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Current Medical Science 2021年第6期41卷 1187-1191页

作者： Chen LIU Shuang LIU Hui LI yu-long guo Department of Cardiology Fuwai Yunnan Cardiovascular HospitalKunming 650000China Department of Rheumatology First Affiliated Hospital of Kunming Medical UniversityKunming 650000China Department of Radiology Fuwai Yunnan Cardiovascular HospitalKunming 650000China

Objective:Thrombosis in patients with atrial arrhythmias might be associated with remodeling of the left atrium(LA).We aimed to describe this relationship and identify a novel factor,in addition to the CHA_(2)DS_(2)-VASc score,to guide therapeutic strategies for preventing thromboembolism in the hope of improving the prognosis for such ***:Patients diagnosed with atrial arrhythmias and who met our inclusion criteria were enrolled in this *** clinical parameters were recorded;diameters reflecting remodeling of the LA were measured and thrombosis was diagnosed by enhanced ***:Totally,192 patients were enrolled in the *** overall prevalence of left atrial thrombosis was 8.3%.Patients with persistent atrial fibrillation exhibited the highest anteroposterior diameter of the LA(45.1±7.2 mm)and prevalence of thrombosis(15.6%).An anteroposterior LA diameter of≥50 mm was a strong independent impact risk factor for thrombosis(OR=10.1,95%CI:2.8-36.9,P<***1).The prevalence of LA thrombosis in patients with and without anteroposterior LA diameter of≥50 mm was 25.8%and 5.0%,***:Marked remodeling of the LA characterized by an anteroposterior LA diameter of≥50 mm is a strong independent risk factor of thrombosis,and should be considered for the prevention of thromboembolism through various strategies.

关键词： atrial arrhythmia atrial fibrillation remodeling thrombosis thromboembolism prophylaxis

Updating of Optical Inspection System for 6 GHz Superconducting Cavities

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Updating of Optical Inspection System for 6 GHz Superconduct...

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

作者： yu guo-long Department of Nuclear Technology Application

As a validation tool for the material properties and the surface treatment process,6 GHz superconducting cavity needs complex surface treatment process during its *** is verynecessary to record and monitor the statues of the internal surface of the cavity after each surface treatment,such as ultrasonic washing,mechanical polishing,electronic polishing(EP),buffered chemical

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： yunfan long Jiajia Liu yu Wang Haidong guo guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Identification of candidate genes related to soluble sugar contents in soybean seeds using multiple genetic analyses

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Journal of Integrative Agriculture 2022年第7期21卷 1886-1902页

作者： PAN Wen-jing HAN Xue HUANG Shi-yu yu Jing-yao ZHAO Ying QU Ke-xin ZHANG Ze-xin YIN Zhen-gong QI Hui-dong yu guo-long ZHANG Yong XIN Da-wei ZHU Rong-sheng LIU Chun-yan WU Xiao-xia JIANG Hong-wei HU Zhen-bang ZUO yu-hu CHEN Qing-shan QI Zhao-ming College of Agriculture Northeast Agricultural UniversityHarbin 150030P.R.China Heilongjiang Bayi Agricultural University Daqing 163000P.R.China Keshan Branch of Heilongjiang Academy of Agricultural Sciences Qiqihar 161300P.R.China

Soluble sugar content in seeds is an important quality trait of soybean. In this study, 57 quantitative trait loci(QTLs) related to soluble sugar contents in soybean seeds were collected from databases and published papers. After meta-overview-collinearity integrated analysis to refine QTL intervals, eight consensus QTLs were identified. To further verify the consensus QTLs, a population of chromosome segment substitution lines(CSSLs) was analyzed. Two lines containing fragments covering the regions of consensus QTLs and the recurrent parent were selected: one line showed high soluble sugar contents associated with a consensus QTL fragment, and the other line showed low soluble sugar contents. Transcriptome sequencing was conducted for these two lines at the early, middle, and late stages of seed development, which identified 158, 109 and 329 differentially expressed genes, respectively. Based on the analyses of re-sequencing data of the CSSLs and the consensus QTL region, three candidate genes(Glyma.19 G146800, Glyma.19 G122500, and Glyma.19 G128500) were identified in the genetic fragments introduced from wild soybean. Sequence comparisons between the two CSSL parents SN14 and ZYD00006 revealed a single nucleotide polymorphism(SNP) mutation in the coding sequence of Glyma.19 G122500, causing a nonsynonymous mutation in the amino acid sequence that affected the predicted protein structure. A Kompetitive allele-specific PCR(KASP) marker was developed based on this SNP and used to evaluate the CSSLs. These results lay the foundation for further research to identify genes related to soluble sugar contents in soybean seeds and for future soybean breeding.

