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Conflict detection in collaborative architectural pipe routing design based on constraint network

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High Technology Letters 2013年第2期19卷 117-124页

作者：苏孝钐 tian Ling Department of Precision Instruments and Mechanology Tsinghua University

This paper analyzes conflict features in architecture pipe routing,and builds a pipe routing design conflict model by taking into account of discrete nominal internal diameter selection of pipes,material costs,and conflict solution *** pipe routing as an assembling process,a conflict detection approach for pipe routing in collaborative architectural design is proposed based on an aforementioned *** network is used to describe the relationship among pipe routing design parameters and constraints;design conflicts are detected by matching designers' input and constraint network;and detected design conflicts are reordered according to the number of pipe parameters in *** order to support the collaborative requirement of pipe routing design,a prototype system using browser/server architecture is *** illustrative example of water pipe routing in a room is used to show the effectiveness and efficiency of the approach.

关键词： conflict detection constraint network piping routing collaborative design archi-tectural pipe routing

Effect of the Nanoparticle Functionalization on the Cavitation and Crazing Process in the Polymer Nanocomposites

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Chinese Journal of Polymer Science 2021年第2期39卷 249-257,I0008页

作者： Yan-Long Luo tian-tian Li Bin Li Xian-Ling Chen Zhen-Yang Luo Yang-Yang Gao Li-Qun Zhang College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing 100029China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The nanoparticle(NP) functionalization is an effective method for enhancing their compatibility with polymer which can influence the fracture property of the polymer nanocomposites(PNCs). This work aims to further understand the cavitation and crazing process, hoping to uncover the fracture mechanism on the molecular level. By adopting a coarse-grained molecular dynamics simulation, the fracture energy of PNCs first increases and then decreases with increasing the NP functionalization degree α while it shows a continuous increase with increasing the interaction εpa between polymer and modified beads. The bond orientation degree is first characterized which is referred to as the elongation. Meanwhile, the stress by polymer chains is gradually reduced with increasing the α or the εpa while that by NPs is ***, the percentage of stress by polymer chains first increases and then decreases with increasing the strain while that by NPs shows a contrast trend. Moreover, the number of voids is quantified which first increases and then decreases with increasing the strain which reflects their nucleation and coalescence process. The voids prefer to generate from the polymer-NP interface to the polymer matrix with increasing α o r ε*** a result, the number of voids first increases and then decreases with increasing α while it continuously declines with the εpa. In summary, our work provides a clear understanding on how the NP functionalization influences the cavitation and crazing process during the fracture process.

关键词： Nanoparticle functionalization Cavitation and crazing Polymer nanocomposites Molecular dynamics simulation

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

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Protein & Cell 2015年第1期6卷 6-11页

作者： tian Yu John Bachman Zhi-Chun Lai Intercollege Graduate Degree Program in Molecular Cellular and Integrative Biosciences The Pennsylvania State University University Park PA 16802 USA Department of Biology The Pennsylvania State University University Park PA 16802 USA Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 USA

In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these muta- tions mean for cancer is a challenging question to address, especially for those from less understood putative new cancer genes. As a powerful approach, in silico bioinformatics analysis could efficiently sort out mutations that are predicted to damage gene function. Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1/12 as negative growth regulators and tumor suppressors.

关键词： LATS1 & LATS2 hippo signaling cancergenome human cancer

Accurate theoretical evaluation of strain energy of all-carboatomic ring(cyclo[2n]carbon),boron nitride ring,and cyclic polyacetylene

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Chinese Physics B 2022年第12期31卷 357-363页

作者： tian Lu Zeyu Liu Qinxue Chen Beijing Kein Research Center for Natural Sciences Beijing 100024China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Cyclocarbon fully consists of sp-hybridized carbon atoms,which shows quite unusual electronic and geometric structures compared to common *** this work,we systematically studied strain energy(SE)of cyclocarbons of different sizes using regression analysis method based on electronic energies evaluated at the very accurate DLPNO-CCSD(T)/ccp VTZ theoretical *** addition,ring strain of two systems closely related to cyclocarbon,boron nitride(BN)ring,and cyclic polyacetylene(c-pa),is also *** ideal relationships between SE and number of repeat units(n)are built for cyclo[2n]carbon,B_(n)N_(n),and[2n]c-pa as SE=555.0·n^(-1),145.1·n^(-1),and 629.8·n^(-1)kcal·mol^(-1),respectively,and the underlying reasons of the difference and similarity in their SEs are discussed from electronic structure *** addition,force constant of harmonic potential of C-C-C angles in cyclocarbon is derived based on SE values,the result is found to be 56.23 kcal·mol^(-1)·rad^(-2).The possibility of constructing homodesmotic reactions to calculate SEs of cyclocarbons is also explored in this work,although this method is far less rigorous than the regression analysis method,its result is qualitatively correct and has the advantage of much lower computational *** addition,comparisons show thatωB97XD/def2-TZVP is a good inexpensive alternative to the DLPNO-CCSD(T)/cc-p VTZ for evaluating energies used in deriving SE,while the popular and very cheap B3LYP/6-31G(d)level should be used with caution for systems with global electron conjugation such as c-pa.

