检索结果-南通市图书馆

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

引用

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-hui yu Yan Xie Jian yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Typical Cell Signaling Response to Ionizing Radiation: DNA Damage and Extranuclear Damage

引用

Chinese Journal of Cancer Research 2012年第2期24卷 83-89页

作者： hui yu Department of Radiation Oncology University of Texas Health Science Centerat San Antonio7703 Floyd Curl DriveSan AntonioTexas 78229USA

To treat many types of cancer, ionizing radiation （IR） is primarily used as external-beam radiotherapy, brachytherapy, and targeted radionuclide therapy. Exposure of tumor cells to JR can induce DNA damage as well as generation of reactive oxygen species （ROS） and reactive nitrogen species （RNS） which can cause non-DNA lesions or extracellular damage like lipid perioxidation. The initial radiation-induced cell responses to DNA damage and ROS like the proteolytic processing, as well as synthesis and releasing ligands （such as growth factors, cytokines, and hormone） can cause the delayed secondary responses in irradiated and unirradiated bystander cells through paracrine and autocrine pathways.

关键词： Radiation Bystander effect DNA damage Extranuclear damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HOW DOES THE RETAILER MAKE PRICING DECISION WHEN CONSUMERS HAVE JUSTICE REFERENCE PRICE

引用

Journal of Systems Science and Systems Engineering 2015年第4期24卷 433-449页

作者： huimin Liu hui yu School of Economics and Business Administration Chongqing University

A series of studies demonstrate that consumers have fairness judgments about the retailer＇s price which will impact their shopping decisions. Thus, it is necessary for the retailer to take consumers＇ fairness concerns into account when setting his pricing policies. We assume that when the retailer＇s price is lower than a consumer＇s justice reference price, the consumer is likely to sense a positive price unfairness that will lead to increased consumer utility, and when the retailer＇s price is higher than a consumer＇s justice reference price, the consumer is likely to sense a negative price unfairness-that will have a negative effect on consumer utility. According to the information conditions of the consumers＇ justice reference price, the retailer should consider three situations： certain information, random information and partial information. In all situations, we show that the retailer has a unique optimal pricing strategy. Finally, through numerical examples, we find that our distribution-free policies perform almost the same as the results under the distributions that maximize the entropy. Our results reveal that it is important for the retailer to consider consumers＇ fairness concerns, otherwise he may suffer losses when Pc is very small.

关键词： Justice reference price certain information random information partial information,pricing strategy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THE DISTRIBUTION-FREE NEWSVENDOR PROBLEM WITH BALKING AND PENALTIES FOR BALKING AND STOCKOUT

引用

Journal of Systems Science and Systems Engineering 2014年第2期23卷 153-175页

作者： hui yu Jia Zhai School of Economics and Business Administration Chongqing University School of Business Administration Chongqing University of Technology

This paper investigates the ordering policy for the newsvendor problem with customer balking and penalties for balking and stockout. Our analysis is based on the assumption that only the mean and the variance of the demand distribution are known. In contrast to the existing research, we provide a new tradeoff tool as a replacement of the traditional one to weigh the holding cost and the goodwill cost segment： the balking penalty cost and the stockout penalty cost. Specifically, in addition to the stockout penalty, we also introduce the balking penalty, provide a new proof of the optimality of robust ordering policy to guarantee that the lower bound of expected profit obtained by us is tight, and get an robust optimal order quantity which is an exact solution but not an approximate one as before. Numerical experiments are conducted to illustrate the effect of penalties for balking and stockout.

关键词： Newsvendor problem distribution-free customer balking balking penalty stockout penalty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A PARTIAL ROBUST OPTIMIZATION APPROACH TO INVENTORY MANAGEMENT FOR THE OFFLINE-TO-ONLINE PROBLEM UNDER DIFFERENT SELLING PRICES

引用

Journal of Systems Science and Systems Engineering 2017年第6期26卷 774-803页

作者： hui yu Jie Deng School of Economics and Business Administration Chongqing University Chongqing China

