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International Journal of Ophthalmology(English edition) 2018年第1期11卷 58-65页

作者： Tong Ding Dan-Na shi xiang Fan Mi-yun Zheng Wei Wang Wei-qiang Qiu Peking University Third Hospital Eye Center Beijing 100191China

AIM： To detect the relationship between infusion pressure and postoperative ganglion cells ***： This prospective observational cohort study included sixty-one eyes that underwent uncomplicated cataract surgery. Patients were divided into two groups according to infusion time（IT） recorded using surgery equipment [Group A： IT〉IT_（mean）（27 eyes）; Group B： IT

关键词： isolated-check visual evoked potential optical coherence tomography ganglion cell inner plexiform layer cataract extraction

Sodiophilicity/potassiophilicity chemistry in sodium/potassium metal anodes

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Journal of Energy Chemistry 2020年第12期29卷 1-6页

作者： xiang Chen yun-Ke Bai Xin Shen Hong-Jie Peng qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA

Heteroatom-doped carbon materials have been widely used as sodium(Na) and potassium(K) metal anode frameworks to achieve uniform Na and K depositions. If the origin of the Sodiophilicity and potassiophilicity of doping sites in heteroatom-doped carbon host are clearly understood, the nucleation and growth behavior of Na and K can be precisely regulated in working batteries. Herein the Sodiophilicity and potassiophilicity chemistries of carbon materials are probed through first-principles calculations. The local dipole of doping functional groups and charge transfer during Na/K deposition are regarded as key principles to reveal the sodiophilic and potassiophilic nature of doping sites. Especially, O–B, O–S, and O–P co-doping strategy are predicted to be effective methods to improve the Sodiophilicity and potassiophilicity of carbon hosts and thus render safe and dendrite-free Na and K metal anodes. This work affords a deep and insightful understanding of Sodiophilicity and potassiophilicity chemistry of Na and K anodes and establishes general principles of designing highly sodiophilic and potassiophilic carbon frameworks.

关键词： Sodium and potassium metal anodes Sodiophilicity and potassiophilicity Carbon materials First-principles calculations Dendrite-free electrode

Synthesis of EPR-g-styrene by anionic coupling technique

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Chinese Chemical Letters 2007年第8期18卷 963-965页

作者： xiang Li xia Zi qiang Zhao Qian Zhang Yan shi Xiao ping Cai Zhi Feng Fu State Key Laboratory of Chemical Resource Engineering Beifing University of Chemical Technology Beifing 100029 China Jilin PetroChemical Company Lt-d. PetroChina Jilin 132021 China

Ethylene-propylene rubber （EPR） graft copolymers were prepared successfully by anionic coupling technique between chlorinated EPR （C1-EPR） and living anionic polystyrene chain. The EPR-g-styrene was characterized ... 详细信息

关键词： EPR Graft copolymer Living polystyrene Anionic coupling

Constructing the wolfberry(Lycium spp.) genetic linkage map using AFLP and SSR markers

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Journal of Integrative Agriculture 2022年第1期21卷 131-138页

作者： YIN Yue AN Wei ZHAO Jian-hua LI Yan-long FAN yun-fang CHEN Jin-huan CAO you-long ZHAN xiang-qiang State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China National Wolfberry Engineering Research Center Ningxia Academy of Agricultural and Forestry SciencesYinchuan 751002P.R.China College of Biological Sciences and Technology Beijing Forestry UniversityBeijing 100083P.R.China

Genetic linkage maps are important for quantitative trait locus(QTL) and marker-assisted selection breeding. The wolfberry(Lycium spp.) is an important food and traditional medicine in China. However, few construction genetic linkage maps have been reported because of the lack of genomic and genetic resources. In this study, a population of 89 F1 seedings was derived from a cross between two heterozygous parents, L. chinense var. potaninii ‘BF-01’(female)and L. barbarum var. auranticarpum ‘NH-01’(male), in order to construct a genetic linkage map using simple sequence repeat(SSR) and amplified fragment length polymorphism(AFLP) markers based on the double pseudo-test cross mapping strategy. The resulting genetic map consisted of 165 markers(74 AFLPs and 91 SSRs) distributed across 12 linkage groups and spanned a total length of 557.6 cM with an average distance of 3.38 cM between adjacent *** 12 linkage groups contained 3 to 21 markers and ranged in length from 8.6 to 58.3 cM. Twenty-nine segregated markers distributed in the map were mainly located on LG4 and LG9 linkage groups at P<0.05. This is the first linkage map of Lycium species using SSR and AFLP markers, which can serve as basis for improving genes and selective breeding of the genome assembly.

