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Phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance

Nano Research 2022年第5期15卷 4334-4343页

作者： Zhimin tian Junlong Zhao Shoujie Zhao Huicheng Li Zhixiong Guo Zechen Liang Jiayuan Li Yongquan Qu Dongfeng Chen Lei Liu Department Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Cancer Biology Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China The State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400042China

Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and *** solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(pa)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation *** doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor *** Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse ***,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of *** anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases.

关键词： Ca^(2+)nano-inhibitor nanoceria tumor drug resistance phytic acid nanozyme

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EFFECT OF Ar PRESSURE ON STRUCTURAL AND ELECTRICAL PROPERTIES OF Cu FILMS DEPOSITED ON GLASS BY DC MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 39-44页

作者： P. Wu F.P. Wang L.Q. pan Y. tian H. Qiu Department of Physics University of Science and Technology Beijing Beijing 100083China Beijing Keda-tianyu Microelectronic Material Technology Development Co. Ltd. Beijing 100083 China

Cu films with thickness of 630-1300nm were deposited on glass substrates without heating by DC magnetron sputtering in pure Ar gas. Ar pressure was controlled to 0.5, 1.0 and 1.5pa respectively. The target voltage was fixed at 500V but the target current increased from 200 to 1150mA with Ar pressure increasing. X-ray diffraction, scanning electron microscopy and atomic force microscopy were used to observe the structural characterization of the films. The resistivity of the films was measured using four-point probe technique. At all the Ar pressures, the Cu films have mixture crystalline orientations of [111], [200] and [220] in the direction of the film growth. The film deposited at lower pressure shows more [111] orientation while that deposited at higher pressure has more [220] orientation. The amount of larger grains in the film prepared at 0.5pa Ar pressure is slightly less than that prepared at 1.0pa and 1.5pa Ar pressures. The resistivities of the films prepared at three different Ar pressures represent few differences, about 3-4 times of that of bulk material. Besides the deposition rate increases with Ar pressure because of the increase in target current. The contribution of the bombardment of energetic reflected Argon atoms to these phenomena is discussed.

关键词： Cu film DC magnetron sputtering deposition Ar pressure structure reststivity

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Surface modification of mesoporous silica nanoparticle with 4-triethoxysilylaniline to enhance seawater desalination properties of thin-film nanocomposite reverse osmosis membranes

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 99-108页

作者： Jian Wang Qun Wang Xueli Gao Xinxia tian Yangyang Wei Zhen Cao Chungang Guo Huifeng Zhang Zhun Ma Yushan Zhang The Institute of Seawater Desalination and Multipurpose Utilization Ministry of Natural Resources(Tianjin)Tianjin 300192China College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) Ocean University of ChinaQingdao 266100China

Mesoporous silica nanoparticles(MSN),with higher water permeability than NaA zeolite,were used to fabricate thin-film nanocomposite(TFN)reverse osmosis(RO)***,only aminoalkyl-modified MSN and low-pressure(less than 2.1 Mpa)RO membrane were *** this study,aminophenyl-modified MSN(AMSN)were synthesized and used to fabricate high-pressure(5.52 Mpa)RO *** the increasing of AMSN dosage,the crosslinking degree of the aromatic polyamide decreased,while the hydrophilicity of the membranes *** membrane morphology was maintained to show a ridge-and-valley structure,with only a slight increase in membrane surface *** the optimum conditions(AMSN dosage of 0.25 g/L),when compared with the pure polyamide RO membrane,the water flux of the TFN RO membrane(55.67 L/m^2/h)was increased by about 21.6%,while NaCl rejection(98.97%)was slightly decreased by only 0.29%.However,the water flux of the membranes was much lower than *** considered that the enhancement of RO membrane permeability is attributed to the reduction of the effective thickness of the pa layer.

关键词： Thin film nanocomposite membrane Reverse osmosis Seawater desalination Aminophenyl-functionalized m esoporous silica nanoparticles

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Weak Decays of First Radial Excited Dq(2S) and Bq(2S) States

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Chinese Physics Letters 2012年第7期29卷 56-59页

作者： WANG Zhi-Hui WANG Guo-Li ZHANG Jin-Mei WANG tian-Hong Department of Physics Harbin Institute of TechnologyHarbin 150001 PITT paCC Department of Physics&AstronomyUniversity of PittsburghPA 15260USA Xiamen Institute of Standardization Xiamen 361004

We study the exclusive semileptonic and nonleptonic decays of the first radial excited heavy-light pseudoscalars Dq(2S) and Bq(2S) (q =u,d,s) with the improved Bethe-Salpeter (B-S) method which takes into account the ... 详细信息

关键词： excited decay relativistic

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Exact quantum dynamics study of the H(^(2)S)+SiH^(+)(X^(1)Σ^(+))reaction on a new potential energy surface of SiH_(2)^(+)(X^(2)A_(1))

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Chinese Physics B 2021年第12期30卷 399-405页