关键词： soybean soluble sugar contents consensus QTL meta-overview-collinearity integrated analysis population validation RNA-seq and candidate gene mining

GmDRR1,a dirigent protein resistant to Phytophthora sojae in Glycine max (L.) Merr.

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Journal of Integrative Agriculture 2018年第6期17卷 1289-1298页

作者： CHEN Qing-shan yu guo-long ZOU Jia-nan WANG Jing QIU Hong-mei ZHU Rong-sheng CHANG Hui-lin JIANG Hong-wei HU Zhen-bang LI Chang-yu ZHANG Yan-jiao WANG Jin-hui WANG Xue-ding GAO Shan LIU Chun-yan QI Zhao-ming FU Yong-fu XIN Da-wei Key Laboratory of Soybean Biology Ministry of Education/College of AgricultureNortheast Agricultural University Key Laboratory of Soybean Biology (Beijing) Ministry of Agriculture/National Key Facility of Crop Gene Resource and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural Sciences

Soil-borne pathogen Phytophthora sojae is an oomycete that causes devastating damage to soybean yield. To mine original resistant genes in soybean is an effective and environmentally-friend approach controlling the disease. In this study, soybean proteins were extracted from the first trifoliolates infected by predominant P. sojae race 1 and analyzed by twodimensional gel electrophoresis. Nineteen differently-expressed protein spots were detected, and 10 of them were further applied for Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry Assay. One protein containing a dirigent （DIR） domain was identified and belonged to the DIR-b/d family. Therefore, it was named as GmDRR1 （Glycine max Disease Resistance Response 1）. Then, GmDRR1 gene was pathologically confirmed to be involved in the resistant to P. sojae in soybean. GmDRR1-GFP （green fluorescent protein） fusion proteins localized in the cell membrane. qRTPCR results showed GmDRR1 gene expressed differently in P. sojae resistant- and susceptible-soybean cultivars. By the promoter analysis, we found a haplotype H8 was existing in most resistant soybean varieties, while a haplotype H77 was existing in most susceptible soybean varieties. The H77 haplotype had seven SNPs （C to A, G to C, C to A, T to A, T to C, T to C, and T to A） and two single nucleotide insertions. The results supported that the expression difference of GmDRR1 genes between P. sojae resistant- and susceptible-soybean cultivars might depend on the GmDRR1 promoter SNPs. The results suggested that GmDRR1 was a dirigent protein involved in soybean resistant to P. sojae and paved a novel way for investigation of the molecular regulatory mechanism of the defense response to P. sojae in soybean.

关键词： dirigent domain GmDRR1 soybean Phytophthora sojae oomycete proteomics

动脉粥样硬化与干燥综合征的关系:现有证据及可能机制

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中国全科医学 2017年第12期20卷 1523-1526页

作者：郭雨龙刘爽昆明医科大学第一附属医院心内科云南省昆明市650032 昆明医科大学第一附属医院风湿免疫科云南省昆明市650032

动脉粥样硬化(AS)是一种炎性疾病,与自身免疫性疾病关系密切。干燥综合征(SS)是以外分泌腺受累为特征的自身免疫性疾病。有研究发现SS患者的AS风险显著升高,但其中具体机制尚未清楚。本综述总结现有研究证据,以明确SS与AS之间的相关性,... 详细信息

动脉粥样硬化(AS)是一种炎性疾病,与自身免疫性疾病关系密切。干燥综合征(SS)是以外分泌腺受累为特征的自身免疫性疾病。有研究发现SS患者的AS风险显著升高,但其中具体机制尚未清楚。本综述总结现有研究证据,以明确SS与AS之间的相关性,并提出可能的机制。

关键词：动脉粥样硬化干燥综合征危险因素

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心血管疾病患者心理障碍的识别与治疗

中国全科医学 2018年第22期21卷 2750-2754页

作者：余国龙邓云龙中南大学湘雅医院心内科湖南省长沙市410008 中南大学湘雅三医院临床心理科湖南省长沙市410013

临床上心血管疾病合并心理障碍(双心疾病)非常常见,但国内综合医院医生、基层医院全科医生有时尚不能及时准确识别,已成为突出的问题。本文结合国内外有关心血管疾病合并心理障碍诊治的近期进展,针对其流行病学、诊治现状及临床常见类... 详细信息