关键词： Lycium genetic linkage map AFLP SSR

Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang Chen-Li Zhang xiang Cui qiang Li Lei Yang Zhi-yun He Ze Yang miao-miao Zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its ***,a natural anticancer agent,exhibits therapeutic promise in gastric *** effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and *** noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and *** investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric *** study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and *** To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and ***,these findings were validated in clinical *** The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 *** blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin *** expression of lncRNAs before and after curcumin treatment was assessed using lncRNA seq

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway Lymph metastasis

Proteomic Analysis of the Response of Liangyoupeijiu(Super High-Yield Hybrid Rice) Seedlings to Cold Stress

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Journal of Integrative Plant Biology 2006年第8期48卷 945-951页

作者： ping-Fang Yang Xiao-Juan Li Yu Liang Yu-xiang Jing shi-Hua Shen Ting-yun Kuang Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Graduate College of the Chinese Academy of Sciences Beijing 100039 China

Liangyoupeijiu is a super high-yield hybrid rice. Despite its advantages with respect to yield and grain quality, it is sensitive to cold, which keeps it from being widely cultivated. We subjected Liangyoupeijiu seedlings to 4 ℃ cold treatment, then extracted the leaf proteins. After 2-D gel electrophoresis separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis, a series of differentially displayed proteins were identified. Some metabolism-associated proteins were found among the downregulated proteins, such as carbamoyl phosphate synthetase, transketolase 1, dihydrolipoamide dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase. The upregulated proteins included both stress-resistance proteins such as nucleoside diphosphate kinase I and proteins that are negative for rice growth, such as FtsH-like protein, plastid fusion and/or translocation factor （Pftf） and actin. Our results indicate that cold may inhibit Liangyoupeijiu growth through decreasing metabolic activity and damaging cell structure.

关键词： cold stress Oryza sativa proteome super high-yield hybrid rice.

Repair mechanism of astrocytes and non-astrocytes in spinal cord injury

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World Journal of Clinical Cases 2020年第5期8卷 854-863页

作者： xiang-yun Liu Jian-Wei guo Jian-qiang Kou Yuan-Liang Sun Xiu-Jun Zheng Department of Spinal Surgery The Affiliated Hospital of Qingdao University

BACKGROUND Spinal cord injury(SCI)is a destructive disease that incurs huge personal and social costs,and there is no effective *** the pathogenesis and treatment mechanism of SCI has always been a strong scientific focus,the pathogenesis of SCI is still under *** To determine the key genes based on the modularization of in-depth analysis,in order to identify the repair mechanism of astrocytes and non-astrocytes in *** Firstly,the differences between injured and non-injured spinal cord of astrocyte(HA),injured and non-injured spinal cord of non-astrocyte(FLOW),injured spinal cord of non-injured astrocyte(HA)and non-injured spinal cord of nonastrocyte(FLOW),and non-injured spinal cord of astrocyte(HA)and nonastrocyte(FLOW)were *** total number of differentially expressed genes was obtained by merging the four groups of differential ***,the genes were co-expressed and ***,the enrichment of GO function and KEGG pathway of module genes was ***,non-coding RNA,transcription factors and drugs that regulate module genes were predicted using hypergeometric *** In summary,we obtained 19 expression modules involving 5216 differentially expressed *** them,miR-494,XIST and other genes were differentially expressed in SCI patients,and played an active regulatory role in dysfunction module,and these genes were recognized as the driving genes of *** results showed that module genes were significantly involved in the biological processes of inflammation,oxidation and *** pathways such as NF-kappa B/A20,AMPK and MAPK were significantly *** addition,non-coding RNA pivot(including miR-136-5p and let-7d-5p,etc.)and transcription factor pivot(including NFKB1,MYC,etc.)were identified as significant regulatory dysfunction *** Overall,this study uncovered a co-expression network of key genes involved in astrocyte and non-astrocyte regulation in