This study examines an optimal inventory strategy when a retailer markets a product at different selling prices through a dual-channel supply chain, comprising an online channel and an offiine channel. Using the operating pattern of the offiine-to-online （020） business model, we develop a partial robust optimization （PRO） model. Then, we provide a closed-form solution when only the mean and standard deviation of the online channel demand distribution is known and the offiine channel demand follows a uniform distribution （partial robust）. Specifically, owing to the good structural properties of the solution, we obtain a heuristic ordering formula for the general distribution case （i.e., the offiine channel demand follows a general distribution）. In addition, a series of numerical experiments prove the rationality of our conjecture. Moreover, after comparing our solution with other possible policies, we conclude that the PRO approach improves the performance of incorporating the internet into an existing supply chain and, thus, is able to adjust the level of conservativeness of the solution. Finally, in a degenerated situation, we compare our PRO approach with a combination of information approach. The results show that the PRO approach has more ＂robust＂ performance. As a result, a reasonable trade-off between robustness and performance is achieved.

关键词： Supply chain management partial robust optimization decision support inventory,dual-channel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel eco-friendly spherical porous adsorbent fabricated from Pickering middle internal phase emulsions for removal of Pb(Ⅱ) and Cd(Ⅱ)

引用

Journal of Environmental Sciences 2022年第2期34卷 320-330页

作者： hui yu Yongfeng Zhu Aiping hui Aiqin Wang Key Laboratory of Clay Mineral Applied Research of Gansu Province Center of Eco-material and Green ChemistryLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Spherical porous materials prepared from the emulsion template used in the water treatment have displayed a vast prospect, as the high surface area, abundant porous structure, convenient operation and excellent adsorption performance. But the tedious fabrication process, high consumption of organic solvent and surfactant limited the application widely. Herein, a facile and eco-friendly spherical porous adsorbent(SPA) is fabricated from the green surfactant-free(corn oil)-in-water Pickering medium internal phase emulsions(Pickering MIPEs) via the convenient ion crosslinking procedure. The Pickering MIPEs synergistically stabilized with the semi-coke(SC), which is the natural particle produced from the shale oil distillation, and sodium alginate(SA) has excellent storage and anti-coalescence stability. The as-prepared porous adsorbent possessed the abundant pore structure, which provided favorable conditions for effective mass transfer in adsorption, and could be tuned by varying the SA dosage. The saturation adsorption capacities of Pb(II) and Cd(II) can be achieved with 460.54 and 278.77 mg/g within 45 min at 25 ℃, respectively. Overall, this study supplied a viable and eco-friendly route for fabricating the spherical porous adsorbent with a tunable porous structure for heavy metal ion wastewater.

关键词： Spherical porous adsorbent(SPA) Emulsion template Semi-coke Adsorption Heavy metal ion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Existence Results for Superlinear Elliptic Equations with Nonlinear Boundary Value Conditions

引用

Acta Mathematica Sinica,English Series 2019年第10期35卷 1655-1680页

作者： Xiao hui yu College of Mathematics and Statistics Shenzhen University

In this paper, we study the existence of solutions for the following superlinear elliptic equation with nonlinear boundary value condition{-△u+u=|u|^r-2u in Ω,■u/■v=|u|^q-2u on ■Ω, where Ω■R^N, N≥3 is a bounded domain with smooth boundary. We will prove the existence results for the above equation under four different cases:(i) Both q and r are subcritical;(ii) r is critical and q is subcritical;(iii) r is subcritical and q is critical;(iv) Both q and r are critical.

关键词： Existence result critical exponent trace inequality nonlinear boundary value (PS) condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation

引用

Cellular & Molecular Immunology 2015年第2期12卷 231-242页

作者： yu-hui Lee Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Obstetrics & Gynecology University of Toronto Toronto Canada

