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Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

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World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers susan Read john Feldman Casey Gooden Diana P English Department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radiology University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** sUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： Cervical adenocarcinoma Breast metastases Immunotherapy Pembrolizumab Carboplatin Paclitaxel Case report

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Review of Networked Microgrid Protection:Architectures,Challenges,solutions,and Future Trends

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CsEE Journal of Power and Energy systems 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu john E.Candelo-Becerra Juan C.Vasquez Josep M.Guerrero Center for Research on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

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Latest updates on structure and recommendations of cardiac rehabilitation programs in chronic heart failure

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World Journal of Clinical Cases 2024年第8期12卷 1382-1387页

作者： Christos Kourek Alexandros Briasoulis Dimitrios E Magouliotis john skoularigis Andrew Xanthopoulos Medical school of Athens National and Kapodistrian University of AthensAthens 15772Greece Department of Clinical Therapeutics Alexandra HospitalFaculty of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Department of surgery University Hospital of LarissaLarissa 41110Greece of Cardiology University Hospital of LarissaLarissa 41110Greece

Chronic heart failure(HF)is a clinical syndrome with high morbidity and mor-tality *** rehabilitation(CR)is a medically supervised program designed to maintain or improve cardiovascular health of people living with HF,recommended by both American and European guidelines.A CR program con-sists of a multispecialty group including physicians,nurses,physiotherapists,trainers,nutritionists,and psychologists with the common purpose of improving functional capacity and quality of life of chronic HF *** activity,lifestyle,and psychological support are core components of a successful CR *** has been shown to be beneficial in all ejection fraction categories in HF and most patients,who are stable under medication,are capable of *** individualized exercise prescription should be developed on the basis of a baseline evaluation in all *** main modalities of exercise training are aerobic exercise and muscle strength training of different intensity and *** is important to set the appropriate clinical outcomes from the beginning,in order to assess the effectiveness of a CR *** are still significant limitations that prevent patients from participating in these programs and need to be solved.A significant limitation is the generally low quality of research in CR and the presence of negative trials,such as the rehabilitation after myocardial infarction trial,where comprehensive rehabilitation following myocardial infraction had no important effect on mortality,morbidity,risk factors,or health-related quality of life or *** the present editorial,we present all the updated knowledge and recommendations in CR programs.

关键词： Cardiac rehabilitation Heart failure Outcomes Exercise protocols Prescription Future perspectives Limitations

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Resection and reconstruction in high-grade pancreatic head injuries

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World Journal of Gastrointestinal surgery 2024年第5期16卷 1467-1469页

作者： Jake Krige Eduard Jonas Andrew john Nicol Pradeep Harkson Navsaria HPB surgery University of Cape Town Health Sciences FacultyCape Town 7925Western CapeSouth Africa Trauma Center Department of SurgeryGroote Schuur HospitalCape Town 7925Western CapeSouth Africa Department of surgery Trauma CenterGroote Schuur HospCape Town 7925Western CapeSouth Africa

This study by Chui et al adds further important evidence in the treatment of highgrade pancreatic injuries and endorses the concept of the model of pancreatic trauma care designed to optimize treatment,minimize morbidity and enhance survival in patients with complex pancreatic *** the authors have demonstrated favorable outcomes based on their limited experience of 5 patients who underwent a pancreaticoduodenectomy(PD),including 2 patients who were“unstable”and did not have damage control surgery(DCs),we would caution against the general recommendations promoting index PD without DCs in“unstable”grade 5 pancreatic head injuries.

关键词： Pancreas Injury surgery Pancreaticoduodenectomy

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Early-onset gastrointestinal cancer:An epidemiological reality with great significance and implications

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 583-597页

作者： john K Triantafillidis Konstantinos Georgiou Manousos M Konstadoulakis Apostolos E Papalois Department of IBD and GI Endoscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd Department of surgery University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the last few years,epidemiological data from many countries suggest that the incidence and prevalence of many cancers of the digestive system are shifting from the older to the younger ages,the so-called“early-onset cancer”.This is particularly evident in colorectal cancer and secondarily in other malignant digestive neoplasms,mainly stomach and in a lesser degree pancreas,and biliary *** should be emphasized that data concerning digestive neoplasms,except for those referring to the colon and stomach,could be characterized as rather *** exact magnitude of the shift in younger ages is expected to become clearer shortly,as long as relevant epidemiological data from many parts of the world would be *** most important question concerns the etiology of this phenomenon,since its magnitude cannot be explained solely by the better diagnostic methodology and the preventive programs applied in many *** existing data support the assumption that a number of environ-mental factors may play a primary role in influencing carcinogenesis,sometimes from *** that have appeared in the last decades related mainly to eating habits,consistency of gut microbiome and an increase of obese people interacting with genetic factors,ultimately favor the process of *** these factors however,are not entirely sufficient to explain the age-related changes in the frequency of digestive *** of the individual effect of each of the already known factors or factors likely to be involved in the etiology of this phenomenon and studies using state-of-the-art technologies to accurately determine the degree of the population exposure to these factors are *** this article,we attempt to describe the epidemiological data supporting the age-shifting of digestive malignancies and their possible ***,we propose some measures regarding the attitude of the scientific community to this alarming phenomenon.

