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Development and Validation of a New Prognostic Model for Predicting Survival Outcomes in Patients with Acute-onchronic Liver Failure

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 834-844页

作者： Wende Li Wanshu Liu Yihui Rong Dongze Li Bing Zhu Shaobo Yang Shidong Sun Shaoli You yu Chen Jun Li Department of Infection and Liver Diseases Peking University International HospitalBeijingChina Department of Hepatology Medicine Fifth Medical Center of Chinese PLA General HospitalBeijingChina Fourth Department of Liver Disease Beijing Youan HospitalCapital Medical UniversityBeijingChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesZhejiang University School of Medicine First Affiliated HospitalHangzhouZhejiangChina

Background and Aims:Early determination of prognosis in patients with acute-on-chronic liver failure(ACLF)is crucial for optimizing treatment options and liver *** study aimed to identify risk factors associated with ACLF and to develop new prognostic models that accurately predict patient ***:We retrospectively selected 1,952 hospitalized patients diagnosed with ACLF between January 2010 and June *** cohort was used to develop new prognostic scores,which were subsequently validated in external ***:The study included 1,386 ACLF patients and identified six independent predictors of 28-day mortality through multivariate analysis(all p<0.05).The new score,based on a multivariate regression model,demonstrated superior predictive accuracy for both 28-day and 90-day mortalities,with Areas under the ROC curves of 0.863 and 0.853,respectively(all p<0.05).This score can be used to stratify the risk of mortality among ACLF patients with ACLF,showing a significant difference in survival between patients categorized by the cut-off value(log-rank(Mantel-Cox)χ^(2)=487.574 and 606.441,p=0.000).Additionally,the new model exhibited good robustness in two external ***:This study presents a refined prognostic model,the Model for end-stage liver disease-complication score,which accurately predicts short-term mortality in ACLF *** model offers a new perspective and tool for improved clinical decision-making and short-term prognostic assessment in ACLF patients.

关键词： Acute-on-chronic liver failure ACLF Outcome prediction Mortality Prognosis Model

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长江流域洪灾规律、成因及对策研究

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湘潭师范学院学报（自然科学版） 2004年第1期26卷 95-97页

作者：万昕吴玉锋中国地质大学研究生院湖北武汉430074

长江流域是一个洪涝灾害频繁发生的地区 ,尤其是 1998年特大洪水造成了严重的损失。从历史上长江流域的洪涝灾害出发 ,总结了从元代至今的长江流域洪灾资料 ,并进行整理和分析 ,初步探索了洪灾的发生规律和原因。

关键词：长江流域洪灾规律形成原因气候异常水土流失生态建设

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Variable selection via generalized SELO-penalized linear regression models

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Applied mathematics(A Journal of Chinese Universities) 2018年第2期33卷 145-162页

作者： SHI yue-yong CAO Yong-xiu yu Ji-chang JIAO yu-ling school of Econoraics and Management China University of GeosciencesWuhan 430074China school of statistics and mathematics Zhongnan University of Economics and LawWuhan 430073China Center for Resources and Environmental Economic Research China University of GeosciencesWuhan 430074China

The seamless-L0 （SELO） penalty is a smooth function on [0, ∞） that very closely resembles the L0 penalty, which has been demonstrated theoretically and practically to be effective in nonconvex penalization for variable selection. In this paper, we first generalize SELO to a class of penalties retaining good features of SELO, and then propose variable selection and estimation in linear models using the proposed generalized SELO （GSELO） penalized least squares （PLS） approach. We show that the GSELO-PLS procedure possesses the oracle property and consistently selects the true model under some regularity conditions in the presence of a diverging number of variables. The entire path of GSELO-PLS estimates can be efficiently computed through a smoothing quasi-Newton （SQN） method. A modified BIC coupled with a continuation strategy is developed to select the optimal tuning parameter. Simulation studies and analysis of a clinical data are carried out to evaluate the finite sample performance of the proposed method. In addition, numerical experiments involving simulation studies and analysis of a microarray data are also conducted for GSELO-PLS in the high-dimensional settings.

关键词： continuation coordinate descent BIC LLA oracle property SELO smoothing quasi-Newton

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Fish Assemblage and Abundance Distribution in Nanji Islands Marine Nature Reserve in Relation to Season change

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 13-32页

作者： Cheikh Sarr Cungen yu Ousmane Ndiaye Hamet Diadhiou Ngor Ndour Laboratory of Fishery Resources Zhejiang Ocean University Zhoushan China Laboratory of Agriculture and Environmental Sciences National High School of Agriculture Thies Senegal Senegalese Institute of Agriculture Research Oceanographic Research Center of Dakar Thiaroye Dakar Senegal Laboratory of Agroforestry and Plant Production Assane Seck University of Ziguinchor Ziguinchor Senegal

