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体育学刊 2006年第2期13卷 104-107页

作者：俞爱玲绍兴文理学院体育系浙江绍兴312000

对20世纪80年代以来在加拿大学校体育中有着广泛影响的“高质量的日常体育活动计划”的思想基础和目标、产生的社会背景、基本内容和特点、评价模式等进行了综合分析和研究,认为对我国学校体育改革很有借鉴意义,并提出了若干建议。

关键词：加拿大高质量的日常体育活动计划学校体育

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美国公立学校休闲体育的发展历程

体育学刊 2007年第3期14卷 77-79页

作者：俞爱玲绍兴文理学院体育学院浙江绍兴312000

对19世纪初以来的美国公立学校休闲体育的发展进行了研究。美国公立学校休闲体育发展经历了4个阶段。即从为青少年提供玩耍、娱乐的场馆开始到融入式课程模式以及与个人成长,满足家庭、社区和社会需求相联系的一系列改革和发展;目前的... 详细信息

对19世纪初以来的美国公立学校休闲体育的发展进行了研究。美国公立学校休闲体育发展经历了4个阶段。即从为青少年提供玩耍、娱乐的场馆开始到融入式课程模式以及与个人成长,满足家庭、社区和社会需求相联系的一系列改革和发展;目前的学校休闲体育致力于作为个人发展和终身学习过程的一部分,继续发挥其积极作用。

关键词：休闲体育公立学校美国

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体育教育专业健康教育课程主要内容的构建

北京体育大学学报 2006年第5期29卷 665-667页

作者：俞爱玲绍兴文理学院浙江绍兴312000

采用文献资料法、问卷调查法等。通过对美国印第安纳大学健康体育和娱乐学院健康教育师资培养课程方案作个案分析,试图揭示其学校健康教育师资培养所应具备健康教育学科的知识系统,为充实与调整我国普通高校体育教育专业健康教育课程主... 详细信息

采用文献资料法、问卷调查法等。通过对美国印第安纳大学健康体育和娱乐学院健康教育师资培养课程方案作个案分析,试图揭示其学校健康教育师资培养所应具备健康教育学科的知识系统,为充实与调整我国普通高校体育教育专业健康教育课程主要内容提供参考。

关键词：体育教育专业健康教育课程内容

Recent advances in age-related metabolic dysfunction-associated steatotic liver disease

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World Journal of Gastroenterology 2024年第7期30卷 652-662页

作者： Qian-Jun He Yi-Fei Li ling-Tong Zhao Chun-Tong Lin Chun-Yan yu Dan Wang College of Basic Medicine Beihua UniversityJilin 132013Jilin ProvinceChina Department of Traumatic Surgery Jilin Central HospitalJilin 132001Jilin ProvinceChina

Metabolic dysfunction-associated steatotic liver disease(MASLD)affects approximately 25%of the world's population and has become a leading cause of chronic liver *** recent years,an increasing amount of data suggests that MASLD is associated with *** the population ages,age-related MASLD will become a major global health *** an aging will become a new approach to the treatment of *** paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD,including:Oxidative stress,autophagy,mitochondrial homeostasis,bile acid metabolism homeostasis,and *** aim is to identify effective therapeutic targets for age-related MASLD and its progression.

关键词： Metabolic dysfunction-associated steatotic liver disease Aging Mitochondrial homeostasis Bile acid homeostasis Dysbiosis

全面建设小康社会中农村体育文化的困境与出路

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北京体育大学学报 2005年第11期28卷 1481-1482,1494页

作者：俞爱玲绍兴文理学院体育学院浙江绍兴312000

从文化学的视角,通过文献资料、逻辑、社会学等方法,论述现阶段我国农村体育文化建设面临的种种矛盾与冲突即“统一模式”与需求层次多样化的文化冲突;挥霍浪费与勤俭节约的文化冲突;真假体育的文化冲突;“传统人”与“现代人”的文化... 详细信息

从文化学的视角,通过文献资料、逻辑、社会学等方法,论述现阶段我国农村体育文化建设面临的种种矛盾与冲突即“统一模式”与需求层次多样化的文化冲突;挥霍浪费与勤俭节约的文化冲突;真假体育的文化冲突;“传统人”与“现代人”的文化冲突以及体力劳动替代体育锻炼与身体素质低下的矛盾。指出了我国农村体育文化改革的方向即加强对传统体育文化的改造;加强以奥林匹克为代表的西方体育文化的渗透以及加强体育文化制度建设促进农村体育文化的发展。

