检索结果-南通市图书馆

Unlocking T cell exhaustion:Insights and implications for CAR-T cell therapy

Acta Pharmaceutica Sinica B 2024年第8期14卷 3416-3431页

作者： Dian Xiong haijun yu Zhi-Jun Sun State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyFrontier Science Center for Immunology and MetabolismTaikang Center for Life and Medical ScienceWuhan UniversityWuhan 430079China Department of Radiation and Medical Oncology Hubei Province Cancer Clinical Study CenterHubei Key Laboratory of Tumor Biological BehaviorsZhongnan Hospital of Wuhan UniversityWuhan 430071China

Chimeric antigen receptor T(CAR-T)cell therapy as a form of adoptive cell therapy(ACT)has shown significant promise in cancer treatment,demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell maturation antigen(BCMA)for hematological malignancies,albeit with moderate outcomes in solid ***,despite these advancements,the efficacy of CAR-T therapy is often compromised by T cell exhaustion,a phenomenon that impedes the persistence and effector function of CAR-T cells,leading to a relapse rate of up to 75%in patients treated with CD19 or CD22 CAR-T cells for hematological *** to overcome CAR-T exhaustion employ state-of-the-art genomic engineering tools and single-cell sequencing *** this review,we provide a comprehensive understanding of the latest mechanistic insights into T cell exhaustion and their implications for the current efforts to optimize CAR-T cell *** insights,combined with lessons learned from benchmarking CAR-T based products in recent clinical trials,aim to address the challenges posed by T cell exhaustion,potentially setting the stage for the development of tailored next-generation approaches to cancer treatment.

关键词： Cancer immunotherapy CAR-T therapy T cell exhaustion Tumor immune microenvironment Spatial immune contexture Single-cell technologies CAR-T engineering Combination therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Selective leaching of lithium from spent lithium-ion batteries using sulfuric acid and oxalic acid

引用

International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 688-696页

作者： haijun yu Dongxing Wang Shuai Rao Lijuan Duan Cairu Shao Xiaohui Tu Zhiyuan Ma Hongyang Cao Zhiqiang Liu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of Resources Utilization and Rare Earth Development Guangdong Academy of SciencesGuangzhou 510650China State Key Laboratory of Separation and Comprehensive Utilization of Rare Metals Guangzhou 510650China Guangdong Province Key Laboratory of Rare Earth Development and Application Guangzhou 510650China

Traditional hydrometallurgical methods for recovering spent lithium-ion batteries(LIBs)involve acid leaching to simultaneously extract all valuable metals into the *** methods usually are followed by a series of separation steps such as precipitation,extraction,and stripping to separate the individual valuable *** this study,we present a process for selectively leaching lithium through the synergistic effect of sulfuric and oxalic *** optimal leaching conditions(leaching time of 1.5 h,leaching temperature of 70°C,liquid-solid ratio of 4 mL/g,oxalic acid ratio of 1.3,and sulfuric acid ratio of 1.3),the lithium leaching efficiency reached89.6%,and the leaching efficiencies of Ni,Co,and Mn were 12.8%,6.5%,and 21.7%.X-ray diffraction(XRD)and inductively coupled plasma optical emission spectrometer(ICP-OES)analyses showed that most of the Ni,Co,and Mn in the raw material remained as solid residue oxides and *** study offers a new approach to enriching the relevant theory for selectively recovering lithium from spent LIBs.

关键词： selective leaching oxalic acid sulfuric acid spent lithium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mn-based cathode materials for rechargeable batteries

引用

Science China Chemistry 2024年第1期67卷 87-105页

作者： Xu Zhang Shiqi Liu Boya Wang Guoqing Wang Haozhe Du Xuanyu Wang Haidong Zhang Shu Zhao Lin Wang haijun yu Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Create Energy&Benefit Future Co.Ltd. Beijing 100176China

