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Acute Myeloid Leukemia： Advancements in Diagnosis and Treatment

Chinese Medical Journal 2017年第2期130卷 211-218页

作者： Meng-ge yu Hu-Yong Zheng Beijing Key Laboratory of Pediatric Hematology Oncology Beijing 100045 China National Key Discipline of Pediatrics Ministry of Education Beijing 100045 China Key Laboratory of Major Diseases in Children Ministry of Education Beijing 100045 China Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing 100045 China

Objective： Leukemia is the most common pediatric malignancy and a major cause of morbidity and mortality in children. Among all subtypes, a lack of consensus exists regarding the diagnosis and treatment of acute myeloid leukemia （AML）. Patient survival rates have remained modest for the past three decades in AML. Recently, targeted therapy has emerged as a promising treatment. Data Sources： We searched the PubMed database for recently published research papers on diagnostic development, target therapy, and other novel therapies of AML. Clinical trial information was obtained from ***. For the major purpose of this review that is to outline the latest therapeutic development of AML, we only listed the ongoing clinical trials lbr reference. However, the published results of complete clinical trials were also mentioned. Study Selection： This article reviewed the latest developments related to the diagnosis and treatment of AML In the first portion, we provided some novel insights on the molecular basis of AML, as well as provided an update on the classification of AML In the second portion, we summarized the results of research on potential molecular therapeutic agents including monoclonal antibodies, tyrosine kinase/Fms-like tyrosine kinase 3 （FLT3） inhibitors, epigenetic/demethylating agents, and cellular therapeutic agents. We will also highlight ongoing research and clinical trials in pediatric AML. Results： We described clonal evolution and how it changes our view on leukemogenesis, treatment responses, and disease relapse. Pediatric-specific genomic mapping was discussed with a novel diagnostic method highlighted. In the later portion of this review, we summarized the researches on potential molecular therapeutic agents including monoclonal antibodies, tyrosine kinase/FLT3 inhibitors, epigenetic/demethylating agents, and cellular therapeutic agents. Conclusion： gene sequencing techniques should set the basis for next-generation diagnostic methods o

关键词： Acute Myeloid Leukemia Advancements Diagnosis Target Therapy

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Construction of High Expression Plasmid of Human Augmenter of Liver Regeneration(hALR), Expression and Purification of hALR

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Chemical Research in Chinese Universities 2006年第2期22卷 201-204页

作者： SUN Tian-xu WU Yong-ge yu Xiang-hui JIANG Chun-lai JIN Ying-hua CHENG yue KONG Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P. R. China

Experimental evidence has been presented to suggest that the human augmenter of liver regeneration （hALR） serves as a hepatotruphic growth factor during liver regeneration and as a generalized growth factor during pancreas transplant/regeneration. A prokaryotic expression plasmid, pRSET/6his-c-myc-hALR was constructed, by cloning synthesized hALR cDNA into pRSET/6his-c-myc that was improved on the basis of pRSET B by the group. As a result, the protein was highly expressed in E. coli BL21. The recombinant hALR was over 60% of the total protein in E. coli. Its validity was confirmed by means of Western Blotting. The protein was purified by Ni-NTA affinity chrumatography and this FAD-dependent sulthydryl oxidase activity was measured.

关键词： Augmenter of liver regeneration Prokayotic expression plasmid FAD-dependent sulthydryl oxidase

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Recent progress in subatomic particle detection technology

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Frontiers of physics 2013年第5期8卷 548-554页

作者： Zhi-Huan Li Jian-Ling Lou Qi-Te Li yu-Cheng ge Zhe-Wei Yin Yan-Lin Ye School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

Particle detection technologies have been largely advanced in ,boratory over the past decade. A neutron sphere was built to detect the decay neutron emitted from the implanted unstable nu eleus, whereas a multi-neutron correlation spectrometer was implemented to detect the forward moving neutrons resulting from breakup reactions. Charged particle telescopes are now equipped with double sided Silicon strip detectors which have excellent energy and position resolutions. Large size gas chambers, such as resistive plate chambers, have been developed in order to achieve high Derformances related to timing or position measurements. The advances of these technologies con tribute substantially to such large science project, as LHC-CMS, and to the experiments with the radioactive nucleus beams.