关键词： Astrocyte Non-astrocyte Spinal cord injury Repair mechanism Dysfunction module Module genes

Ligation-assisted endoscopic submucosal resection with circumferential mucosal incision for duodenal carcinoid tumor

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World Journal of Gastroenterology 2015年第34期21卷 10041-10044页

作者： Iri Take qiang shi Zhi-peng Qi shi-lun Cai li-Qing Yao ping-hong Zhou yun-shi Zhong Endoscopy Center Zhongshan Hospital of Fudan University Endoscopy Research Institute of Fudan University

Here we present the case of a 64-year-old female with a duodenal carcinoid tumor treated by ligation-assisted endoscopic submucosal resection(ESMR-L) with circumferential mucosal incision(CMI). Band ligation was effective in resecting the duodenal carcinoid tumor after CMI,with an uneventful post-procedural course. Histopathological examination showed clear tumor margins at deeper tissue levels. Thus,in the present case,ESMR-L with CMI was useful for the treatment of duodenal carcinoid tumor.

关键词： Carcinoid tumor Submucosal tumor Duodenum Ligation

GOMA:functional enrichment analysis tool based on GO modules

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Chinese Journal of Cancer 2013年第4期32卷 195-204页

作者： qiang Huang Ling-yun Wu Yong Wang xiang-Sun Zhang National Center for Mathematics and Interdisciplinary Sciences Institute of Applied Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences

Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but most output a long list of significantly enriched terms that are often redundant, making it difficult to extract the most meaningful functions. In this paper, we present GOMA, a novel enrichment analysis method based on the new concept of enriched functional Gene Ontology (GO) modules. With this method, we systematically revealed functional GO modules, i.e., groups of functionally similar GO terms, via an optimization model and then ranked them by enrichment scores. Our new method simplifies enrichment analysis results by reducing redundancy, thereby preventing inconsistent enrichment results among functionally similar terms and providing more biologically meaningful results.

关键词： GO enrichment analysis, modules, functional redundancy, network, relationships

Hot Rolled Strip Re-reddening Temperature Changing Law during Ultra-fast Cooling

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Journal of Iron and Steel Research International 2015年第8期22卷 694-702页

作者： Lian-yun JIANG Chun-jiang ZHAO Jian-hui shi guo YUAN Xue-qiang WANG Qing-xue HUANG State Key Laboratory of Rolling and Automation Northeastern University School of Mechanical Engineering Taiyuan University of Science and Technology Shougang Qian'an Iron and Steel Co. Ltd.

Temperature deviation between surface and the center of hot rolled strip is formed during ultra-fast cooling （UFC）. Surface temperature would rise when temperature deviation goes up to an extent, and strip re-reddening phenomenon will appear. Strip re-reddening affects the stability of strip microstructure, property and temperature control precision. Thus, it is necessary to conduct research on re-reddening temperature changing law to improve strip property and temperature control precision. Strip temperature trends for various strip thicknesses and ultra-fast cooling rates were obtained by numerical calculation method. Re-reddening temperature, temperature deviation between surface and center, and boundary layer position changing law were obtained. By comparison, some conclusions were obtained： UFC re-reddening temperature and laminar cooling （LC） re-reddening temperature were linear to ultra-fast cooling rate respectively. Ultra-fast cooling rate affected UFC re-reddening temperature greatly, but it had little effect on LC re-reddening temperature. Equations which were used to calculate UFC re-reddening temperature, LC re-reddening temperature and maximum temperature deviation were obtained. The position of boundary layer stayed in 1/4 strip thickness.

关键词： ultra-fast cooling laminar cooling cooling rate re-reddening temperature