The rapid expansion of renewable energies asks for great progress of energy-storage technologies for sustainable energy supplies,which raises the compelling demand of high-performance rechargeable *** satisfy the huge demand from the coming energy-storage market,the resource and cost-effectiveness of rechargeable batteries become more and more ***(Mn)as a key transition element with advantages including high abundance,low cost,and low toxicity derives various kinds(spinels,layered oxides,polyanions,Prussian blue analogs,etc.)of high-performance Mn-based electrode materials,especially cathodes,for rechargeable batteries ranging from Li-ion batteries,Na-ion batteries,aqueous batteries,to multivalent metal-ion *** is anticipated that Mn-based materials with Mn as the major transition-metal element will constitute a flourishing family of Mn-based rechargeable batteries(Mn RBs)for large-scale and differentiated energy-storage *** the other hand,several critical issues including Jahn-Teller effect,Mn dissolution,and O release greatly hinder the pace of Mn RBs,which require extensive material optimizations and battery/system *** review aims to provide an investigation about Mn-based materials and batteries for the coming energy-storage demands,with compelling issues and challenges that must be overcome.

关键词： manganese cathode materials Mn-based rechargeable batteries energy storage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Roadmap for rechargeable batteries:present and beyond

引用

Science China Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin Wang haijun yu Xin Chang yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Core-shell ZSM-5@ Ordered Mesoporous Silica by Tetradecylamine Surfactant

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 332-336页

作者：马扩彦 ZHAO Pengxian YI Hongyu 俞海军 ZHOU Moxi ZHANG Lingling LIU yupu Chongqing Key laboratory of Scientific Utilization of Tobacco Resource Chongqing 400060China Department of Chemistry Laboratory of Advanced MaterialsFudan UniversityShanghai 200433China

A core-shell composite consisting of ZSM-5 zeolite as the core and ordered mesoporous silica as the shell was prepared by a surfactant-controlled sol-gel process and using tetradecylamine(TDA) as the template and Tetraethylorthosilicate(TEOS) as the silica *** pores of the silica shell were found to be ordered and perpendicular to the crystal faces of the zeolite *** thickness of the shell in the coreshell structured composite can be adjusted in the range of 20-90 nm,while the surface morphology and the pore size distribution were modified by changing the mass ratio of TEOS to *** composite molecular sieves have higher surface area for capturing molecules than ZSM-5,and with the increase of mesoporous shell layer,the ZSM-5@SiO_(2)-x composites show stronger adsorption capacity of ***,when the shell thickness exceeds 90 nm,the adsorption capacity of butyraldehyde decreases *** composites have a huge potential for environmental applications.

关键词： core-shell composite tetradecylamine surfactant adsorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

空间科学实验数据可视化分析系统技术研究

引用

载人航天 2024年第3期30卷 328-336页

作者：于海军杨梦博李盛阳中国科学院太空应用重点实验室中国科学院空间应用工程与技术中心北京100094 中国科学院大学北京100049

为提升空间科学实验数据的分析效率与利用水平,设计以数据可视化为切入点,支持多领域、长周期空间科学实验数据交互分析的系统架构,对系统关键技术进行研究。设计分析算法动态扩展和服务映射流程,支持数据分析算法的扩展与更新,建立算... 详细信息

为提升空间科学实验数据的分析效率与利用水平,设计以数据可视化为切入点,支持多领域、长周期空间科学实验数据交互分析的系统架构,对系统关键技术进行研究。设计分析算法动态扩展和服务映射流程,支持数据分析算法的扩展与更新,建立算法的快速处理模式和复杂分析模式,兼容与支持不同类型分析算法的处理流程。通过多可视化组件之间的数据联动,直观且同步呈现相关联数据之间的相关性。采用可视化视图交互调整和布局,支持不同数据、不同显示屏幕的个性可视化需求。系统应用表明:系统已集成了十余种空间科学实验数据分析算法,实现了多领域空间科学实验数据的可视化分析。

关键词：可视化分析空间科学多领域人机交互系统架构

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Ionic liquids for electrochemical energy storage devices applications

引用

Journal of Materials Science & Technology 2019年第4期35卷 674-686页

作者： Huan Liu haijun yu College of Materials Science & Engineering Key Laboratory of Advanced Functional MaterialsMinistry of EducationBeijing University of Technology

