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Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease

Animal Models and Experimental Medicine 2024年第2期7卷 166-178页

作者： Xuecui Yin Lin Dong Xiaohan Wang Zhenzhen Qin Yuying Ma Xiaofei Ke Ya Li Qingde Wang Yang Mi Quanjun Lyu Xia Xu Pengyuan Zheng youcai tang Department of Internal Medicine the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Pediatrics the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Clinical Nutrition the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education of ChinaCo-innovation Center of Henan Province for New drug R&D and Preclinical SafetySchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pediatrics GastroenterologyHenan Key Laboratory of Rehabilitation MedicineHenan Joint International Research Laboratory of Chronic Liver Injury and Henan Provincial Outstanding Overseas Scientists Chronic Liver Injury Studiothe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Background:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases *** stellate cells(HSCs)are the major effector cells of liver *** contain abundant lipid droplets(LDs)in their cytoplasm during *** 5(PLIN 5)is a LD surface-associated protein that plays a crucial role in lipid ***,little is known about the role of PLIN 5 in HSC ***:PLIN 5 was overexpressed in HSCs of Sprague–Dawley rats by lentivirus *** the same time,PLIN 5 gene knockout mice were constructed and fed with a high-fat diet(HFD)for 20 weeks to study the role of PLIN 5 in *** corresponding reagent kits were used to measure TG,GSH,Caspase 3 activity,ATP level,and mitochondrial DNA copy *** analysis of mice liver tissue metabolism was performed based on UPLC-MS/***,mitochondrial function,cell proliferation,and apoptosis-related genes and proteins were detected by western blotting and ***:Overexpression of PLIN 5 in activated HSCs led to a decrease in ATP levels in mitochondria,inhibition of cell proliferation,and a significant increase in cell apoptosis through AMPK *** addition,compared with the HFD-fed C57BL/6J mice,PLIN 5 knockout mice fed with HFD showed reduced liver fat deposition,decreased LD abundance and size,and reduced liver ***:These findings highlight the unique regulatory role of PLIN 5 in HSCs and the role of PLIN 5 in the fibrosis process of NAFLD.

关键词： AMPK apoptosis hepatic stellate cell liver fibrosis perilipin 5

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GPR176 mRNA与胃癌预后及免疫治疗反应关系的生物信息学分析

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郑州大学学报（医学版） 2024年第2期59卷 181-186页

作者：朱怡臻王迎汤有才郑州大学第五附属医院胃肠甲状腺外科郑州450052 郑州大学第五附属医院输血科郑州450052 郑州大学第五附属医院儿科郑州450052 河南省康复医学重点实验室郑州450052 河南省慢性肝损伤国际联合实验室郑州450052 郑州市代谢相关脂肪性肝病重点实验室郑州450052 河南省慢性肝损伤杰出外籍科学家工作室郑州450052

目的:基于生物信息学技术探讨G蛋白偶联受体176(GPR176)在胃癌中的表达水平,挖掘其预测胃癌预后和免疫检查点阻断剂应答的潜力。方法:利用R软件比较TCGA-STAD和GEO数据集中胃癌组织和正常胃组织中GPR176 mRNA的表达,调取Human Protein A... 详细信息

目的:基于生物信息学技术探讨G蛋白偶联受体176(GPR176)在胃癌中的表达水平,挖掘其预测胃癌预后和免疫检查点阻断剂应答的潜力。方法:利用R软件比较TCGA-STAD和GEO数据集中胃癌组织和正常胃组织中GPR176 mRNA的表达,调取Human Protein Atlas中免疫组化图谱,比较胃癌组织和正常胃组织中GPR176蛋白的表达。利用TCGA-STAD数据集分析不同临床特征胃癌患者GPR176 mRNA表达的差异。利用TCGA-STAD和GEO数据集分析GPR176 mRNA表达水平预测胃癌预后及免疫检查点阻断剂应答的价值。结果:与正常胃组织比较,胃癌组织中GPR176 mRNA和蛋白表达水平均上调,且与胃癌患者的不良临床特征有关。GPR176 mRNA高表达患者总生存期短于低表达者;ROC曲线分析表明,GPR176 mRNA对胃癌1、3、5 a生存率具有较高的预测价值。GPR176 mRNA高表达患者免疫细胞(未激活NK细胞和M2巨噬细胞)的浸润丰度高,免疫表型评分低。结论:GPR176在胃癌组织中高表达,可作为潜在的预测胃癌预后和免疫检查点阻断剂应答的新型分子标志物。

