检索结果-南通市图书馆

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge hao Li yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

三棱总黄酮的提取工艺研究

时珍国医国药 2013年第12期24卷 2840-2841页

作者：林琪宇苏湘耘杨菁彭腾余成浩四川省自贡市食品药品检验所643000 成都中医药大学四川成都610075

目的研究提取三棱总黄酮的最佳工艺条件。方法以芦丁为对照,三棱总黄酮得率为考察指标,采用正交设计L9(34),以溶媒体积(A)、提取时间(B)和提取次数(C)为参数进行提取工艺的优选。结果最佳提取工艺为:60%乙醇用量为药材10倍量,提取3次,每... 详细信息

目的研究提取三棱总黄酮的最佳工艺条件。方法以芦丁为对照,三棱总黄酮得率为考察指标,采用正交设计L9(34),以溶媒体积(A)、提取时间(B)和提取次数(C)为参数进行提取工艺的优选。结果最佳提取工艺为:60%乙醇用量为药材10倍量,提取3次,每次1.5h。结论该方法简便、快速、准确,适用于三棱总黄酮的提取工艺研究。

关键词：三棱总黄酮提取工艺正交实验

在线全文

学校读者我要写书评

暂无评论

清胆颗粒利胆作用的实验研究

四川动物 2005年第4期24卷 627-630页

作者：余成浩文昌凡张宏刘彬廖建成都中医药大学成都610075 四川好医生制药有限公司四川省药品检验所

目的:通过研究清胆颗粒对正常大鼠及模型动物胆汁及病理组织的影响,确定其利胆功效,为临床应用提供依据。方法:采用胆管引流法测定清胆颗粒对正常大鼠胆汁量的影响;应用石胆酸(lithocholic acid,LCA)造成豚鼠胆囊炎模型,测定其对模型动... 详细信息

目的:通过研究清胆颗粒对正常大鼠及模型动物胆汁及病理组织的影响,确定其利胆功效,为临床应用提供依据。方法:采用胆管引流法测定清胆颗粒对正常大鼠胆汁量的影响;应用石胆酸(lithocholic acid,LCA)造成豚鼠胆囊炎模型,测定其对模型动物肝重、肝指数、胆囊容积及胆囊病理组织的影响。结果:清胆颗粒能显著增加正常大鼠胆汁流量,明显减轻模型动物肝湿重和肝指数,缩小胆囊容积,能明显降低胆汁中TB、DB及UCB/TB含量,对Ca2+增高有明显的抑制作用,对模型动物胆囊粘膜上皮增生有明显的抑制作用。结论:清胆颗粒具有显著的利胆作用。

关键词：清胆颗粒利胆实验研究

双龙方对大鼠心肌缺血／再灌注后无复流影响的研究

在线全文

学校读者我要写书评

暂无评论

中国药理学通报 2018年第4期34卷 583-588页

作者：李峰杰李贻奎何萍郝新梅李超华赵乐郝伟余丞浩张金艳中国中医科学院西苑医院基础医学研究所中药药理北京市重点实验室北京100091

目的探索双龙方对大鼠心肌缺血/再灌注后无复流的影响。方法将200只大鼠随机分为5组,每组40只:模型组、假手术组、双龙方5 g生药/kg组、双龙方2.5 g生药/kg组、双龙方1.25 g生药/kg组。各组大鼠在造模前连续灌胃5 d,模型组和假手术组灌... 详细信息

目的探索双龙方对大鼠心肌缺血/再灌注后无复流的影响。方法将200只大鼠随机分为5组,每组40只:模型组、假手术组、双龙方5 g生药/kg组、双龙方2.5 g生药/kg组、双龙方1.25 g生药/kg组。各组大鼠在造模前连续灌胃5 d,模型组和假手术组灌胃同体积蒸馏水。给药结束后,对大鼠冠状动脉左前降支进行结扎,假手术动物只穿线不结扎。结扎后4 h,实施再灌注。再灌注4 h后,采用小动物高分辨率超声影像系统对各组大鼠行超声心动图检查和心肌声学造影;超声检查结束后,于腹主动脉取血,分离血清,测定血清cTnT、CRP、CK、LDH水平;大鼠取血完毕后,取出心脏,切片,分别用硫磺素S和硝基四氮唑蓝(N-BT)染色评估心肌无复流面积和梗死面积。结果与模型组比较,双龙方组的心肌无复流面积和梗死面积均明显减小(P<0.01或P<0.05);心脏B超显示心功能指标明显改善,左心室前壁缺血区厚度明显增加,收缩末期左心室内径和容积明显降低,短轴缩短率、射血分数和每搏输出量明显提高(P<0.01或P<0.05);心肌声学造影显示心肌血液灌注明显改善,左心室前壁心肌组织的微血管密度、血流速和血液灌注量明显增加(P<0.01或P<0.05);心肌损伤相关的血液学指标未见明显改善,血清cTnT、CRP、CK、LDH水平未见明显变化。结论双龙方可以明显减小大鼠的心肌梗死面积和无复流面积,可明显对抗心肌缺血/再灌注后的无复流,改善受损心肌组织的血液灌注,改善心功能,抑制心肌损伤。

关键词：双龙方大鼠心肌缺血/再灌注心肌梗死无复流超声心动图检查心肌声学造影

利用EXCEL回归分析功能处理水准仪测微器数据

在线全文

学校读者我要写书评

暂无评论

北京测绘 2009年第3期23卷 10-12页

作者：柯明于成浩中科院上海应用物理研究所上海201210

利用数显游标卡尺检验了几台水准仪测微器的精度,对一台出现问题的水准仪测微器读数,利用EXCEL具有的数据回归分析功能进行处理,得到了较好的回归曲线,修正后的数据可满足精密水准测量的要求。

