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Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats

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World Journal of Gastroenterology 2018年第48期24卷 5505-5524页

作者： xing-xin Yang Jia-Di Wei Jian-Kang Mu xin Liu Jin-Cai Dong Lin-xi Zeng Wen Gu Jing-Ping Li Jie yu College of Pharmaceutical Science Yunnan University of Traditional Chinese Medicine Kunming 650500 Yunnan Province China Beijing Entry-Exit Inspection and Quarantine Bureau Beijing 100026 China

AIM To identify the effects and mechanism of action of Polygonatum kingianum(P. kingianum) on dyslipidemia in rats using an integrated untargeted metabolomic *** A rat model of dyslipidemia was induced with a high-fat diet(HFD) and rats were given P. kingianum [4 g/(kg·d)] intragastrically for 14 wk. Changes in serum and hepatic lipid parameters were evaluated. Metabolites in serum, urine and liver samples were profiled using ultra-highperformance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to identify potential biomarkers and metabolic *** P. kingianum significantly inhibited the HFD-induced increase in total cholesterol and triglyceride in the liver and serum. P. kingianum also significantly regulated metabolites in the analyzed samples toward normal status. Nineteen, twenty-four and thirty-eight potential biomarkers were identified in serum, urine and liver samples, respectively. These biomarkers involved biosynthesis of phenylalanine, tyrosine, tryptophan, valine, leucine and isoleucine, along with metabolism of tryptophan, tyrosine, phenylalanine, starch, sucrose, glycerophospholipid, arachidonic acid, linoleic acid, nicotinate, nicotinamide and *** P. kingianum alleviates HFD-induced dyslipidemia by regulating many endogenous metabolites in serum, urine and liver samples. Collectively, our findings suggest that P. kingianum may be a promising lipid regulator to treat dyslipidemia and associated diseases.

关键词： Dyslipidemia Lipid regulation Metabolomics Multivariate statistical analysis Polygonatum kingianum Ultra-high performance liquid chromatography/mass spectrometry

Two-dimensional Perturbative Analysis of Slant Grating in Photorefractive Crystals in an External Electric Field

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Chinese Physics Letters 1998年第6期15卷 423-425页

作者： JIANG yong-yuan FENG yu-wen ZHOU Zhong-xiang LI Yan SUN xiu-dong XU Ke-bin Department of Applied Physics Harbin Institute of TechnologyHarbin 150001

A slant grating was recorded with two laser beams incident on photorefractive crystal in an external dc electric ***-dimensional perturbative analytical solution for the first two-order space-charge field for steady-state photorefractive slant grating recording has been *** is shown that the inclusion of the longitudinal component of the space-charge field during photorefractive two-wave coupling can predict reduction of the fundamental harmonic and enhancement or reduction of the second-order harmonic for various applied field strength and various grating slant *** dependence of the first two-order harmonics on the slant angle and on the applied field strength is examined.

关键词： Photorefractive Crystal harmonic

Temporal,Spectral and Spatial Characterization of High-Energy Laser Pulse with Small Bandwidth Propagating through Long Path

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Chinese Physics Letters 2012年第12期29卷 112-115页

作者： DENG Xue-Wei WANG Fang JIA Huai-Ting xiANG yong FENG Bin LI Ke-yu ZHOU Li-Dan Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900

Temporal,spectral and spatial characters of 0.3-nm-bandwidth high-energy laser pulse propagating through a long path are studied in detail in one newly constructed beamline of our laser *** evolution of propagation,pulse energy and near-field deterioration are analyzed theoretically and *** argon for air is demonstrated effectively to suppress stimulated rotational Raman scattering and the experimental result provides operating criterion,and engineering parameters for the under-constructed beamlines.