The fishing survey station located in the warm waters of the East china Sea is one of the abundant fishery resources of waters;with a large number of economic fish breeding grounds and economic juvenile feeding grounds. Several fish species according to this bottom trawl survey results which appear in the annual survey from winter to autumn give us a total of 58 species, which have appeared throughout the year. But the vast majority of species appears only in certain seasons, according to the sea fish survey and based on seasonal migratory species or species mainly small endemic species. The survey of fish is tropical and subtropical warm water species and warm temperate species, and the history of the area has several types of 397 different species. There are many reasons, in addition to recent years, human disturbance and adverse consequences of environmental changes brought about, but also with the relevant sampling methods and sampler time, the survey sampled only trawl based, from Ping yang Ocean and Fisheries Bureau, the waters are still other jobs method net, gill nets, fishing industry, etc. Survey results show that the type of fish in the summer (58 species) > spring (55 species) > winter (51 species) > autumn (42 species). The type of season was among spring to summer rose, summer to autumn decline. The survey found that in the reef area of the Nanji Islands, no one species of fish is the dominant species throughout the year (according to the dominant species, each species is dominant only in one season). From the dominant species turnover accounting for the four seasons, in winter it has 53.72% of the total biomass or annual biomass, spring it has 41.53% of the overall biomass, summer it has 31.85% and autumn it has 38.56% of total biomass. Visible, seasonal succession of dominant species of fish phenomenon is very obvious, especially in the spring and winter, summer transfers dominate species at this stage show the greatest change, but winter, the transf

关键词： Nanji Islands Species Composition Abundance Distribution Seasons

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Quasi-real time inversion method of three-dimensional epicenter coordinate, trigger time, and magnitude based on CORS

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Earthquake Engineering and Engineering Vibration 2016年第3期15卷 425-433页

作者： Xiao Dongsheng chang Ming Su Yong Hu Qijun yu Bing school of Civil Engineering and Architecture Southwest Petroleum University State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology

This study explores the quasi-real time inversion principle and precision estimation of three-dimensional coordinates of the epicenter, trigger time and magnitude of earthquakes with the aim to improve traditional methods, which are flawed due to missing information or distortion in the seismograph records. The epicenter, trigger time and magnitude from the Lushan earthquake are inverted and analyzed based on high-frequency GNSS data. The inversion results achieved a high precision, which are consistent with the data published by the china Earthquake Administration. Moreover, it has been proven that the inversion method has good theoretical value and excellent application prospects.

关键词： continuous operation reference station (CORS) trigger time three dimensional coordinate magnitude inversion

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Clinical study of neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1647-1659页

作者： Mu-Sen Xu Jia-Le Xu Xin Gao Shao-Jian Mo Jia-yu Xing Jia-Hang Liu Yan-Zhang Tian Xi-Feng Fu The Third Hospital of Shanxi Medical university Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various *** categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and *** A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were *** patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 *** collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital *** The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP *** the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥***,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥***,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP *** NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.

关键词： Acute pancreatitis Gallstone Hypertriglyceridemia Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Persistent organ failure

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Isolation and short term cultivation of swine hepatocytes for bioartificial liver support system

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 249-253页

作者： Jun Li, Lan-Juan Li, Hong-Cui Chao, Qian Yang, Xiao-Li Liu, Ji-Fang Sheng, Hai-Ying yu and Jian-Rong Huang Hangzhou, china Key Laboratory of Infectious Disease, Ministry of Pub- lic Health of china Institute of Infectious Disease, Department of Infectious Diseases, First Affiliated Hospital, Zhejiang university school of Medicine, Hangzhou 310003, china Department of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. lilj@***

BACKGROUND: The demand for the clinical use of hepa- tocytes is increasing. The aim of this study was to develop a method for procurement of high qualitative pig hepatocytes and to evaluate the state of freshly isolated and cultured hepatocytes. METHODS: The domestic extracorporeal circulating perfu- sion apparatus was used to isolate and harvest swine hepato- cytes by the two-step perfusion method with EDTA and collagenase. The viability, function and morphology of the freshly isolated and cultured cells were evaluated and ob- served by the trypan blue exclusion test, biochemical mea- surements, phase contrast microscopy and transmission electron micrography (TEM). RESULTS: The total yield of isolated hepatocytes reached to 1.5(±0.4)×l010 per liver with a viability of 92(±5)%, and the purity of hepatocytes reached to 98% Immediately after isolation, phase-contrast microscope and TEM showed that undamaged hepatocytes appeared bright, translucent and spherical in shape, with a characteristic well-contrasted border. After 24 hours, the concentrations of alanine aminotransferase (ALT), aspartate aminotrans- ferase ( AST ), lactate dehydrogenase ( LDH ), albumin (ALB), creatinine (Cr) and blood urea nitrogen (BUN) in the fluid of culture were declined significantly. CONCLUSION: This method of procuring swine hepato- cytes could get high quality cells with active metabolic function.