关键词： strain energy ring strain cyclocarbon boron nitride ring cyclic polyacetylene quantum chemistry

dr1127:A novel gene of Deinococcus radiodurans responsible for oxidative stress

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Chinese Science Bulletin 2007年第15期52卷 2081-2087页

作者： WU YuanYuan tian Bing HUA YueJint Institute of Nuclear-Agricultural Sciences Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural SciencesZhejiang University Hangzhou 310029 China

The functional analysis of dr1127,a novel gene in Deinococcus radiodurans was performed in this pa-per. The dr1127 gene was found occasionally in our microarray and 2-DE gel experiments. Mutation of the dr1127 gene decreased the γ-radiation and H2O2 resistance of D. radiodurans,and weakened the scavenging abilities of cell extracts for free radicals (superoxide anion,hydrogen peroxide,and hy-droxyl radical). Further oxidative damage assays demonstrated that the purified DR1127 protein of D. radiodurans could bind to double stranded DNA in vitro and protect DNA from oxidative damage in this way. These results suggest that the dr1127 gene is an important gene that can maintain γ-radiation and oxidative resistance in D. radiodurans and may take part in the oxidative stress process.

关键词： dr1127 异常基因氧化损伤基因突变

High performance word level sequential and parallel coding methods and architectures for bit plane coding

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Science in China(Series F) 2008年第4期51卷 337-351页

作者： XIONG ChengYi tian JinWen LIU Jian College of Electronic Information Engineering South-Central University for Nationalities Wuhan 430074 China Institute of pattern Recognition & Artificial Intelligence Key Laboratory of Education Ministry for Image Processing and Intelligent Control Huazhong University of Science & Technology Wuhan 430074 China

This paper introduced a novel high performance algorithm and VLSI architectures for achieving bit plane coding （BPC） in word level sequential and parallel mode. The proposed BPC algorithm adopts the techniques of coding pass prediction and parallel ＆ pipeline to reduce the number of accessing memory and to increase the ability of concurrently processing of the system, where all the coefficient bits of a code block could be coded by only one scan. A new parallel bit plane architecture （pa） was proposed to achieve word-level sequential coding. Moreover, an efficient high-speed architecture （HA） was presented to achieve multi-word parallel coding. Compared to the state of the art, the proposed pa could reduce the hardware cost more efficiently, though the throughput retains one coefficient coded per clock. While the proposed HA could perform coding for 4 coefficients belonging to a stripe column at one intra-clock cycle, so that coding for an NxN code-block could be completed in approximate N2/4 intra-clock cycles. Theoretical analysis and experimental results demonstrate that the proposed designs have high throughput rate with good performance in terms of speedup to cost, which can be good alternatives for low power applications.

关键词： bit plane coding high performance word-level sequential multi-word parallel

Tourism Competitiveness Evaluation and Spatio-temporal Characteristics of Chinese Border Counties

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Chinese Geographical Science 2016年第6期26卷 817-828页

作者： SHI Yuqing ZHONG Linsheng CHEN tian YU Hu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Under the current government strategy of building a Silk Road economic belt, tourism in Chinese border counties has becoming increasingly popular. Studying tourism competitiveness in Chinese border counties is of sizable theoretical and practical importance, as there are several notable factors involved. In this study, we constructed a tourism competitiveness evaluation model based on eight factors: natural environment, tourism resource, location and transportation, social environment, tourism service facility, border port, tourism industrial cluster and tourism market. We then analyzed the spatial characteristics of tourism competitiveness in border counties and identified five types of border counties: resource advantage type(RA), border-port advantage type(pa), location advantage type(LA), agglomeration advantage type(AA), and relative balance type(RB), and examined the correlation between tourism market competitiveness and interior competitiveness factors in the counties from 2006 to 2011. Results showed that tourism resource, location and transportation, and tourism service facility are the most important competition factors for RA border counties during the study period. Competition factors in pa counties transferred from tourism resource, social environment and tourism service facility to border port and tourism industrial cluster; competition factors in LA counties transferred from natural environment and tourism resource to tourism service facility and tourism industrial cluster and border port. Competition factors in AA counties transferred from tourism service facility to tourism resource. Tourism industrial cluster, tourism service facility and tourism resource proved to be important competition factors in RB counties. The findings of this study can be used to target tourism strategies according to different county types.