关键词： scattering Small Spatial

Structure Design of Turbo-Jet Engine Blade with Feature Based Parametric Modeling

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Computer Aided Drafting,Design and Manufacturing 2006年第2期16卷 7-11页

作者： SONG yu-wang ZHAO Hui xi Ping School of Mechanical Engineering and Automation Beijing University of Aeronautics and Astronautics Beijing 100083 China

On the platform of UG general CAD system, a customized module dedicated to turbo-jet engine blade design is implemented to support the integration of CAD/CAE/CAM processes and multidisciplinary optimization of structu... 详细信息

关键词： aeroengine turbine blade parametric design feature modeling MDO

Research and Design on Framework of Quality Risk Control System for Livestock Products

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Animal Husbandry and Feed Science 2010年第5期2卷 44-48页

作者： xi Wei-dong SUN yong-hai TIAN xiao-na College of Economics and Management Northeast Dianli University Jilin 132012 China College of Biological and Agricultural Engineer- ing Jilin University Changchun 130022 China

In view of the currant status of the quality risk control of livestock products, the differences between the quality, safety and risk of the livestock products were pointed clearly; the derivative mechanism model of the quality risk was studied; the risk system of livestock products was established; and the types of controllable risk were identified. On this basis, the design principles of risk control framework were established. Then the modular system of risk control was constructed and the attributes of production system were detailed into the describable indicators of risk control based on the thrae-dimensional risks.

关键词： Livestock products Quality dsk Controllable dsk Control framework

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我国学校体育场地对外开放和经营

武汉体育学院学报 2007年第4期41卷 79-83页

作者：张永保席玉宝皖西学院体育系安徽六安237012 安徽师范大学体育学院安徽芜湖241000

对第5次全国体育场地普查有关资料的研究显示,学校体育场地对外开放比例偏低,不开放率达70.80%。研究认为,国家及地方政府应继续完善相关法规,促使和监督学校体育场地设施有序开放和规范经营,学校也应增强服务意识,加大法规贯彻力度,采... 详细信息

对第5次全国体育场地普查有关资料的研究显示,学校体育场地对外开放比例偏低,不开放率达70.80%。研究认为,国家及地方政府应继续完善相关法规,促使和监督学校体育场地设施有序开放和规范经营,学校也应增强服务意识,加大法规贯彻力度,采用合理的经营管理方式,提高体育场馆设施管理水平和使用效率,并积极宣传和引导大众体育消费。

关键词：学校体育场地对外开放经营收入第5次全国体育场地普查

Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules

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Bioactive Materials 2021年第8期6卷 2303-2314页

作者： Na Li Wei Cui Peifang Cong Jie Tang yong Guan Caihao Huang yunen Liu Chengzhong yu Rui Yang xing Zhang Institute of Metal Research Chinese Academy of SciencesShenyangLiaoning110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefeiAnhui230026China Department of Emergency Medicine General Hospital of Northern Theater CommandShenyangLiaoning110016China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhui230029China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD4072Australia

Amorphous calcium phosphate(ACP)has been widely found during bone and tooth biomineralization,but the meta-stability and labile nature limit further biomedical *** present study found that the chelation of polyacrylic acid(PAA)molecules with Ca^(2+)ions in Mg-ACP clusters(~2.1±0.5 nm)using a biomineralization strategy produced inorganic-organic Mg-ACP/PAA hybrid nanoparticles with better thermal ***-ACP/PAA hybrid nanoparticles(~24.0±4.8 nm)were pH-responsive and could be efficiently digested under weak acidic conditions(pH 5.0-5.5).The internalization of assembled Mg-ACP/PAA nanoparticles by MC3T3-E1 cells occurred through endocytosis,indicated by laser scanning confocal microscopy and cryo-soft X-ray *** results showed that cellular lipid membranes remained intact without pore formation after Mg-ACP/PAA particle *** assembled Mg-ACP/PAA particles could be digested in cell lysosomes within 24 h under weak acidic conditions,thereby indicating the potential to efficiently deliver encapsulated functional *** the in vitro and in vivo results preliminarily demonstrated good biosafety of the inorganic-organic Mg-ACP/PAA hybrid nanoparticles,which may have potential for biomedical applications.