关键词： Gastrointestinal cancer Endoscopy Epidemiology Early-onset Environment

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A four-band index for both liquid and solid water and its applications in the Aral sea Basin

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science China Earth sciences 2024年第3期67卷 769-788页

作者： Bing YUE Xi CHEN saibo LI Zhengping DU john WILsON Junhui YANG Yimen JIAO shuangyan HUANG Chenghu ZHOU Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute of Geographical sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China spatial sciences Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

Various investigations have been conducted to analyze the water-coverage area of the Aral sea and the Aral sea Basin(AsB). However, the investigations incorporated considerable uncertainty and the used water indices had misclassification problem, which made different research groups present different results. Thus we first ascertain the boundaries of the AsB, the syr and Amu river basins as well as their upper, middle and lower reaches. Then a four-band index for both liquid and solid water(ILsW) is proposed to address the misclassification problems of the classic water indices. ILsW is calculated by using the reflectance values of the green, red, near infrared, and thermal infrared bands, which combines the normalized difference water index(NDWI) and land surface temperature(LsT) together. Validation results show that the ILsW water index has the highest accuracy by far in the Aral sea Basin. Our results indicate that annual average decline of the water-coverage area was 963 km^(2) in the southern Aral sea, whereas the northern Aral sea has experienced little change. In the meanwhile, permanent ice and snow in upper reach of AsB has retreated considerably. Annual retreating rates of the permanent ice and snow were respectively 6233and 3841 km^(2) in upper reaches of Amu river basin(UARB) and syr river basin(UsRB). One of major reasons is that climate has become warmer in AsB. The climate change has caused serious water deficit problem. The water deficit had an increasing trend since the 1990s and its increasing rates was 3.778 billion m^(3) yearly on average. The total water deficit was 76.967 billion m^(3) on average in the whole area of AsB in the 2010s. However, up reaches of syr river basin(UsRB), a component area of AsB, had water surplus of 25.461 billion m^(3). These conclusions are useful for setting out a sustainable development strategy in AsB.

关键词： Aral sea Basin syr river basin Amu river basin Water indices Water-coverage area Water deficit Climate change

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A new diatom genus spargeria ***.(Bacillariophyceae)from Xizang,China,and the description of two new species

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Journal of Oceanology and Limnology 2024年第1期42卷 291-303页

作者： Yan LIU john Patrick KOCIOLEK Li WANG Xinxin LU Huan ZHU Guoxiang LIU Fengyang sUI Yawen FAN College of Life science and Technology Harbin Normal UniversityHarbin 150025China Museum of Natural History and Department of Ecology and Evolutionary Biology University of ColoradoBoulder CO 80309USA Key Laboratory of Algal Biology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

During our investigation of diatom biodiversity in Xizang,two species exhibited unique morphological features discriminative from all previously known *** we describe these two species and describe as new the genus,spargeria *** new genus features narrow to wide rectangular valves,narrow valve mantles,filiform raphe branches that occur on the valve face only,terminal raphe fissures straight or slightly deflected to same side,bow-tie shaped central areas,chambered striae present on the valve face only,being absent from the mantle,wider striae near the axial area and very narrow near the margin,multiseriate striae with small and round areolae that are occluded ***,spargeria zhuii *** larger and robust valves,radiate striae,with one divergent stria near the apices,while spargeria chenia *** smaller,with narrow valves,striae slightly radiate in the middle,becoming convergent or parallel near *** new genus belongs to the family Pinnulariaceae,and it was compared and contrasted with other genera of this *** work suggests the need for continued studies to document the biodiversity of diatoms in Xizang.