关键词：回归分析测微器水准仪数显游标卡尺

Mechanical properties and microstructures of Mg-6Si alloys fabricated using the tungsten-inert-gas arc additive manufacturing

在线全文

学校读者我要写书评

暂无评论

China Foundry 2025年

作者： Peng-cheng Zhou Guo-qiang You Jin-yu Feng Lei Wang Xiao Lin Bin Jiang College of Materials Science and Engineering Chongqing University National Engineering Research Center for Magnesium Alloys Chongqing University National Key Laboratory of Advanced Casting Technologies Chongqing University

Si-containing Mg alloys solidified at conventional rates often contain coarse and sharp Mg2Si phases,which can result in inferior material *** this study,Mg-6wt.%Si （Mg-6Si） alloy was prepared by wire arc additive manufacturing （WAAM）,employing the gas tungsten arc welding technique with rapid *** microstructures and mechanical properties of the WAAM alloy were investigated and compared with those of the as-cast samples produced using a metal *** results indicate that the WAAM Mg-6Si is harder and stronger than the as-cast *** microhardness of the WAAM Mg-6Si increases by 36.6%in comparison to that of as-cast Mg-6Si ***,the average tensile strengths at room temperature and 150°C increases by 63.4%and 21.3%,*** refines both the Mg2Si phase and the overall grains,resulting in a homogeneous morphology and improved mechanical *** granular Mg2Si phase,characterized by fine particles with a diffused distribution,shows a significant increase in *** acicular Mg2Si phase is distributed along the grain boundaries,and its concentration significantly *** average grain size of the Mg2Si phase is about 9.20μm,about 5 times *** refinement and distribution of the granular Mg2Si phase,as well as the reduction in the amount of needle-like Mg2Si particles,are the key factors for improving the mechanical properties of WAAM Mg-6Si alloy.

关键词：

制川乌配伍白芍不同配伍比例对酯型生物碱含量的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

成都中医药大学学报 2007年第4期30卷 43-45页

作者：余成浩彭成余葱葱郭力成都中医药大学四川成都610075

目的：研究制川乌白芍配伍药对的不同配伍比例在水煎液环境中对酯型生物碱含量的影响，探讨配伍规律的科学性和合理性。方法：采用改良异羟肟酸铁分光光度法测定酯型生物碱的含量。结果：与制川乌单煎液相比较，制川乌白芍各配伍组含量... 详细信息

目的：研究制川乌白芍配伍药对的不同配伍比例在水煎液环境中对酯型生物碱含量的影响，探讨配伍规律的科学性和合理性。方法：采用改良异羟肟酸铁分光光度法测定酯型生物碱的含量。结果：与制川乌单煎液相比较，制川乌白芍各配伍组含量均升高，幅度达到7．8％-21．7％。在各配伍组中，酯型生物碱含量大小为制川乌白芍2：3〉1：1〉1：2〉2：1。结论：在制川乌配伍白芍各配伍组中，酯型生物碱含量呈现升高趋势，为不同配伍关系在临床使用的减毒增效科学内涵提供一定的科学依据。

关键词：配伍药对改良异羟肟酸铁分光光度法酯型生物碱含量

村改社区集体经济发展问题与对策——以山东省A县为例

在线全文

学校读者我要写书评

暂无评论

德州学院学报 2022年第6期38卷 61-65,92页

作者：郭乐群成宇昊天津市河西区委党校天津300000 南安普顿大学商学院南安普顿市SO171BJ

A县村改社区集体经济发展亟需解决的主要问题是:建立健全村改社区经济合作组织“带头人”的激励机制;推动村改社区合作经济组织高质量发展;优化村改社区集体经济发展与公共服务之间的关系。鉴于此,发展壮大村改社区集体经济的对策建议是... 详细信息

A县村改社区集体经济发展亟需解决的主要问题是:建立健全村改社区经济合作组织“带头人”的激励机制;推动村改社区合作经济组织高质量发展;优化村改社区集体经济发展与公共服务之间的关系。鉴于此,发展壮大村改社区集体经济的对策建议是:强化党建引领,建立多元主体共建组织体系;深化资产改制,探索社区专业化与市场化运作;破解人才瓶颈,加强集体经济发展的队伍建设。

关键词：村改社区新型集体经济产权制度

Unveiling the relationship between Fabry-Perot laser structures and optical field distribution via symbolic regression

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第3期21卷 149-154页

作者： LI Wenqiang WU Min LI Weijun hao Meilan yu Lina Ann Lab Institute of Semiconductors Chinese Academy of Sciences School of Electronic Electrical and Communication Engineering & School of Integrated Circuits University of Chinese Academy of Sciences Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology

In recent years, machine learning (ML) techniques have been shown to be effective in accelerating the development process of optoelectronic devices. However, as"black box"models, they have limited theoretical interpretability. In this work, we leverage symbolic regression (SR) technique for discovering the explicit symbolic relationship between the structure of the optoelectronic Fabry-Perot (FP) laser and its optical field distribution, which greatly improves model transparency compared to ML. We demonstrated that the expressions explored through SR exhibit lower errors on the test set compared to ML models, which suggests that the expressions have better fitting and generalization capabilities.

关键词：