关键词： border counties tourism competiveness spatio-temporal characteristics type classification

Effects of Phenylacetate on Cell Proliferation and Homeobox Genes Expression in the HCT-8 Colorectal Carcinoma Cell Line

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Chemical Research in Chinese Universities 2006年第2期22卷 239-241页

作者： ZHANG Yan REN Hui FANG Xue-dong tian Yu China-Japan Union Hospital Jilin University Changchun 130033 P. R. China No. 2 Affiliated Hospital Jilin University Changchun 130041 P. R. China

To study the effects of phenylacetate （pa） on cell proliferation and homeobox （HOX） genes expression in the colorectal carcinoma HCT-8 cell line, HCT-8 cells were grown in the presence or absence of pa. The cellular proliferation inhibition was evaluated by the MTT assay. Twenty-two HOX genes were divided into three groups （ P1, P2, P3） according to their primer sequences, and the samples of cells were analyzed for the HOX genes＇ mRNA expression by means of the semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR）. The level of the HOX genes＇ expression was expressed as the ratio expression rate of HOX gene to the β-actin. HCT-8 cells were treated with 1.0-5.0 mmol/L pa for 24-72 h. With the increase of the pa concentration or the prolongation of the treating time, the cell proliferation is inhibited in a dose- and time-dependent manner. The P1 group mRNA＊ expression（0. 5781 ±0. 0836） is significantly lower than that of the untreated group （0. 7701 ± 0. 0883 ） in HCT-8 cells （p 〈 0. 001 ）. Both the mRNA expressions of groups P2 （0. 3941 ± 0. 0819） and P3 （0. 5601 ± 0. 0736） in the pa treated group are significantly higher than those of the untreated groups P2（0. 1221±0. 0782） and P3 （0. 1806 ± 0. 0811 ） in HCT-8 cells（p 〈 0. 001）. pa could effectively inhibit cell proliferation by regulating the HOX genes expression and the mechanisms of the pa action are correlated with the transcription process in HCT-8 cells.

关键词： Phenylacetate Colorectal carcinoma Homeobox gene

Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in young Adult Rats

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Current Medical Science 2022年第5期42卷 981-990页

作者： Xiang-tian XIAO Shui-qing HE Nan-nan WU Xue-chun LIN Jing ZHAO Chong tian Medical College of Wuhan University of Science and Technology Wuhan430081China Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and SafetySchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Public Health and Management Research Center for Medicine and Social DevelopmentInnovation Center for Social Risk Governance in HealthChongqing Medical UniversityChongqing400016China School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Epidemiology studies indicate that green tea polyphenols(GTP)perform a protective effect on cardiovascular diseases,but the underlying mechanisms are *** present study aimed to investigate the effect of GTP on high-fat diets(HFD)induced-early vascular *** Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP(200 mg/kg body weight)for 18 *** vitro experiment,human umbilical vascular endothelial cells(HUVECs)were treated with palmitic acid(pa)and *** The results showed that GTP alleviated the disorganized arterial wall and the increased intima-media thickness induced by *** addition,the vascular oxidative injury was suppressed following GTP ***,GTP elevated the ratio of LC3-II/LC3-I and suppressed expression of p62/SQSTM1,and restored SIRT3 expression in the aorta of HFD ***,in cultured HUVECs,GTP inhibited cell senescence indicated by SA-β-gal and promoted endothelial autophagy compared with the pa treatment *** activity of SIRT3 was specifically inhibited by 3-TYP,and the protective effect of GTP was consequently *** The findings indicated that GTP protected against early vascular senescence in young HFD rats via ameliorating oxidative injury and promoting autophagy which was partially regulated by the SIRT3 pathway.

关键词： high-fat diets green tea polyphenols early vascular aging autophagy Sirtuin 3