊随机集向普通随机集转化,然后利用点估计法求解边坡的可靠度指标。鉴于岩土体物理力学参数的近似分布类型,采用区别于梯形模糊数的正态模糊数对随机变量进行模糊随机化处理,使其更趋近于物理力学参数的近似分布类型。该方法考虑了各个力学参数的模糊性,计算结果更能反映边坡的真实工作状态。算例分析结果表明,该法使用简便,计算效率高,结果可靠,避免了传统分析方法的缺点,对复杂边坡或者功能函数为隐式表达的边坡工程可靠性分析具有很大的潜力,为边坡可靠性分析提供了一条新的途径,具有广泛的应用前景。

关键词：边坡工程模糊随机可靠性模糊点估计法正态模糊数可靠性指标

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一种定点数权值神经网络的优化方法及其应用

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计算机应用 2009年第1期29卷 230-233页

作者：包健余红明华东理工大学信息科学与工程学院上海200237 杭州电子科技大学智能与软件技术研究所杭州310018

为了使得神经网络的应用符合嵌入式系统快速计算、存储量精简的要求,提出了一种定点数权值神经网络的优化方法。采用精度可调的比例数格式定点数表示神经网络的权值和阈值,用遗传算法对神经网络进行训练,并用最小二乘法对网络的非线性... 详细信息

为了使得神经网络的应用符合嵌入式系统快速计算、存储量精简的要求,提出了一种定点数权值神经网络的优化方法。采用精度可调的比例数格式定点数表示神经网络的权值和阈值,用遗传算法对神经网络进行训练,并用最小二乘法对网络的非线性连续节点激励函数进行了线性离散化。将这种优化的神经网络应用于触摸屏校准。实验表明,采用该方法进行触摸屏校准比传统的校准方法具有更高的准确率。

关键词：神经网络优化定点数权值激励函数触摸屏校准嵌入式系统

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