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Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach

Oncology Research 2024年第2期32卷 409-419页

作者： KEGANG JIA YAWEI wang QI CAO youyu wang Department of Thoracic Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina School of Medicine University of Electronic Science and Technology of ChinaChengduChina Department of Assisted Reproductive Medicine Sichuan Provincial Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina

Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death *** failure in lung cancer(LUAD)is heavily influenced by drug *** challenge stems from the diverse cell populations within the tumor,each having unique genetic,epigenetic,and phenotypic *** variations lead to varied therapeutic responses,thereby contributing to tumor relapse and disease ***:The Genomics of Drug Sensitivity in Cancer(GDSC)database was used in this investigation to obtain the mRNA expression dataset,genomic mutation profile,and drug sensitivity information of *** Learning(ML)methods,including Random Forest(RF),Artificial Neurol Network(ANN),and Support Vector Machine(SVM),were used to predict the response status of each compound based on the mRNA and mutation characteristics determined using statistical *** most suitable method for each drug was proposed by comparing the prediction accuracy of different ML methods,and the selected mRNA and mutation characteristics were identified as molecular features for the drug-responsive cancer ***,the prognostic influence of molecular features on the mutational subtype of LUAD in publicly available ***:Our analyses yielded 1,564 gene features and 45 mutational features for 46 *** the ML approach to predict the drug response for each medication revealed an upstanding performance for SVM in predicting Afuresertib drug response(area under the curve[AUC]0.875)using CIT,GAS2L3,STAG3L3,ATP2B4-mut,and IL15RA-mut as molecular ***,the ANN algorithm using 9 mRNA characteristics demonstrated the highest prediction performance(AUC 0.780)in Gefitinib with ***:This work extensively investigated the mRNA and mutation signatures associated with drug response in LUAD using a machine-learning approach and proposed a priority algorithm to predict drug response for different drugs.

关键词： Lung adenocarcinoma Drug resistance Machine learning Molecular features Personalized treatment

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Strength test of 3D printed artificial rock mass with pre-existing fracture

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Underground Space 2021年第5期6卷 492-505页

作者： youyu wang Li wang Fanfei Meng Kang Chen College of Civil Engineering Chongqing UniversityChongqing 400050China School of Civil Engineering and Transportation Hebei University of TechnologyTianjin 300132China

Discontinuities or structural planes are widely distributed in natural rock masses and significantly influence their geo-mechanical and geometric ***,a batch of rock samples,each with a single structural plane,is created using a 3D printer equipped with two robotic *** of the manipulators is connected via a nozzle to a concrete pumping truck,which can extrude brittle rock-like material to form layered intact rock masses;the rock-like material is mainly composed of cement,silica fume,sand and *** other manipulator features a knife,which can carve discontinuities onto each layer of the printed *** means of this system,rock masses with discontinuous joints are formed,and the failure strengths of rock masses with different joints are demonstrated via uniaxial compression tests and direct shear *** results thereof obtained via digital image correlation technology show that discontinuities lower the strength of the rock mass models *** the increase of the angle between the fracture and horizontal plane,the uniaxial compressive strength first decreases,and then *** shear testing,the shear strength of the rock mass models increases with the surface roughness of the preset *** test results indicate that the influence of artificial joints on the mechanical properties of the models is consistent with that of natural rock mass *** digital modeling and 3D printing technology,cracks hidden in a rock mass can be reproduced.

关键词： Discontinuous rock mass 3D printing Digital image correlation Rock-like material Strength failure

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Design of a Flexible Capture Mechanism Inspired by Sea Anemone for Non-cooperative Targets

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 236-248页

作者： Jiankun Yang Chengwei Ren Chenghao Yang youyu wang Shumin Wan Rongjie Kang Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin 300350China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110169China Beijing Institute of Spacecraft System Engineering CAST Beijing 100094China

Robotic grippers have been used in industry as end-effectors but are usually limited to operations in pre-defined ***,few devices can capture irregularly shaped dynamic targets in space,underwater and other unstructured *** this paper,a novel continuum arm group mechanism inspired by the morphology and motions of sea anemones is *** is able to dissipate and absorb the kinetic energy of a fast moving target in omni-direction and utilize multiple arms to wrap and lock the target without accurate positioning ***-driven actuation systems are implemented in the individual continuum arms,achieving both bending motion and stiffness *** finite element method,the influence of different configurations of the continuum arm group on the capture performance is analyzed.A robotic prototype is constructed and tested,showing the presented arm group mechanism has high adaptability to capture targets with different sizes,shapes,and incident angles.