作者： Wen-Li Zhao Rui-Shan Tan Xue-Cheng Cao Feng Gao Qing-tian Meng School of Information Science and Engineering Shandong Agricultural UniversityTaian 271018China Department of Science Shandong Jianzhu UniversityJinan 250101China School of Physics and Electronics Shandong Normal UniversityJinan 250358China

Based on a new global potential energy surface of SiH_(2)^(+)(X^(2)A_(1)),the exact quantum dynamical calculation for the H(^(2)S)+SiH^(+)(X^(1)Σ^(+))→H_(2)+Si^(+)reaction has been carried out by using the Chebyshev wave packet *** initial state specified(νi=0,ji=0)probabilities,integral cross sections(ICS)and thermal rate constants of the title reaction are *** partial wave contributions up to J=90 are calculated in exact quantum calculation including the full Coriolis coupling(CC)*** dynamical behaviors of probabilities,ICSs and rate constants are found to be in accord with an exothermic reaction without potential *** comparing the probabilities of CC with the corresponding centrifugal sudden(CS)approximation ones,it can be concluded that neglecting CC effect will decrease the collision time,increase the amplitude of oscillation and lead to overestimation or underestimation of the reaction *** ICSs and rate constants,it is found that the deviation of CC and CS ICSs is small in the most of collision energy range except for the range of 0 eV-0.05 eV,while the deviation of both rate constants is considerable in the temperature range of 16 K-1000 K.

关键词： Chebyshev wave packet method reaction probability integral cross section rate constant

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CoS_(2)/N,S co-doped mesoporous carbon with 3D micro-nano crosslinked structure as efficient bifunctional oxygen electrocatalysts for zinc-air batteries

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Chinese Chemical Letters 2023年第5期34卷 604-609页

作者： Wei Wang Liqin Li Jie Ouyang Jialin Gong Jie tian Liang Chen Junlin Huang Binhong He Zhaohui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials School of Chemistry and Chemical EngineeringHunan Institute of Science and TechnologyYueyang 414006China Guangxi Key Laboratory of Low Energy Material Guangxi Normal UniversityGuilin 541004China Hubei Key Laboratory of Pollutant Analysis&Reuse Technology Hubei Normal UniversityHuangshi 435002China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China

This work describes a bifunctional oxygen catalyst made of cobalt disulfide encapsulated in N,S codoped mesoporous carbon with a novel three-dimensional micro-nano crosslinking *** proposed composite materials exhibit promising oxygen electrocatalytic activity and *** composite assembled rechargeable zinc-air battery can achieve a high power density of 208.9 m W/cm^(2),and can be stably cycled for more than 160 ***,the all-solid zinc-air battery assembled with the electrocatalyst also performs *** micro-nano crosslinking and high porosity structure,as well as the large number of active sites generated by the synergy of N,S doping and the close interface between carbon matrix and CoS_(2),contribute to the composite's exceptional electrochemical *** study's rational strategy lays the path for the development of other high-performance bifunctional electrocatalysts.

关键词： Micro-nano crosslinked CoS_2 ORR OER Zn-air battery

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Giant room temperature elastocaloric effect in metal-free thinfilm perovskites

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npj Computational Materials 2021年第1期7卷 1194-1201页

作者： Cheng Li Yu Hui Huang Jian-Jun Wang Bo Wang Yong Jun Wu He tian Long-Qing Chen Zijian Hong Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouChina Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Cyrus Tang Center for Sensor Materials and Applications State Key Laboratory of Silicon MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhouChina Center of Electron Microscopy State Key Laboratory of Silicon MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhouChina

Solid-state refrigeration which is environmentally benign has attracted considerable ***(mC)materials,in which the phase transitions can be induced by mechanical stresses,represent one of the most promising types of solid-state caloric ***,we have developed a thermodynamic phenomenological model and predicted extraordinarily large elastocaloric(eC)strengths for the(111)-oriented metal-free perovskite ferroelectric[MDABCO](NH_(4))I_(3)*** predicted room temperature isothermal eC ΔS_(eC)/Δσ(eC entropy change under unit stress change)and adiabatic eCΔTeC/Δσ(eC temperature change under unit stress change)for[MDABCO](NH_(4))I_(3) are−60.0 J K^(−1)kg^(−1)Gpa^(−1) and 17.9 K Gpa^(−1),respectively,which are 20 times higher than the traditional ferroelectric oxides such as BaTiO_(3) thin *** have also demonstrated that the eC performance can be improved by reducing the young’s modulus or enhancing the thermal expansion coefficient(which could be realized through chemical doping,etc.).We expect these discoveries to spur further interest in the potential applications of metal-free organic ferroelectrics materials towards next-generation eC refrigeration devices.