关键词： spargeria new genus Pinnulariaceae morphology Xizang

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Better engineering layered vanadium oxides for aqueous zinc‐ion batteries: Going beyond widening the interlayer spacing

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smartMat 2024年第1期5卷 83-109页

作者： Yue Guo Hanmei Jiang Binbin Liu Xingyang Wang Yifu Zhang Jianguo sun john Wang Department of Materials science and Engineering National University of SingaporeSingaporeSingapore state Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

Aqueous zinc‐ion batteries(ZIBs)are regarded as among the most promising candidates for large‐scale grid energy storage,owing to their high safety,low costs,and environmental *** the past decade,vanadium oxides,which are exemplified by V2O5,have been widely developed as a class of cathode materials for ZIBs,where the relatively high theoretical capacity and structural stability are among the main ***,there are considerable challenges in the construction of vanadium‐based ZIBs with high capacity,long lifespan,and excellent rate *** widenings of the interlayer spacing in the layered vanadium oxides by pre‐intercalations appear to have reached their limitations in improving the energy density and other key performance parameters of ZIBs,although various metal ions(Na+,Ca2+,and Al3+)and even organic cations/groups have been ***,we discuss the advances made more recently,and also the challenges faced by the high‐performance vanadium oxides(V2O5‐based)cathodes,where there are several strategies to improve their electrochemical performance ranging from the new structural designs down to sub‐nano‐scopic/molecular/atomic levels,including cation pre‐intercalation,structural water optimization,and defect engineering,to macroscopic structural *** key principles for an optimal structural design of the V2O5‐based cathode materials for high energy density and fast‐charging aqueous ZIBs are examined,aiming at paving the way for developing energy storage designed for those large scales,high safety,and low‐cost systems.

关键词： aqueous zinc‐ion batteries cations pre‐intercalation defect engineering structural water vanadium oxides

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Recent progress in functional metal-organic frameworks for bio-medical application

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Regenerative Biomaterials 2024年第2期3卷 37-54页

作者： Wenwen Chai Xiaochen Chen Jing Liu Liyan Zhang Chunyu Liu Li Li john Robert Honiball Haobo Pan Xu Cui Deping Wang school of Materials science and Engineering Tongji UniversityShanghai 201804China shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Orthopaedics&Traumatology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)have a high specific surface area,adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly,which has intrigued wide interest in a broad range of *** the arena of biomedical engineering,the functionalized modification of MOFs has produced drug carriers with excellent dispersion and functionalities such as target delivery and response release,with promising applications in bio-detection,disease therapy,tissue healing,and other *** review summa-rizes the present state of research on the functionalization of MOFs by physical binding or chemical cross-linking of small *** *** hvdrogels and evaluates the role and approach of MOFs functionalization in boosting the reactivity of *** this basis,research on the application of functionalized MOFs composites in biomedical engineering fields such as drug delivery,tissue repair,disease treatment,bio-detection and imaging is surveyed,and the development trend and application prospects of functionalized MOFs as an important new class of biomedical materials in the biomedical field are anticipated,which may provide some inspiration and reference for further development of MOF for bio-medical applications.

关键词： metal-organic frameworks porous functionalization tissue repair disease treatment

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Use of infrared thermography to detect reactions to stressful events:does animal personality matter?

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Integrative Zoology 2024年第2期19卷 224-239页

作者： Maria Vittoria MAZZAMUTO Marina MORANDINI William LAMPMAN Lucas Armand WAUTERs Damiano PREATONI john Lad KOPROWsKI Adriano MARTINOLI school of Natural Resources and Environment College of Agriculture and Life ScienceUniversity of ArizonaArizonaUSA Unitàdi Analisi e Gestione delle Risorse Ambientali Dipartimento di Scienze Teoriche e ApplicateGuido Tosi Research GroupUniversitàdegli Studi dell’InsubriaVareseItaly Haub school of Environment and Natural Resources University of WyomingWyomingUSA

The study of the relationship between animal stress and personality for free-ranging animals is limited and provides contrasting *** perception of stressors by an individual may vary due to its personality,and certain personality traits may help individuals to better cope with *** non-invasive infrared thermography(IRT),we investigated the link between physiological and behavioral components expressed during an acute stress event by free-ranging Fremont’s squirrels(Tamiasciurus fremonti).We expected that,during the acute stress event of being approached by the researcher,individuals that showed a fast pace-of-life syndrome(bolder,more active,and less social/more aggressive)based on an arena test would exhibit stronger sympathetic-adrenal-medullary system reactivity showing a more intense stress-induced hyperthermia(high core body temperature and low peripheral temperature)than individuals with a slow pace of life(shy,less active,and more social).We successfully employed IRT technology to images of Fremont’s squirrels with identification of the individuals’body parts(eye,nose,ear,hind foot).However,we found no support for our ***’body surface temperatures told us more about a squirrel’s external environment and less about the thermal state of the body in that environment following a stressful *** studies need to assess how to make IRT effective and efficient in the field and improve its performance in studying the relationships between physiology and personality in wildlife.

关键词： non-invasive method open field test physiology stress-induced hyperthermia Tamiasciurus fremonti

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