Spontaneous term labour is associated with amplified inflammatory events in the myometrium including cytokine production and leukocyte infiltration; however, potential mechanisms regulating such events are not fully understood. We hypothesized that mechanical stretch of the uterine wall by the growing fetus facilitates peripheral leukocyte extravasation into the term myometrium through the release of various cytokines by uterine myocytes. Human myometrial cells （hTERT-HM） were subjected to static mechanical stretch; stretch-conditioned media was collected and analysed using 48-plex Luminex assay and ELISA. Effect of stretch-conditioned media on cell adhesion molecule expression of human uterine microvascular endothelial cells （UtMVEC-Myo） was detected by quantitative polymerase chain reaction （qPCR） and flow cytometry; functional assays testing leukocyte-endothelial interactions： adhesion of leukocytes to endothelial cells and transendothelial migration of calcein-labelled primary human neutrophils as well as migration of THP-1 monocytic cells were assessed by fluorometry. The current in vitrostudy demonstrated that mechanical stretch （i） directly induces secretion of multiple cytokines and chemokines by hTERT-HM cells （IL-6, CXCL8, CXCL1, migration inhibitory factor （MIF）, VEGF, G-CSF, IL-12p70, bFGF and platelet-derived growth factor subunit B （PDGF-bb）, P〈0.05）; stretch-induced cytokines （ii） enhance leukocyte adhesion to the endothelium of the surrounding uterine microvasculature by （iii） inducing the expression of endothelial cell adhesion molecules and （iv） directing the transendothelial migration of peripheral leukocytes. （vi） Chemokine-neutralizing antibodies and broad-spectrum chemokine inhibitor block leukocyte migration. Our data provide a proof of mechanical regulation for leukocyte recruitment from the uterine blood vessels to the myometrium, suggesting a putative mechanism for the leukocyte infiltrate into the uterus during labour and postpartum involu

关键词： endothelium labour leukocyte infiltration stretch uterus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical simulation study on the hygrothermal performance of building exterior walls under dynamic wind-driven rain condition

引用

Building Simulation 2024年第2期17卷 207-221页

作者： Xing Hu huibo Zhang hui yu School of Design Shanghai Jiao Tong UniversityShanghai200240China

Wind-driven rain(WDR)has a significant influence on the hygrothermal performance,durability,and energy consumption of building *** calculation of WDR loads using semi-empirical models has been incorporated into the boundary conditions of coupled heat and moisture transfer ***,prior research often relied on fixed WDR absorption ratio,which fail to accurately capture the water absorption characteristics of porous building materials under rainfall ***,this study aims to investigate the coupled heat and moisture transfer of exterior walls under dynamic WDR boundary conditions,utilizing an empirically obtained WDR absorption ratio model based on field *** developed coupled heat and moisture transfer model is validated against the HAMSTAD *** findings reveal that the total WDR flux calculated with the dynamic WDR boundary is lower than that obtained with the fixed WDR boundary,with greater disparities observed in orientations experiencing higher WDR *** variations in moisture flow significantly impact the surface temperature and relative humidity of the walls,influencing the calculation of cooling and heating loads by different *** to the transient heat transfer model,the coupled heat and moisture transfer model incorporating dynamic WDR boundary exhibits maximum increases of 17.6%and 16.2%in cooling and heating loads,*** dynamic WDR boundary conditions provide more precise numerical values for surface moisture flux,offering valuable insights for the thermal design of building enclosures and load calculations for HVAC systems.

关键词： wind-driven rain building component hygrothermal model transient simulation cooling and heating loads

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanozyme-mediated elemental biogeochemical cycling and environmental effects

引用

Science China Earth Sciences 2021年第7期64卷 1015-1025页

作者： Zhi-Lai CHI Guang-hui yu Institute of Surface-Earth System Science School of Earth System ScienceTianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai RimBohai Coastal Critical Zone National Observation and Research StationTianjin UniversityTianjin 300072China College of Resources&Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China

In Earth systems,thousands of terragrams(Tg)(1 Tg=10^(12) g)of mineral nanoparticles move around *** mineral nanoparticles have exhibited unexpected intrinsic enzyme-like characteristics(so called“mineral nanozymes”),and are ubiquitously distributed in natural ecosystems such as the atmosphere,oceans,waters,and *** with natural enzymes,these mineral nanozymes have several advantages such as tunable catalytic efficiency and robustness to harsh conditions,e.g.,heat,acid,and alkaline *** mineral nanozymes are new products of multidisciplinary cross-cutting,they have been widely applied in various *** review,for the first time,systematically introduces the species and properties of mineral nanozymes in Earth systems,discusses the critical roles played by nanozymes in environmental biogeochemical cycles,compiles the interfacial processes and mechanisms of mineral nanozymes,and provides an overview of the future prospects of mineral nanozymes.

关键词： Nanozymes Peroxidase Nanominerals Reactive oxygen species Biogeochemical cycles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：