关键词： Non-cooperative targets Continuum arm group Wire-driven mechanism

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A semi-analytical approach for stiffness modeling of PKM by considering compliance of machine frame with complex geometry

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Chinese Science Bulletin 2008年第16期53卷 2565-2574页

作者： wang youyu HUANG Tian ZHAO XueMan MEI JiangPing Derek G CHETWYND School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Engineering University of Warwick Coventry CV4 7AL UK

Stiffness modeling is one of the most significant issues in the design of parallel kinematic machine (PKM). This paper presents a semi-analytical approach that enables the stiffness of PKM with complex machine frame geometry to be estimated effectively. This approach can be implemented by three steps: (i) decomposition of the entire system into two sub-systems associated with the parallel mechanism and the machine frame respectively; (ii) stiffness modeling of each sub-system using the analytical approach and the finite element analysis; and (iii) generation of the stiffness model of the entire system by means of linear superposition. In the modeling process of each sub-system, the virtual work princi- ple and overall deflection Jacobian are employed with special attention to the bending rigidity of the constrained passive limb and the interface stiffness of the machine frame. The stiffness distribution of a 5-DOF hybrid robot named TriVariant-B is investigated as an example to illustrate the effectiveness of this approach. The contributions of component rigidities to that of the system are evaluated using global indices. It shows that the results achieved by this approach have a good match to those obtained through finite element analysis and experiments.

关键词：运动学模型柔度 PKM 几何学

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Testing and modeling of rockfill materials:A review

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第3期8卷 415-422页

作者： Yang Xiao Hong Liu Wengang Zhang Hanlong Liu Feng Yin youyu wang Key Laboratory of New Technology for Construction of Cities in Mountain Area(Chongqing University) Ministry of Education School of Civil Engineering Chongqing University College of Civil and Transportation Engineering Hohai University School of Civil and Environmental Engineering Nanyang Technological University

The research development of rockfill materials （RFM） was investigated by a series of large-scale triaxial tests. It is observed that confining pressure and particle breakage play important roles in the mechanical property, dilatancy relation and constitutive model of RFM. In addition, it is observed that the conven- tional dilatancy relation and constitutive model are not suitable for RFM due to the complex mechanical behavior. Hence, it needs to propose a unified constitutive model of RFM, considering the statedependent and particle breakage behavior.

关键词： Large-scale triaxial testConfining pressureParticle breakageDilatancy relationConstitutive model

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Non-metallic Inclusions in Continuously Cast Aluminum Killed Steels

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International Journal of Minerals,Metallurgy and Materials 2000年第3期14卷 193-196页

作者： Wenjun wang, Xinhua wang, Jiongming Zhang, Wanjun wang, youyu Zhou ( Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China Steelmaking Research Institute, Wuhan Iron and Steel Group, Wuhan 430080, China) Metallurgy School University of Science and Technology Beijing Beijing 100083 China Steelmaking Research Institute Wuhan Iron and Steel Group Wuhan 430080 China

In aluminum killed steels, the size, shape, quantity and formation of non-metallic inclusions in ladle steel (before and after RH vacuum treatment) and in tundish as well as in slabs were studied by EPMA (Electron Probe Microanalysis) and by analyzing the total oxygen. The results showed that in the slabs the total oxygen was quite low and the inclusions discovered were mainly small-sized angular alumina inclusions. This indicates that most inclusions have been removed by floating out during the continuous casting process. In addition, the countermeasures were discussed to decrease the alumina inclusions in the slabs further.

关键词： aluminum killed steel non-metallic inclusion alumina continuous casting

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EXISTENCE OF PERIODIC SOLUTION FOR HIGHER ORDER NONLINEAR DIFFERENTIAL EQUATION

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Annals of Differential Equations 2005年第3期21卷 431-434页

作者： wang youyu Ge Weigao Dept. of Math. Beijing Institute of Technology Beijing 100081

The existence of periodic solutions is proved for the higher order nonlinear differential equation by applying Leray-Schauder principle and Wirtinger＇s inequality.