关键词： G蛋白偶联受体176 胃癌预后免疫检查点阻断剂生物信息学分析

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Structure of the Upper Mantle and Transition Zone Beneath the South China Block Imaged by Finite Frequency Tomography

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1637-1652页

作者： SUN Ya LIU Jianxin tang youcai CHEN Jiawei ZHOU Keping CHEN Bo School ofGeosciences andlnfo-Physics Central South University Changsha 410083 China. School of Resources and Safety Engineering Central South University Changsha 410083 China Key Laboratory ofmetallogenicprediction of Non-Ferrous metals Ministry of Education Central South University Changsha 410083 China. State Key Laboratory of Petroleum Resource and Prospecting and Unconventional Natural Gas Institute China University of Petroleum Beij'ing 102249 China. Key Laboratory of CrustalDynamics Institute of Crustal Dynamics CEA Beijing 100085 China

We applied the finite frequency tomography method to S wave data recorded by 350 broadband stations beneath the South China Block（SCB） and its surroundings from earthquakes occurring between July 2007 and July 2010,to better understand upper mantle *** travel-times in the pair of stations with appropriate weighting for each station are used in the *** results are consistent with previous tomography that show a high velocity anomaly beneath the Sichuan basin and a high velocity anomaly in the transition zone beneath the Yangtze ***,the resolution of mantle heterogeneity provides new insight into the tectonic framework of subduction of Burmese lithosphere in the west part of the study region and subduction of oceanic lithosphere in the *** the subduction realm,west of 107°E,a significant fast S-wave anomaly is located on the southeast of Sichuan *** of 107°E,and two narrow and discontinuous fast S-wave anomalies occur at a depth of 400-600 km beneath the middle of the South China block overlain by the pronounced low S-wave anomalies at a depth of 100 and 400 *** the fast anomalies located in the mantle transition zone represent stagnant slabs,their fragmented nature may suggest that they could be produced by different episodes of subduction beneath western Pacific island and the above slow velocity anomaly may associated with the back-arc regions of ongoing *** addition,tomography also reveals an anomalously high S-wave velocity continental root extends eastward to a depth 400 km beneath the eastern Sichuan *** anomaly may be related to eastern extrusion of Indian lithosphere associated with the collision of India and ***,our results also show large slow anomalies beneath the Red River fault region connected to deeper anomalies beneath the South China Fold Belt and South China *** these observations are consistent with the scenario that the South China block has been built by both

关键词： finite frequency tomography South China Block station pairs subduction Paleo-pacific plate

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基于高分辨率层序约束的薄储层地震预测方法研究

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地球物理学进展 2024年第2期39卷 606-619页

作者：成锁赵光亮王鑫吴亚宁邓忠毅陈强肖文黄捍东唐有彩中国石油塔里木油田公司勘探开发研究院库尔勒841000 中国石油大学(北京)地球物理学院北京102249

塔里木油田碎屑岩储层埋深大,储层物性好且油气资源含量大,但面临砂岩和泥岩频繁交互发育、岩性横向变化快、单储层厚度较薄的难题.常规地震反演技术由于低频初始模型精度低和横向约束性弱,难以满足深部薄储层预测需求.本文基于贝叶斯... 详细信息

塔里木油田碎屑岩储层埋深大,储层物性好且油气资源含量大,但面临砂岩和泥岩频繁交互发育、岩性横向变化快、单储层厚度较薄的难题.常规地震反演技术由于低频初始模型精度低和横向约束性弱,难以满足深部薄储层预测需求.本文基于贝叶斯反演理论和INPEFA(Integrated Prediction Error Filter Analysis)层序划分理论,提出了一种高分辨率层序约束的叠后贝叶斯反演方法.该方法首先通过INPEFA技术建立井上高分辨率层序格架,结合序贯高斯模拟方法建立精度高低频初始模型,同时在高分辨率层序约束下利用相邻道的相近性,在地震反演中引入横向约束算子,最终获得高分辨率和高稳定性的反演结果.该方法在轮古地区深部碎屑岩储层预测应用,有效提高了薄储层成像精度,纵向结果可识别3 m的薄储层,同时能准确刻画砂体的横向变化情况,解决了该地区深部碎屑岩薄储层预测的难题,为研究区进一步的勘探部署提供了有力支撑.

