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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT yousef a.bin jardan FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD JAMIL The Second Affiliated Hospital of Ha.bin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

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Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

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World Journal of Gastroenterology 2021年第7期27卷 592-608页

作者： Mushtaq Ahmad Ansari Mohammad Raish yousef a.bin jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer *** mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue *** To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in *** Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal *** was administered orally once daily starting 7 d before LPS/D-GalN *** Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model ***,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling *** In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.

关键词： Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis Antioxidant Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

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Modeling and Performance Simulation of an Innovative Concept of Linear Fresnel Reflector based CSP System

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Journal of Thermal Science 2021年第5期30卷 1614-1624页

作者： DANISH Syed Noman ALMUTAIRI Zeyad EL-LEATHY Abdelrahman AL-ANSARY Hany jardan Yazeed ALAQEL Shaker Sustainable Energy Technologies Center King Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia K.A.CARE Energy Research and Innovation Center at Riyadh RiyadhSaudi Arabia Mechanical Engineering Department King Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia Mechanical Power Engineering Department Faculty of EngineeringEl-MatariaHelwan UniversityCairo11718Egypt

Concentrating solar power technology is one of the most promising alternative energy *** recent past,Linear Fresnel Reflector systems have received great attention and novel designs have been proposed keeping in view the objective to enhance its functionality and *** achieving the same objective,this study presents a novel concept where a conventional LFR is enclosed in a greenhouse called *** was expected that such an enclosure can:(1)increase the incoming solar radiation,(2)further improve the overall efficiency due to simplified cleaning process and(3)reduce the capital cost for the construction of LFR support system.A complete thermal and optical analysis was presented for modeling and performance evaluation of the solar field of both conventional-LFR and novel *** of non-linear equations for each system were solved using Newton-Raphson *** detailed optical analysis was further performed for conventional-LFR considering the seasonal *** results concluded that the greenhouse-LFR is better than the conventional-LFR as it had higher efficiency and useful heat with lesser heat *** greenhouse-LFR,the maximum thermal efficiency was 73.2%whereas for conventional-LFR it was 37.2%.Also,there was an average increase of useful heat by 3 times in the month of February and 4.7 times in the month of ***^(TM) analysis indicated significant spillage loss when a conventional-LFR was used without a secondary reflector or slight curvature of the mirrors.

关键词： solar energy concentrated solar power linear Fresnel reflector greenhouse thermal and optical analysis experimentation

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