临床上心血管疾病合并心理障碍(双心疾病)非常常见,但国内综合医院医生、基层医院全科医生有时尚不能及时准确识别,已成为突出的问题。本文结合国内外有关心血管疾病合并心理障碍诊治的近期进展,针对其流行病学、诊治现状及临床常见类型进行充分阐述,并重点介绍心血管疾病合并心理障碍的识别、诊断方法与主要治疗措施,以期提升综合医院医生尤其是基层医院全科医生对双心疾病的认识及诊治水平。

关键词：心血管疾病心理障碍双心疾病

One Innovation of Mechanical Polishing Apparatus for Surface Treatment of 6 GHz TESLA Superconducting Cavity

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一种计及波激振动的船舶结构疲劳损伤的计算方法

作者： yu guo-long A.A.Rossi R.K.Thakur V.Palmieri Department of Nuclear Technology Application Laboratori Nazionali di Legnaro

6 GHz spinning seamless superconducting radio frequency(SRF)cavities are a very useful tool for testing alternative surface treatments in the fabrication of TESLA ***,the surface is damaged in internal part for the us...

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船舶力学 2022年第1期26卷 103-112页

作者：乐京霞李建锋郭宇龙武汉理工大学交通学院武汉430063 上海船舶运输科学研究所上海200135

船舶的大型化与高强钢在船舶建造中的应用,导致船舶在航行过程中易发生波激振动,增大了船体结构疲劳破坏的风险。目前,基于谱分析的疲劳损伤计算方法是相对较为精确的船舶疲劳评估方法,但此种方法的工作量巨大,给实际应用带来了许多不... 详细信息

船舶的大型化与高强钢在船舶建造中的应用,导致船舶在航行过程中易发生波激振动,增大了船体结构疲劳破坏的风险。目前,基于谱分析的疲劳损伤计算方法是相对较为精确的船舶疲劳评估方法,但此种方法的工作量巨大,给实际应用带来了许多不便。而设计波法的计算效率高,但其累积损伤结果相对偏小,可能给船舶疲劳安全带来安全隐患。本文基于传统的设计波法,提出了一种计及波激振动的船舶结构疲劳损伤计算方法,并用该方法对一艘集装箱船的典型结构进行疲劳评估,给出了各计算热点的累积损伤值。将该方法所得结果与谱分析法和试验计算所得的结果比较可知,本方法所得结果与试验结果符合较好,验证了本文提出的方法是合理可靠的。因此,本文提出的新方法能够高效可靠地计算考虑波激振动的船舶结构疲劳损伤。

关键词：累积损伤波激振动设计波法模型试验

房室结折返性心动过速不同消融终点有效性及安全性的Meta分析比较

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中国循环杂志 2017年第9期32卷 894-898页

作者：郭雨龙刘爽云南省阜外心血管病医院心内科昆明市650000 昆明医科大学第一附属医院风湿免疫科

目的:慢径消融是房室结折返性心动过速(AVNRT)的根治方法。本研究用Meta分析,比较完全阻断慢径传导和慢径传导仍存两种主要消融终点的有效性及安全性。方法:计算机检索Pubmed、Cochrane Library、万方数据库、维普全文数据库,纳入比较AV... 详细信息

目的:慢径消融是房室结折返性心动过速(AVNRT)的根治方法。本研究用Meta分析,比较完全阻断慢径传导和慢径传导仍存两种主要消融终点的有效性及安全性。方法:计算机检索Pubmed、Cochrane Library、万方数据库、维普全文数据库,纳入比较AVNRT两种消融终点(A组:完全阻断慢径传导;B组:慢径传导仍存)的队列研究,应用Revman5.3进行Meta分析。结果:纳入24项研究,共4 799例患者。A组心动过速复发风险显著降低(OR=0.24,P<0.0001),两组房室传导阻滞发生风险之间的差异无统计学意义(OR=2.58,P=0.18)。结论:AVNRT患者以完全阻断慢径传导为消融终点时复发率显著降低,且房室传导阻滞风险不增加。

关键词：心动过速房室结折返性导管消融治疗结果