关键词： periodic solutions nth order ordinary differential equation,existence Leray-Schauder principle

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装备空投多体系统动力学建模与仿真方法研究进展

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南京理工大学学报 2023年第4期47卷 423-434页

作者：王国平汪有钰孙雨田张宇南京理工大学发射动力学研究所南京理工大学复杂多体系统动力学全国重点实验室江苏南京210094

装备空投是将装备向指定的地面区域快速投送的技术,拥有快速响应和长距离作战的特点。装备空投系统是典型的多体系统,目前,仍然面临落点精度及安全性等关键瓶颈问题,与空投所涉及的流固耦合、强非线性、接触碰撞、大变形结构动力学密切... 详细信息

装备空投是将装备向指定的地面区域快速投送的技术,拥有快速响应和长距离作战的特点。装备空投系统是典型的多体系统,目前,仍然面临落点精度及安全性等关键瓶颈问题,与空投所涉及的流固耦合、强非线性、接触碰撞、大变形结构动力学密切相关。因此,该文从多体系统动力学建模、动力学性能预测与优化设计等方面综合阐述装备空投的国内外研究进展,总结装备空投的研究发展趋势以及技术难题,指出了提高装备空投精度和安全性的前沿研究方向。

关键词：装备空投多体系统动力学性能预测优化设计

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基于3D打印模型试验的含结构面异形隧洞的变形破坏研究

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土木与环境工程学报（中英文） 2022年第1期44卷 36-44页

作者：孟凡斐王酉钰李之建马国伟河北工业大学土木与交通学院天津300401 重庆大学土木工程学院重庆400045

隧洞交叉段稳定性受围岩结构面影响较大,物理模型试验是研究结构面影响机制的有效手段。针对模型难以制备的技术瓶颈,采用3D打印增减材技术制备含非贯通结构面的异形隧洞模型。基于数字图像相关技术与内窥摄像头观测模型在单轴加载下的... 详细信息

隧洞交叉段稳定性受围岩结构面影响较大,物理模型试验是研究结构面影响机制的有效手段。针对模型难以制备的技术瓶颈,采用3D打印增减材技术制备含非贯通结构面的异形隧洞模型。基于数字图像相关技术与内窥摄像头观测模型在单轴加载下的破坏过程,评估打印路径对隧洞模型破坏模式的影响,并研究结构面倾角对异形隧洞破坏机制的影响规律。结果表明,3D打印路径对隧洞模型破坏模式的影响较小,采用3D打印增减材方法制备结构面起控制作用的隧洞模型具有有效性及可行性;含软弱填充物的非贯通结构面导致围岩应力向两侧岩柱卸荷,客观上保护了洞室,提高了隧洞的安全性;当结构面尖端距隧洞较远时,模型表现为贯通裂纹造成的岩柱失稳破坏,当结构面尖端位于隧洞附近时,模型表现为洞顶块体分离破坏;隧洞交叉段扩挖后形成的异形隧洞与常规隧洞的破坏机制不同,其拱结构效应明显减弱。

关键词：异形隧洞结构面模型试验 3D打印数字图像相关技术

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基于排气型气囊的多管火箭炮着陆缓冲特性研究

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南京理工大学学报 2023年第4期47卷 486-493页

作者：张宇王国平孙雨田汪有钰伍根洋南京理工大学发射动力学研究所江苏南京210094

为研究排气型气囊作用下多管火箭炮在不同工况下的着陆冲击性能,建立多管火箭炮着陆缓冲系统有限元模型,利用LS-DYNA软件计算了炮车系统在刚性地面条件、土壤地面条件、蜂窝铝辅助缓冲条件、后排气囊失效的恶劣工况下的着陆过程动力学... 详细信息

为研究排气型气囊作用下多管火箭炮在不同工况下的着陆冲击性能,建立多管火箭炮着陆缓冲系统有限元模型,利用LS-DYNA软件计算了炮车系统在刚性地面条件、土壤地面条件、蜂窝铝辅助缓冲条件、后排气囊失效的恶劣工况下的着陆过程动力学响应。结果表明,不同地面条件对多管火箭炮着陆缓冲性能影响较小,车架、框架、定向管应力超过许用应力,应注意防护;在货台和车身之间设计蜂窝铝辅助缓冲装置能有效降低车架应力,实现对车架的保护;后排气囊失效情况下货台冲击过载从40 g提高到80g,超出空投安全标准,安全隐患增加。该文研究结果对于多管火箭炮空投方案设计和试验验证有一定参考意义。

关键词：排气型气囊 LS-DYNA 多管火箭炮蜂窝铝着陆缓冲

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