Ionic liquids, defined here as room-temperature molten salts, composed mainly of organic cations and(in)organic anions ions that may undergo almost unlimited structural variations with melting points below 100?C. They offer a unique series of physical and chemical properties that make them extreme important candidates for several energy applications, especially for clean and sustainable energy storage and conversion materials and devices. Ionic liquids exhibit high thermal and electrochemical stability coupled with low volatility, create the possibility of designing appropriate electrolytes for different type batteries and supercapacitors. Herein, varieties of ionic liquids applications are reviewed on their utilization as electrolytes for Li-ion batteries, Na-ion batteries, Li-O_2(air) batteries, Li-Sulfur(Li-S) batteries, supercapacitors and as precursors to prepare and modify the electrode materials, meanwhile,some important research results in recent years are specially introduced, and the perspective on novel application of ionic liquids is also discussed.

关键词： Ionic liquids Batteries Supercapacito Electrolyte Electrode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

定向循环技术回收制锂的研究进展

引用

电池 2024年第1期54卷 111-115页

作者：李爱霞余海军谢英豪广东邦普循环科技有限公司广东佛山528137

从退役锂离子电池中回收锂是解决锂资源短缺的重要途径之一。从退役锂离子电池产业链出发,分别研究退役三元正极材料和磷酸铁锂(LiFePO_(4))锂离子电池中定向循环回收制锂的技术进展,分析不同技术优缺点,并展望该工艺的发展趋势和前景... 详细信息

从退役锂离子电池中回收锂是解决锂资源短缺的重要途径之一。从退役锂离子电池产业链出发,分别研究退役三元正极材料和磷酸铁锂(LiFePO_(4))锂离子电池中定向循环回收制锂的技术进展,分析不同技术优缺点,并展望该工艺的发展趋势和前景。三元正极材料锂离子电池前端提锂工艺有助于提高锂回收率,磷酸铁锂锂离子电池湿法回收有较高的锂回收率。同时,提出构建高效低成本浸出体系、优化低温焙烧体系,构建全链条一体化定向循环低碳回收体系的设想。

关键词：退役锂离子电池定向循环技术(DRT) 回收火法冶金浸出锂回收

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Symmetry-breaking of LiMn6 hexatomic-ring in grain surface of Li2MnO3

引用

Journal of Energy Chemistry 2023年第6期81卷 110-117页

作者： Lihang Wang Shu Zhao Boya Wang haijun yu Institute of Advanced Battery Materials and Devices Faculty of Materials and Manufacturing Beijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Beijing University of Technology

LiMn6hexatomic-rings act as functional units in Li-rich layered oxides(LLOs), which determine the capacity, voltage, and structural stability of LLOs. However, the symmetry of the LiMn6hexatomic-ring is always broken, especially in the grain surface of LLOs, which will greatly affect its electrochemical performance. Herein, the symmetry-breaking of LiMn6hexatomic-ring in the grain surface of Li2MnO3was studied, and their effect on charge compensation mechanism and structure evolution behavior was thoroughly investigated. The results show that the electrochemical activity of the symmetry-broken LiMn6hexatomic-ring is higher than that of the unbroken LiMn6, and the former is more favorable for spinelization on the grain surface. Furthermore, the exposure proportion of crystallographic planes with different symmetry-broken LiMn6hexatomic-ring has also been discussed, which can be adjusted by changing the partial pressure of oxygen. The in-depth understanding of the symmetry-breaking of LiMn6hexatomic-ring will provide more targeted strategies for designing high-performance LLOs cathodes for lithium-ion batteries.

关键词： Li-rich layered oxides LiMn6 functional unit Symmetry-breaking Surface structure Density functional theory

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Editorial of Special Column on A New Era of Nanobiomaterial-based Drug Delivery

引用

Acta Pharmaceutica Sinica B 2022年第9期12卷 3453-3455页

作者： haijun yu Zhiyong Qian Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityCollaborative Innovation Center of BiotherapyChengdu 610041China

In the present era of nano/biomaterials,nanosized drug delivery systems(NDDS)have been extensively contributed to the advancement of *** research is carried out on a diverse range of nano-biomaterials,such as liposomes,dendrimers,micelles and so ***,nanobiomaterial-based delivery systems yet need to be further optimized to achieve convincing therapeutic performance2.

关键词： biomaterials biomaterial advancement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：