关键词：高分辨率层序 INPEFA技术贝叶斯理论低频初始模型薄储层预测

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Doppler effect of the rupture process of the great M_W7.9 Wenchuan earthquake

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Earthquake Science 2010年第6期23卷 535-539页

作者： Ge Jin youcai tang Shiyong Zhou Yongshun John Chen Institute of Theoretical and Applied Geophysics (ITA G) School of Earth and Space Sciences Peking University Beijing 100871 China Lamont-Doherty Earth Observatory Columbia University in the New York City Palisades NY 10964 USA

In this study we performed a classical spectrum analysis of seismic waveforms recorded at far field stations of the great MW7.9 Wenchuan earthquake to observe the shifts of the corner frequency with azimuth due to the Doppler *** results show that this damaging great earthquake had a dominating rupture propagation direction of 64.0°.The equivalent radius of the fault rupture surface was estimated to be 33 km,yielding the rupture area of about 3 500 *** the length of the rupture fault surface is about 230 km if the depth（or width） extent is 15 *** computer program developed in this study can quickly provide the information about the source of a future large（damaging） earthquake,which could be very useful for predicting aftershocks and planning the rescue operations.

关键词： Doppler effect rupture process Wenchuan earthquake corner frequency unidirectional

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Crust and upper mantle structures beneath Northeast China from receiver function studies

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Earthquake Science 2014年第3期27卷 265-275页

作者： Zhen Guo Yuliang Cao Xianguang Wang Y.John Chen Jieyuan Ning Weiguang He youcai tang Yongge Feng School of Earth and Space Sciences Institute of Theoretical and Applied Geophysics (ITAG)Peking University State Key Laboratory of Petroleum Resource and Prospecting and Unconventional Natural Gas InstituteChina University of Petroleum

P-wave and S-wave receiver function analyses have been performed along a profile consisted of 27 broadband seismic stations to image the crustal and upper mantle discontinuities across Northeast China. The results show that the average Moho depth varies from about 37 km beneath the Daxing＇anling orogenic belt in the west to about 33 km beneath the Songliao Basin, and to about 35 km beneath the Changbai mountain region in the east. Our results reveal that the Moho is generally flat beneath the Daxing＇anling region and a remarkable Moho offset （about 4 km） exists beneath the basin-mountain boundary, the Daxing＇anling-Taihang Gravity Line. Beneath the Tanlu faults zone, which seperates the Songliao Basin and Changbai region, the Moho is uplift and the crustal thick- ness changes rapidly. We interpret this feature as that the Tanlu faults might deeply penetrate into the upper mantle, and facilitate the mantle upwelling along the faults during the Cenozoic era. The average depth of the lithosphereasthenosphere boundary （LAB） is - 80 km along the profile which is thinner than an average thickness of a continental lithosphere. The LAB shows an arc-like shape in the basin, with the shallowest part approximately beneath the center of the basin. The uplift LAB beneath the basin might be related to the extensive lithospheric stretching in the Mesozoic. In the mantle transition zone, a structurally complicated 660 km discontinuity with a maximum 35 km depression beneath the Changbai region is observed. The 35 km depression is roughly coincident with the location of the stagnant western pacific slab on top of the 660 km discontinuity revealed by the recent P wave tomography.

关键词： Northeast China NCC - Receiver function Migration - CCP - Moho - LAB Mantle transition zone

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双重转型、双重张力与流动人口治理框架的建构

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社会科学 2015年第6期 78-85页

作者：唐有财华东理工大学社会学系

当前流动人口治理正经历深刻的双重转型和双重张力。转型之一是代际更替带来的群体特征大转变,表现为第二代流动人口的权利意识增强、权利诉求增多及抗争能力提高;转型之二是政府治理的行为逻辑从管控向服务与治理兼重的转变。双重转型... 详细信息

当前流动人口治理正经历深刻的双重转型和双重张力。转型之一是代际更替带来的群体特征大转变,表现为第二代流动人口的权利意识增强、权利诉求增多及抗争能力提高;转型之二是政府治理的行为逻辑从管控向服务与治理兼重的转变。双重转型造成了双重张力:其一是流动人口的需求与社会治理体制回应之间的张力,其二是治理理念、管理体制与工作机制之间的张力。在清晰地认识和准确地判断当前中国流动人口治理困境的基础上,我们可以创新流动人口的社会治理体制,构建"治理理念—管理体制—工作机制—流动人口需求"的四位一体框架。该框架的基本思路是突出各类行动主体的权限、责任、行动及其互动,因而既注重赋予和增强流动人口的社会权利,也强调提升以政府为核心的各类社会主体的治理能力。