关键词：农村体育体育文化冲突

Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： Shi-Lin Lv Pei Guo Jun-Rong Zou Ren-Sheng Chen ling-yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer ***3 phosphorylation is a crucial prognostic marker in gastric *** To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric *** This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April *** were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)*** expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC *** and survival information of the patients was recorded by Outdo Biotech from May 2007 to July *** relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation *** relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival *** TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous *** positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multiva

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

Simultaneously enhancing erosion and compression resistance:designing AlCoCrFeNi high-entropy alloy strengthened Ag-based contacts

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Rare Metals 2024年第9期43卷 4476-4492页

作者： Xiao-Yang Xue Zhe Wang Hui-ling Nie Zhao yuan Jun Wang Chang-Hu Xu Kai Wen Cong-Hao yu School of Materials Science and Engineering Xi’an Polytechnic University School of Physics Xi’an Jiaotong University Key Laboratory of Pulsed Power Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology

Designing microstructures and unveiling dynamic erosion mechanisms remain important challenges for Ag-based contacts. To simultaneously enhance erosion and compression resistance, an Al Co Cr Fe Ni high-entropy alloy(HEA) is introduced into Ag-based materials to fabricate novel Ag-HEA contacts with island-and skeletonrestricted microstructures. The arc erosion experimental results reveal that the skeleton-restricted HEA microstructure is the key factor in reducing the hill and crater morphologies of the contact surface, effectively delaying material transfer between the movable and stationary contacts. The molten bridge evolution and compressive deformation behavior of Ag-HEA contacts with various microstructures are investigated using molecular dynamics(MD) simulations. MD results indicate that the constraint of Ag atom diffusion in the molten pool and the involvement of HEA atoms in the molten bridge are the primary mechanisms for improving erosion resistance. The skeleton-restricted HEA microstructure reduces the total energy and structural stability of the molten bridge system and promotes its fracture and disintegration. Moreover, the synergistic effect of the twin and Lomerz–Cottrell lock structures can hinder dislocation glide, generating dispersed and small-area stacking faults in the Ag matrix and mitigating the concentration of shear strains. Thus, the skeleton-restricted HEA microstructure contributes positively to compression resistance. This study presents a novel approach to designing Ag-based contacts.

关键词： Arc erosion Electrical contact materials High entropy alloys Microstructures Molecular dynamics

Sea-level change in coastal areas of China:Status in 2021

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Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： Wen-Shan LI Hui WANG Wen-Xi XIANG ai-Mei WANG Wei-Qing XU yu-Xi JIANG Xin-Hui WU Meng-yuan QUAN National Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒Shanghai Jiao Tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li Gan yun Hao Feng ling Liang lingyun yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

Moyamoya syndrome may result from psoriasis: Four case reports

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World Journal of Clinical Cases 2024年第10期12卷 1830-1836页

作者： Zhi-Ying Chen Xiao-Qin yu yuan-yuan Xiang ling-Hua Liu Xiao-Ping Yin Department of Neurology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina Department of Dermatology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Moyamoya syndrome(MMS)is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular *** is a chronic immune skin disease closely linked to high blood pressure and heart ***,psoriasis-related MMS has not been *** SUMMARY We collected data on patients with stroke due to MMS between January 2017 and December 2019 and identified four cases of *** histories,imaging,and hematological data were *** average age of the initial stroke onset was 58.25±11.52 years;three cases of hemorrhagic and one case of ischemic stroke were *** average duration from psoriasis confirmation to the initial MMS-mediated stroke onset was 17±3.56 *** MMS-related stenoses involved the bilateral cerebral arteries:Suzuki grade III in one case,grade IV in two cases,and grade V in one *** elevated plasma interleukin-6 levels were observed in four *** patients had abnormally elevated immunoglobulin E levels,and two had *** four patients received medication instead of *** an average follow-up time of 2 years,two causing transient ischemic attacks occurred in two patients,and no hemorrhagic events *** Psoriasis may be a potential risk factor for *** with psoriasis should be screened for MMS when they present with neurological symptoms.

关键词： Moyamoya syndrome Psoriasis Stroke Interleukin-6 Immune Hypertension Case report