关键词： ferroelectric perovskite free

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Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma

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Protein & Cell 2013年第1期4卷 71-81页

作者： Yun Yang tian Xia Ning Li Jin Zhang Yuan Yang Wenming Cong Qiang Deng Ke Lan Weiping Zhou The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200433China Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200025China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of pathology Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200433China

The p53 signaling pathway works as a potent barrier to tumor *** single nucleotide polymor-phisms(SNPs)in the gene loci of p53 pathway,p53 codon 72 Arg72Pro and MDM2 SNP309(T>G),have been shown to cause perturbation of p53 function,but the effect of the two SNPs on the risk of hepatocellular carcinoma(HCC)remains *** study in-vestigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of developing HCC in pa-tients with chronic hepatitis B virus infection,and evaluated the significance of the two combined SNPs on patient *** total,350 HCC patients,230 non-HCC patients,and 96 healthy controls were geno-typed for the p53 Arg72Pro and MDM2 *** combined p53 Pro/Pro and MDM2 G/G genotype was significantly associated with HCC risk(P=0.047).Mul-tivariate analysis indicated that combined p53 Pro/Pro and MDM2 G/G genotype was an independent factor affecting recurrence and survival(Ppatients with combined p53 Pro/Pro and MDM2 G/G genotypes had a poorer prognosis than other genotypes,Ppatients with combined p53 Pro/Pro and MDM2 G/G and other genotypes(P<0.05).Thus,the combined p53 Pro/Pro and MDM2 G/G genotype is associated with increased risk of developing HCC and is an independ-ent adverse prognostic indicator in early stage HCC.

关键词： hepatocellular carcinoma p53 MDM2 single nucleotide polymorphisms prognosis

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Study on Floral and Pollen Characters of Tetraploid Rice

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Agricultural Sciences in China 2009年第10期8卷 1149-1158页

作者： LIU Jian-xin CHEN Jian-guo CHEN Dong-ling SONG Zhao-jian DAI Bing-cheng CAI De-tian College of Life Sciences Hubei University Wuhan 430062 P.R.China Cotton and Fibre Research Institute of Xiaoshan Zhejiang Academy of Agricultural Sciences Hangzhou 311202 P.R. China

Polyploidization is the evolution trend of many crops, and the yield increased obviously after polyploidization. The polyploidization of rice often brings ＂gigas＂ of both vegetative organs and seeds. Howevere, in rice breeding, it is required for restoring lines to have not only big anthers but also abundant pollens. People often doubt that the enlargement of the floral organ may just be enlargement of cell size in polyploid rice. So, it is of significance to study characteristics of floral organs and pollens of several tetraploid rice varieties or lines. Floral organ and pollen characteristics of Sg99012 and HN2026 were studied comparatively by stages and different ploidy levels, with the materials 9311, HD9802S, and pa64S as the control. The results showed that chromosome doubling had much more influence on floral characteristics of every lines than seeding by stages, and the tetraploids of every lines displayed ＂gigas＂. In correlation analysis, spikelet length, spikelet width, and anther length had significant correlation; spikelet width and anther width had significant correlation, too. Both seeding by stages and chromosome doubling made the correlations of characters between every floral organ changed to some extent. Seeding by stages had little effect on pollen diameter and fertility of HN2026-4X and Sg99012-4X. But chromosome doubling increased pollen size of every lines remarkably, and also increased the pollen quantity of PMeS （polyploid meiosis stability） restoring line HN2026-4X and gene map restoring line 9311-4X remarkably, whereas only had little effect on that of sterile lines. Moreover, chromosome doubling changed pollen fertility and made the number of fertility pollen of 9311 reduced significantly, but the pollen fertility of HN2026 （PMeS restoring line） and pa64S （sterile line） almost had no change after chromosome doubling. The results showed that tetraploid restoring lines had advantage of abundant and big size pollens, and tetraploid sterile li

关键词： polyploid rice floral organ pollen significance testing correlation analysis

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Two‑Dimensional Black Phosphorus Nanomaterials:Emerging Advances in Electrochemical Energy Storage Science

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Nano-Micro Letters 2020年第12期12卷 284-317页

作者： Junye Cheng Lingfeng Gao tian Li Shan Mei Cong Wang Bo Wen Weichun Huang Chao Li Guangping Zheng Hao Wang Han Zhang Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Collaborative Innovation Center for Optoelectronic Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronic Science and Technology of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong UniversityNantong 226019JiangsuPeople’s Republic of China

Two-dimensional black phosphorus(2D BP),well known as phosphorene,has triggered tremendous attention since the first discovery in *** unique puckered monolayer structure endows 2D BP intriguing properties,which facilitate its potential applications in various fields,such as catalyst,energy storage,sensor,*** to the large surface area,good electric conductivity,and high theoretical specific capacity,2D BP has been widely studied as electrode materials and significantly enhanced the performance of energy storage *** the rapid development of energy storage devices based on 2D BP,a timely review on this topic is in demand to further extend the application of 2D BP in energy *** this review,recent advances in experimental and theoretical development of 2D BP are presented along with its structures,properties,and synthetic ***,their emerging applications in electrochemical energy storage,including Li−/K−/Mg−/Na-ion,Li–S batteries,and supercapacitors,are systematically summarized with milestones as well as the *** from the fast-growing dynamic investigation of 2D BP,some possible improvements and constructive perspectives are provided to guide the design of 2D BP-based energy storage devices with high performance.

关键词： 2D black phosphorus Electronic structure Supercapacitors Batteries

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