关键词： bioartificial liver support system porcine hepatocytes cell isolation cell transplantation

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桐子营水电站工程的水土流失及防治措施

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湘潭师范学院学报（自然科学版） 2004年第4期26卷 93-95页

作者：余明勇程胜高中国地质大学环境学院湖北武汉430074

分析了桐子营水电站建设过程中道路、大坝、引水隧洞、厂房及土石料场等主要施工环节对水土流失的影响 ,阐述了水土流失的诸多危害 ,采用通用土壤流失方程对工程建设期造成的水土流失量预测分析 ,提出了水电站建设过程中防治水土流失应... 详细信息

分析了桐子营水电站建设过程中道路、大坝、引水隧洞、厂房及土石料场等主要施工环节对水土流失的影响 ,阐述了水土流失的诸多危害 ,采用通用土壤流失方程对工程建设期造成的水土流失量预测分析 ,提出了水电站建设过程中防治水土流失应采取措施。

关键词：水土流失量通用土壤流失方程防治措施危害预测分析水电站建设水电站工程引水隧洞大坝厂房

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Performance Analysis of the Distribution-Transform-Based PAR Reduction Method for OFDM Signal

Performance Analysis of the Distribution-Transform-Based PAR...

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2006 10th International Conference on Communication Technology（ICCT 2006）

作者： Hua yu Leming Hu Fei Ji and Gang Wei school of Electronic and Information Engineering South china university of Technology Guangzhou 510640 china

Recently, a very effective peak-to-average power ratio （PAR） reduction scheme based on the distribution transform （DT） for OFDM signals is proposed. Key idea of DT is to transform the distribution of the OFDM signal amplitudes into a target distribution, which has limited dynamic range and very low PAR. But, the PAR-reduction performance and the BER performance of DT are conflicting with each other similar to other signal-distortion-type PAR-reduction schemes. In this paper, the trade-off between the PAR and BER performances of DT is addressed. An analysis framework is proposed to select the optimum transform function for DT with minimum consumed energy-to-noise ratio （SNRC）. Simulation shows DT with the optimum transform function can obtain about 2dB SNRC gain compared to the original OFDM signal.

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LASSO-LSSVM与激光诱导击穿光谱技术结合提高铝合金中Mn成分检测精度研究

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光谱学与光谱分析 2024年第4期44卷 977-982页

作者：戴宇佳高勋刘子源浙江农林大学光机电工程学院浙江杭州311300 长春理工大学物理学院吉林长春130022

铝合金作为一种重要的航空航天装备材料,其元素含量是决定铝合金材料质量和性能的关键因素,其组成成分的多样性对铝合金的铸造、冶炼以及回收分类有较大的影响,其中Mn是铝合金中的重要元素,能够止铝合金的再结晶过程,提高再结晶温度。... 详细信息

铝合金作为一种重要的航空航天装备材料,其元素含量是决定铝合金材料质量和性能的关键因素,其组成成分的多样性对铝合金的铸造、冶炼以及回收分类有较大的影响,其中Mn是铝合金中的重要元素,能够止铝合金的再结晶过程,提高再结晶温度。铝合金成分的定量测定是合金成分在线检测的重要组成部分。信号波动(激光能量波动、等离子体不稳定性、样品不均匀性等)和自吸收效应对激光诱导击穿光谱(LIBS)技术测定铝合金中微量元素有一定影响。为了消除自吸收效应和信号波动所引起的偏差,提出了一种利用LIBS技术结合LASSO-LSSVM机器学习法检测铝合金材料中微量元素含量的新方法。利用最小绝对收缩和选择算子(LASSO)模型对光谱特征向量进行选择,降低光谱数据的维度从而与训练样本相匹配,降低了过拟合风险,有效提取表征LIBS光谱最重要的特征。利用最小二乘支持向量机(LSSVM)模型对LASSO所选择的特征光谱进行训练,分析结果与内标法和偏最小二乘回归(PLSR)相比,LASSO-LSSVM回归模型的精度和准确性都有所提高,其中,Mn元素回归曲线的相关系数(R^(2))从74.62%提高到99.29%,平均相对误差(ARE)从22.38%降低到3.56%,训练集均方根误差(RMSEC)从0.66 wt%降低到0.040 wt%,测试集均方根误差(RMSEP)从0.58 wt%降低到0.042 wt%。LASSO-LSSVM回归模型适用于复杂、不确定性较高的高维光谱数据,能够大大降低输入光谱数据的维数和冗余信息,因此,该模型减少了LSSVM的过拟合问题。研究结果表明,LIBS技术和LASSO-LSSVM回归模型的结合可以有效改善LIBS技术对于铝合金材料的定量分析性能,是一种简单、可靠、高精度检测合金含量的新方法。

关键词：激光诱导击穿光谱铝合金 LASSO-LSSVM 定量分析

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