关键词：双重转型双重张力流动人口治理

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Land Collectivization and the Structural Transformation of Traditional Rural Families

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Social Sciences in China 2016年第3期37卷 111-129页

作者： Wang Tianfu Wang Fei tang youcai Department of Sociology Tsinghua University School of Architecture Tsinghua University Department of Sociology East China University of Science and Engineering

We use oral history materials from elderly rural people aged over seventy to analyze the circumstances of rural family production and daily life prior to collectivization in the mid- 1950s; during collectivization in the 1950s to the 1970s; and under the household contract responsibility system of the late 1970s. We find that the transition from the traditional to the nuclear family did not involve industrialization in the traditional Western sense. As an early state industrialization strategy after 1949, rural collectivization fundamentally changed the organizational pattern of traditional family production and daily life and of inter-generational relations and structures under the patriarchal system, launching the historical process of structural transition in the family. This explanation differs from the classic ＂theory of modernization＂ of family change.

关键词： land collectivization traditional family structural transition

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cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells

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Oncology Research 2021年第2期29卷 87-103页

作者： BIN LIU HAIPENG LIU FEIFEI REN HANGFAN LIU IHTISHAM BUKHARI YUMING FU WANQINGWU MINGHAI ZHAO SHAOGONG ZHU HUI MO FAZHAN LI MICHAEL B.ZHENG youcai tang PENGYUAN ZHENG YANG MI Henan Key Laboratory of Helicobacter Pylori&Microbiota and Gastrointestinal Cancer The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Academy of Medical Science Zhengzhou UniversityZhengzhouChina Clinical and Translational Research Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Gastrointestinal Surgery The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastrointestinal Surgery Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Gastrointestinal Surgery People Hospital of Zhengzhou UniversityZhengzhouChina Faculty of Science School of Interdisciplinary ScienceHonours Life SciencesMcMaster UniversityHamiltonONCanada

The activation of some oncogenes promote cancer cell proliferation and growth,facilitate cancer progression and metastasis by induce DNA replication stress,even genome *** of the cyclic GMP-AMP synthase(cGAS)mediates classical DNA sensing,is involved in genome instability,and is linked to various tumor development or ***,the function of cGAS in gastric cancer remains *** this study,the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell *** employing cGAS high-expression gastric cancer cell lines,including AGS and MKN45,ectopic silencing of cGAS caused a significant reduction in the proliferation of the cells,tumor growth,and mass in xenograft ***,database analysis predicted a possible involvement of cGAS in the DNA damage response(DDR),further data through cells revealed protein interactions of the cGAS and MRE11-RAD50-NBN(MRN)complex,which activated cell cycle checkpoints,even increased genome instability in gastric cancer cells,thereby contributing to gastric cancer progression and sensitivity to treatment with DNA damaging ***,the upregulation of cGAS significantly exacerbated the prognosis of gastric cancer patients while improving radiotherapeutic ***,we concluded that cGAS is involved in gastric cancer progression by fueling genome instability,implying that intervening in the cGAS pathway could be a practicable therapeutic approach for gastric cancer.

关键词： Gastric cancer Cell proliferation cGAS DNA damage response MRN complex

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以岗位胜任力为导向的康复治疗专业实习带教方案研究

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成都中医药大学学报（教育科学版） 2024年第1期26卷 28-30页

作者：关晨霞董安琴杨慎峭汤有才李哲张子英王国胜申利坊郑州大学第五临床学院康复治疗学教研室河南郑州450052 成都中医药大学养生康复学院四川成都611137

新形势下对康复治疗人才培养提出更高的要求,郑州大学第五临床学院康复教学团队以提升能力为目标,以岗位胜任力为导向改革了康复治疗专业的实习带教方法,对小讲课形式、带教内容、考核方式进行了革新,提高了学生的实习效果,帮助其毕业... 详细信息

新形势下对康复治疗人才培养提出更高的要求,郑州大学第五临床学院康复教学团队以提升能力为目标,以岗位胜任力为导向改革了康复治疗专业的实习带教方法,对小讲课形式、带教内容、考核方式进行了革新,提高了学生的实习效果,帮助其毕业后更好胜任康复治疗师的工作岗位。

关键词：岗位胜任力康复治疗实习带教

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