关键词： subatomic particles detection nuclear physics

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Insight-HXMT observations of the Crab pulsar

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Research in Astronomy and Astrophysics 2019年第6期19卷 109-116页

作者： You-Li Tuo Ming-yu ge Li-Ming Song Lin-Li Yan Qing-Cui Bu Jin-Lu Qu Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of the Chinese Academy of Sciences Beijing 100049 China School of Mathematics and Physics Anhui Jianzhu University Hefei 230601 China

We report on X-ray emission properties of the Crab pulsar(PSR B0531+21) using observations by Insight-HXMT during its first year after launch. We obtained high signal-to-noise profiles in the X-ray energy band 11–250 keV. We have confirmed an increase in the flux ratio of the second peak over the main peak with increasing energy, consistent with other missions. The separation of the two peaks shows no significant trend with increasing energy. The phase-averaged spectrum, fitted by a logpar model, and the phase-resolved spectra of the Crab pulsar, fitted by a powerlaw in the different energy bands of HXMT, are consistent with RXTE and NuSTAR in that photon indices evolve as a function of phase as well as a function of energy, contributing to a broadband modeling.

关键词： stars neutron star-pulsars individual(Crab)-X-rays

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A Novel Verification Approach of Workflow Schema

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1292-1296页

作者： WANG Guangqi WANG Juying WANG Yan SONG Baoyan yu ge School of Computer Science and Engineering Northeastern University Shenyang 110004 LiaoningChina School of Computer Science and Technology Liaoning University Shenyang 110036 Liaoning China

A workflow schema is an abstract description of the business processed by workflow model, and plays a critical role in analyzing, executing and reorganizing business processes. The verification issue on the correctness of complicated workflow schemas is difficult in the field of workflow. We make an intensive study of it in this paper. We present here local errors and schema logic errors （global errors） in workflow schemas in detail, and offer some constraint rules trying to avoid schema errors during modeling. In addition, we propose a verification approach based on graph reduction and graph spread, and give the algorithm. The algorithm is implemented in a workflow prototype system e-ScopeWork.

关键词： workflow workflow model schema verifica tion transition structure

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Construction and Expression of Human Survivin and Preparation of Its Polyclonal Antibody

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Chemical Research in Chinese Universities 2008年第6期24卷 767-770页

作者： ZHANG Hai-hong ZHANG Xi-zhen ZHAO Dong-hai SHI He-liang yu Yong-hui WU Yong-ge yu Xiang-hui KONG Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P R. China

Survivin, a novel member of inhibitor of apoptosis（IAP） protein family, is aberrantly expressed in cancer but undetectable in normal, differentiated adult tissues. The cancer-specific expression of survivin, coupled with its importance in inhibiting cell death and in regulating cell division makes it a useful diagnostic marker of cancer and a potential target for cancer treatment. Survivin cDNA amplified from the total RNA of 293 cells through RT-PCR was cloned into prokaryotic expression vector pRSET-B. The recombinant plasmid pRSET-B-Surv was expressed in *** BL21, and the relative molecule mass（Mr） of expressed fusion protein was approximately 21000. The recombinant protein was purified through Ni^2＋ affinity chromatography column and characterized by SDS-PAge and Western blot. The purified recombinant protein was then injected into rabbits, and antisurvivin polyclonal antibody with a high titer was obtained.

关键词： Clone Survivin Expression Polyclonal antibody

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Extracting Result Schema Based on Query Instances in the Deep Web

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Wuhan University Journal of Natural Sciences 2007年第5期12卷 835-839页

作者： NIE Tiezheng yu ge SHEN Derong KOU yue LIU Wei College of Information Science and Engineering Northeastern University Shenyang 110004 Liaoning China

Deep Web sources contain a large of high-quality and query-related structured date. One of the challenges in the Deep Web is extracting result schemas of Deep Web sources. To address this challenge, this paper describes a novel approach that extracts both result data and the result schema of a Web database. The approach first models the query interface of a Deep Web source and fills in it with a specifically query instance. Then the result pages of the Deep Web sources are formatted in the tree structure to retrieve subtrees that contain elements of the query instance, Next, result schema of the Deep Web source is extracted by matching the subtree＇ nodes with the query instance, in which, a two-phase schema extraction method is adopted for obtaining more accurate result schema. Finally, experiments on real Deep Web sources show the utility of our approach, which provides a high precision and recall.