关键词： Inorganic-organic hybrid pH responsive ACP clusters Cellular degradation Cryo-soft X-ray tomography

Triple-induced gardenia fruit extract-enriched gelatin/polysaccharides microgels for O/W emulsions, and food 3D printing

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FOOD BIOSCIENCE 2023年第3期53卷 1360-1371页

作者： Ouyang, Zhiying Zhu, Juncheng Cheng, Yang Chen, Liangzhe Yang, yuxin Ma, Liang Zhu, Hankun yu, yong Zhang, yuhao Wang, Hongxia Southwest Univ Coll Food Sci State Key Lab Silkworm Genome Biol Chongqing 400715 Peoples R China Chongqing Key Lab Special Food Cobuilt Sichuan & C Chongqing 400715 Peoples R China Southwest Univ Key Lab Luminescence Anal & Mol Sensing Minist Educ Chongqing 400715 Peoples R China Southwest Univ Key Lab Qual & Safety Control Citrus Fruits Minist Agr & Rural Affairs Chongqing 400712 Peoples R China Key Lab Condiment Supervis Technol State Market Re Chongqing 400715 Peoples R China Jingchu Univ Technol Jingmen 448000 Peoples R China 2 Tiansheng Rd Chongqing Peoples R China

Gardenia fruit extract like gardenia blue is untable under light exposure and its application need expansion. Gardenia blue was proposed to be stabilized in triple-induced microgels from cooperative effects of gelatin, beta-cyclodextrin and chitooligosaccharide, and its emulsifying ability and 3D printing potential were subesequently explored. The synergetic effects on gardenia blue due to the intermolecular interactions including hydrogen bonding and electrostatic interaction, contributed to the high UV irradiation stability of complexes. The complex microgels could absorb onto oil-water interface with emulsifying property, and the obtained high internal phase emulsions (HIPEs) illustrated outstanding centrifugal stability and great storage stability with low and uniform optical microscopic droplet diameters. The obtained HIPEs possessed excellent shearing thinning properties, excellent structure reversibility, high-degree reticulation, outstanding thixotropy, great elasticity, high cohesive energy and mechanical strength. 3D printing of HIPEs onto food also demonstrated high shape fidelity with low deviation. The findings illustrate the way of stabilizing gardenia blue in microgels by triple synergies, demonstrate the potential as stabilizer for developing HIPEs, and offered reference for highly-addedvalue utilization in the personalized 3D food products.

关键词： Gelatin Gardenia fruit blue extract High internal phase emulsions Thixotropy Elasticity 3D printing

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基于浸入界面方法的平面波导模式分析

物理学报 2023年第14期72卷 9-16页

作者：肖勇曹雨生宁夏大学物理学院银川750021

光波导模式分析是先进波导器件和光波线路设计中的一项基本任务.如何处理电磁异质界面和吸收边界问题是光波导高效数值分析面对的两大困难.现有高阶精度有限差分模式分析方法均未考虑吸收边界条件,导致漏模和辐射模难以精确模拟.本文基... 详细信息

光波导模式分析是先进波导器件和光波线路设计中的一项基本任务.如何处理电磁异质界面和吸收边界问题是光波导高效数值分析面对的两大困难.现有高阶精度有限差分模式分析方法均未考虑吸收边界条件,导致漏模和辐射模难以精确模拟.本文基于浸入界面方法和完美匹配层吸收边界条件,提出一种具有二阶和四阶精度的有限差分方法.利用该方法对单界面等离子波导、平面对称波导和一维光子晶体波导进行模式分析,数值实验结果表明二阶和四阶算法对于导模、漏模和辐射模的收敛速度均与期望的阶数相符,二阶算法约在归一化步长10^(-4)时提供有效折射率相对误差约为10^(-9)的极限精度,四阶算法约在归一化步长10^(-3)时提供有效折射率相对误差约为10^(-10)的极限精度.对一维光子晶体波导中导模和包层模场分布进行的研究表明,界面处横电模式的场及其一阶导数的连续,横磁模式的场的连续及其一阶导数的不连续,均可以被精确解析.本文提出的方法只需利用折射率的值而不依赖于模场的特定函数表示,即可用于计算任意折射率剖面下的任意模式,为阶跃折射率平面波导模式分析提供一种简单而高效的工具.

关键词：浸入界面方法完美匹配层波导模式