关键词： Deep Web schema extraction result schema query instance

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Impacts of Climate Change on Locust Outbreaks in China's History

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Bulletin of the Chinese Academy of Sciences 2009年第4期23卷 234-236页

作者： yu ge Nanjing Institute of geography and Limnology Chinese Academy of Sciences Nanjing 210008 China

Global warming is causing the climate to change,lakes to dry up and less rain to fall. In population ecology,researchers have found that climate change plays an important role in controlling the size of species popula... 详细信息

关键词：气候变化影响历史记录爆发蝗灾中国研究人员人口数量全球变暖

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KDS-CM:A Cache Mechanism Based on Top-K Data Source for Deep Web Query

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Wuhan University Journal of Natural Sciences 2007年第5期12卷 830-834页

作者： KOU yue SHEN Derong yu ge LI Dong NIE Tiezheng College of Information Science and Engineering Northeastem University Shenyang 110004 Liaoning China Business Software Division Neusoft Group Limited Company Shenyang 110004 Liaoning China

Caching is an important technique to enhance the efficiency of query processing. Unfortunately, traditional caching mechanisms are not efficient for deep Web because of storage space and dynamic maintenance limitations. In this paper, we present on providing a cache mechanism based on Top-K data source （KDS-CM） instead of result records for deep Web query. By integrating techniques from IR and Top-K, a data reorganization strategy is presented to model KDS-CM. Also some measures about cache management and optimization are proposed to improve the performances of cache effectively. Experimental results show the benefits of KDS-CM in execution cost and dynamic maintenance when compared with various alternate strategies.

关键词： cache Top-K Deep Web data reorganization cache management and optimization

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Protective effect of cyclophilin A against Alzheimer＇s amyloid beta-peptide （25-35）-induced oxidative stress in PC12 cells

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Chinese Medical Journal 2009年第6期122卷 716-724页

作者： ge yu-song TENG Wei-yu ZHANG Chao-dong Department of Neurology First Affiliated Hospital China Medical University Shenyang Liaoning 110001 China

Background β-amyloid peptide （Aβ） is considered responsible for the pathogenesis of Alzheimer＇s disease （AD）. Possible mechanisms underlying Aβ-induced neuronal cytotoxicity include excessive production of reactive oxidative species （ROS） and apoptosis. Cyclophilin A （CypA）, exhibits antioxidant properties and protects neurons against oxidative stress induced injury. This study was conducted to demonstrate whether CyPA added to cultured PC12 cells could alleviate Aβ-induced oxidative stress and protect them from apoptosis.Methods PC12 cells were pre-incubated for 30 minutes with recombinant human cyclophilin A （rhCyPA） in 0.1 nmol/L, 1.0 nmol/L, 10 nmol/L and 100 nmol/L and then incubated with 10 μmol/L Aβ25-35. In every group, cell viability, apoptotic morphology, apoptotic rate, intracellular ROS accumulation, the activities of superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px） of PC12 cells and mitochondrial transmembrane potential were detected. Subsequently, the expression of the active form of caspase-3 was determined by Western blotting.Results It was shown that cultures treated with 1.0 nmol/L, 1U nmol/L or 100 nmol/L rnL, rhCyPA＋Aβ25-35 had significantly higher cell viability and a lower rate of apoptosis compared with the cultures exposed only to Aβ25-35. In addition, rhCyPA attenuated Aβ25-35-induced overproduction of intracellular ROS and Aβ25.35-induced a decrease in activity of the key antioxidant enzymes SOD and GSH-Px. Furthermore, rhCyPA also attenuated Aβ25.35-induced mitochondrial dysfunction and the activation of caspase-3.Conclusion CyPA may act as an ROS scavenger, and prevent Aβ25-35-induced neurotoxicity through attenuating oxidative stress induced by Aβ25-35.

关键词： Alzheimer's disease cyclophilin A β-amyloid oxidative stress apoptosis

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